BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 85
Cdd:cd18414    1 ESDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 163792201  86 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
Cdd:cd18414   81 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 85
Cdd:cd18414    1 ESDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 163792201  86 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
Cdd:cd18414   81 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 117

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDahsHFDYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPLYE 88
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELE---CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFL 77

                          90
                  ....*....|....*.
gi 163792201   89 EELAFWGIDETDVEPC 104
Cdd:pfam02214  78 EEAEFYGLDELALELC 93

voltage-gated potassium channel protein;

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 163792201 386 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPV-----PVIVNNF 439
Cdd:PRK10537 168 SLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSIsaifgPVIRGNL 226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 85
Cdd:cd18414    1 ESDRIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAHSNFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 163792201  86 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 122
Cdd:cd18414   81 LYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSF 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHS-----------HFDYDPRADEFFFDRHPGVFAHILNYYRTGK 75
Cdd:cd18415    1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGdcltqcsqvggSDGSPGGGNEFFFDRHPGVFAYVLNYYRTGK 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 163792201  76 LHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 119
Cdd:cd18415   81 LHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  189 ARYVAFASLFFILVSITTFCLETHERFNPIVNKteienvrngtqvryyreaeteaFLTYIEGVCVVWFTFEFLMRVIFCP 268
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT----------------------VLEILDYVFTGIFTLEMLLKIIAAG 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  269 NKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSkaakdvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 348
Cdd:pfam00520  59 FKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNL 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  349 IIFLALGVLIFATMIY----YAERIGAQPNDPsaseHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGM-------LVG 417
Cdd:pfam00520 133 LLLLLLFLFIFAIIGYqlfgGKLKTWENPDNG----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFV 208

                         250       260       270
                  ....*....|....*....|....*....|
gi 163792201  418 ALCALAGVLTIAMPVPVIVNNFGMYYSLAM 447
Cdd:pfam00520 209 SFIILGGFLLLNLFIAVIIDNFQELTERTE 238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPAD 81
Cdd:cd18378    1 SRRVLLNVGGVRHEVLWRTLDRLPRTRLGRLRECNTHESLlelcdDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 163792201  82 VCGPLYEEELAFWGIDETDVEPCCwmtyrQHR 113
Cdd:cd18378   81 MCVLSFSQELEYWGIDEIYLESCC-----QHR 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   9 RIVINVGGTRHQTYRSTLRTLPGTRLAwlaepDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYE 88
Cdd:cd18380    1 RIVINVSGRRFETWKNTLEKYPDTLLG-----STEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISAYD 75

                         90       100
                 ....*....|....*....|....*
gi 163792201  89 EELAFWGIDETDVEPCCWMTYRQHR 113
Cdd:cd18380   76 DELAFFGILPEIIGDCCYEDYRDRK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAwlaepDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEE 89
Cdd:cd18418    2 IVLNVSGTRFQTWRNTLERYPDTLLG-----SSERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDE 76

                         90       100
                 ....*....|....*....|....
gi 163792201  90 ELAFWGIDETDVEPCCWMTYRQHR 113
Cdd:cd18418   77 ELAFFGIIPEIIGDCCYEEYKDRR 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   6 ESERIVINVGGTRHQTYRSTLRTLPGTRLAwlaepDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 85
Cdd:cd18420   34 DDEKLIINVSGRRFETWRNTLEKYPDTLLG-----SNEREFFYDEETKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLT 108

                         90       100
                 ....*....|....*....|....*...
gi 163792201  86 LYEEELAFWGIDETDVEPCCWMTYRQHR 113
Cdd:cd18420  109 AYDEELAFFGIMPDIIGDCCYEDYRDRK 136

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTRLAwlaepDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLY 87
Cdd:cd18417   35 EILVVNVSGRRFQTWKNTLDRYPDTLLG-----SSEKEFFYNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAF 109

                         90       100
                 ....*....|....*....|....*.
gi 163792201  88 EEELAFWGIDETDVEPCCWMTYRQHR 113
Cdd:cd18417  110 DEELSFYGIIPEIIGDCCLEEYRDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCG 84
Cdd:cd18426    1 ININVGGLKRRLSSSTLSKFPDTRLGRLLSCDSEESIlqicdDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80

                         90       100
                 ....*....|....*....|....*...
gi 163792201  85 PLYEEELAFWGIDETDVEPCCwmTYRQH 112
Cdd:cd18426   81 FSFSQEIEYWGINEFFLDSCC--SYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGP 85
Cdd:cd18424    1 FTINVGGSRFVLSQQVLSSHPETRLGKLAVSVRDSVLelcdDANFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAI 80

                         90       100
                 ....*....|....*....|
gi 163792201  86 LYEEELAFWGIDETDVEPCC 105
Cdd:cd18424   81 SFLQEIEYWGIDELSIDSCC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCG 84
Cdd:cd18384    1 IRINVGGFRRRLSASALLRFPGTRLGRLLACHSEEAIlelcdDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                         90       100
                 ....*....|....*....|....*...
gi 163792201  85 PLYEEELAFWGIDETDVEPCCwmTYRQH 112
Cdd:cd18384   81 FSFSQEIEYWGINEFFLDSCC--SYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDydPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEE 89
Cdd:cd18187    1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGREFTFP--NETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLRE 78

                 ....*
gi 163792201  90 ELAFW 94
Cdd:cd18187   79 ECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-------DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADV 82
Cdd:cd18381    3 IVVNVGGVRQVLYGDVLNRYPETRLAELLNCLSGGYDaifslcdDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKKGI 82

                         90       100
                 ....*....|....*....|...
gi 163792201  83 CGPLYEEELAFWGIDETDVEPCC 105
Cdd:cd18381   83 CPICFKNEMDFWRVDLDFLDECC 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  12 INVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPL 86
Cdd:cd18425    3 INVGGTSYQISYRVAASYPKTRIGRLATYTDRSRKldlcdDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPRN 82

                         90       100
                 ....*....|....*....|....*
gi 163792201  87 YEEELAFWGIDETDVEPCCWMTYRQ 111
Cdd:cd18425   83 FLEEINYWGVRIKNTPRCCRISFEE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCG 84
Cdd:cd18422    1 VTLNVGGTRYSFSREVIKDFPLRRVSRLHGCLSEQDVlevcdDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80

                         90       100
                 ....*....|....*....|.
gi 163792201  85 PLYEEELAFWGIDETDVEPCC 105
Cdd:cd18422   81 LSFYNEMIYWGLERSHLEYCC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTrlaWLAEPDAHSHFdYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPL 86
Cdd:cd18408    6 ERVVLNVAGLRFETRARTLGRFPDT---LLGDPARRGRF-YDDRRREYFFDRHRPSFDAVLYYYQSgGRLRRPAHVPLDV 81

                         90
                 ....*....|..
gi 163792201  87 YEEELAFWGIDE 98
Cdd:cd18408   82 FLEEVAFYGLGA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shaker and similar proteins; Shaker, also termed protein minisleep, represents a family of putative potassium channel proteins in the nervous system of Drosophila. It is a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Shaker plays a role in the regulation of sleep need or efficiency. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaker is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTrlaWLAEPDAHSHFdYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPL 86
Cdd:cd18410    1 ERVVINVSGLRFETQLKTLNQFPDT---LLGDPQRRNRY-YDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDV 76

                         90
                 ....*....|....*.
gi 163792201  87 YEEELAFWGIDETDVE 102
Cdd:cd18410   77 FSEEIKFYELGENAFE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTrlaWLAEPDAHSHFdYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPL 86
Cdd:cd18405    1 ERVVINVSGLRFETQLKTLAQFPET---LLGDPEKRMRY-FDPLRNEYFFDRNRPSFDAILYYYQSgGRLKRPVNVPFDI 76

                         90
                 ....*....|..
gi 163792201  87 YEEELAFWGIDE 98
Cdd:cd18405   77 FSEEVKFYELGE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTrlaWLAEPDAHSHFdYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPL 86
Cdd:cd18409    1 QKVIINIAGLRFETQLKTLDQFPDT---LLGDPEKRMKY-FDSMRNEYFFDRNRPSFDGILYYYQSgGKIRRPANVPLDV 76

                 ....*...
gi 163792201  87 YEEELAFW 94
Cdd:cd18409   77 FADEIIFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 1 (KCNA1); KCNA1 is also called voltage-gated K(+) channel HuKI, voltage-gated potassium channel HBK1, or voltage-gated potassium channel subunit Kv1.1. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. It is involved in the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTrlaWLAEPDAHSHFdYDPRADEFFFDRHPGVFAHILNYYRT-GKLHCPADVCGPL 86
Cdd:cd18402    9 ERVVINIAGLRFETQLKTLAQFPNT---LLGNPKKRMRY-FDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDM 84

                         90
                 ....*....|..
gi 163792201  87 YEEELAFWGIDE 98
Cdd:cd18402   85 FSEEIKFYELGE 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRadeFFFDRHPGVFAHILNYYRTGKLHCPAD 81
Cdd:cd18364    2 VTLNVGGYLYITQRQTLTKYPDSFLEGMVNGKIQCTVDADGN---YFIDRDGLLFRHVLNFLRNGELLLPEG 70

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   7 SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDydpRADEFFFDRHPGVFAHILNYYRTGKLH-CPADVCGP 85
Cdd:cd18363    1 GDIINLNVGGKRFSTSRQTLTWIPDSFFTSLLSGRISSLKD---ETGAIFIDRDPKLFSIILNYLRTKEIDlRNVDISSL 77

                         90
                 ....*....|.
gi 163792201  86 LYEEElaFWGI 96
Cdd:cd18363   78 RHEAE--FYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201   8 ERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRadeFFFDRHPGVFAHILNYYRTGKLHcPADVCGPLY 87
Cdd:cd18366    4 EVVPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRHHIPKDSEGR---YFIDRDGSYFGYILNFLRDGDLP-PRERARAVY 79

                 ..
gi 163792201  88 EE 89
Cdd:cd18366   80 KE 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163792201  10 IVINVGGTRHQTYRSTL-RTLPGTRLAWLAEPDAHSHFDYDPRAdEFFFDRHPGVFAHILNYYRTGKLHCPADVC--GPL 86
Cdd:cd18368    3 IKLNVGGRIFTTTRSTLvKKEPDSMLARMFSDDSTWPSSRDENG-AYLIDRSPEYFEPILNYLRHGQLILNDGLNplGVL 81

                         90
                 ....*....|..
gi 163792201  87 yeEELAFWGIDE 98
Cdd:cd18368   82 --EEAKFFGIQS 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWL----AEPDAHSHFDydpRADEFFFDRHPGVFAHILNYYRTGKLHCP 79
Cdd:cd18370    1 VTLNVGGTLYSTTLETLTRFPDSMLGAMfragTPIPPNLNMQ---GGGHYFIDRDGKAFRHILNFLRLGRLDLP 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 163792201  10 IVINVGGTRHQTYRSTLRTLPGTRLAWLA--EPDAHSHFDydpRADEFFFDRHPGVFAHILNYYRTGKL 76
Cdd:cd18362    2 VKLNVGGTYFLTTRTTLCRDPKSFLCRLCqeDPDLPSDKD---ETGAYLIDRDPTYFGPILNYLRHGKL 67