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Conserved domains on  [gi|153792647|ref|NP_001093165|]
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DNA-binding protein REPIN1 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416201)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048  191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048  269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                        330       340
                 ....*....|....*....|....*....
gi 153792647 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048  283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048  363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*.
gi 153792647 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048  442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048  191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048  269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                        330       340
                 ....*....|....*....|....*....
gi 153792647 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792647  558 NLVSHRRIHTGERPYACPDCDRSFSQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048  283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048  363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*.
gi 153792647 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048  442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
PHA00733 PHA00733
hypothetical protein
 571-624 9.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153792647 571 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 624
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
290-597 1.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 290 DRPFQCACCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIHTGEKPY-PCKECGRRFRHKPNLLS 366
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 367 HSKIHKRSEGSAQAAPGPGSPQ------------------LPAGPQESAAEPTPA---VPLKPAQEPPPGAPPEHPQDPI 425
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdllsisnlrnnpLPGNNSSSVNTPQSNslhPPLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 426 EAPPSLYS--CDDCGRSFRLERFLRAHQRQHTGERPFTCAECgkNFGKKTHLVAHSRVH--SGERPFACEECGR------ 495
Cdd:COG5048  191 NVSTSIPSssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSlsSSDSSSSASESPRsslpta 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 496 RFSQGSHLAAHRRDH-APDRPFVCPDCGKAFRHKPYLAAHRR--IHTGE--KPYVCP--DCGKAFSQKSNLVSHRRIHTG 568
Cdd:COG5048  269 SSQSSSPNESDSSSEkGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS 348

                        330       340
                 ....*....|....*....|....*....
gi 153792647 569 ERPYACPDCDRSFSQKSNLITHRKSHIRD 597
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-622 3.22e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 319 RPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFR----------------HKPNLLSHSKIHKRSEGSAQAAP 382
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfsrplelsrhlrthhnNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 383 GPGS-------------------PQLP---------------------AGPQESAAEPtPAVPLKPAQEPPPGAPPEHPQ 422
Cdd:COG5048  112 SSSSnsndnnllsshslppssrdPQLPdllsisnlrnnplpgnnsssvNTPQSNSLHP-PLPANSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 423 DPIEAPPSLYSCDDCGRS-------------------------FRLERFLRAHQRQHTGER--PFTCAECGKNFGKKTHL 475
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSysipssssdqnlensssslplttnsQLSPKSLLSQSPSSLSSSdsSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 476 VAHSRVHSGER-------PFACEECGRRFSQGSHLAAHRR--DH--APDRPFVCP--DCGKAFRHKPYLAAHRRIHTGEK 542
Cdd:COG5048  271 QSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHsgESLKPFSCPysLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 543 PYVCP--DCGKAFSQKSN-----LVSHRRIHTGERPYAC--PDCDRSFSQKSNLITHRKSHIRDGAFCC--AICGQTFDD 611
Cdd:COG5048  351 PAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNR 430

                        410
                 ....*....|.
gi 153792647 612 EERLLAHQKKH 622
Cdd:COG5048  431 HYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
311-597 1.12e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 311 HRRVHTGERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLLSHSKIHKRSEgSAQAAPGPGSPQLP 390
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS-SSSASESPRSSLPT 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 391 AGPQESAAEPTPAVPLKpaqepppgappehpqdpieAPPSLYSCDDCGRSFRLERFLRAHQRQ--HTGE--RPFTCAE-- 464
Cdd:COG5048  268 ASSQSSSPNESDSSSEK-------------------GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYsl 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 465 CGKNFGKKTHLVAHSRVHSGERPFAC--EECGRRFSQGSH-----LAAHRRDHAPDRPFVC--PDCGKAFRHKPYLAAHR 535
Cdd:COG5048  329 CGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHI 408

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 153792647 536 RIHTGEKPYVC--PDCGKAFSQKSNLVSHRRIHTGERPYACPDCDRSFSQKsnlitHRKSHIRD 597
Cdd:COG5048  409 ITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL-----DLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
292-481 4.41e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 292 PFQCACCGKRFRHKPNLIAHRR--VHTGE--RPHQCPE--CGKRFTNKPYLTSHRRIHTGEKPYPCKECGRRFRHKPNLl 365
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL- 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 366 shskiHKRSEGSAQAAPGP--GSPQLPAGPQESAAEPTPAVPLKpaqepppgappeHPQDPIEAPPSLYSCDDCGRSFRL 443
Cdd:COG5048  368 -----NNEPPQSLQQYKDLknDKKSETLSNSCIRNFKRDSNLSL------------HIITHLSFRPYNCKNPPCSKSFNR 430

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 153792647 444 ERFLRAHQRQHTGERPFTCAECGKNFGKKtHLVAHSRV 481
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKSFRRDL-DLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 1.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792647  558 NLVSHRRIHTGERPYACPDCDRSFSQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
530-555 2.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.45e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792647  530 YLAAHRRIHTGEKPYVCPDCGKAFSQ 555
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-360 3.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792647  335 YLTSHRRIHTGEKPYPCKECGRRFRH 360
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-332 4.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 153792647  307 NLIAHRRVHTGERPHQCPECGKRFTN 332
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 544-566 6.52e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|...
gi 153792647  544 YVCPDCGKAFSQKSNLVSHRRIH 566
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-594 2.27e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.27e-03
                          10        20
                  ....*....|....*....|...
gi 153792647  572 YACPDCDRSFSQKSNLITHRKSH 594
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 321-343 4.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|...
gi 153792647  321 HQCPECGKRFTNKPYLTSHRRIH 343
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 6.67e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.67e-03
                          10        20
                  ....*....|....*....|...
gi 153792647  516 FVCPDCGKAFRHKPYLAAHRRIH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-369 8.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 8.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 195 HSAAKRPIACPKCERRFWRRKQLRAHLRRCHPPAPEARPFICG--NCGRSFAQWDQLVAHKRVHVAEALEEAAAKALGPR 272
Cdd:COG5048  283 EKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSK 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 153792647 273 PRG-----RPAVTAPRPGGDAvDRPFQCA--CCGKRFRHKPNLIAHRRVHTGERPHQC--PECGKRFTNKPYLTSHRRIH 343
Cdd:COG5048  363 FSPllnnePPQSLQQYKDLKN-DKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIH 441

                        170       180
                 ....*....|....*....|....*.
gi 153792647 344 TgEKPYPCKECGRRFRHKPNLLSHSK 369
Cdd:COG5048  442 T-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-469 8.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.92e-03
                          10        20
                  ....*....|....*....|...
gi 153792647  447 LRAHQRQHTGERPFTCAECGKNF 469
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
PHA00733 PHA00733
hypothetical protein
 571-624 9.45e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 9.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 153792647 571 PYACPDCDRSFSQKSNLithrKSHIR--DGAFCCAICGQTFDDEERLLAHQ-KKHDV 624
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSL----KQHIRytEHSKVCPVCGKEFRNTDSTLDHVcKKHNI 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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