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Conserved domains on  [gi|193788532|ref|NP_001123309|]
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voltage-dependent L-type calcium channel subunit alpha-1C isoform 11 [Homo sapiens]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1476 7.32e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.85  E-value: 7.32e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1296 VDIAITEVNnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1375
Cdd:pfam00520   81 ISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1376 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1455
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 193788532  1456 IINLFVAVIMDNFDYLTRDWS 1476
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 1.48e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.08  E-value: 1.48e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 2.06e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.86  E-value: 2.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 193788532  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 1.53e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.16  E-value: 1.53e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 193788532   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1548-1641 2.78e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.33  E-value: 2.78e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1548 NATLFALVRTALRIKTEegpspseahqgaedpfrPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFY 1627
Cdd:pfam08763    1 TATLFALIRTSLKIKLA-----------------PAGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIY 63
                           90
                   ....*....|....
gi 193788532  1628 ATFLIQEYFRKFKK 1641
Cdd:pfam08763   64 AALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1661-2096 2.84e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.84e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1661 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1740
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1741 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1820
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1821 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1895
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1896 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1974
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1975 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2047
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 193788532  2048 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2096
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1485-1538 3.46e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.46e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532  1485 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1538
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1476 7.32e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.85  E-value: 7.32e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1296 VDIAITEVNnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1375
Cdd:pfam00520   81 ISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1376 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1455
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 193788532  1456 IINLFVAVIMDNFDYLTRDWS 1476
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 1.48e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.08  E-value: 1.48e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 2.06e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.86  E-value: 2.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 193788532  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 1.53e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.16  E-value: 1.53e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 193788532   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1548-1641 2.78e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.33  E-value: 2.78e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1548 NATLFALVRTALRIKTEegpspseahqgaedpfrPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFY 1627
Cdd:pfam08763    1 TATLFALIRTSLKIKLA-----------------PAGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIY 63
                           90
                   ....*....|....
gi 193788532  1628 ATFLIQEYFRKFKK 1641
Cdd:pfam08763   64 AALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1661-2096 2.84e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.84e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1661 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1740
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1741 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1820
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1821 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1895
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1896 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1974
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1975 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2047
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 193788532  2048 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2096
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1485-1538 3.46e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.46e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532  1485 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1538
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1619-1649 3.33e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.33e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 193788532   1619 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1649
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1476 7.32e-70

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.85  E-value: 7.32e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1296 VDIAITEVNnaeenSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIA 1375
Cdd:pfam00520   81 ISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1376 LNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFISFYMLCAFL 1455
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|.
gi 193788532  1456 IINLFVAVIMDNFDYLTRDWS 1476
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 1.48e-69

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 234.08  E-value: 1.48e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   283 AIIGLELFMGKMHKtcynqegiadvpaeddpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532   363 EGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 2.06e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.86  E-value: 2.06e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 193788532  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 1.53e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 185.16  E-value: 1.53e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   523 SNVFYWLVIFLVFLNTLTIASEHYNQPNW-LTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFVVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 193788532   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1548-1641 2.78e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.33  E-value: 2.78e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1548 NATLFALVRTALRIKTEegpspseahqgaedpfrPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFY 1627
Cdd:pfam08763    1 TATLFALIRTSLKIKLA-----------------PAGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIY 63
                           90
                   ....*....|....
gi 193788532  1628 ATFLIQEYFRKFKK 1641
Cdd:pfam08763   64 AALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1661-2096 2.84e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.59  E-value: 2.84e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1661 AGLRTLHDIGPEIRRAISGDLTAEEEldkamkeavsaaseddifrragglfgnhvsyyqsdgrsafpqtfttqrplhinK 1740
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEE-----------------------------------------------------E 27
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1741 AGSSQGDTESPSHEKLVDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAirvqevawkls 1820
Cdd:pfam16885   28 EEGQEGEEEEDSKDPKAPIGSQPPSRSRISVSLPVGDRLPDSLSLGPSDDDGGAPNSRQPSVPQTGSHT----------- 96
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1821 snrcHSRESQAAMAGQEETSQDETYEVK-MNHDTEACSEPSLLSteML-SYQDDENRQLTLP---EEDKRDIRQSPKRGF 1895
Cdd:pfam16885   97 ----HRRSSGVLMFTIPEEGSSQPKGTKgQDKQDEEEEVPDQLS--YLdEQAGTPSRPVLLPphrPQHYPLREPVDRRRL 170
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1896 LRSASLGRRASFHLECLKRQkdrggdiSQKTVLPLhlvhhqalavaglspllqrshsPASFPRPFATPPA-TPGSRGWPP 1974
Cdd:pfam16885  171 LPPTPAGRKPSFNIQCLRRQ-------GSCEDLPI----------------------PGTYHRGRNSGPSrAQGSWATPP 221
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1975 QP-----VPTLRLEgvesseklnssfpsihcgswaETTPGGG--GSSAARRVRPVSLMVPSQAGAPGRQFHGSASSLVEA 2047
Cdd:pfam16885  222 QRgrllyAPLLLVE---------------------EGAAGEGylGKSPGPLRTFTCLRVPGTHSDPSHGKRGSADSLVEA 280
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 193788532  2048 VLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQ 2096
Cdd:pfam16885  281 VLISEGLGLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1485-1538 3.46e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 3.46e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 193788532  1485 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1538
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1619-1649 3.33e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.33e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 193788532   1619 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1649
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1246-1469 1.67e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 57.29  E-value: 1.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1246 LFKIAMNILNMLFTGLFTVEMILKlIAFKPKHYFCDAWNTFDALIVVGSIV---------DIAITEVNNAEENSRISITF 1316
Cdd:pfam08016    8 LFILLCEIVFVVFFLYFVVEEILK-IRKHRPSYLRSVWNLLDLAIVILSVVlivlniyrdFLADRLIKSVEASPVTFIDF 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1317 FRLFRV----------------MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGkialndtt 1380
Cdd:pfam08016   87 DRVAQLdnlyriilaflvfltwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-------- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193788532  1381 eiNRNNNFQTFPQAVLLLFR-CATGEAWQDIMlacmpgkkcapesepsnstegetPCGSSFAVFYFISFYMLCAFLIINL 1459
Cdd:pfam08016  159 --TQAPNFSNFVKSILTLFRtILGDFGYNEIF-----------------------SGNRVLGPLLFLTFVFLVIFILLNL 213
                          250
                   ....*....|
gi 193788532  1460 FVAVIMDNFD 1469
Cdd:pfam08016  214 FLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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