Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 124486690  1008 TLWALDIHGKLWFRTGVVPKKPQGddDHWWQV 1039
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124486690    90 DLVAAGTASGRVAVF----QLVSSLPGRNKQLRrfdvtgvhktsITALAWSPNGMKLFSGDDKGKI 151
Cdd:pfam12894    8 DLIALATEDGELLLHrlnwQRVWTLSPDKEDLE-----------VTSLAWRPDGKLLAVGYSDGTV 62

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 124486690  1008 TLWALDIHGKLWFRTGVVPKKPQGddDHWWQV 1039
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTG--TSWEHV 30

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 124486690   1360 DYWKKIPGSVSCFTVTSSDELWAVGSSGCLLQR 1392
Cdd:smart00706    1 GSWTQVPGELVQVSVGPSDTVWAVNSDGNIYRR 33

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;

                            10        20
                    ....*....|....*....|....*..
gi 124486690    997 EPVCITLGDQHTLWALDIHGKLWFRTG 1023
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35

Tectonin domain; This entry represents proteins homologous to tectonin. This protein adopts a 6 bladed beta propeller structure.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486690  1195 WALDSLGQVFIRTLSKscptgmhWTKLDlsqlGtvRLTSLACGNQHIWACDSRGGVYFRVGTQplnpslmlpaWimiepp 1274
Cdd:pfam19193   13 WGVDSAGNVYYLTGSS-------WVRVP----G--RLKHVSVGPAGVWGVNSNNKIYKYVGGS----------W------ 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486690  1275 VQLAGvTLVSVHSSPnDQMLWALDSRWNVHVRTGITEEMPVGTDWEHVPGLQAcQLALSTRTVWARCPNGDLARRYGITD 1354
Cdd:pfam19193   64 VPVDG-SLKQVDAGG-DGQVWGVNSADDIYCLNGDDASSYAGLPWTQVDGSLK-YYSCGPGGCWGVNSNDDIYYRRYVGP 140

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 124486690  1355 KNPAGDYWKKIPGSVSCFTVTSSDELWAVGSSGCLLQRLTKTFShshNPQ 1404
Cdd:pfam19193  141 STCGGTGWTQVPGKLKMIEVGSDGSVFGVNSNGNVYQRTGISSS---NPT 187

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.

                           10        20        30
                   ....*....|....*....|....*....|
gi 124486690  1336 TVWARCPNGDLARRYGITDKNPAGDYWKKI 1365
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWEHV 30

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.

                           10        20
                   ....*....|....*....|....*...
gi 124486690   959 VVWALTEQRALLYREGVSSFCPEGEQWK 986
Cdd:pfam06462    1 QVWAVTSDGRVYFRTGVTPSNPTGTSWE 28

Propeller; Tectonins I and II are two dominant proteins in the nuclei and nuclear matrix from plasmodia of Physarum polycephalum (Slime mold) and both proteins contain six tandem repeats that are each 33-37 amino acids in length. Homologous repeats are found in L-6, a bacterial lipopolysaccharide-binding lectin from horseshoe crab hemocytes. The repetitive sequences of the tectonins and L-6 are reminiscent of the WD repeats of the beta-subunit of G proteins, suggesting that they form beta-propeller domains. The tectonins may be lectins that function as part of a transmembrane signalling complex during phagocytosis. Tectonin beta-propeller repeat-containing protein 1 (TECPR1) has a critical function during autophagosome maturation and autophagosome-lysosome fusion.

                           10        20        30
                   ....*....|....*....|....*....|
gi 124486690  1193 ALWALDSLGQVFIRT-LSKSCPTGMHWTKL 1221
Cdd:pfam06462    1 QVWAVTSDGRVYFRTgVTPSNPTGTSWEHV 30

Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins;

                            10        20
                    ....*....|....*....|....*..
gi 124486690    997 EPVCITLGDQHTLWALDIHGKLWFRTG 1023
Cdd:smart00706    9 ELVQVSVGPSDTVWAVNSDGNIYRRTG 35