|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
1-368 |
1.48e-163 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 474.27 E-value: 1.48e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPA--VE 78
Cdd:cd01703 14 EIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVYRLLRSYSWNdrVE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 79 RLGFDENFVDLTEMvekrlqqlpseevpsvtvfghvynnqsvnlhnimhrRLVVGSQIAAEMREAMYNQLGLTGCAGVAP 158
Cdd:cd01703 94 RLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIENELGLTCCAGIAS 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 159 NKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPI------------- 223
Cdd:cd01703 138 NKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsll 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 224 --KTLEKELGIAIAQRIQQLSFGEDKSPV-TPSGPPQSFSEEDTFKKCSSEV--EAKAKIEELLSSLLTRVCQ------- 291
Cdd:cd01703 218 elLLMVKEFGEGIGQRIWKLLFGRDTSPVkPASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevka 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 292 -DGRKPHTVRLVIRRYSD--KHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVK--MPFHLTLMSVCF 366
Cdd:cd01703 298 gDGRRPHTLRLTLRRYTStkKHYNRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCF 377
|
..
gi 209863006 367 CN 368
Cdd:cd01703 378 TN 379
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-359 |
4.65e-70 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 231.19 E-value: 4.65e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGV---QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAV 77
Cdd:COG0389 17 QRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRDVSRRVMAILERYTPLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 78 ERLGFDENFVDLTEMveKRLqqLPSEEvpsvtvfghvynnqsvnlhnimhrrlvvgsQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:COG0389 96 EPLSIDEAFLDVTGS--ARL--FGSAE------------------------------AIARRIRRRIRRETGLTVSVGIA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAiAQR 237
Cdd:COG0389 142 PNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKV-GER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 238 IQQLSFGEDKSPVTPSGPPQSFSEEDTFKKcssEVEAKAKIEELLSSLLTRVC----QDGRKPHTVRLVIrRYSDKHCNR 313
Cdd:COG0389 220 LYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKL-RTSDFRTTT 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 209863006 314 ESRQCPIPShviqklgtgnhDSMPPLIDILMKLFRNMVNVKMPFHL 359
Cdd:COG0389 296 RSRTLPEPT-----------DDTAELLRAARELLERIYRPGRPVRL 330
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
4-308 |
1.14e-55 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 193.03 E-value: 1.14e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGV----QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAVER 79
Cdd:PRK02406 13 NPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIREIFRRYTDLIEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 80 LGFDENFVDLTEmvekrlqqlpseevpsvtvfghvynnqsvNLHNImhrrlvvGS--QIAAEMREAMYNQLGLTGCAGVA 157
Cdd:PRK02406 92 LSLDEAYLDVTD-----------------------------NKLCI-------GSatLIAQEIRQDIFEELGLTASAGVA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGiAIAQR 237
Cdd:PRK02406 136 PNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRR 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209863006 238 IQQLSFGEDKSPVTPSGPPQSFSEEDTFKK-CSSEVEAKAKIEEL---LSSLLTRVcQDGRKPHTVRLVIrRYSD 308
Cdd:PRK02406 214 LYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTVGVKL-KFAD 286
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-167 |
3.20e-37 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 135.78 E-value: 3.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGVQQKY---LVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVnGEDLSRYREMSYKVTELLEEF-SPA 76
Cdd:pfam00817 12 LLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKIFEILRRFsTPK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 77 VERLGFDENFVDLTEMVEKrlqqlpseevpsvtvFGHVynnqsvnlhnimhrrlvvgSQIAAEMREAMYNQLGLTGCAGV 156
Cdd:pfam00817 91 VEQASIDEAFLDLTGLEKL---------------FGAE-------------------EALAKRLRREIAEETGLTCSIGI 136
|
170
....*....|.
gi 209863006 157 APNKLLAKLVS 167
Cdd:pfam00817 137 APNKLLAKLAS 147
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
636-664 |
6.86e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 34.89 E-value: 6.86e-03
10 20
....*....|....*....|....*....
gi 209863006 636 LPFPPDIDPQVFYELPEEVQKELMAEWER 664
Cdd:cd19318 6 LPSFSQVDPSVLAALPPDLQEELEAAYAQ 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
1-368 |
1.48e-163 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 474.27 E-value: 1.48e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPA--VE 78
Cdd:cd01703 14 EIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVYRLLRSYSWNdrVE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 79 RLGFDENFVDLTEMvekrlqqlpseevpsvtvfghvynnqsvnlhnimhrRLVVGSQIAAEMREAMYNQLGLTGCAGVAP 158
Cdd:cd01703 94 RLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIENELGLTCCAGIAS 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 159 NKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPI------------- 223
Cdd:cd01703 138 NKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsll 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 224 --KTLEKELGIAIAQRIQQLSFGEDKSPV-TPSGPPQSFSEEDTFKKCSSEV--EAKAKIEELLSSLLTRVCQ------- 291
Cdd:cd01703 218 elLLMVKEFGEGIGQRIWKLLFGRDTSPVkPASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevka 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 292 -DGRKPHTVRLVIRRYSD--KHCNRESRQCPIPSHVIQKLGTGNHDSMPPLIDILMKLFRNMVNVK--MPFHLTLMSVCF 366
Cdd:cd01703 298 gDGRRPHTLRLTLRRYTStkKHYNRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCF 377
|
..
gi 209863006 367 CN 368
Cdd:cd01703 378 TN 379
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
1-367 |
4.01e-106 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 325.85 E-value: 4.01e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGVQQKY----LVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNgEDLSRYREMSYKVTELLEEFSPA 76
Cdd:cd00424 14 QLARPELKGRPVVVVPFNsdstCVIACSYEARKYGVKRGMPVREARKMCPNLILVP-ARLDLYRRLSERLLSELEEVAPL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 77 VERLGFDENFVDLTEMVekrlqqlpseevpsvtvfghvynnqsvnlhnimhRRLVVGSQIAAEMREAMYNQLG-LTGCAG 155
Cdd:cd00424 93 VEVASIDELFLDLTGSA----------------------------------RLLGLGSEVALRIKRHIAEQLGgITASIG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 156 VAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIhSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIA 235
Cdd:cd00424 139 IASNKLLAKLAAKYAKPDGLTILDPEDLPGFL-SKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALWGGVSG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 236 QRIQQLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSEVE-AKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSD---KHC 311
Cdd:cd00424 218 ERLWYALRGIDDEPLSPPRPRKSFSHERVLPRDSRNAEdARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGrwsGHA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 209863006 312 NRESRQCPIPSHViqklgtgnhdSMPPLIDILMKLFRNMVNVKMPFHLTLMSVCFC 367
Cdd:cd00424 298 DIPSRSAPRPIST----------EDGELLHALDKLWRALLDDKGPRRLRRLGVRLS 343
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-359 |
4.65e-70 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 231.19 E-value: 4.65e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGV---QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAV 77
Cdd:COG0389 17 QRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRDVSRRVMAILERYTPLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 78 ERLGFDENFVDLTEMveKRLqqLPSEEvpsvtvfghvynnqsvnlhnimhrrlvvgsQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:COG0389 96 EPLSIDEAFLDVTGS--ARL--FGSAE------------------------------AIARRIRRRIRRETGLTVSVGIA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAiAQR 237
Cdd:COG0389 142 PNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKV-GER 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 238 IQQLSFGEDKSPVTPSGPPQSFSEEDTFKKcssEVEAKAKIEELLSSLLTRVC----QDGRKPHTVRLVIrRYSDKHCNR 313
Cdd:COG0389 220 LYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKL-RTSDFRTTT 295
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 209863006 314 ESRQCPIPShviqklgtgnhDSMPPLIDILMKLFRNMVNVKMPFHL 359
Cdd:COG0389 296 RSRTLPEPT-----------DDTAELLRAARELLERIYRPGRPVRL 330
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
1-328 |
6.09e-70 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 230.87 E-value: 6.09e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGV---QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAV 77
Cdd:cd03586 14 QRDNPELKGKPVAVggsSDRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPP-RFDKYREVSRQIMEILREYTPLV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 78 ERLGFDENFVDLTEmvekrlqqlpseevpsvtvfgHVYNNQSvnlhnimhrrlvvGSQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:cd03586 93 EPLSIDEAYLDVTD---------------------YVRLFGS-------------ATEIAKEIRARIREETGLTASAGIA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGiAIAQR 237
Cdd:cd03586 139 PNKFLAKIASDLNKPNGLTVIPPEDVEEFLAPL-PVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFG-KSGRR 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 238 IQQLSFGEDKSPVTPSGPPQSFSEEDTF-KKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIrRYSDKHCNRESR 316
Cdd:cd03586 217 LYELARGIDNRPVEPDRERKSIGVERTFsEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKL-KYADFSTRTRSR 295
|
330
....*....|..
gi 209863006 317 QCPIPSHVIQKL 328
Cdd:cd03586 296 TLPEPTDDAEDI 307
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
4-308 |
1.14e-55 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 193.03 E-value: 1.14e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGV----QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAVER 79
Cdd:PRK02406 13 NPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIREIFRRYTDLIEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 80 LGFDENFVDLTEmvekrlqqlpseevpsvtvfghvynnqsvNLHNImhrrlvvGS--QIAAEMREAMYNQLGLTGCAGVA 157
Cdd:PRK02406 92 LSLDEAYLDVTD-----------------------------NKLCI-------GSatLIAQEIRQDIFEELGLTASAGVA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGiAIAQR 237
Cdd:PRK02406 136 PNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRR 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209863006 238 IQQLSFGEDKSPVTPSGPPQSFSEEDTFKK-CSSEVEAKAKIEEL---LSSLLTRVcQDGRKPHTVRLVIrRYSD 308
Cdd:PRK02406 214 LYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTVGVKL-KFAD 286
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
4-368 |
5.12e-46 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 167.11 E-value: 5.12e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLV------NGED----------------LSRYRE 61
Cdd:cd01702 17 LGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILAhvatykKGEDeadyhenpsparhkvsLDPYRR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 62 MSYKVTELLEEFSPAVERLGFDENFVDLtemvekrlqqlpseevpsvtvfghvynnqsvnlhnimhrrlvvGSQIAAEMR 141
Cdd:cd01702 97 ASRKILNILKRFGDVVEKASIDEAYLDL-------------------------------------------GSRIVEEIR 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 142 EAMYNQLGLTGCAGVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRL-EVLGINSVHDLQT 220
Cdd:cd01702 134 QQVYDELGYTCSAGIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLP-ITSIRGLGGKLGEEIiDLLGLPTEGDVAG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 221 FPIKT--LEKELGIAIAQRIQQLSFGEDKSPVTPSGPPQSFSEEDTF--KKCSSEVEAKAKIEELLSSLLTRVCQD---- 292
Cdd:cd01702 213 FRSSEsdLQEHFGEKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFpgKTALSTEDVQHWLLVLASELNSRLEDDryen 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863006 293 GRKPHTVRLVIRRYSDKhcNRESRQCPIPSHVIQKLgtgNHDSMppliDILMKLFRNMVNVKMPFHLTLMSVCFCN 368
Cdd:cd01702 293 NRRPKTLVLSLRQRGDG--VRRSRSCALPRYDAQKI---VKDAF----KLIKAINEEGLGLAWNYPLTLLSLSFTK 359
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
1-308 |
3.81e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 154.80 E-value: 3.81e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGV-----QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNgEDLSRYREMSYKVTELLEEFSP 75
Cdd:PRK01810 21 IAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDRYREASRQMFQILSEFTP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 76 AVERLGFDENFVDLTEMVEKrlqqlpseevpsvtvfGHVYnnqsvnlhnimhrrlvvgsQIAAEMREAMYNQLGLTGCAG 155
Cdd:PRK01810 100 LVQPVSIDEGYLDITDCYAL----------------GSPL-------------------EIAKMIQQRLLTELQLPCSIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 156 VAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAiA 235
Cdd:PRK01810 145 IAPNKFLAKMASDMKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN-G 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 236 QRIQQLSFGEDKSPVTPS--------GPPQSFSEE--------DTFKKCSSEVEAKAKIEELLSSlltrvcqdgrkphTV 299
Cdd:PRK01810 223 VRLQRRANGIDDRPVDPEaiyqfksvGNSTTLSHDmdeekellDVLRRLSKSVSKRLQKKTVVSY-------------NV 289
|
....*....
gi 209863006 300 RLVIrRYSD 308
Cdd:PRK01810 290 QIMI-RYHD 297
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-167 |
3.20e-37 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 135.78 E-value: 3.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 1 MISNPELKDRPLGVQQKY---LVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVnGEDLSRYREMSYKVTELLEEF-SPA 76
Cdd:pfam00817 12 LLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKIFEILRRFsTPK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 77 VERLGFDENFVDLTEMVEKrlqqlpseevpsvtvFGHVynnqsvnlhnimhrrlvvgSQIAAEMREAMYNQLGLTGCAGV 156
Cdd:pfam00817 91 VEQASIDEAFLDLTGLEKL---------------FGAE-------------------EALAKRLRREIAEETGLTCSIGI 136
|
170
....*....|.
gi 209863006 157 APNKLLAKLVS 167
Cdd:pfam00817 137 APNKLLAKLAS 147
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
5-306 |
6.28e-36 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 140.84 E-value: 6.28e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 5 PELKDRPL---GVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLG 81
Cdd:PRK03348 25 PTLRGRPVlvgGLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVVLPPRFVVYRAASRRVFDTLRELSPVVEQLS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 82 FDENFVDLTEmvekrLQQLPSEEVpsvtvfghvynnqsvnlhnimhrrlvvgSQIAAEMREAMYNQLGLTGCAGVAPNKL 161
Cdd:PRK03348 105 FDEAFVEPAE-----LAGASAEEV----------------------------EAFAERLRARVREETGLPASVGAGSGKQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 162 LAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQL 241
Cdd:PRK03348 152 IAKIASGLAKPDGIRVVPPGEERELLAPLP-VRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATVGPALHRL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209863006 242 SFGEDKSPVTPSGPPQSFSEEDTFKK-CSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRY 306
Cdd:PRK03348 231 ARGIDDRPVAERAEAKQISAESTFAVdLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKS 296
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
5-322 |
6.53e-33 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 131.28 E-value: 6.53e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 5 PELKDRPLGV-QQKYL---VVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVnGEDLSRYREMSYKVTELLEEFSPAVERL 80
Cdd:cd01701 67 PDLKGKPVAVcHGKGPnseIASCNYEARSYGIKNGMWVGQAKKLCPQLVTL-PYDFEAYEEVSLTFYEILASYTDNIEAV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 81 GFDENFVDLTEmvekrlqqLPSEEVPSVTVFGhvynnqsvnlhnimhrrlvvgSQIAAEMREAmynqlglTGC---AGVA 157
Cdd:cd01701 146 SCDEALIDITS--------LLEETYELPEELA---------------------EAIRNEIRET-------TGCsasVGIG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHD--LQTFPIKTLEKELGIAIA 235
Cdd:cd01701 190 PNILLARLATRKAKPDGQYHLSAEKVEEFLSQLK-VGDLPGVGSSLAEKLVKLFGDTCGGleLRSKTKEKLQKVLGPKTG 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 236 QRIQQLSFGEDKSPVTPSGPPQSFSEEDT----FKKcssEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIRRYSDKH- 310
Cdd:cd01701 269 EKLYDYCRGIDDRPVTGEKERKSVSAEINygirFTN---VDDVEQFLQRLSEELSKRLEESNVTGRQITLKLMKRAPGAp 345
|
330 340
....*....|....*....|...
gi 209863006 311 -----------CNRESRQCPIPS 322
Cdd:cd01701 346 ieppkymghgiCDSFSKSSTLGV 368
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-265 |
1.85e-32 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 130.05 E-value: 1.85e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPL--GVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGeDLSRYREMSYKVTELLEEFSPAVERLG 81
Cdd:PRK02794 55 NPELRDKPViiGGGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKP-DMEKYVRVGREVRAMMQALTPLVEPLS 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 82 FDENFVDL--TEmvekRLQQLPseevPSVTVfghvynnqsvnlhnimhrrlvvgSQIAAEMREamynQLGLTGCAGVAPN 159
Cdd:PRK02794 134 IDEAFLDLsgTE----RLHGAP----PAVVL-----------------------ARFARRVER----EIGITVSVGLSYN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 160 KLLAKLVSGVFKPNQQTVLLPESCQHLIHSlNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGiAIAQRIQ 239
Cdd:PRK02794 179 KFLAKIASDLDKPRGFSVIGRAEALAFLAP-KPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG-SMGLRLW 256
|
250 260
....*....|....*....|....*.
gi 209863006 240 QLSFGEDKSPVTPSGPPQSFSEEDTF 265
Cdd:PRK02794 257 RLARGIDDRKVSPDREAKSVSAETTF 282
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
4-348 |
1.99e-31 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 125.35 E-value: 1.99e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGVqqkyL------VVTCNYEARKLGVRKLMNVRDAKEKCPQL-VLVNGEDLSRYREMSYKVTELLEEFSPA 76
Cdd:cd01700 17 RPLLLGRPLVV----LsnndgcVIARSPEAKALGIKMGSPYFKVPDLLERHgVAVFSSNYALYGDMSRRIMSILERFSPD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 77 VERLGFDENFVDLTEMvekrlqqlpseevpsvtvfghvynNQSVNLHnimhrrlvvgsQIAAEMREAMYNQLGLTGCAGV 156
Cdd:cd01700 93 VEVYSIDESFLDLTGS------------------------LRFGDLE-----------ELARKIRRRILQETGIPVTVGI 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 157 APNKLLAKLVSGVFKPNQQT----VLLPESCQHLIHSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGI 232
Cdd:cd01700 138 GPTKTLAKLANDLAKKKNPYggvvDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 233 aIAQRIQQLSFGEDKSPVTPSGPP-QSFseedtfkkCSSE-----VEAKAKIEELLSSLLTRVC----QDGRKPHTVRLV 302
Cdd:cd01700 218 -VGERLVRELNGIDCLPLEEYPPPkKSI--------GSSRsfgrdVTDLDELKQALAEYAERAAeklrRQKSVARTISVF 288
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 209863006 303 IRrysdkhCNRESRQCPIPSHViQKLGTGNHDSMppliDILMKLFR 348
Cdd:cd01700 289 IG------TSGFSRQPKYYSAT-NTLPYPTNDTR----EIVKAALR 323
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-323 |
2.25e-30 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 123.96 E-value: 2.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGV-----QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEdLSRYREMSYKVTELLEEFSPAVE 78
Cdd:PRK03103 22 NPELKGRPVIVsgdpeRRSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPR-MQRYIDVSLQITRILEDFTDLVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 79 RLGFDENFVDLTEmvekrlqqlpseevpSVTVFGHVYnnqsvnlhnimhrrlvvgsQIAAEMREAMYNQLGLTGCAGVAP 158
Cdd:PRK03103 101 PFSIDEQFLDVTG---------------SQKLFGSPL-------------------EIAQKIQQRIMRETGVYARVGIGP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 159 NKLLAKLVSGVF---KPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIaIA 235
Cdd:PRK03103 147 NKLLAKMACDNFakkNPDGLFTLDKEDVPADLWPLP-VRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGI-NG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 236 QRIQQLSFGEDKSPVTPSGPP--QSFSEEDTFKKCSSEVEakaKIEELLSSLLTRVCQDGRKPH----TVRLVIRRYSDK 309
Cdd:PRK03103 225 EVLWRTANGIDYSPVTPHSLDrqKAIGHQMTLPRDYRGFE---EIKVVLLELCEEVCRRARAKGymgrTVSVSLRGADFD 301
|
330
....*....|....
gi 209863006 310 HCNRESRQCPIPSH 323
Cdd:PRK03103 302 WPTGFSRQMTLPEP 315
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
4-267 |
1.09e-29 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 120.59 E-value: 1.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPL---GVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEdLSRYREMSYKVTELLEEFSPAVERL 80
Cdd:PRK14133 22 NPKLKGKPVivgGISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVR-HERYKEVSKNIFKILYEVTPIVEPV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 81 GFDENFVDLTEMVEKrlqqlpseevpsvtvfghvynnqsvnlhnimhrrlvvGSQIAAEMREAMYNQLGLTGCAGVAPNK 160
Cdd:PRK14133 101 SIDEAYLDITNIKEE-------------------------------------PIKIAKYIKKKVKKETGLTLSVGISYNK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 161 LLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEK---ELGIAIAQR 237
Cdd:PRK14133 144 FLAKLASDWNKPDGIKIITEDMIPDILKPLP-ISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEyfgKFGVEIYER 222
|
250 260 270
....*....|....*....|....*....|
gi 209863006 238 IQqlsfGEDKSPVTPSGPPQSFSEEDTFKK 267
Cdd:PRK14133 223 IR----GIDYREVEVSRERKSIGKETTLKK 248
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
4-250 |
9.47e-28 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 115.85 E-value: 9.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPL----GVqqkylVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEdLSRYREMSYKVTELLEEFSPAVER 79
Cdd:PRK03858 23 DPALRGRPVivggGV-----VLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPR-MSAYSRASKAVFEVFRDTTPLVEG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 80 LGFDENFVDLTEMveKRLQQLPseevpsvtvfghvynnqsvnlhnimhrrlvvgSQIAAEMREAMYNQLGLTGCAGVAPN 159
Cdd:PRK03858 97 LSIDEAFLDVGGL--RRISGTP--------------------------------VQIAARLRRRVREEVGLPITVGVART 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 160 KLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQ 239
Cdd:PRK03858 143 KFLAKVASQVAKPDGLLVVPPDRELAFLHPLP-VRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPAAGRHLH 221
|
250
....*....|.
gi 209863006 240 QLSFGEDKSPV 250
Cdd:PRK03858 222 ALAHNRDPRRV 232
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
2-252 |
2.15e-26 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 111.03 E-value: 2.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 2 ISNPELKDRPLGV-------QQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNGEDlSRYREMSYKVTELLEEFS 74
Cdd:PRK01216 18 VLNPSLKGKPVVVcvysgrfEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRK-EVYQQVSNRIMKLLREYS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 75 PAVERLGFDENFVDLTEMVEkrlqqlpseevpsvtvfghvyNNQSvnlhnimhrrlvvGSQIAAEMREAMYNQLGLTGCA 154
Cdd:PRK01216 97 EKIEIASIDEAYLDISDKVK---------------------NYQD-------------AYNLGLEIKNKILEKEKITVTV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 155 GVAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAI 234
Cdd:PRK01216 143 GISKNKVFAKIAADMAKPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAK 221
|
250
....*....|....*...
gi 209863006 235 AQRIQQLSFGEDKSPVTP 252
Cdd:PRK01216 222 AKYLFSLARNEYNEPVRA 239
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
5-322 |
1.34e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 108.57 E-value: 1.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 5 PELKDRPLGV------QQKYLVVTC-NYEARKLGVRKLMNVRDAKEKCPQLVLVNgEDLSRYREMSYKVTELLEEFSPAV 77
Cdd:PRK03352 25 PELAGLPVIVggngdpTEPRKVVTCaSYEARAFGVRAGMPLRTAARRCPDAVFLP-SDPAAYDAASEEVMATLRDLGVPV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 78 ERLGFDENFVDLTEmvekrlqqlpseEVPSvtvfghvynnqsvnlhnimhrrlvvgsQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:PRK03352 104 EVWGWDEAFLGVDT------------DDPE---------------------------ALAEEIRAAVLERTGLSCSVGIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 158 PNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQR 237
Cdd:PRK03352 145 DNKLRAKIATGFAKPAGVFRLTDANWMAVMGDRP-TDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPW 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 238 IQQLSFGEDKSPVTpSGP--PQSFSEEDTFKK---CSSEVEakAKIEELLSSLLTRVCQDGRKPHTVRLVIrRYSDKHCN 312
Cdd:PRK03352 224 LLLLARGGGDTEVS-AEPwvPRSRSREVTFPQdltDRAEVE--SAVRELARRVLDEVVAEGRPVTRVAVKV-RTATFYTR 299
|
330
....*....|
gi 209863006 313 RESRQCPIPS 322
Cdd:PRK03352 300 TKIRKLPEPT 309
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
4-218 |
1.03e-14 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 77.37 E-value: 1.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 4 NPELKDRPLGVQQKYLVVTCNYEARKLGVRKLMNVRDAKEKCPQLVLVNgEDLSRYREMSYKVTELLEEFSPAVERLGFD 83
Cdd:PTZ00205 152 HPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP-PDFDAYNEESNTVRRIVAEYDPNYISFGLD 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 84 ENFVDLTEMVEKRLQQLPSEEVpsvtvfghvynnqsvnlhnimhrrlvvgsqiAAEMREAMYNQLGLTGCAGVAPNKLLA 163
Cdd:PTZ00205 231 ELTLEVSAYIERFEGTKTAEDV-------------------------------ASELRVRVFGETKLTASAGIGPTAALA 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 209863006 164 KLVSGVFKPNQQTVL---LPESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGINSVHDL 218
Cdd:PTZ00205 280 KIASNINKPNGQHDLnlhTRGDVMTYVRDLG-LRSVPGVGKVTEALLKGLGITTLSDI 336
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
5-245 |
2.39e-14 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 75.57 E-value: 2.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 5 PELKDRPLGV--QQKYLVVTCNYEARKLGVR---KLMNVRDAKEKCPQLVLVNGEDLsrYREMSYKVTELLEEFSPAVER 79
Cdd:PRK03609 20 PDLRGKPVVVlsNNDGCVIARSAEAKALGIKmgdPWFKQKDLFRRCGVVCFSSNYEL--YADMSNRVMSTLEELSPRVEI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 80 LGFDENFVDLTEMVEKRlqqlpseevpSVTVFGHvynnqsvnlhnimhrrlvvgsqiaaEMREAMYNQLGLTGCAGVAPN 159
Cdd:PRK03609 98 YSIDEAFCDLTGVRNCR----------DLTDFGR-------------------------EIRATVLQRTHLTVGVGIAQT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 160 KLLAKLVSGVFKP-NQQT---VLL--PESCQHLIhSLNHIKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIA 233
Cdd:PRK03609 143 KTLAKLANHAAKKwQRQTggvVDLsnLERQRKLL-SLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVV 221
|
250
....*....|..
gi 209863006 234 IAQRIQQLSfGE 245
Cdd:PRK03609 222 LERTVRELR-GE 232
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
5-260 |
2.02e-11 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 65.87 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 5 PELKDRPLGV--QQKYLVVT-CNYEARKLGVRKLMNVRDAKEKCPQLVLVNgEDLSRYREMSYKVTELLEEFSPAVERLG 81
Cdd:cd03468 18 PADDEAPLAVveRKKAGRILaCNAAARAAGVRPGMPLAEALALCPNLQVVE-YDPEADARALQELALWLLRFTPLVALDG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 82 FDENFVDLTemvekrlqqlpseevPSVTVFGhvynnqsvnlhnimhrrlvvGSQIAAEMREAMYNQLGLTGCAGVAPNKL 161
Cdd:cd03468 97 PDGLLLDVT---------------GCLHLFG--------------------GEDALAASLRAALATLGLSARAGIADTPG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 162 LAKLVSgvFKPNQQTVLLPESCQHLIHSLNH-IKEIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEKELGIAIAQRIQQ 240
Cdd:cd03468 142 AAWLLA--RAGGGRGVLRREALAAALVLLAPlPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQ 219
|
250 260
....*....|....*....|
gi 209863006 241 LsFGEDKSPVTPSGPPQSFS 260
Cdd:cd03468 220 A-YGRDPEPLLFSPPPPAFD 238
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
256-369 |
4.73e-08 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 51.41 E-value: 4.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863006 256 PQSFSEEDTF-KKCSSEVEAKAKIEELLSSLLTRVCQDGRKPHTVRLVIrRYSDKHcnRESRQCPIPSHViqklgtgnhD 334
Cdd:pfam11799 1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKI-RYSDFR--TITRSVTLPSPT---------D 68
|
90 100 110
....*....|....*....|....*....|....*
gi 209863006 335 SMPPLIDILMKLFRNMVNvkmPFHLTLMSVCFCNL 369
Cdd:pfam11799 69 DTDEIYRAALRLLRRLYR---GRPVRLLGVSLSNL 100
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
180-212 |
1.15e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 42.38 E-value: 1.15e-05
10 20 30
....*....|....*....|....*....|...
gi 209863006 180 PESCQHLIHSLNhIKEIPGIGYKTAKRLEVLGI 212
Cdd:pfam11798 1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
195-238 |
7.32e-04 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 37.85 E-value: 7.32e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 209863006 195 EIPGIGYKTAKRLEVLGINSVHDLQTFPIKTLEK--ELGIAIAQRI 238
Cdd:pfam14520 6 SISGIGPKTALALLSAGIGTVEDLAEADVDELAEipGIGEKTAQRI 51
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
636-664 |
6.86e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 34.89 E-value: 6.86e-03
10 20
....*....|....*....|....*....
gi 209863006 636 LPFPPDIDPQVFYELPEEVQKELMAEWER 664
Cdd:cd19318 6 LPSFSQVDPSVLAALPPDLQEELEAAYAQ 34
|
|
| |
