NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|161078262|ref|NP_001097773|]
View 

flyers-cup, isoform D [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-307 2.69e-42

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.09  E-value: 2.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   7 DINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNalvelpPEIGKLEKLVRL 86
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  87 NVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELP 166
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 167 PDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKI 246
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKT 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262 247 LDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDI 307
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-307 2.69e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.09  E-value: 2.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   7 DINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNalvelpPEIGKLEKLVRL 86
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  87 NVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELP 166
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 167 PDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKI 246
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKT 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262 247 LDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDI 307
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-298 5.57e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 5.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 94
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  95 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 166
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 167 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 220
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 221 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 297
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 161078262 298 N 298
Cdd:PLN00113 557 N 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-305 8.90e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 8.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 151 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 230
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 231 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 279
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 161078262 280 LPVTLSSLAHLISLQVEGNPIKTIRR 305
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
37-93 6.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 161078262   37 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 93
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
7-307 2.69e-42

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.09  E-value: 2.69e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   7 DINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNalvelpPEIGKLEKLVRL 86
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  87 NVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELP 166
Cdd:COG4886  119 DLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLP 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 167 PDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKI 246
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPP--LANLTNLKT 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262 247 LDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDI 307
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-296 1.75e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 150.08  E-value: 1.75e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   5 LYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNtlthisPKIENLQSLTVLTLHDNALVELPPEIGKLEKLV 84
Cdd:COG4886   66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLK 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  85 RLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKE 164
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTD 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 165 LPPDLVNMRSLQKIDLMHNDLTSLPEdMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHL 244
Cdd:COG4886  220 LPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161078262 245 KILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 296
Cdd:COG4886  299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
15-293 7.50e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.15  E-value: 7.50e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  15 SKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLS 94
Cdd:COG4886   93 GDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLT 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  95 QLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPpDLVNMRS 174
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTN 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 175 LQKIDLMHNDLTSLPEDMGLlRKLDCLYLQHNDI-------LELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKIL 247
Cdd:COG4886  252 LEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLtdlklkeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 161078262 248 DLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISL 293
Cdd:COG4886  331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-322 7.94e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.98  E-value: 7.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  32 WNQVPLNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNI 111
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 112 SYNEfvelnpDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPED 191
Cdd:COG4886  104 SGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEE 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 192 MGLLRKLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPdELCLLRNLNRL 270
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNQLTDLP-ELGNLTNLEEL 255

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 161078262 271 DVSNNTISVLPvTLSSLAHLISLQVEGNPIKTIRRDILQCGTTRILKTLHDR 322
Cdd:COG4886  256 DLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-303 2.04e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 2.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEF 116
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 117 VELNPDISDLHMLEFLDGGHNNiqslpgGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 196
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 197 KLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNN 275
Cdd:COG4886  160 NLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260
                 ....*....|....*....|....*...
gi 161078262 276 TISVLPVtLSSLAHLISLQVEGNPIKTI 303
Cdd:COG4886  239 QLTDLPE-LGNLTNLEELDLSNNQLTDL 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-298 5.57e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 5.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 94
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  95 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 166
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 167 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 220
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 221 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 297
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 161078262 298 N 298
Cdd:PLN00113 557 N 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-300 2.21e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.65  E-value: 2.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-------------------------ELPPEIGKLEKLVRLNVSH 90
Cdd:PLN00113 166 LKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLDLVY 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  91 NKLS-------------------------QLPRAMYSLPELRHLNISYN----EFVELnpdISDLHMLEFLDGGHNNIQ- 140
Cdd:PLN00113 246 NNLTgpipsslgnlknlqylflyqnklsgPIPPSIFSLQKLISLDLSDNslsgEIPEL---VIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 141 SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-------------------------SLPEDMGL 194
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGA 402

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 195 LRKLDCLYLQHNDIL-ELP-EFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKIT-ELPDeLCLLRNLNRLD 271
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPsEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD-SFGSKRLENLD 481

                        330       340       350
                 ....*....|....*....|....*....|
gi 161078262 272 VSNNTIS-VLPVTLSSLAHLISLQVEGNPI 300
Cdd:PLN00113 482 LSRNQFSgAVPRKLGSLSELMQLKLSENKL 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-234 3.18e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPpEIGKLEKLVRLNVSHNKLSQLPrAMYSLPELRHLNISYNEF 116
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 117 VELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLL 195
Cdd:COG4886  285 TDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 161078262 196 RKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIP 234
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-293 1.72e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 1.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  72 ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLP-ELRHLNISYNEFV-----------------------ELNPDISDL 126
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgsiprgsipnletldlsnnmlsgEIPNDIGSF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 127 HMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPYNH-IKELPPDLVNMRSLQKI------------------------DL 180
Cdd:PLN00113 164 SSLKVLDlGGNVLVGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIylgynnlsgeipyeiggltslnhlDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 181 MHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGN-EALNELHA-SNNFIKI 232
Cdd:PLN00113 244 VYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgpippsifslqklisldlsdnslsgEIPELVIQlQNLEILHLfSNNFTGK 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161078262 233 IPKAMCSnLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISL 293
Cdd:PLN00113 324 IPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKL 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 151-305 8.90e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 8.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 151 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 230
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 231 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 279
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 161078262 280 LPVTLSSLAHLISLQVEGNPIKTIRR 305
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-228 1.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.26  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTL-THISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISY 113
Cdd:PLN00113 382 LFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLAR 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 114 NEFVELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLP- 189
Cdd:PLN00113 462 NKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPa 541

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 161078262 190 --EDMGLLRKLDclyLQHNDIL-ELPEFEGN-EALNELHASNN 228
Cdd:PLN00113 542 sfSEMPVLSQLD---LSQNQLSgEIPKNLGNvESLVQVNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
61-284 2.50e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  61 TVLTLHDNALVELPPEIGklEKLVRLNVSHNKLSQLPRAMYSlpELRHLNISYNEFVELNPDISDlhMLEFLDGGHNNIQ 140
Cdd:PRK15370 181 TELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD--TIQEMELSINRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 141 SLPGGIGflVRLTALLLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEfEGNEAL 220
Cdd:PRK15370 255 ELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPE-TLPPGL 327

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161078262 221 NELHASNNFIKIIPKAMCsnlPHLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL 284
Cdd:PRK15370 328 KTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLPENL 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-189 6.81e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.95  E-value: 6.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  34 QVPLNN-LDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQ-LPRAMYSLPELRHLN 110
Cdd:PLN00113 426 KLPLVYfLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLK 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 111 ISYNEFVELNPD-ISDLHMLEFLDGGHNNIQ-SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDL-T 186
Cdd:PLN00113 506 LSENKLSGEIPDeLSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhG 585


                 ...
gi 161078262 187 SLP 189
Cdd:PLN00113 586 SLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 37-149 3.02e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHISP-KIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISY 113
Cdd:PLN00113 477 LENLDLSRNQFSGAVPrKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 161078262 114 NEFV-ELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFL 149
Cdd:PLN00113 557 NQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFL 594
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 47-258 1.52e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  47 LTHIS------PKIENL---QSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQLPRaMYSLPELRHLNISYNEFV 117
Cdd:cd21340    4 ITHLYlndkniTKIDNLslcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 118 ELNpDISDLHMLEFLdggHNNIQSLPGGIGFLVR---LTALLlpynhikelppdlvnmRSLQKIDLMHNDLTSLpEDMGL 194
Cdd:cd21340   82 VVE-GLENLTNLEEL---HIENQRLPPGEKLTFDprsLAALS----------------NSLRVLNISGNNIDSL-EPLAP 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161078262 195 LRKLDCLYLQHNDILELPEFEGnealnelhasnnfikiipkaMCSNLPHLKILDLRDNKITELP 258
Cdd:cd21340  141 LRNLEQLDASNNQISDLEELLD--------------------LLSSWPSLRELDLTGNPVCKKP 184
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
60-300 1.59e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.01  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  60 LTVLTLHDNALVELP---PEIGKLEklvrlnVSHNKLSQLPRAMyslPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 136
Cdd:PRK15387 224 ITTLVIPDNNLTSLPalpPELRTLE------VSGNQLTSLPVLP---PGLLELSIFSNPLTHLPALPSGLCKLWIFGNQL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 137 NNIQSLPGGI-------GFLVRLTAL------LLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEdmgLLRKLDCLYL 203
Cdd:PRK15387 295 TSLPVLPPGLqelsvsdNQLASLPALpselckLWAYNNQLTSLPTLPS--GLQELSVSDNQLASLPT---LPSELYKLWA 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 204 QHNDILELPEFEgnEALNELHASNNFIKIIPKamcsnLP-HLKILDLRDNKITELPdelCLLRNLNRLDVSNNTISVLPV 282
Cdd:PRK15387 370 YNNRLTSLPALP--SGLKELIVSGNRLTSLPV-----LPsELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPE 439

                        250
                 ....*....|....*...
gi 161078262 283 TLSSLAHLISLQVEGNPI 300
Cdd:PRK15387 440 SLIHLSSETTVNLEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-189 1.87e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 1.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHIsPKIENLQSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQL-------------------- 96
Cdd:cd21340   26 LKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVVeglenltnleelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  97 --------PRAMYSL-PELRHLNISYNEFVELNPdISDLHMLEFLDGGHNNIQSlpggigflvrltalllpynhIKELPP 167
Cdd:cd21340  104 pgekltfdPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISD--------------------LEELLD 162

                        170       180
                 ....*....|....*....|..
gi 161078262 168 DLVNMRSLQKIDLMHNDLTSLP 189
Cdd:cd21340  163 LLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
37-93 6.14e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.14e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 161078262   37 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 93
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
196-254 1.33e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.33e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262  196 RKLDCLYLQHNDILELPE--FEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKI 254
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
151-290 1.48e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 151 RLTALLLPYNHIKELPPDL-VNMRSLQkidLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEFegnealnelhasnnf 229
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIPAT--LPDTIQEMELSINRITELPER--------------- 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161078262 230 ikiIPKAmcsnlphLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL-SSLAHL 290
Cdd:PRK15370 260 ---LPSA-------LQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLpSGITHL 309
LRR_8 pfam13855
Leucine rich repeat;
82-139 3.19e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 3.19e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   82 KLVRLNVSHNKLSQL-PRAMYSLPELRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNI 139
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
151-208 2.30e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.30e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  151 RLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDLTSL-PEDMGLLRKLDCLYLQHNDI 208
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
37-210 6.33e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 6.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHIsPKI-----------ENLQSLTV-------LTLHDNALVELPPEIGKLEKLVRLNvshNKLSQLPr 98
Cdd:PRK15387 264 LLELSIFSNPLTHL-PALpsglcklwifgNQLTSLPVlppglqeLSVSDNQLASLPALPSELCKLWAYN---NQLTSLP- 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  99 amySLPE-LRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLV----RLTALLLPYNHIKELPPDLVNMR 173
Cdd:PRK15387 339 ---TLPSgLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIvsgnRLTSLPVLPSELKELMVSGNRLT 415

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 161078262 174 SLQ-------KIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILE 210
Cdd:PRK15387 416 SLPmlpsgllSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN03150 PLN03150
hypothetical protein; Provisional
 37-104 1.31e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.31e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262  37 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKLS-QLPRAMYSLP 104
Cdd:PLN03150 444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
LRR_8 pfam13855
Leucine rich repeat;
104-162 1.61e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.61e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161078262  104 PELRHLNISYNEFVELNPDI-SDLHMLEFLDGGHNNIQSL-PGGIGFLVRLTALLLPYNHI 162
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 131-206 2.96e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 131 FLDGGHNNIQSL----PGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQ 204
Cdd:PLN03150 419 FIDGLGLDNQGLrgfiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLN 498


                 ..
gi 161078262 205 HN 206
Cdd:PLN03150 499 GN 500
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 81-224 5.13e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.94  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   81 EKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPY 159
Cdd:PLN03210  611 ENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKlSDCSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161078262  160 NHIKELPPDLVNMRSLQKIDLMH-NDLTSLPEdmgLLRKLDCLYLQHNDILELPEFEGNEALNELH 224
Cdd:PLN03210  691 CENLEILPTGINLKSLYRLNLSGcSRLKSFPD---ISTNISWLDLDETAIEEFPSNLRLENLDELI 753
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-196 8.23e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 8.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  37 LNNLDLSSNTLTHIsPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEF 116
Cdd:COG4886  252 LEELDLSNNQLTDL-PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 117 VELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 196
Cdd:COG4886  331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
LRR_8 pfam13855
Leucine rich repeat;
220-300 1.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  220 LNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPdelcllrnlnrldvsnntisvlPVTLSSLAHLISLQVEGNP 299
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS----------------------PGAFSGLPSLRYLDLSGNR 60


                  .
gi 161078262  300 I 300
Cdd:pfam13855  61 L 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 34-256 2.34e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262  34 QVPLNNLDLSSNTLTHISPKIENLQSLTV--LTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPE------ 105
Cdd:cd00116    2 QLSLKGELLKTERATELLPKLLCLQVLRLegNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQgltkgc 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262 106 -LRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVrLTALllpynhiKELPPDLvnmrslQKIDLMHN 183
Cdd:cd00116   82 gLQELDLSDNALGPDGCGvLESLLRSSSLQELKLNNNGLGDRGLRLL-AKGL-------KDLPPAL------EKLVLGRN 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161078262 184 DLTS-----LPEDMGLLRKLDCLYLQHNDILElpefEGNEALNELHASNnfikiipkamcsnlPHLKILDLRDNKITE 256
Cdd:cd00116  148 RLEGasceaLAKALRANRDLKELNLANNGIGD----AGIRALAEGLKAN--------------CNLEVLDLNNNGLTD 207
LRR_8 pfam13855
Leucine rich repeat;
129-185 2.65e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.65e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 161078262  129 LEFLDGGHNNIQSLPGGIGF-LVRLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDL 185
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 18-241 4.06e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 39.86  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   18 VNLEQLTIKEEDAWWNQVPLNNLdlssntLTHISPkienlqSLTVLTLHDN-ALVELPPEIGKLEKLVRLNVSHNK-LSQ 95
Cdd:PLN03210  750 DELILCEMKSEKLWERVQPLTPL------MTMLSP------SLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLET 817

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161078262   96 LPRAMySLPELRHLNISYNEFVELNPDISdlhmlefldgghNNIQSlpggigflvrltaLLLPYNHIKELPPDLVNMRSL 175
Cdd:PLN03210  818 LPTGI-NLESLESLDLSGCSRLRTFPDIS------------TNISD-------------LNLSRTGIEEVPWWIEKFSNL 871

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161078262  176 QKIDLMH-NDLTSLPEDMGLLRKLDclYLQHNDILELPEFEGNEALNEL-HASNNFIKIIPKAMCSNL 241
Cdd:PLN03210  872 SFLDMNGcNNLQRVSLNISKLKHLE--TVDFSDCGALTEASWNGSPSEVaMATDNIHSKLPSTVCINF 937
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 220-259 7.34e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 7.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 161078262  220 LNELHASNNFIKIIPkaMCSNLPHLKILDLRDN-KITELPD 259
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 195-257 7.34e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 7.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161078262 195 LRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITEL 257
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH