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Conserved domains on  [gi|215276950|ref|NP_001093969|]
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plakophilin-2 [Rattus norvegicus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 12192440)

armadillo/beta-catenin-like repeat-containing protein similar to catenin delta and plakophilin

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-382 8.31e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 8.31e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 215276950   342 KSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVF 382
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 584-625 7.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 34.74  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215276950  584 SPRGIEWLWHSIVIRMYLSLIaKSSRNYTQEASLGALQNLTA 625
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-382 8.31e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 8.31e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 215276950   342 KSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVF 382
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 343-381 7.34e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 7.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 215276950  343 SEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLV 381
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 584-625 7.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 34.74  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215276950  584 SPRGIEWLWHSIVIRMYLSLIaKSSRNYTQEASLGALQNLTA 625
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 342-382 8.31e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.96  E-value: 8.31e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 215276950   342 KSEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLVF 382
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 343-381 7.34e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.29  E-value: 7.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 215276950  343 SEARKRVNQLQGIPKLLQLLKVQNEDVQRAVCGALRNLV 381
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 584-625 7.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 34.74  E-value: 7.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 215276950  584 SPRGIEWLWHSIVIRMYLSLIaKSSRNYTQEASLGALQNLTA 625
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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