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Conserved domains on  [gi|84875513|ref|NP_001034178|]
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protein sel-1 homolog 1 isoform a precursor [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12186032)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
359-548 2.05e-50

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 177.04  E-value: 2.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 359 YYQFLAEKGDVQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAA 438
Cdd:COG0790  53 AAAAAAAAGGAEAQYNLGLMYAEG-RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEWYEKAA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 439 DMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAF 518
Cdd:COG0790 131 EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQ 210

                       170       180       190
                ....*....|....*....|....*....|
gi 84875513 519 YNLAQMHASGTGVMRSCHTAVELFKNVCER 548
Cdd:COG0790 211 YNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 116-164 3.80e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.53  E-value: 3.80e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 84875513    116 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 660-693 4.23e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


:

Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 84875513   660 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 693
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 625-658 1.02e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 84875513    625 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 658
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 251-286 8.49e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


:

Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 8.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 84875513    251 PKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGN 286
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
359-548 2.05e-50

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 177.04  E-value: 2.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 359 YYQFLAEKGDVQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAA 438
Cdd:COG0790  53 AAAAAAAAGGAEAQYNLGLMYAEG-RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEWYEKAA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 439 DMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAF 518
Cdd:COG0790 131 EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQ 210

                       170       180       190
                ....*....|....*....|....*....|
gi 84875513 519 YNLAQMHASGTGVMRSCHTAVELFKNVCER 548
Cdd:COG0790 211 YNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 116-164 3.80e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.53  E-value: 3.80e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 84875513    116 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 117-164 1.52e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 93.91  E-value: 1.52e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 84875513 117 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
123-164 3.92e-22

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 89.55  E-value: 3.92e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 84875513   123 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 479-514 6.11e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 6.11e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 84875513    479 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 514
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 443-477 3.31e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 3.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 84875513   443 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 477
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 660-693 4.23e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 84875513   660 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 693
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 660-692 6.73e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 6.73e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 84875513    660 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 692
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 625-658 1.02e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 84875513    625 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 658
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 625-656 6.28e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 6.28e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 84875513   625 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 656
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 251-286 8.49e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 8.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 84875513    251 PKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGN 286
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
359-548 2.05e-50

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 177.04  E-value: 2.05e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 359 YYQFLAEKGDVQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAA 438
Cdd:COG0790  53 AAAAAAAAGGAEAQYNLGLMYAEG-RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEWYEKAA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 439 DMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAF 518
Cdd:COG0790 131 EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQ 210

                       170       180       190
                ....*....|....*....|....*....|
gi 84875513 519 YNLAQMHASGTGVMRSCHTAVELFKNVCER 548
Cdd:COG0790 211 YNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
357-509 5.70e-42

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 153.16  E-value: 5.70e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 357 IQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKK 436
Cdd:COG0790  87 LEWFEKAAEQGDAEAQYNLGLMYEE-GLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRK 164

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 84875513 437 AADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLA 509
Cdd:COG0790 165 AAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
TPR COG0790
TPR repeat [General function prediction only];
358-549 2.77e-40

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 148.54  E-value: 2.77e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 358 QYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKA 437
Cdd:COG0790  15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRG-VPKDYEKALEWFEKA 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 438 ADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILA 517
Cdd:COG0790  94 AEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADA 173

                       170       180       190
                ....*....|....*....|....*....|..
gi 84875513 518 FYNLAQMHASGTGVMRSCHTAVELFKNVCERG 549
Cdd:COG0790 174 QYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205
TPR COG0790
TPR repeat [General function prediction only];
393-694 7.38e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 144.30  E-value: 7.38e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 393 AFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 472
Cdd:COG0790  13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 473 AAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKnvcergrws 552
Cdd:COG0790  93 AAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYR--------- 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 553 erlmtaynsykdedynaavvqylllaeqgyevaqsnaafildqreativgenetyprallhwnRAASQGYTVARIKLGDY 632
Cdd:COG0790 164 ---------------------------------------------------------------KAAEQGDADAQYNLGVL 180

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 84875513 633 HFYGFGTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEAS 694
Cdd:COG0790 181 YENGRGVPKDPAKALEWYRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQA 241
TPR COG0790
TPR repeat [General function prediction only];
153-476 7.33e-30

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 118.49  E-value: 7.33e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 153 YDYKTDEKWGFCETEEDAAKRRQMQEAEMIYQAGMKILNGSNRKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLT 232
Cdd:COG0790   1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 233 QNIQAAKEMFEKLTEEGSPKGQTGLGFLYASGLGVNSSQAKAlvyytfgalggnliahmilgyrywagigvlqscesalt 312
Cdd:COG0790  81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKA-------------------------------------- 122

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 313 hyrlvanhvasdisltggsvvqrirlpdevenpgmnsgmleedlIQYYQFLAEKGDVQAQVGLGQLHLHgGRGVEQNHQR 392
Cdd:COG0790 123 --------------------------------------------LEWYEKAAEQGDADAQYNLGLLYLN-GEGVPKDPAK 157

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 393 AFDYFNLAANAGNSHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQK 472
Cdd:COG0790 158 AAEWYRKAAEQGDADAQYNLGVLYENGRG-VPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRK 236


                ....
gi 84875513 473 AAEQ 476
Cdd:COG0790 237 AAEQ 240
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 116-164 3.80e-25

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 98.53  E-value: 3.80e-25
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 84875513    116 GTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:smart00059   1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 117-164 1.52e-23

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 93.91  E-value: 1.52e-23
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 84875513 117 TAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:cd00062   1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
123-164 3.92e-22

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 89.55  E-value: 3.92e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 84875513   123 CHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFC 164
Cdd:pfam00040   1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 479-514 6.11e-08

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 49.09  E-value: 6.11e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 84875513    479 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGH 514
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 443-477 2.00e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 47.55  E-value: 2.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 84875513    443 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 477
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 443-477 3.31e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 3.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 84875513   443 PVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQG 477
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 660-693 4.23e-07

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 46.75  E-value: 4.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 84875513   660 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEA 693
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 660-692 6.73e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 6.73e-07
                           10        20        30
                   ....*....|....*....|....*....|...
gi 84875513    660 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAE 692
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 354-587 7.43e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 7.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 354 EDLIQYYQFLAEKGD--VQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDIvpqsnET 429
Cdd:COG2956  59 DRAIRIHQKLLERDPdrAEALLELAQDYLKAGL-----LDRAEELLEklLELDPDDAEALRLLAEIYEQEGDW-----EK 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 430 ALHYFKKAADMGNPVGQSGLGMAYLYGRgvQVNYDLALKYFQKA--AEQGWVDGQLQLGSMYYNgigvKRDYKQALKYFN 507
Cdd:COG2956 129 AIEVLERLLKLGPENAHAYCELAELYLE--QGDYDEAIEALEKAlkLDPDCARALLLLAELYLE----QGDYEEAIAALE 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 508 --LASQGGHILAFYNLAqmhasgtgvmrschtavELFKNVCERGRWSERLMTAYNSYKDEDYNAAVVQyLLLAEQGYEVA 585
Cdd:COG2956 203 raLEQDPDYLPALPRLA-----------------ELYEKLGDPEEALELLRKALELDPSDDLLLALAD-LLERKEGLEAA 264


                ..
gi 84875513 586 QS 587
Cdd:COG2956 265 LA 266
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 479-513 9.20e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.89  E-value: 9.20e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 84875513   479 VDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGG 513
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 406-442 1.97e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 42.16  E-value: 1.97e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 84875513    406 SHAMAFLGKMYSEGsDIVPQSNETALHYFKKAADMGN 442
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 406-441 6.36e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.58  E-value: 6.36e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 84875513   406 SHAMAFLGKMYSEGSDiVPQSNETALHYFKKAADMG 441
Cdd:pfam08238   1 AEAQYRLGYLYLYGLG-VPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 369-405 7.70e-05

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 40.23  E-value: 7.70e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 84875513    369 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAGN 405
Cdd:smart00671   1 AEAQYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
368-620 7.90e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 7.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 368 DVQAQVGLGQLHLHGGRgveqnHQRAFDYFN--LAANAGNSHAMAFLGKMYSEGSDivpqsNETALHYFKKAADM--GNP 443
Cdd:COG0457   7 DAEAYNNLGLAYRRLGR-----YEEAIEDYEkaLELDPDDAEALYNLGLAYLRLGR-----YEEALADYEQALELdpDDA 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 444 VGQSGLGMAYLYgRGvqvNYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFY 519
Cdd:COG0457  77 EALNNLGLALQA-LG---RYEEALEDYDKALELdpDDAEALYNLGLALLE----LGRYDEAIEAYEraLELDPDDADALY 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 520 NLAQMHASgtgvMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDEDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREAT 599
Cdd:COG0457 149 NLGIALEK----LGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLL 224

                       250       260
                ....*....|....*....|.
gi 84875513 600 IVGENETYPRALLHWNRAASQ 620
Cdd:COG0457 225 LALALLLALRLAALALYQYRA 245
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 625-658 1.02e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 39.85  E-value: 1.02e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 84875513    625 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQH 658
Cdd:smart00671   3 AQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 369-404 2.44e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 39.04  E-value: 2.44e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 84875513   369 VQAQVGLGQLHLHGgRGVEQNHQRAFDYFNLAANAG 404
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 462-704 1.86e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 462 NYDLALKYFQKAAEQ--GWVDGQLQLGSMYYNgigvKRDYKQALKYFN--LASQGGHILAFYNLAQMHASgTGVMRScht 537
Cdd:COG2956  23 QPDKAIDLLEEALELdpETVEAHLALGNLYRR----RGEYDRAIRIHQklLERDPDRAEALLELAQDYLK-AGLLDR--- 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 538 AVELFKNVCERGRWSE----RLMTAYNSYKDEDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREAtivgenetYPRALLH 613
Cdd:COG2956  95 AEELLEKLLELDPDDAealrLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD--------YDEAIEA 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 84875513 614 WNRA--ASQGYTVARIKLGDYHFYGFgtdvDYETAFIHYRLASEQQH-SAQAMFNLGYMHEKgLGIKQDihlAKRFYDMA 690
Cdd:COG2956 167 LEKAlkLDPDCARALLLLAELYLEQG----DYEEAIAALERALEQDPdYLPALPRLAELYEK-LGDPEE---ALELLRKA 238

                       250
                ....*....|....
gi 84875513 691 AEASPDAQVPVFLA 704
Cdd:COG2956 239 LELDPSDDLLLALA 252
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 519-549 2.60e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.00  E-value: 2.60e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 84875513    519 YNLAQMHASGTGVMRSCHTAVELFKNVCERG 549
Cdd:smart00671   5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 625-656 6.28e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 34.80  E-value: 6.28e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 84875513   625 ARIKLGDYHFYGFGTDVDYETAFIHYRLASEQ 656
Cdd:pfam08238   3 AQYRLGYLYLYGLGVPKDPEKALEWYEKAAEL 34
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 251-286 8.49e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 8.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 84875513    251 PKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGN 286
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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