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Conserved domains on  [gi|195972803|ref|NP_001124399|]
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myocyte-specific enhancer factor 2A isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HJURP_C super family cl13744
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 29-84 1.56e-04

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


The actual alignment was detected with superfamily member pfam12347:

Pssm-ID: 463543  Cd Length: 63  Bit Score: 39.64  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195972803   29 ESPD---ADDYFEHSPLSEDRFSKLNEDSDFIFKR--GPPGLPPQNFSMSVTVPVTSPNAL 84
Cdd:pfam12347   3 ISPVkaiSRPRTELPGRGENRYREIKEEFDKLHQEycLSSPKQPPNTKMPVSVAVSNYRAG 63
MADS super family cl00109
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-25 4.43e-04

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


The actual alignment was detected with superfamily member smart00432:

Pssm-ID: 469617 [Multi-domain]  Cd Length: 59  Bit Score: 38.31  E-value: 4.43e-04
                           10        20
                   ....*....|....*....|....*..
gi 195972803     2 GRKKIQITRIMDERNRQTL---RKKGL 25
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTfskRRNGL 27
 
Name Accession Description Interval E-value
HJURP_C pfam12347
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 29-84 1.56e-04

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


Pssm-ID: 463543  Cd Length: 63  Bit Score: 39.64  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195972803   29 ESPD---ADDYFEHSPLSEDRFSKLNEDSDFIFKR--GPPGLPPQNFSMSVTVPVTSPNAL 84
Cdd:pfam12347   3 ISPVkaiSRPRTELPGRGENRYREIKEEFDKLHQEycLSSPKQPPNTKMPVSVAVSNYRAG 63
MADS smart00432
MADS domain;
2-25 4.43e-04

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 38.31  E-value: 4.43e-04
                           10        20
                   ....*....|....*....|....*..
gi 195972803     2 GRKKIQITRIMDERNRQTL---RKKGL 25
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTfskRRNGL 27
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-25 1.61e-03

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 36.72  E-value: 1.61e-03
                         10        20
                 ....*....|....*....|....*..
gi 195972803   2 GRKKIQITRIMDERNRQTL---RKKGL 25
Cdd:cd00120    1 GRGKIEIKRIENKTSRQVTfskRRNGL 27
 
Name Accession Description Interval E-value
HJURP_C pfam12347
Holliday junction regulator protein family C-terminal repeat; Although this family is ...
 29-84 1.56e-04

Holliday junction regulator protein family C-terminal repeat; Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, pfam10384, family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in the higher eukaryotes.


Pssm-ID: 463543  Cd Length: 63  Bit Score: 39.64  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195972803   29 ESPD---ADDYFEHSPLSEDRFSKLNEDSDFIFKR--GPPGLPPQNFSMSVTVPVTSPNAL 84
Cdd:pfam12347   3 ISPVkaiSRPRTELPGRGENRYREIKEEFDKLHQEycLSSPKQPPNTKMPVSVAVSNYRAG 63
MADS smart00432
MADS domain;
2-25 4.43e-04

MADS domain;


Pssm-ID: 197721 [Multi-domain]  Cd Length: 59  Bit Score: 38.31  E-value: 4.43e-04
                           10        20
                   ....*....|....*....|....*..
gi 195972803     2 GRKKIQITRIMDERNRQTL---RKKGL 25
Cdd:smart00432   1 GRRKIEIKRIENKTNRQVTfskRRNGL 27
MADS cd00120
MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic ...
 2-25 1.61e-03

MADS: MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptonal regulators. Binds DNA and exists as hetero and homo-dimers. Composed of 2 main subgroups: SRF-like/Type I and MEF2-like (myocyte enhancer factor 2)/ Type II. These subgroups differ mainly in position of the alpha 2 helix responsible for the dimerization interface; Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238067 [Multi-domain]  Cd Length: 59  Bit Score: 36.72  E-value: 1.61e-03
                         10        20
                 ....*....|....*....|....*..
gi 195972803   2 GRKKIQITRIMDERNRQTL---RKKGL 25
Cdd:cd00120    1 GRGKIEIKRIENKTSRQVTfskRRNGL 27
MADS_MEF2_like cd00265
MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, ...
 2-25 1.68e-03

MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I subgroup mainly in position of the alpha helix responsible for the dimerization interface. Important in homeotic regulation in plants and in immediate-early development in animals. Also found in fungi.


Pssm-ID: 238165 [Multi-domain]  Cd Length: 77  Bit Score: 37.15  E-value: 1.68e-03
                         10        20
                 ....*....|....*....|....*..
gi 195972803   2 GRKKIQITRIMDERNRQ-TL--RKKGL 25
Cdd:cd00265    1 GRGKIEIKRIENSTNRQvTFskRRNGL 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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