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Conserved domains on  [gi|157786804|ref|NP_001099349|]
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rho GTPase-activating protein 31 [Rattus norvegicus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138166)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 1.88e-120

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 373.76  E-value: 1.88e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384     1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384    81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 157786804  177 NLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384   161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1184-1347 3.93e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1184 QAKAVPVIPPKIQYTQIPQPLPSQNTgEGGAQPPErnQEEPGSTPETPQKPTkddSPSSLGSPEEEQPKQEQGASASRRK 1263
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLARPAVSRST-ESFALPPD--QPERPPQPQAPPPPQ---PQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1264 ASTTSCVAEGSFCSAEPGPSTLVSSQDAMGQCRKRTSETEPSEDNllsskleRASGGPKPTHRPRPGR---PQSLILFPI 1340
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-------PASSTPPLTGHSLSRVsswASSLALHEE 3016


                  ....*..
gi 157786804 1341 MDHLPSS 1347
Cdd:PHA03247 3017 TDPPPVS 3023
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 1.88e-120

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 373.76  E-value: 1.88e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384     1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384    81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 157786804  177 NLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384   161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 32-212 1.97e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 193.25  E-value: 1.97e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804     32 QDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYE 110
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAF--DSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804    111 LYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKieaticn 190
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------- 151

                           170       180
                    ....*....|....*....|...
gi 157786804    191 GDAAFLA-VRVQQVVIEFILNHA 212
Cdd:smart00324  152 GEVASLKdIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 35-182 1.47e-55

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 189.68  E-value: 1.47e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804    35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAF--DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157786804   114 KFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1184-1347 3.93e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1184 QAKAVPVIPPKIQYTQIPQPLPSQNTgEGGAQPPErnQEEPGSTPETPQKPTkddSPSSLGSPEEEQPKQEQGASASRRK 1263
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLARPAVSRST-ESFALPPD--QPERPPQPQAPPPPQ---PQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1264 ASTTSCVAEGSFCSAEPGPSTLVSSQDAMGQCRKRTSETEPSEDNllsskleRASGGPKPTHRPRPGR---PQSLILFPI 1340
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-------PASSTPPLTGHSLSRVsswASSLALHEE 3016


                  ....*..
gi 157786804 1341 MDHLPSS 1347
Cdd:PHA03247 3017 TDPPPVS 3023
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-211 1.88e-120

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 373.76  E-value: 1.88e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCK 96
Cdd:cd04384     1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04384    81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 157786804  177 NLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04384   161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 32-212 1.97e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 193.25  E-value: 1.97e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804     32 QDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYE 110
Cdd:smart00324    1 KPIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAF--DSGPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYE 78

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804    111 LYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKieaticn 190
Cdd:smart00324   79 LYEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPD------- 151

                           170       180
                    ....*....|....*....|...
gi 157786804    191 GDAAFLA-VRVQQVVIEFILNHA 212
Cdd:smart00324  152 GEVASLKdIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 35-182 1.47e-55

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 189.68  E-value: 1.47e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804    35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAF--DRGPDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157786804   114 KFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK 182
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPP 147
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 35-211 5.10e-51

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 177.49  E-value: 5.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   35 PYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLCKLYFRELPNPLLTYELYE 113
Cdd:cd00159     1 PLIIEKCIEYLEKNGLnTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDY---DVHDVASLLKLYLRELPEPLIPFELYD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  114 KFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEATIcngda 193
Cdd:cd00159    78 EFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDEL----- 152

                         170
                  ....*....|....*...
gi 157786804  194 aFLAVRVQQVVIEFILNH 211
Cdd:cd00159   153 -LEDIKKLNEIVEFLIEN 169
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 1.83e-41

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 151.02  E-value: 1.83e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPD----LTREVYLQDIHCVGS 93
Cdd:cd04398     1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLnLEGIYRLSGNVSRVNKLKELFDKD--PLnvllISPEDYESDIHSVAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04398    79 LLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAII 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 157786804  174 WAPNLLRSKKIEATicngDAAFlavrvQQVVIEFILNHADQIF 216
Cdd:cd04398   159 WGPTLMNAAPDNAA----DMSF-----QSRVIETLLDNAYQIF 192
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-220 2.63e-39

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 145.29  E-value: 2.63e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSdQCPDLTREVYLQDIHCVGSLC 95
Cdd:cd04386     3 PVFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEeGLFRVGGGASKLKRLKAALDA-GTFSLPLDEFYSDPHAVASAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04386    82 KSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 157786804  176 PNLLRSkKIEATICNGDAAFLAVRVqqVVIEFILNHADQIFNGGA 220
Cdd:cd04386   162 PNLLWA-KNEGSLAEMAAGTSVHVV--AIVELIISHADWFFPGEV 203
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 19-209 3.41e-39

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 144.46  E-value: 3.41e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTrEVYLQDIHCVGSLCKL 97
Cdd:cd04403     1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLdVDGIYRVSGNLAVIQKLRFAVDHDEKLDLD-DSKWEDIHVITGALKL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   98 YFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04403    80 FFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                         170       180       190
                  ....*....|....*....|....*....|..
gi 157786804  178 LLRSKKIeaticNGDAAFLAVRVQQVViEFIL 209
Cdd:cd04403   160 LLRPEQE-----TGNIAVHMVYQNQIV-ELIL 185
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 8.48e-38

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 140.73  E-value: 8.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEFGSD-QCPDLTREVYlQDIHCVGSLCK 96
Cdd:cd04372     1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQsEGLYRVSGFAEEIEDVKMAFDRDgEKADISATVY-PDINVITGALK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   97 LYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAP 176
Cdd:cd04372    80 LYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGP 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 157786804  177 NLLRSKKIEATICNGDaaflaVRVQQVVIEFILNHADQIF 216
Cdd:cd04372   160 TLMRPPEDSALTTLND-----MRYQILIVQLLITNEDVLF 194
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-180 6.11e-33

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 126.40  E-value: 6.11e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPDltrEVYLQD--IHCVGSLC 95
Cdd:cd04377     1 FGVSLSS-LTSEDRSVPLVLEKLLEHIEMHGLyTEGIYRKSGSANKIKELRQGLDTD--PD---SVNLEDypIHVITSVL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04377    75 KQWLRELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154


                  ....*
gi 157786804  176 PNLLR 180
Cdd:cd04377   155 PCILR 159
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 18-181 5.60e-32

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 124.05  E-value: 5.60e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   18 AFGCDLTEYLESSGQD-VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF--GSDQCpDLTREVYlQDIHCVGS 93
Cdd:cd04395     1 TFGVPLDDCPPSSENPyVPLIVEVCCNIVEARGLeTVGIYRVPGNNAAISALQEELnrGGFDI-DLQDPRW-RDVNVVSS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04395    79 LLKSFFRKLPEPLFTNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIV 158


                  ....*...
gi 157786804  174 WAPNLLRS 181
Cdd:cd04395   159 FGPTLVRT 166
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 30-182 5.51e-31

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 120.88  E-value: 5.51e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   30 SGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcpdlTREVYL----QDIHCVGSLCKLYFRELPN 104
Cdd:cd04385    11 TDNDIPVIVDKCIDFITQHGLmSEGIYRKNGKNSSVKKLLEAFRKD-----ARSVQLregeYTVHDVADVLKRFLRDLPD 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157786804  105 PLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSK 182
Cdd:cd04385    86 PLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 5.88e-30

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 118.21  E-value: 5.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQD--VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLC 95
Cdd:cd04404     6 FGVSLQFLKEKNPEQepIPPVVRETVEYLQAHALtTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYE---DVHLPAVIL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   96 KLYFRELPNPLLTYELYEKFTeAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04404    83 KTFLRELPEPLLTFDLYDDIV-GFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFG 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 157786804  176 PNLLRSKKIEATICngdaaflAVRVQQVVIEFILNHADQIF 216
Cdd:cd04404   162 PNLLWAKDASMSLS-------AINPINTFTKFLLDHQDEIF 195
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-184 8.34e-29

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 114.45  E-value: 8.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESS----GQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLtrEVYlqDIHCVGS 93
Cdd:cd04381     1 FGASLSLAVERSrchdGIDLPLVFRECIDYVEKHGMkCEGIYKVSGIKSKVDELKAAYNRRESPNL--EEY--EPPTVAS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04381    77 LLKQYLRELPEPLLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIV 156

                         170
                  ....*....|.
gi 157786804  174 WAPNLLRSKKI 184
Cdd:cd04381   157 LSPTVQISNRL 167
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 34-216 1.89e-28

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 114.07  E-value: 1.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   34 VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsdQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04376     9 VPRLVESCCQHLEKHGLqTVGIFRVGSSKKRVRQLREEF---DRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELY 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  113 EKFTEAVSHCPEEgQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKT-----------NMHARNLALVWAPNLLRS 181
Cdd:cd04376    86 TAFIGTALLEPDE-QLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnKMTSLNLATIFGPNLLHK 164

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 157786804  182 KKIEATICNGDAAFLAVRVQQV-VIEFILNHADQIF 216
Cdd:cd04376   165 QKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 38-211 5.44e-28

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 112.87  E-value: 5.44e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   38 LKSCAEFIETHGIVD-GIYRLSGVTSNIQRLrQEFGSDQ----CPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04374    32 VRKCIEAVETRGINEqGLYRVVGVNSKVQKL-LSLGLDPktstPGDVDLDNSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  113 EKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKkiEATIcngd 192
Cdd:cd04374   111 NDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQ--EETV---- 184

                         170
                  ....*....|....*....
gi 157786804  193 AAFLAVRVQQVVIEFILNH 211
Cdd:cd04374   185 AAIMDIKFQNIVVEILIEN 203
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-211 5.98e-28

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 112.52  E-value: 5.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHG-IVDGIYRLSGVTSNIQRLRQEF--GSDQcpdltreVYLQDI--HCVGS 93
Cdd:cd04378     1 FGVDFSQVPRDFPDEVPFIIKKCTSEIENRAlGVQGIYRVSGSKARVEKLCQAFenGKDL-------VELSELspHDISS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKF------------TEAVSHCPEEGQ--LARIQNVIQELPPPHYRTLEYLIRHLAHIASF 159
Cdd:cd04378    74 VLKLFLRQLPEPLILFRLYNDFialakeiqrdteEDKAPNTPIEVNriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQ 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157786804  160 SSKTNMHARNLALVWAPNLLRSKKIEATI---CNGDAAFlavrvQQVVIEFILNH 211
Cdd:cd04378   154 FEENKMSPNNLGIVFGPTLIRPRPGDADVslsSLVDYGY-----QARLVEFLITN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 34-211 4.93e-27

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 110.02  E-value: 4.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQcPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04387    16 VPYIVRQCVEEVERRGMEEvGIYRISGVATDIQALKAAFDTNN-KDVSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  113 EKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEA---TIC 189
Cdd:cd04387    95 PNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESkipTNT 174

                         170       180
                  ....*....|....*....|..
gi 157786804  190 NGDAAFLAVRVQQVVIEFILNH 211
Cdd:cd04387   175 MTDSWSLEVMSQVQVLLYFLQL 196
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-210 9.93e-27

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 108.66  E-value: 9.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEF--GSDQCPDLTREvylQDIHCVGSLC 95
Cdd:cd04383     3 FNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQhQGIFRVSGSQVEVNDIKNAFerGEDPLADDQND---HDINSVAGVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04383    80 KLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFG 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 157786804  176 PNLLRSKKieaticNGDAAFLAVRVQQVVIEFILN 210
Cdd:cd04383   160 PTLMPVPE------GQDQVSCQAHVNELIKTIIIH 188
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 19-195 3.65e-26

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 107.06  E-value: 3.65e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESS-----GQDVPYVLKSCAEFIETHGIV--DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCV 91
Cdd:cd04400     2 FGSPLEEAVELSshkynGRDLPSVVYRCIEYLDKNRAIyeEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHTV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   92 GSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARI-QNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNL 170
Cdd:cd04400    82 AGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALElKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                         170       180
                  ....*....|....*....|....*.
gi 157786804  171 ALVWAPNLLRSKKIEAT-ICNGDAAF 195
Cdd:cd04400   162 CIVFSPTLNIPAGIFVLfLTDFDCIF 187
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-190 1.24e-25

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 105.62  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEyLESSGQ---DVPYVLKSCAEFIETHGIV-DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREvylQDIHCVGSL 94
Cdd:cd04393     3 FGVPLQE-LQQAGQpenGVPAVVRHIVEYLEQHGLEqEGLFRVNGNAETVEWLRQRLDSGEEVDLSKE---ADVCSAASL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   95 CKLYFRELPNPLLTYELYEKFTEAVSHCPEEG-QLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04393    79 LRLFLQELPEGLIPASLQIRLMQLYQDYNGEDeFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAV 158

                         170       180
                  ....*....|....*....|..
gi 157786804  174 WAPNLLR-----SKKIEATICN 190
Cdd:cd04393   159 FGPDVFHvytdvEDMKEQEICS 180
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 34-213 1.51e-25

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 105.60  E-value: 1.51e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEFGSDQCPDLTREVylqDIHCVGSLCKLYFRELPNPLLTYELY 112
Cdd:cd04390    22 VPILVEQCVDFIREHGLKEeGLFRLPGQANLVKQLQDAFDAGERPSFDSDT---DVHTVASLLKLYLRELPEPVIPWAQY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  113 EKF---TEAVSHCPEEGqLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSkKIE--AT 187
Cdd:cd04390    99 EDFlscAQLLSKDEEKG-LGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATVFGPNILRP-KVEdpAT 176

                         170       180
                  ....*....|....*....|....*.
gi 157786804  188 ICNGdaaflAVRVQQVVIEFILNHAD 213
Cdd:cd04390   177 IMEG-----TPQIQQLMTVMISKHEP 197
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 27-180 8.98e-25

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 103.15  E-value: 8.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   27 LESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcPDltrEVYLQD--IHCVGSLCKLYFRELP 103
Cdd:cd04407     8 LTSNKTSVPIVLEKLLEHVEMHGLyTEGIYRKSGSANRMKELHQLLQAD--PE---NVKLENypIHAITGLLKQWLRELP 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157786804  104 NPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
Cdd:cd04407    83 EPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPCLLR 159
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-180 1.70e-24

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 102.39  E-value: 1.70e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDqcpdlTREVYLQD--IHCVGSLC 95
Cdd:cd04406     1 FGVELSR-LTSEDRSVPLVVEKLINYIEMHGLyTEGIYRKSGSTNKIKELRQGLDTD-----ANSVNLDDynIHVIASVF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWA 175
Cdd:cd04406    75 KQWLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154


                  ....*
gi 157786804  176 PNLLR 180
Cdd:cd04406   155 PCILR 159
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-188 1.32e-23

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 100.27  E-value: 1.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHG-IVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVgslCKL 97
Cdd:cd04409     1 FGADFAQVAKKSPDGIPFIIKKCTSEIESRAlCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNV---LKL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   98 YFRELPNPLLTYELYEKF---TEAVSHCPEEGQ-------------------LARIQNVIQELPPPHYRTLEYLIRHLAH 155
Cdd:cd04409    78 YLRQLPEPLILFRLYNEFiglAKESQHVNETQEakknsdkkwpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHLHR 157

                         170       180       190
                  ....*....|....*....|....*....|...
gi 157786804  156 IASFSSKTNMHARNLALVWAPNLLRSKKIEATI 188
Cdd:cd04409   158 VSEQAEENKMSASNLGIIFGPTLIRPRPTDATV 190
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 17-178 1.93e-22

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 97.49  E-value: 1.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   17 SAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIvD--GIYRLSGVTSNIQRLRQEfgSDQCPDLTreVY-LQDIHCVGS 93
Cdd:cd04375     3 NVFGVPLLVNLQRTGQPLPRSIQQAMRWLRNNAL-DqvGLFRKSGVKSRIQKLRSM--IESSTDNV--NYdGQQAYDVAD 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04375    78 MLKQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVC 157


                  ....*
gi 157786804  174 WAPNL 178
Cdd:cd04375   158 LAPSL 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-210 5.42e-22

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 94.83  E-value: 5.42e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEyLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYlqDIHCVGSLCKL 97
Cdd:cd04373     1 FGVPLAN-VVTSEKPIPIFLEKCVEFIEATGLeTEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDF--TVNAVAGALKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   98 YFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04373    78 FFSELPDPLIPYSMHLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPT 157

                         170       180       190
                  ....*....|....*....|....*....|....
gi 157786804  178 LLRskkieATICNGDaAFLAVRVQQVVIE-FILN 210
Cdd:cd04373   158 LMR-----PDFTSME-ALSATRIYQTIIEtFIQQ 185
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 52-216 4.01e-21

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 92.75  E-value: 4.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   52 DGIYRLSGVTSNIQRLRQEFGSDQCPDLTREvylqDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARI 131
Cdd:cd04402    34 EGIFRRSANAKACKELKEKLNSGVEVDLKAE----PVLLLASVLKDFLRNIPGSLLSSDLYEEWMSALDQENEEEKIAEL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  132 QNVIQELPPPHYRTLEYLIRHLAHIaSFSSKTN-MHARNLALVWAPNLLRSKkieaTICNGDAAFLavRVQQVVIEFILN 210
Cdd:cd04402   110 QRLLDKLPRPNVLLLKHLICVLHNI-SQNSETNkMDAFNLAVCIAPSLLWPP----ASSELQNEDL--KKVTSLVQFLIE 182


                  ....*.
gi 157786804  211 HADQIF 216
Cdd:cd04402   183 NCQEIF 188
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-178 1.21e-20

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 91.20  E-value: 1.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   34 VPYVLKSCAEFIETHGIVD-GIYRLSGVTSNIQRLRQEF-GSDQCPDLTrevyLQDIHCVGSLCKLYFRELPNPLLTYEL 111
Cdd:cd04382    17 IPALIVHCVNEIEARGLTEeGLYRVSGSEREVKALKEKFlRGKTVPNLS----KVDIHVICGCLKDFLRSLKEPLITFAL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157786804  112 YEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASfSSKTNMHARNLALVWAPNL 178
Cdd:cd04382    93 WKEFMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTI 158
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 19-211 1.62e-20

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 91.03  E-value: 1.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEF--GSDQcpdltreVYLQDI--HCVGS 93
Cdd:cd04408     1 FGVDFSQLPRDFPEEVPFVVVRCTAEIENRALgVQGIYRISGSKARVEKLCQAFenGRDL-------VDLSGHspHDITS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   94 LCKLYFRELPNPLLTYELYEKF----------TEAVSHCPEEGQ--LARIQNVIQELPPPHYRTLEYLIRHLAHIASFSS 161
Cdd:cd04408    74 VLKHFLKELPEPVLPFQLYDDFialakelqrdSEKAAESPSIVEniIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFE 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157786804  162 KTNMHARNLALVWAPNLLR--SKKIEATICNGDAAFlavrvQQVVIEFILNH 211
Cdd:cd04408   154 DNKMSPNNLGIVFGPTLLRplVGGDVSMICLLDTGY-----QAQLVEFLISN 200
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 19-183 4.03e-20

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 90.22  E-value: 4.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYL--ESSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP-DLTREVYlQDIHCVGSL 94
Cdd:cd04379     1 FGVPLSRLVerEGESRDVPIVLQKCVQEIERRGLdVIGLYRLCGSAAKKKELRDAFERNSAAvELSEELY-PDINVITGV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   95 CKLYFRELPNPLLTYELYEKFTEAVSHCPE---EGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLA 171
Cdd:cd04379    80 LKDYLRELPEPLITPQLYEMVLEALAVALPndvQTNTHLTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLA 159

                         170
                  ....*....|..
gi 157786804  172 LVWAPNLLRSKK 183
Cdd:cd04379   160 VCFGPVLMFCSQ 171
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 51-206 4.16e-20

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 90.50  E-value: 4.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   51 VDGIYRLSGvtsNIQRLRQ-----EFGSDQCPDLTREVYLQdihcVGSLCKLYFRELPNPLLTYELYEKFTEAVSHCPEE 125
Cdd:cd04397    45 VEGVFRKNG---NIRRLKElteeiDKNPTEVPDLSKENPVQ----LAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  126 GQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFS-----SKTNMHARNLALVWAPNLLRSKKIEATIcnGDAAFLAVRV 200
Cdd:cd04397   118 ERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFShideeTGSKMDIHNLATVITPNILYSKTDNPNT--GDEYFLAIEA 195


                  ....*.
gi 157786804  201 QQVVIE 206
Cdd:cd04397   196 VNYLIE 201
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-216 9.45e-17

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 80.85  E-value: 9.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLE-----SSGQDVPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEfgsdqcpdLTREVYLQD----- 87
Cdd:cd04391     2 FGVPLSTLLErdqkkVPGSKVPLIFQKLINKLEERGLeTEGILRIPGSAQRVKFLCQE--------LEAKFYEGTflwdq 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   88 --IHCVGSLCKLYFRELPNPLLTYELYEKFTeAVSHCPE-EGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTN 164
Cdd:cd04391    74 vkQHDAASLLKLFIRELPQPLLTVEYLPAFY-SVQGLPSkKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNK 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157786804  165 MHARNLALVWAPNLLRSKKIEATICNGDAA--FLAVRVQQvVIEFILNHADQIF 216
Cdd:cd04391   153 MNLWNVAMIMAPNLFPPRGKHSKDNESLQEevNMAAGCAN-IMRLLIRYQDLLW 205
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 19-180 9.45e-16

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 77.05  E-value: 9.45e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   19 FGCDLTEYLESS-----GQDVPYVLKSCAEFIETHG--IVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTrevyLQDIHCV 91
Cdd:cd04389     1 FGSSLEEIMDRQkekypELKLPWILTFLSEKVLALGgfQTEGIFRVPGDIDEVNELKLRVDQWDYPLSG----LEDPHVP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   92 GSLCKLYFRELPNPLLTYELYEKFTEAvSHCPEEgqlarIQNVIQELPPPHYRTLEYLIRHLAHIASFS--SKTNMHARN 169
Cdd:cd04389    77 ASLLKLWLRELEEPLIPDALYQQCISA-SEDPDK-----AVEIVQKLPIINRLVLCYLINFLQVFAQPEnvAHTKMDVSN 150

                         170
                  ....*....|.
gi 157786804  170 LALVWAPNLLR 180
Cdd:cd04389   151 LAMVFAPNILR 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-215 1.78e-15

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 77.07  E-value: 1.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   34 VPYVLKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFgsDQCPDLTREVYLQD--IHCVGSLCKLYFRELPNPLLTYE 110
Cdd:cd04396    32 IPVVVAKCGVYLKENATeVEGIFRVAGSSKRIRELQLIF--STPPDYGKSFDWDGytVHDAASVLRRYLNNLPEPLVPLD 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  111 LYEKFTEAVSHCPE-----------------EGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALV 173
Cdd:cd04396   110 LYEEFRNPLRKRPRilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAI 189

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 157786804  174 WAPNLLRSKKIEatICNGDaaflaVRVQQVVIEFILNHADQI 215
Cdd:cd04396   190 FQPGILSHPDHE--MDPKE-----YKLSRLVVEFLIEHQDKF 224
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-181 7.56e-14

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 71.73  E-value: 7.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   21 CDLTEYlessgQDVPYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDltrEVYLqdIHCVGSLCKLYFR 100
Cdd:cd04394    12 STVPEY-----GNVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACL---SSAL--PCDVAGLLKQFFR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  101 ELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR 180
Cdd:cd04394    82 ELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVIFAPNLFQ 161


                  .
gi 157786804  181 S 181
Cdd:cd04394   162 S 162
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 43-227 1.25e-12

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 68.64  E-value: 1.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   43 EFIETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYlqDIHCVGSLCKLYFRELPNPLLTYELYE--------- 113
Cdd:cd04392    18 EYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGF--HAHDCATVLKGFLGELPEPLLTHAHYPahlqiadlc 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  114 KFTEAVSHCP---EEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEATICN 190
Cdd:cd04392    96 QFDEKGNKTSapdKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRNLTPEDLH 175

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 157786804  191 GDAAFLAvrvqqVVIEFILNHADQIFNggAPGALQQD 227
Cdd:cd04392   176 ENAQKLN-----SIVTFMIKHSQKLFK--APAYLRED 205
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 12-182 1.58e-07

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 53.50  E-value: 1.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   12 RKGAASAFGCDLTEYLESSGQDVPY----VLKSCAEFIETHGIVD-GIYRLSGVTSN----IQRLRQEFGSDQcPDLTRE 82
Cdd:cd04380    24 PDPGIRNLIDQLELGDNPDYSEVPLsipkEIWRLVDYLYTRGLAQeGLFEEPGLPSEpgelLAEIRDALDTGS-PFNSPG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   83 vylqDIHCVGSlCKLYF-RELPNPLLTYELYEKFTEAVSHCPEE-GQLARIQnviqeLPPPHYRTLEYLIRHLAHIASFS 160
Cdd:cd04380   103 ----SAESVAE-ALLLFlESLPDPIIPYSLYERLLEAVANNEEDkRQVIRIS-----LPPVHRNVFVYLCSFLRELLSES 172

                         170       180
                  ....*....|....*....|..
gi 157786804  161 SKTNMHARNLALVWAPNLLRSK 182
Cdd:cd04380   173 ADRGLDENTLATIFGRVLLRDP 194
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 22-180 7.18e-07

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 51.41  E-value: 7.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   22 DLTEylESSGQDV-PYVLKSCAEFIETHGIVDGIYRLSGVTSNIQRLRQefgSDQCPDLTREVYLQDIHCVGSLCKLYFR 100
Cdd:cd04388     4 DLTE--QFSPPDVaPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQ---ILDCDAASVDLEQFDVAALADALKRYLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804  101 ELPNPLLTYELYE---KFTEAVSHCPEEGQLARIQNVIQELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPN 177
Cdd:cd04388    79 DLPNPVIPAPVYSemiSRAQEVQSSDEYAQLLRKLIRSPNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPL 158


                  ...
gi 157786804  178 LLR 180
Cdd:cd04388   159 LFR 161
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 91-216 2.04e-06

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 50.41  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804   91 VGSLCKLYFRELPNPLLTYELYEKFTEAVSHCP------EEGQLARIQNVIQELPPPHYRTLEYLIRHLA---HIASFSS 161
Cdd:cd04399    81 VASVLKLYLLELPDSLIPHDIYDLIRSLYSAYPpsqedsDTARIQGLQSTLSQLPKSHIATLDAIITHFYrliEITKMGE 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157786804  162 KTNMHARNLALVWAPNLLRSkKIEATICNGDaaflavRVQQVVIEFILNHADQIF 216
Cdd:cd04399   161 SEEEYADKLATSLSREILRP-IIESLLTIGD------KHGYKFFRDLLTHKDQIF 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1184-1347 3.93e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 3.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1184 QAKAVPVIPPKIQYTQIPQPLPSQNTgEGGAQPPErnQEEPGSTPETPQKPTkddSPSSLGSPEEEQPKQEQGASASRRK 1263
Cdd:PHA03247 2870 SPAAKPAAPARPPVRRLARPAVSRST-ESFALPPD--QPERPPQPQAPPPPQ---PQPQPPPPPQPQPPPPPPPRPQPPL 2943

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157786804 1264 ASTTSCVAEGSFCSAEPGPSTLVSSQDAMGQCRKRTSETEPSEDNllsskleRASGGPKPTHRPRPGR---PQSLILFPI 1340
Cdd:PHA03247 2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-------PASSTPPLTGHSLSRVsswASSLALHEE 3016


                  ....*..
gi 157786804 1341 MDHLPSS 1347
Cdd:PHA03247 3017 TDPPPVS 3023
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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