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Conserved domains on  [gi|207113160|ref|NP_001128715|]
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treacle protein isoform d [Homo sapiens]

Protein Classification

LisH domain-containing protein; WD40 repeat domain-containing protein( domain architecture ID 12218018)

LIS1 homology (LisH) domain-containing protein similar to Homo sapiens LisH domain-containing protein ARMC9 that is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length| WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.05e-74

Treacher Collins syndrome protein Treacle;


:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.05e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle super family cl25490
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


The actual alignment was detected with superfamily member pfam03546:

Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


:

Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 207113160      6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
 
Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.05e-74

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.05e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
PHA03247 PHA03247
large tegument protein UL36; Provisional
 157-535 5.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247 2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 207113160  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-676 1.00e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247 2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 207113160  628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247 2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 207113160      6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
 
Name Accession Description Interval E-value
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
387-904 6.05e-74

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 256.92  E-value: 6.05e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546    1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546   81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546  161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546  237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546  315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546  394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546  474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
212-511 2.56e-09

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 61.63  E-value: 2.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546  252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546  332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160   364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546  407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207113160   444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546  466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
PHA03247 PHA03247
large tegument protein UL36; Provisional
 157-535 5.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247 2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 207113160  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-676 1.00e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247 2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 207113160  628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247 2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
Treacle pfam03546
Treacher Collins syndrome protein Treacle;
883-926 1.58e-04

Treacher Collins syndrome protein Treacle;


Pssm-ID: 460967 [Multi-domain]  Cd Length: 531  Bit Score: 46.22  E-value: 1.58e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 207113160   883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA 926
Cdd:pfam03546   43 TPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTGPAAAQA 86
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
234-499 1.91e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 1.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  234 PARKAAPAPGkvGDVTPQVKGGALPPAKRAkkpeeesesseEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGK 313
Cdd:PRK07003  360 PAVTGGGAPG--GGVPARVAGAVPAPGARA-----------AAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  314 GATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PRK07003  427 PAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAA 506

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA---------------SAPAKESPRKGAAPAPPRK 458
Cdd:PRK07003  507 VPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAldvlrnagmrvssdrGARAAAAAKPAAAPAAAPK 586

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 207113160  459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Cdd:PRK07003  587 PAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 385-467 7.66e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 44.11  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT----- 459
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAavede 116

                          90
                  ....*....|...
gi 207113160  460 -----GPAAAQVQ 467
Cdd:PRK12270  117 vtplrGAAAAVAK 129
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
214-463 1.08e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.68  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  214 GKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTpqvkGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293
Cdd:PRK07003  371 GVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAA----GAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGD 446

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  294 SEkiLQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Cdd:PRK07003  447 AP--VPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  374 ASAPAKES-PRKGAAPAPPGKTGPAVAK----AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA------ASAP 442
Cdd:PRK07003  525 AAPPAPEArPPTPAAAAPAARAGGAAAAldvlRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVqvptprARAA 604

                         250       260
                  ....*....|....*....|.
gi 207113160  443 AKESPRKGAAPAPPRKTGPAA 463
Cdd:PRK07003  605 TGDAPPNGAARAEQAAESRGA 625
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 177-465 2.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Cdd:PRK07764  391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAP 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ-------------------VKASEKILQVRAASAPAKG-------- 309
Cdd:PRK07764  471 AAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilaavPKRSRKTWAILLPEATVLGvrgdtlvl 550

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  310 ---TPGKGATPAPPGKAG-----------------AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Cdd:PRK07764  551 gfsTGGLARRFASPGNAEvlvtalaeelggdwqveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPA 630

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  370 QVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Cdd:PRK07764  631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP 710

                         330
                  ....*....|....*.
gi 207113160  450 GAAPAPPRKTGPAAAQ 465
Cdd:PRK07764  711 AGQADDPAAQPPQAAQ 726
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 6-37 2.86e-03

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 36.64  E-value: 2.86e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 207113160      6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667    2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
309-541 3.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 3.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  309 GTPGKGATPAPPgKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 388
Cdd:PRK12323  366 GQSGGGAGPATA-AAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  389 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRktgPAAAQVQV 468
Cdd:PRK12323  445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQ---PDAAPAGW 521

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 207113160  469 GKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAstmgmgplgkgagPVPPGKVGPATPSAQVGKW 541
Cdd:PRK12323  522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVA-------------PRPPRASASGLPDMFDGDW 581
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 378-465 5.76e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.41  E-value: 5.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  378 AKESPRKGAAPAPPGKTGPAVAKAQAgkreedsqssseesdSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPA---------------AAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAA 98


                  ....*...
gi 207113160  458 KTGPAAAQ 465
Cdd:PRK12270   99 PPAAAAAA 106
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
250-466 8.45e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 8.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvrAASAPAKGTPGKGATPAPPGKAGAVASQ 329
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAP------AAAAAARAVAAAPARRSPAPEALAAARQ 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207113160  330 TKAGKPEEDSESSSEESSDSEEETPAAKALLQAKasgktsqvgAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED 409
Cdd:PRK12323  439 ASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV---------AAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 207113160  410 SQSSSEESDSEEEAPAQAKPSGKAPqvRAASAPAKESPRKGAAPAPPRKTGPAAAQV 466
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPDPATADP--DDAFETLAPAPAAAPAPRAAAATEPVVAPR 564
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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