NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|186910188|ref|NP_001119535|]
View 

putative KHDC1-like protein [Homo sapiens]

Protein Classification

KH domain-containing protein( domain architecture ID 10191018)

K homology (KH) domain-containing protein may bind single-stranded RNA or DNA; similar to Homo sapiens KH homology domain-containing protein 1 (KHDC1)

CATH:  3.30.1370.10
Gene Ontology:  GO:0003676
PubMed:  11160884|18422648
SCOP:  4001190

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 1-108 3.09e-38

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


:

Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 125.12  E-value: 3.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186910188   1 MAVGTSALSKEPWWTLPENFHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERcFTATGQTRVTVVGPPMAKQW 80
Cdd:cd12795    8 MSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEA-WDSSGLAEITVFGRPRARRR 86

                         90       100
                 ....*....|....*....|....*...
gi 186910188  81 LLLMFHCVGSQDSKCHARGLKMLERVRS 108
Cdd:cd12795   87 VKRMLLNLAAWHREHRARGREKLEELEE 114
 
Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 1-108 3.09e-38

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 125.12  E-value: 3.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186910188   1 MAVGTSALSKEPWWTLPENFHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERcFTATGQTRVTVVGPPMAKQW 80
Cdd:cd12795    8 MSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEA-WDSSGLAEITVFGRPRARRR 86

                         90       100
                 ....*....|....*....|....*...
gi 186910188  81 LLLMFHCVGSQDSKCHARGLKMLERVRS 108
Cdd:cd12795   87 VKRMLLNLAAWHREHRARGREKLEELEE 114
MOEP19 pfam16005
KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The ...
 10-92 1.23e-35

KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The family is expressed during early embryogenesis. It appears to effect an early form of molecular asymmetry within the murine oocyte cytoplasm. The family marks a defined cortical cytoplasmic domain in oocytes and provides evidence for mammalian oocyte polarity and a form of pre-patterning that persists in zygotes and early embryos through the morula stage.


Pssm-ID: 464969  Cd Length: 85  Bit Score: 117.36  E-value: 1.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186910188   10 KEPWWTLPENFHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERCFTaTGQTRVTVVGPPMAKQWLLLMFHCVG 89
Cdd:pfam16005   1 KRPWWFPPEELKDPLVFYLEAWLLELIFGPDGERIPHIEWMSQTLLQVDVVDS-EGLAEITIFGRPRYQKRVKKMLLSLA 79


                  ...
gi 186910188   90 SQD 92
Cdd:pfam16005  80 SWH 82
 
Name Accession Description Interval E-value
FILIA_N_like cd12795
FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and ...
 1-108 3.09e-38

FILIA-N KH-like domain; This group contains the N-terminal atypical KH domain of FILIA and related domains. FILIA is expressed in oocytes and embryo, and contains an atypical KH domain at the N-terminus with an N-terminal extension that interacts with RNA. RNA-binding may mediate RNA transcript regulation in oogenesis and embryogenesis. FILIA-N differs from typical KH domains by forming a stable dimer in solution and crystal structure.


Pssm-ID: 240613 [Multi-domain]  Cd Length: 114  Bit Score: 125.12  E-value: 3.09e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186910188   1 MAVGTSALSKEPWWTLPENFHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERcFTATGQTRVTVVGPPMAKQW 80
Cdd:cd12795    8 MSMEVLGLVKRPWWFRPEDLKDPLVLYVEAWLLEKIFGPDGALIPGIEWESQTLLQVEA-WDSSGLAEITVFGRPRARRR 86

                         90       100
                 ....*....|....*....|....*...
gi 186910188  81 LLLMFHCVGSQDSKCHARGLKMLERVRS 108
Cdd:cd12795   87 VKRMLLNLAAWHREHRARGREKLEELEE 114
MOEP19 pfam16005
KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The ...
 10-92 1.23e-35

KH-like RNA-binding domain; MOEP19 is a family of mammalian KH-like RNA-binding motifs. The family is expressed during early embryogenesis. It appears to effect an early form of molecular asymmetry within the murine oocyte cytoplasm. The family marks a defined cortical cytoplasmic domain in oocytes and provides evidence for mammalian oocyte polarity and a form of pre-patterning that persists in zygotes and early embryos through the morula stage.


Pssm-ID: 464969  Cd Length: 85  Bit Score: 117.36  E-value: 1.23e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186910188   10 KEPWWTLPENFHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERCFTaTGQTRVTVVGPPMAKQWLLLMFHCVG 89
Cdd:pfam16005   1 KRPWWFPPEELKDPLVFYLEAWLLELIFGPDGERIPHIEWMSQTLLQVDVVDS-EGLAEITIFGRPRYQKRVKKMLLSLA 79


                  ...
gi 186910188   90 SQD 92
Cdd:pfam16005  80 SWH 82
KH-I_KHDC1_like cd22440
type I K homology (KH) RNA-binding domain found in KHDC1-like family; The KHDC1-like family ...
 20-88 2.10e-31

type I K homology (KH) RNA-binding domain found in KHDC1-like family; The KHDC1-like family corresponds to a group of structurally related proteins characterized by an atypical RNA-binding KH domain. They are unique to eutherian mammals and specifically expressed in oocytes and/or embryonic stem cells. Family members include KH homology domain-containing protein 1 (KHDC1), KHDC1-like protein (KHDC1L), KHDC3-like protein (KHDC3L, also called ES cell-associated transcript 1 protein or ECAT1), developmental pluripotency-associated 5 protein (DPPA5, also called embryonal stem cell-specific gene 1 protein or ESG-1), Oocyte-expressed protein (OOEP, also called KH homology domain-containing protein 2 or KHDC2, or Oocyte- and embryo-specific protein 19 or OEP19). KHDC3L is essential for human oocyte maturation and pre-implantation development of the resulting embryos. DPPA5 is involved in the maintenance of embryonic stem (ES) cell pluripotency. OOEP plays an essential role for zygotes to progress beyond the first embryonic cell divisions.


Pssm-ID: 411868  Cd Length: 68  Bit Score: 106.23  E-value: 2.10e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186910188  20 FHSPMVFHMEEDQEELIFGLDDTYLRCIELHSHTLIQLERCFTaTGQTRVTVVGPPMAKQWLLLMFHCV 88
Cdd:cd22440    1 LQDPSVFHVEARLLEKIFGPDGTLIPHLEQESHTLIHVDRWDP-EGKAEITIFGPPRYRQRAKWMLQCL 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH