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Conserved domains on  [gi|126506316|ref|NP_001075432|]
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junctional cadherin 5-associated protein [Mus musculus]

Protein Classification

JCAD domain-containing protein( domain architecture ID 12173170)

JCAD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1308 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


:

Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1918.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316     1 MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHR 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316    81 EHQSTS--RTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGR 158
Cdd:pfam15351   81 EPQSTSasRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   159 TEHVMKNAIWEEELRM------QDMSLESWKKPRELGRQASDGDGRKRPQEkfegLYPFVHGEH--TSQNRKKSQSLPRA 230
Cdd:pfam15351  161 TEHVMKKAVWEEELRMsgpakwQNVSLESWNQPRKLGRQMSDGDGEKLFQD----LYPFIQGEHvlTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   231 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPRG---EGG 307
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   308 FQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVP-EKPETSC 386
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPtEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   387 PLPSGSLAARDLYDAMPGSPpQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSYNPGLLTTQEP 466
Cdd:pfam15351  397 QLPSGSLGTGNEYGASPRSP-RGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   467 AIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLPLGIGPGGFHGQTEHHVMGGLTTNVTDIK---AEGHASS 543
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   544 PQPQSEGTCKTYTKLRKFETGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQS 623
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   624 LLSMSSTDLELQALMGSMAWRRTSPRQGLRESE-DGQIDDPRILHLIKPKELQASSPWPGHQYRDQQTQTSFHEDSKSSQ 702
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   703 LLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQNQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQ 782
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   783 ------LPGANPVPKPEVVKGEsTTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEES---HGGSGSEDSEA 853
Cdd:pfam15351  796 pcvdvrGRGASPVPRGEVVKGE-TTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESsssSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   854 E-QPEDCADSRTKSWALQGT----RTAQQPAGLALEN-VASPDRRLNDSQSWNEEPKPGHSSVHPQSLGPSQEEGSRGVP 927
Cdd:pfam15351  875 EwQPEDCADSRPKSPGFREDsqemRVEQQPRRLVPEDpVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   928 VQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIA---PIDTKAAPLYCLSEPRGSQELTKFGDAVGSVQLGRETPTQVG 1004
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1005 NGGDTEVLPCvlLPLADKYRGHSTPDFRSLELTLGQEQNAYKLE-CLDLENTVEVLPSESLQERAERILGIEVAVESLLP 1083
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1084 SARRTEQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGER-----APQASICSDVDGF 1158
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1159 PTSQATSPEPG----------KKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIR 1228
Cdd:pfam15351 1193 VPSQAPSPEPQpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1229 MREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQ-----NENGHPEVPRDKMSD 1303
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 126506316  1304 QDLWC 1308
Cdd:pfam15351 1353 QDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1308 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1918.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316     1 MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHR 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316    81 EHQSTS--RTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGR 158
Cdd:pfam15351   81 EPQSTSasRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   159 TEHVMKNAIWEEELRM------QDMSLESWKKPRELGRQASDGDGRKRPQEkfegLYPFVHGEH--TSQNRKKSQSLPRA 230
Cdd:pfam15351  161 TEHVMKKAVWEEELRMsgpakwQNVSLESWNQPRKLGRQMSDGDGEKLFQD----LYPFIQGEHvlTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   231 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPRG---EGG 307
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   308 FQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVP-EKPETSC 386
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPtEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   387 PLPSGSLAARDLYDAMPGSPpQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSYNPGLLTTQEP 466
Cdd:pfam15351  397 QLPSGSLGTGNEYGASPRSP-RGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   467 AIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLPLGIGPGGFHGQTEHHVMGGLTTNVTDIK---AEGHASS 543
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   544 PQPQSEGTCKTYTKLRKFETGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQS 623
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   624 LLSMSSTDLELQALMGSMAWRRTSPRQGLRESE-DGQIDDPRILHLIKPKELQASSPWPGHQYRDQQTQTSFHEDSKSSQ 702
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   703 LLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQNQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQ 782
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   783 ------LPGANPVPKPEVVKGEsTTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEES---HGGSGSEDSEA 853
Cdd:pfam15351  796 pcvdvrGRGASPVPRGEVVKGE-TTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESsssSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   854 E-QPEDCADSRTKSWALQGT----RTAQQPAGLALEN-VASPDRRLNDSQSWNEEPKPGHSSVHPQSLGPSQEEGSRGVP 927
Cdd:pfam15351  875 EwQPEDCADSRPKSPGFREDsqemRVEQQPRRLVPEDpVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   928 VQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIA---PIDTKAAPLYCLSEPRGSQELTKFGDAVGSVQLGRETPTQVG 1004
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1005 NGGDTEVLPCvlLPLADKYRGHSTPDFRSLELTLGQEQNAYKLE-CLDLENTVEVLPSESLQERAERILGIEVAVESLLP 1083
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1084 SARRTEQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGER-----APQASICSDVDGF 1158
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1159 PTSQATSPEPG----------KKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIR 1228
Cdd:pfam15351 1193 VPSQAPSPEPQpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1229 MREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQ-----NENGHPEVPRDKMSD 1303
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 126506316  1304 QDLWC 1308
Cdd:pfam15351 1353 QDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1308 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1918.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316     1 MYSVEDLLISHGYKPARDAAAPCEDKSERCRSTRTGPRAGQGLLNGYKDGATAHTHSRTSLGTGHVSNSENRISRPRGHR 80
Cdd:pfam15351    1 MYSVEDLLISHGYKLSRDLPAPREDRYEGRQQARTRTRAGHGLLNGCEDGPAALAHSKKSLGKGHVSDSESRRRGPRGHG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316    81 EHQSTS--RTPEARFLNQPSLAWSSQPQSGRDDIYWSRGRQEGSGSLCPRDWKELESRGMAQAYSLPVHVRENLWEVAGR 158
Cdd:pfam15351   81 EPQSTSasRASEAGFYNQPVLAWSSQPQTGKDHAYWRRRGQEVSGLLGPRDREDLEVRGMAQAHSLPVHVREGPWEVGGR 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   159 TEHVMKNAIWEEELRM------QDMSLESWKKPRELGRQASDGDGRKRPQEkfegLYPFVHGEH--TSQNRKKSQSLPRA 230
Cdd:pfam15351  161 TEHVMKKAVWEEELRMsgpakwQNVSLESWNQPRKLGRQMSDGDGEKLFQD----LYPFIQGEHvlTSQNKGKSQSLPRV 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   231 LSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSFPSPSEPMRNLEKASSSGPFPRPKFGKPLKTPCYSSHSQPRG---EGG 307
Cdd:pfam15351  237 LSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKPPSYESHQQSRGgveNSD 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   308 FQDHQHRDPRGSYPTRSKDPSHELGMLDPGLEPPVYVPPPSYRSPPQHIPNPYLEDPVPRHVSSNQSQQQVP-EKPETSC 386
Cdd:pfam15351  317 YQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVSGGHSQQQHPtEKPGASC 396

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   387 PLPSGSLAARDLYDAMPGSPpQGLPPQPYPIATHGGSIQYIPFDDPRIRHIKLAQPPEFYEEAKLDDTSYNPGLLTTQEP 466
Cdd:pfam15351  397 QLPSGSLGTGNEYGASPRSP-RGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETKLDDKSYSSGPVTAQEP 475

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   467 AIGKRQYDDAPSVPRGPTPSPVNEQSSAFVHSSPRWLQGQLPLGIGPGGFHGQTEHHVMGGLTTNVTDIK---AEGHASS 543
Cdd:pfam15351  476 ARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWPDVRGSQhghAEGQVSS 555

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   544 PQPQSEGTCKTYTKLRKFETGVQSKKSSKKKSNATIFCLVSIPVKSESLVLATDTNNNDFKLVADKTRGLCQGSALQEQS 623
Cdd:pfam15351  556 PSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSADKKNGLDKSGALQEQS 635

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   624 LLSMSSTDLELQALMGSMAWRRTSPRQGLRESE-DGQIDDPRILHLIKPKELQASSPWPGHQYRDQQTQTSFHEDSKSSQ 702
Cdd:pfam15351  636 LLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWPGHQYRDQQTQTSFTEESKSSQ 715

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   703 LLPATKPGEASNVAPTPTCPDTTASEVCLHTALAFSDQNQKPSVPHLQGQTSLSPSRNSAFSRTSSAINQASMSKGTSDQ 782
Cdd:pfam15351  716 LLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRTSSSINQAPVPKAGQSQ 795

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   783 ------LPGANPVPKPEVVKGEsTTGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEES---HGGSGSEDSEA 853
Cdd:pfam15351  796 pcvdvrGRGASPVPRGEVVKGE-TTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQEEEESsssSSGSSSEDSEA 874

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   854 E-QPEDCADSRTKSWALQGT----RTAQQPAGLALEN-VASPDRRLNDSQSWNEEPKPGHSSVHPQSLGPSQEEGSRGVP 927
Cdd:pfam15351  875 EwQPEDCADSRPKSPGFREDsqemRVEQQPRRLVPEDpVFRSGRVKSKSESWSEEPKPGHPCACPQSPGPSQVEDGRGEP 954

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316   928 VQWADGSLTAEQKSQEDLNGMCERDFSPRPVSRIA---PIDTKAAPLYCLSEPRGSQELTKFGDAVGSVQLGRETPTQVG 1004
Cdd:pfam15351  955 FLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQESQKLPDALSSVQLSKAAPPRAG 1034

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1005 NGGDTEVLPCvlLPLADKYRGHSTPDFRSLELTLGQEQNAYKLE-CLDLENTVEVLPSESLQERAERILGIEVAVESLLP 1083
Cdd:pfam15351 1035 GGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNESLQARAARILGIEVAVESLLP 1112

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1084 SARRTEQSQLPEPDASACNPSSSREDSSHSLALPVGPKVATDAFYGRRKCGWTESPLFVGER-----APQASICSDVDGF 1158
Cdd:pfam15351 1113 GARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERdsarrAPQASEHSGVDGV 1192

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1159 PTSQATSPEPG----------KKDEEAKAPFKSTLFHFMEKSTNVVGPEKRLRNPSKVVENLQEKLVSPPKKADSVHLIR 1228
Cdd:pfam15351 1193 VPSQAPSPEPQpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEKLASPPRRADPDRLMR 1272

                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 126506316  1229 MREVNSLSQMRCLSSKSADSVEEPDPLKVIKSSAWLSEGLTSLGGKDEAWQAGHLPSVSQ-----NENGHPEVPRDKMSD 1303
Cdd:pfam15351 1273 MKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVSKgiislEENGHPAAQREKNGD 1352


                   ....*
gi 126506316  1304 QDLWC 1308
Cdd:pfam15351 1353 QDFWC 1357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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