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Conserved domains on  [gi|218563730|ref|NP_001136269|]
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C-X-C chemokine receptor type 3 isoform 2 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606914)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
101-376 1.95e-138

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


:

Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 396.75  E-value: 1.95e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 101 AFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI 180
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 181 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQV--- 257
Cdd:cd15180   81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFPQSdty 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 258 GRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVS-RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARN 336
Cdd:cd15180  161 WWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSsQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 337 CGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15180  241 CGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
 
Name Accession Description Interval E-value
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
101-376 1.95e-138

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 396.75  E-value: 1.95e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 101 AFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI 180
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 181 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQV--- 257
Cdd:cd15180   81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFPQSdty 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 258 GRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVS-RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARN 336
Cdd:cd15180  161 WWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSsQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 337 CGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15180  241 CGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
120-365 1.52e-61

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 199.45  E-value: 1.52e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  120 AVAAVLLSRRTaLSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:pfam00001   5 VILVILRNKKL-RTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhgDWPFGSALCKIVGALFVVNGYASILLLTAISIDR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHC--QYNFPQVGRTALRVLQLVAGFLLP 274
Cdd:pfam00001  84 YLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCfiDFPEDLSKPVSYTLLISVLGFLLP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  275 LLVMAYCYAHILAVLL--------VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESRVDVA 346
Cdd:pfam00001 164 LLVILVCYTLIIRTLRksaskqksSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLD------SLALDCELSRLLDKA 237
                         250
                  ....*....|....*....
gi 218563730  347 KSVTSGLGYMHCCLNPLLY 365
Cdd:pfam00001 238 LSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
121-376 3.44e-38

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 140.68  E-value: 3.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:PHA03087  60 IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYiLFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIA 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF-PQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:PHA03087 140 IVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNkTMNWKLFINFEINIIGMLIPLTIL 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL-LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMH 357
Cdd:PHA03087 220 LYCYSKILITLkGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS-GCKAVKYIQYALHVTEIISLSH 298
                        250
                 ....*....|....*....
gi 218563730 358 CCLNPLLYAFVGVKFRERM 376
Cdd:PHA03087 299 CCINPLIYAFVSEFFNKHK 317
 
Name Accession Description Interval E-value
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
101-376 1.95e-138

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 396.75  E-value: 1.95e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 101 AFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNI 180
Cdd:cd15180    1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 181 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQV--- 257
Cdd:cd15180   81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFPQSdty 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 258 GRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVS-RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARN 336
Cdd:cd15180  161 WWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSsQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRN 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 337 CGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15180  241 CGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
121-376 1.59e-117

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 343.43  E-value: 1.59e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd14984   21 VLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSFLCKLVSALYTINFYSGILFLACISIDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHdeRLNATHCQYNFPQVG----RTALRVLQLVAGFLLPLL 276
Cdd:cd14984  101 VHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSE--ENGSSICSYDYPEDTattwKTLLRLLQNILGFLLPLL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd14984  179 VMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRSCELSKSLDYALQVTESLAFS 258
                        250       260
                 ....*....|....*....|
gi 218563730 357 HCCLNPLLYAFVGVKFRERM 376
Cdd:cd14984  259 HCCLNPVLYAFVGVKFRKYL 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
121-376 7.54e-87

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 265.29  E-value: 7.54e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15178   21 VVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEANFYSGILLLACISVDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLyRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF----PQVGRTALRVLQLVAGFLLPLL 276
Cdd:cd15178  101 VHATRA-LTQKRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCYENLgnesADKWRVVLRILRHTLGFLLPLV 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd15178  180 VMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITETCELRNHVDVALYVTQILGFL 259
                        250       260
                 ....*....|....*....|
gi 218563730 357 HCCLNPLLYAFVGVKFRERM 376
Cdd:cd15178  260 HSCINPVLYAFIGQKFRNNL 279
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
121-373 1.54e-83

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 256.98  E-value: 1.54e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15181   21 VLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTFLCKLVGAIHKLNFYCSSLLLACISVDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCqyNFPQVGRTALRVLQL------VAGFLLP 274
Cdd:cd15181  101 VHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSC--SFHQYGIHESNWWLTsrflyhVVGFFLP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLL-VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGL 353
Cdd:cd15181  179 LLIMGYCYATIVVTLCqSSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKNCKLNDLLDAAITVTESL 258
                        250       260
                 ....*....|....*....|
gi 218563730 354 GYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15181  259 GFSHCCLNPILYAFIGVKFR 278
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
121-373 1.60e-67

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 215.79  E-value: 1.60e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15177   21 VLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGP--PARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQVG----RTALRVLQLVAGFLLP 274
Cdd:cd15177  101 VRATSAHRLRPktLFYSVLTSLIVWLLSILFALPQLIY--SRVENRSELSSCRMIFPEVVsrtvKGATALTQVVLGFAIP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLG 354
Cdd:cd15177  179 LIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELSCSQSKRKDIALLVTSGLA 258
                        250
                 ....*....|....*....
gi 218563730 355 YMHCCLNPLLYAFVGVKFR 373
Cdd:cd15177  259 YVRCCLNPLLYAFVGVRFR 277
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
133-374 1.70e-67

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 215.79  E-value: 1.70e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAT--QLYRRG 210
Cdd:cd15179   33 TMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATnsQRPRKL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVtlTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQ----VGRTALRVLQLVAGFLLPLLVMAYCYAHIL 286
Cdd:cd15179  113 LAEKV--VYVGVWLPALLLTVPDLVF--AKVSELDDRYICDRIYPEdtfeLWVVAFRFQHILVGLVLPGLVILTCYCIII 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15179  189 SKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCEMEQTVHKWISITEALAFFHCCLNPILYA 268

                 ....*...
gi 218563730 367 FVGVKFRE 374
Cdd:cd15179  269 FLGAKFKT 276
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
121-373 2.97e-67

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 215.00  E-value: 2.97e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15174   21 VVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKINFYSCMLLLTCISVDRYIAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHAT--QLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVGRTALRV----LQLVAGFLLP 274
Cdd:cd15174  101 VQATkaHNSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEE--SVTTCTMVYPSNESNRFKVavlaLKVTVGFFLP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLG 354
Cdd:cd15174  179 FVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNITITDCATSQNLDIAGQVTQSIA 258
                        250
                 ....*....|....*....
gi 218563730 355 YMHCCLNPLLYAFVGVKFR 373
Cdd:cd15174  259 FLHSCLNPFLYVFVGVRFR 277
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
133-373 2.70e-66

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 212.69  E-value: 2.70e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR-RGP 211
Cdd:cd15172   33 SMTDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFSCKLLRGIYAINFYSGMLLLACISVDRYIAIVQATKSFRlRSR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 P-ARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQ-----VGRTALRVLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15172  113 TlAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKnstaiMWKLLVLSLQVSLGFFIPLLVMIFCYSFI 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIlMDLGaLARNCGRESRVDVAKSVTSGLGYMHCCLNPLLY 365
Cdd:cd15172  193 IKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEA-INLG-EQQSCSSEKAVAYAKTITECLAFFHCCLNPVLY 270

                 ....*...
gi 218563730 366 AFVGVKFR 373
Cdd:cd15172  271 AFIGVKFR 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
120-365 1.52e-61

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 199.45  E-value: 1.52e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  120 AVAAVLLSRRTaLSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:pfam00001   5 VILVILRNKKL-RTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhgDWPFGSALCKIVGALFVVNGYASILLLTAISIDR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHC--QYNFPQVGRTALRVLQLVAGFLLP 274
Cdd:pfam00001  84 YLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCfiDFPEDLSKPVSYTLLISVLGFLLP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730  275 LLVMAYCYAHILAVLL--------VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESRVDVA 346
Cdd:pfam00001 164 LLVILVCYTLIIRTLRksaskqksSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLD------SLALDCELSRLLDKA 237
                         250
                  ....*....|....*....
gi 218563730  347 KSVTSGLGYMHCCLNPLLY 365
Cdd:pfam00001 238 LSVTLWLAYVNSCLNPIIY 256
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
122-373 4.48e-60

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 196.54  E-value: 4.48e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 122 AAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15188   23 VVLLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNFPQVG---RTALRVLQLVAGFLLPLLVM 278
Cdd:cd15188  103 HAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNN-GVWVCHADYGGHHtiwKLVFQFQQNLLGFLFPLLAM 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYMHC 358
Cdd:cd15188  182 VFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVI-GNCERSRHLDYALQVTESLAFVHC 260
                        250
                 ....*....|....*
gi 218563730 359 CLNPLLYAFVGVKFR 373
Cdd:cd15188  261 CLNPLLYAFVSKRFR 275
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
102-376 7.89e-58

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 190.72  E-value: 7.89e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNIN 181
Cdd:cd15176    2 FLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNGWVLGTAMCKITSALYTMN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 182 FYAGALLLACISFDRYLNIVHATQLYRRGPPARVtlTCLAVWGLCLLFALPDFIFLSAHhdERLNATHCQYNFP-QVGRT 260
Cdd:cd15176   82 FSCGMQFLACISVDRYVAITKATSRQFTGKHCWI--VCLCVWLLAILLSIPDLVFSTVR--ENSDRYRCLPVFPpSLVTS 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 261 A---LRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNC 337
Cdd:cd15176  158 AkatIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLITDC 237
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 218563730 338 GRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15176  238 SMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFKSHI 276
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
135-373 7.66e-56

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 185.35  E-value: 7.66e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15175   35 TDIYLLNLALADILFLLTLPFWAASAAKKWVFGEEMCKAVYCLYKMSFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 V--TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVS 292
Cdd:cd15175  115 FisKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQA 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 293 RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKF 372
Cdd:cd15175  195 RNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKF 274

                 .
gi 218563730 373 R 373
Cdd:cd15175  275 R 275
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
121-375 3.62e-54

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 181.42  E-value: 3.62e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd14985   21 VVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQydWPFGAFLCKVSSYVISVNMFASIFLLTCMSVDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG-RTALRVLQLVAGFLLPLLV 277
Cdd:cd14985  101 AIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEAwHFGLSLELNILGFVLPLLI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSR------GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTS 351
Cdd:cd14985  181 ILTCYFHIARSLRKRYertgknGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAI-RPCFWELFLDLGLPIAT 259
                        250       260
                 ....*....|....*....|....
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd14985  260 CLAFTNSCLNPFIYVFVDRRFRQK 283
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
135-374 8.38e-54

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 179.97  E-value: 8.38e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15173   35 TDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKM 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 V--TLTCLAVWGLCLLFALPDFIFLSAHHDERLNathCQYNFPQVG-RTALRVLQLVAGFLLPLLVMAYCYAHILAVLLV 291
Cdd:cd15173  115 RwgKVVCTLVWVISLLLSLPQFIYSEVRNLSSKI---CSMVYPPDAiEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLH 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNcgresrVDVAKSVTSGLGYMHCCLNPLLYAFVGVK 371
Cdd:cd15173  192 AKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDSTN------FKYAILITEAIAYLHACLNPILYAFVGVK 265

                 ...
gi 218563730 372 FRE 374
Cdd:cd15173  266 FRK 268
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
135-373 9.97e-54

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 179.87  E-value: 9.97e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15182   35 TNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEILCKAVTSIFYIGFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRY 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThCQYNFPQvgRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG 294
Cdd:cd15182  115 ASLVSVAVWVISILASLPELILSTVMKSDEDGSL-CEYSSIK--WKLGYYYQQNLFFLIPLGIIVYCYVRILQTLMRTRT 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218563730 295 QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALarNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15182  192 MRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIP--ICECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
124-376 1.77e-52

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 177.07  E-value: 1.77e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd14982   24 VFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGgwWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFPQVGRTA--LRVLQLVAGFLLPLLVMA 279
Cdd:cd14982  104 HPLKSRRLRRKRYAVGVCAGVWILVLVASVP-LLLLRSTIAKENNSTTCFEFLSEWLASAapIVLIALVVGFLIPLLIIL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAVLLVSRGQ-----RRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLG 354
Cdd:cd14982  183 VCYSLIIRALRRRSKQsqksvRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVRLSFIA-DCSARNSLYKAYRITLCLA 261
                        250       260
                 ....*....|....*....|..
gi 218563730 355 YMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd14982  262 SLNSCLDPLIYYFLSKTFRKRL 283
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
121-373 2.57e-49

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 168.39  E-value: 2.57e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15184   21 VVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILLTIDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVGRTALRVLQL----VAGFLLPLL 276
Cdd:cd15184  101 VHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEG--SHYTCSPHFPPSQYQFWKNFQTlkmnILGLVLPLL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLL-VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGY 355
Cdd:cd15184  179 VMIICYSGILKTLLrCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLN-NCSSSNRLDQAMQVTETLGM 257
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15184  258 THCCINPVIYAFVGEKFR 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-375 9.19e-48

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 165.32  E-value: 9.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15190   35 VFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALgyHWPFGSFLCKLSSYLVFVNMYASVFCLTGLSFDRYLAIV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRT--------ALRVLQLVAGFLL 273
Cdd:cd15190  115 RSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYSGVVSNesewawiaGLGLSSTVLGFLL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHI-------LAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVA 346
Cdd:cd15190  195 PFLIMLTCYFFIgrtvarhFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLGILPFSCGFDLFLMNA 274
                        250       260
                 ....*....|....*....|....*....
gi 218563730 347 KSVTSGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15190  275 HPYATCLAYVNSCLNPFLYAFFDPRFRQQ 303
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
121-373 1.08e-46

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 161.54  E-value: 1.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15186   21 VVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlnathCQYNFPQVGRTALRVLQLV----AGFLLPLL 276
Cdd:cd15186  101 VLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENE------CLGDYPEVLQEIWPVLRNVelnfLGFLLPLL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmDLGALARNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd15186  175 IMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETL-KLYDFFPSCDMKKDLRLALSVTETIAFS 253
                        250
                 ....*....|....*..
gi 218563730 357 HCCLNPLLYAFVGVKFR 373
Cdd:cd15186  254 HCCLNPLIYAFAGEKFR 270
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
138-376 1.83e-46

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 161.06  E-value: 1.83e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15192   38 FLLNLALADLCFLITLPLWAAYTAMeyHWPFGNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVA---GFLLPLLVMAYCYAHILAVLLVS 292
Cdd:cd15192  118 RVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQNSTLLVGLGLMKnllGFLIPFLIILTCYTLIGKALKKA 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 293 RGQRRLR-----AMRLVVVVVVAFALCWTPYHLVVLVDILMDLGaLARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15192  198 YEIQRNKprndeIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQLK-VIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGF 276

                 ....*....
gi 218563730 368 VGVKFRERM 376
Cdd:cd15192  277 VGKNFRKKF 285
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
120-376 1.80e-45

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 158.76  E-value: 1.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSS-TDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15191   19 SLVVCVFCHQSGPKTvASIYIFNLAVADLLFLATLPLWATYYSYgyNWLFGSVMCKICGSLLTLNLFASIFFITCMSVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGpPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGR----TALRVLQLVAGFL 272
Cdd:cd15191   99 YLAVVYPLRSQRRR-SWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNEKYaqwsAGLALMKNTLGFL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVSRG-----QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAK 347
Cdd:cd15191  178 IPLIVIATCYFGIGRHLLKTKGfgknkQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGVIN-NCWVITVIDKAL 256
                        250       260
                 ....*....|....*....|....*....
gi 218563730 348 SVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15191  257 PFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
135-375 5.53e-43

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 151.68  E-value: 5.53e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA--TQLYRRg 210
Cdd:cd14974   34 NTVWFLNLALADFLFCLFLPFLIVYIAMghHWPFGSVLCKLNSFVISLNMFASVFLLTAISLDRCLLVLHPvwAQNHRT- 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 pPARVTLTCLAVWGLCLLFALPDFIFLSAHHDE---RLNATHCQ-YNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAhil 286
Cdd:cd14974  113 -VRLASVVCVGIWILALVLSVPYFVFRDTVTHHngrSCNLTCVEdYDLRRSRHKALTVIRFLCGFLLPLLIIAICYS--- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 aVLLVSRGQRRL----RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd14974  189 -VIAVKLRRKRLakssKPLRVLLAVVVAFFLCWLPYHVFALLELVAAAGLPE-------VVLLGLPLATGLAYFNSCLNP 260
                        250
                 ....*....|...
gi 218563730 363 LLYAFVGVKFRER 375
Cdd:cd14974  261 ILYVFMGQDFRKR 273
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
121-376 8.27e-43

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 151.49  E-value: 8.27e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15187   21 VIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITLMSIDRYLAI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVGRTALRVLQL---VAGFLLPLLV 277
Cdd:cd15187  101 VHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASED--GRLQCIPFYPGQGNSWKVFTNFevnILGLLIPFSI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYMH 357
Cdd:cd15187  179 LIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHII-DGCQNSQRLTLALHLTETISFTH 257
                        250
                 ....*....|....*....
gi 218563730 358 CCLNPLLYAFVGVKFRERM 376
Cdd:cd15187  258 CCLNPVIYAFVGEKFKKHL 276
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
121-375 1.73e-42

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 150.70  E-value: 1.73e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15189   21 VLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQfnWPFGELLCRVVNGVIKVNLYTSIYLLVMISQDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQL-VAGFLLPLLV 277
Cdd:cd15189  101 ALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITACVLLYPHEAWHFAHIVLLnIVGFLLPLLV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQRRL------RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTS 351
Cdd:cd15189  181 ITFCNYNILQALRTREESTRCedrndsKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVGVL-DECFWEHFIDIGLQLAV 259
                        250       260
                 ....*....|....*....|....
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15189  260 FLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
121-375 3.12e-42

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 149.92  E-value: 3.12e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAA--VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15381   21 VLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISngFNWPFGEFLCKSVNAVIYMNLYSSIYFLMMVSIDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG-RTALRVLQLVAGFLLPLLV 277
Cdd:cd15381  101 ALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEGwHVALNILLNVVGFLIPLSI 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQR------RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTS 351
Cdd:cd15381  181 ITFCSTQIIQVLRNNKMQKfkeiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLIS-GCRWEDILDIGTQIAT 259
                        250       260
                 ....*....|....*....|....
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15381  260 FLAYSNSCLNPLLYVIVGKHFRKK 283
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
121-367 1.03e-41

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 148.21  E-value: 1.03e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL-LVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd00637   19 VILVILRNRRLRTVTNYFILNLAVADLLvGLLVIPFSLVSLLLGrWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSaHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd00637   99 AIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWG-VYDYGGYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVI 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLLVSRG---------------QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrV 343
Cdd:cd00637  178 IVCYVRIFRKLRRHRRrirssssnssrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPL--------P 249
                        250       260
                 ....*....|....*....|....
gi 218563730 344 DVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd00637  250 RILYFLALLLAYLNSAINPIIYAF 273
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
102-376 1.08e-41

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 148.44  E-value: 1.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWA-VDAAVQWVFGSGLCKVAGALFNI 180
Cdd:cd15185    2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIhYVRWNNWVFGHGMCKLLSGFYYL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 181 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHhdERLNATHCQYNFPQVGRT 260
Cdd:cd15185   82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQ--ELFEEFLCSPLYPEDTED 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 261 ALRVLQL----VAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmDLGALARN 336
Cdd:cd15185  160 SWKRFHAlrmnIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAF-QSIFFETD 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 337 CGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15185  239 CERSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
121-374 1.37e-40

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 145.40  E-value: 1.37e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWaVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15183   21 VVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFW-IDYKLKddWIFGDAMCKFLSGFYYLGLYSEIFFIILLTIDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAhhdeRLNATH--CQYNFPQVGRTALRVLQLVA----GFL 272
Cdd:cd15183  100 AIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKS----QWEFTHhtCSAHFPRKSLIRWKRFQALKlnllGLI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgALARNCGRESRVDVAKSVTSG 352
Cdd:cd15183  176 LPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDV-LFTPSCEQSQQLDLALQVTEV 254
                        250       260
                 ....*....|....*....|..
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15183  255 IAYTHCCVNPVIYVFVGERFRK 276
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
135-375 3.41e-40

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 144.36  E-value: 3.41e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPA 213
Cdd:cd14970   35 TNIYILNLAVADELFLLGLPFLATSYLLGyWPFGEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIFLSAHHDErLNATHCQYNFP---QVGRTALRVLQLVAGFLLPLLVMAYCYAHIL---- 286
Cdd:cd14970  115 KAKLVSLCVWALSLVLGLPVIIFARTLQEE-GGTISCNLQWPdppDYWGRVFTIYTFVLGFAVPLLVITVCYSLIIrrlr 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 -AVLLVSRGQRRLRAM-----RLVVVVVVAFALCWTPYHLVVLVDILMDLgalarncgRESRVDVAKS-VTSGLGYMHCC 359
Cdd:cd14970  194 sSRNLSTSGAREKRRArrkvtRLVLVVVAVFVVCWLPFHVFQIVRLLIDP--------PETLTVVGVFlFCIALSYANSC 265
                        250
                 ....*....|....*.
gi 218563730 360 LNPLLYAFVGVKFRER 375
Cdd:cd14970  266 LNPILYAFLDENFRKS 281
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
121-375 5.17e-40

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 144.12  E-value: 5.17e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15193   21 VIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALggQWLFGEGLCKLSSFIIAVNRCSSILFLTGMSVDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsahhDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15193  101 AVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVY-----RNLINESVCVEDSSSRFFQGISLATLFLTFVLPLIVI 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSG 352
Cdd:cd15193  176 LFCYCSILVRLrrhfhgAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELGGGVLPCHTTVAIRQGLTITAC 255
                        250       260
                 ....*....|....*....|...
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15193  256 LAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
128-375 8.66e-39

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 140.92  E-value: 8.66e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd15168   28 HLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANgdHWIFGDFMCKLVRFLFYFNLYGSILFLTCISVHRYLGICHPLR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCqYNFPQVGRTALRVLQ----LVAGFLLPLLVMAYC 281
Cdd:cd15168  108 SLGKLKKRHAVAISVAVWILVLLQLLPILFF--ATTGRKNNRTTC-YDTTSPEELNDYVIYsmvlTGLGFLLPLLIILAC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 282 YAHILAVLLVSRGQ-----RRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd15168  185 YGLIVRALIRKLGEgvtsaLRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLSGTASCATLNGIYVAYKVTRPLASL 264
                        250
                 ....*....|....*....
gi 218563730 357 HCCLNPLLYAFVGVKFRER 375
Cdd:cd15168  265 NSCLNPLLYFLAGDKFRRR 283
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
137-376 9.54e-39

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 140.62  E-value: 9.54e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 137 TFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAT--QLYRRGPP 212
Cdd:cd15114   36 VWFLNLAVADLLCCLSLPILAVPIAQdgHWPFGAAACKLLPSLILLNMYASVLLLTAISADRCLLVLRPVwcQNHRRARL 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTltCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRV--LQLVAGFLLPLLVMAYCYAHILAVLL 290
Cdd:cd15114  116 AWIA--CGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVDYGGSTGVEWAVaiIRFLLGFLGPLVVIASCHGVLLVRTW 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGV 370
Cdd:cd15114  194 SRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLI-----IAASAPNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGR 268

                 ....*.
gi 218563730 371 KFRERM 376
Cdd:cd15114  269 GFRKSL 274
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
125-375 9.72e-39

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 140.70  E-value: 9.72e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTaLSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH 202
Cdd:cd15380   26 LLPRRR-LTIAEIYLANLAASDLVFVLGLPFWAENIRNQfnWPFGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 --ATQLYRRGPPARVtlTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQL-VAGFLLPLLVMA 279
Cdd:cd15380  105 tmTSRRQRSRRQAQV--ICLLIWVFGGLLSIPTFLFRSVKHVPDLNISACILLFPHEAWHFARRVELnIVGFLLPLAAIV 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAVLL----VSR----GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTS 351
Cdd:cd15380  183 FFNFHIIASLRerteESRkrcgGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFLFQVEVI-QGCFWEEFIDLGLQLAN 261
                        250       260
                 ....*....|....*....|....
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15380  262 FFAFANSCLNPVIYVFAGKLFRTK 285
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
121-376 3.44e-38

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 140.68  E-value: 3.44e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:PHA03087  60 IVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYiLFQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIA 139
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF-PQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:PHA03087 140 IVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNkTMNWKLFINFEINIIGMLIPLTIL 219
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL-LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMH 357
Cdd:PHA03087 220 LYCYSKILITLkGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS-GCKAVKYIQYALHVTEIISLSH 298
                        250
                 ....*....|....*....
gi 218563730 358 CCLNPLLYAFVGVKFRERM 376
Cdd:PHA03087 299 CCINPLIYAFVSEFFNKHK 317
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
135-376 5.25e-38

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 138.74  E-value: 5.25e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd14987   35 THLYILNLAIADLCVVATLPVWVVSLVQhnQWPMGEFTCKITHLIFSINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQ-------VGrtaLRVLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd14987  115 IVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEesfkewlIG---MELVSIVLGFVIPFPIIAVFYFLL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLY 365
Cdd:cd14987  192 ARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIPFSCQLENFLYAALHVTQCFSLVHCCVNPILY 271
                        250
                 ....*....|.
gi 218563730 366 AFVGVKFRERM 376
Cdd:cd14987  272 SFINRNYRYEL 282
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
129-376 7.68e-35

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 130.24  E-value: 7.68e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQL 206
Cdd:cd15117   28 RMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALgfHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWA 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLnaTHCQYNFPQVGRT----------------ALRVLQLVAG 270
Cdd:cd15117  108 RNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGC--THCYLNFDPWNETaedpvlwletvvqrlsAQVITRFVLG 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 271 FLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdlgALARNCGRESRVDVAKSVT 350
Cdd:cd15117  186 FLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLELVV---ILNQKEDLNPLLILLLPLS 262
                        250       260
                 ....*....|....*....|....*.
gi 218563730 351 SGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15117  263 SSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
128-374 8.63e-35

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 130.32  E-value: 8.63e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd14976   30 KLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDfvWPFGTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPDFIFlSAHHDERLNATHCQYNFP-----QVGRTALRVLQL---VAGFLLPLLV 277
Cdd:cd14976  110 HGWIRKAFGAFATTIAIWAAAALAAIPEAIF-STDTWSSVNHTLCLLRFPknssvTRWYNWLGMYQLqkvVLGFFLPLGI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVL---LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLG 354
Cdd:cd14976  189 ITLSYLLLLRFLqrkRGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSALIKFDDVPFSDAFFAFQTYAFPVAICLA 268
                        250       260
                 ....*....|....*....|
gi 218563730 355 YMHCCLNPLLYAFVGVKFRE 374
Cdd:cd14976  269 HSNSCLNPVLYCLVRREFRD 288
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
138-374 1.99e-32

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 123.72  E-value: 1.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15116   37 WFLNLAVADFLFTFFLPFSIAYTAMdfHWPFGRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF-----------PQVGRTALRVLQL---VAGFLLPLLVMAYC 281
Cdd:cd15116  117 SLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNNFslsgdnsspevNQLRNMRHQVMTItrfLLGFLIPFTIIICC 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 282 YAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarncgrESRVDVAKSVTSGLGYMHCCLN 361
Cdd:cd15116  197 YAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEMEATRSP-------ASVFKIGLPITSSLAFINSCLN 269
                        250
                 ....*....|...
gi 218563730 362 PLLYAFVGVKFRE 374
Cdd:cd15116  270 PILYVFMGQDFKK 282
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
125-376 1.45e-31

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 121.34  E-value: 1.45e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAV--DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH 202
Cdd:cd15967   25 LLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVyyLKGRKWIFGQVFCKITRFCFNLNLYGSIGFLTCISVYRYLAIVH 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 ATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFL------SAHHDERLNATHCQYNFPQVGRTalrvlqlVAGFLLPLL 276
Cdd:cd15967  105 PMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSktnsngTKCFDTTFNDYLESYLTYSLGWT-------VTGFVIPLL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLL----VSRGQRRlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESR-VDVAKSVTS 351
Cdd:cd15967  178 IILGCYGHVVVVLCrnnnVDKGLKQ-RCLKLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQGSCTQWFRgIYIAHQVSR 256
                        250       260
                 ....*....|....*....|....*
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15967  257 GLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
140-376 3.04e-31

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 120.26  E-value: 3.04e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 140 LHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAT--QLYRRGPPARv 215
Cdd:cd15115   39 LNLAVADLLCCLSLPFSIAHLLLngHWPYGRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVwaQNHRSVLLAC- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 tLTCLAVWGLCLLFALPDFIFLSAHHDerLNATHCQYNFpqvgRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQ 295
Cdd:cd15115  118 -LLCGCIWILALLLCLPVFIYRTTVTD--GNHTRCGYDF----LVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFA 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 296 RRL-RAMRLVVVVVVAFALCWTPYHLVvlvdilmdlgALARNCGRESRVDVAKS---VTSGLGYMHCCLNPLLYAFVGVK 371
Cdd:cd15115  191 KSQsKTFRVIIAVVVAFFVCWAPYHII----------GILSLYGDPPLSKVLMSwdhLSIALAYANSCLNPVLYVFMGKD 260

                 ....*
gi 218563730 372 FRERM 376
Cdd:cd15115  261 FKKKA 265
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
124-376 4.42e-31

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 120.15  E-value: 4.42e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15159   24 VICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALgfDWPFGDWLCRLTALLFYINTYAGVNFMTCLSVDRYIAVV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPD-FIFLSAHHDERLnaTHCQY-NFPQVGRTALRVL-QLVAGFLLPLLVM 278
Cdd:cd15159  104 HPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLlFMPMTKEMGGRI--TCMEYpNFEKIKRLPLILLgACVIGFGVPVGII 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL--------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVT 350
Cdd:cd15159  182 LFCYSQITLKLcrtakenpLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIQFMIRKLLYQP-SCSELKAFKISLQIT 260
                        250       260
                 ....*....|....*....|....*.
gi 218563730 351 SGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15159  261 VCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
138-376 4.79e-31

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 119.80  E-value: 4.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15160   38 YLLNLSLSDLLYILTLPLWIDYTANHhnWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFPQVGRTA-LRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG 294
Cdd:cd15160  118 LKVSASIWVLELGTHSV-FLGHDELFRDEPNHTLCYEKYPMEGWQAsYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPS 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 ---QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVK 371
Cdd:cd15160  197 lerEEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQ-NGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTED 275

                 ....*
gi 218563730 372 FRERM 376
Cdd:cd15160  276 VRQDL 280
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
133-372 9.63e-31

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 119.14  E-value: 9.63e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15122   35 SVTCILILNLAVADGAVLLLTPFFITFLTRKtWPFGQAVCKAVYYLCCLSMYASIFIIGLMSLDRCLAVTRPYLAQSLRK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALR-VLQLVAGFLLPLLVMAYCYAHILAVLL 290
Cdd:cd15122  115 KALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIFHyTFETLVAFVLPFGVILFSYSVILVRLK 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 VSRGQRRLRAMRLVVVVVVAFALCWTPYHlvvLVDILMDLGALARNCGRESRVDVAKSVTSG---LGYMHCCLNPLLYAF 367
Cdd:cd15122  195 GARFRRRARVEKLIAAIVVAFALLWVPYH---VVNLLQVVANLAPGEVLEKLGGAAKAARAGataLAFFSSSVNPLLYVF 271

                 ....*
gi 218563730 368 VGVKF 372
Cdd:cd15122  272 AAGDL 276
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
121-374 1.59e-30

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 119.62  E-value: 1.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTaLSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:PHA02834  49 VIAVLIVKRF-MFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNEWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILV 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTcLAVWGLCLLFALPDFIFLsaHHDERLNATHCQYNFPQVGRTALRVLQL---VAGFLLPLLV 277
Cdd:PHA02834 128 VNATKIKNKSISLSVLLS-VAAWVCSVILSMPAMVLY--YVDNTDNLKQCIFNDYHENFSWSAFFNFeinIFGIVIPLII 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMH 357
Cdd:PHA02834 205 LIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLIDIGCYHFKKIVYSIDIAELISFVH 284
                        250
                 ....*....|....*..
gi 218563730 358 CCLNPLLYAFVGVKFRE 374
Cdd:PHA02834 285 CCVNPIIYAFVGKNFKK 301
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
121-376 1.68e-30

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 118.32  E-value: 1.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPL----WAVDAavQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15088   21 VLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFlihqFAIDG--QWYFGEVMCKIITALDANNQFTSTYILTAMSVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDeRLNATHCQYNFPQ-VGRTALRVLQLVAGFLLPL 275
Cdd:cd15088   99 YLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYF-PDGTTFCYVSLPSpDDLYWFTIYHFILGFAVPL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILAVLL-------VSRGQRRL-RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrVDVAK 347
Cdd:cd15088  178 VVITVCYILILHRLArgvapgnQSHGSSRTkRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLA--------FEVAY 249
                        250       260
                 ....*....|....*....|....*....
gi 218563730 348 SVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15088  250 FLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
125-369 1.70e-30

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 118.35  E-value: 1.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH- 202
Cdd:cd14975   25 ILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFlATGTWDFGLAACKGCVYVCAVSMYASVFLITLMSLERFLAVSRp 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 -ATQLYRRGPPARVTLtcLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQVGRTALRV-LQLVAGFLLPLLVMAY 280
Cdd:cd14975  105 fVSQGWRAKALAHKVL--AIIWLLAVLLATPVIAF--RHVEETVENGMCKYRHYSDGQLVFHLlLETVVGFAVPFTAVVL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 281 CYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGR-ESRVDVAKSVTSGLGYMHCC 359
Cdd:cd14975  181 CYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTlGKVAEAGRPIAGALAFLSSS 260
                        250
                 ....*....|
gi 218563730 360 LNPLLYAFVG 369
Cdd:cd14975  261 INPLLYAFAA 270
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
128-376 3.51e-30

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 117.50  E-value: 3.51e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd15161   28 DRKSGTPSNVFLMHLAVADLSYVLILPMRLVYhlSGNHWPFGEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVK 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDERLNATHC-QYNFPQVGRTALrvLQLVAGFLLPLLVMAYCYAH 284
Cdd:cd15161  108 SMKIRKPLYAHVVCGFLWVIVTVAMAP--LLVSPQTVEVNNTTVClQLYREKASRGAL--VSLAVAFTIPFVTTVTCYLL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILAVL-LVSRGQRRL--RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESrVDVAKSVTSGLGYMHCCLN 361
Cdd:cd15161  184 IIRSLrTGKREEKPLkdKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAGASCSSRRG-LALANRITSCLTCLNGALD 262
                        250
                 ....*....|....*
gi 218563730 362 PLLYAFVGVKFRERM 376
Cdd:cd15161  263 PVMYFFVAEKFRETL 277
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
121-374 1.00e-29

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 116.41  E-value: 1.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15093   21 VIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRhWPFGSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQL--YRRGPPARVtlTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNFP---QVGRTALRVLQLVAGFLLP 274
Cdd:cd15093  101 VVHPIKSarWRRPRVAKV--VNLAVWVASLLVILPVVVFAGTRENQD-GSSACNMQWPepaAAWSAGFIIYTFVLGFLLP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHIL-----AVLLVSRGQRRL---RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgalarncgRESRVDVA 346
Cdd:cd15093  178 LLIICLCYLLIVikvksAGLRAGWQQRKRserKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQL--------PETPALVG 249
                        250       260
                 ....*....|....*....|....*....
gi 218563730 347 KS-VTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15093  250 VYhFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
132-373 2.14e-29

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 115.63  E-value: 2.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 132 LSSTDTFLLHLAVADTLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15154   32 HSVVSIYMCNLALSDLLFTLSLPLRIYYYANhYWPFGNFLCQFSGSIFQMNMYGSCLFLMCINVDRYLAIVHPLRFRHLR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAT--HCQYNFP---QVGRTALRVLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15154  112 RPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKvyRCFESFSdndWKGLLPLVVLAEILGFLLPLAAVLYCSCRI 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSR---GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd15154  192 FVELCRTQepqQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRANLVEDTWNIKDTLRKVLSVTVLLASTNCALDP 271
                        250
                 ....*....|.
gi 218563730 363 LLYAFVGVKFR 373
Cdd:cd15154  272 LVYYFSTEGFR 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
121-374 4.24e-29

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 114.20  E-value: 4.24e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTaLSSTDTFLLHLAVADTLLVLT-LPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd14967   21 ILAVYRNRRL-RTVTNYFIVSLAVADLLVALLvMPFSAVYTLLGyWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVgrtaLRVLQLVAGFLLPLLVM 278
Cdd:cd14967  100 AITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI----YVLVSSVISFFIPLLIM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLlvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTSGLGYMHC 358
Cdd:cd14967  176 IVLYARIFRVA-----RRELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF---------CPPDCVPPILYAVFFWLGYLNS 241
                        250
                 ....*....|....*.
gi 218563730 359 CLNPLLYAFVGVKFRE 374
Cdd:cd14967  242 ALNPIIYALFNRDFRR 257
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
121-376 4.32e-29

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 114.84  E-value: 4.32e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15158   21 ALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHkgQWLFGDFLCRISSYALYVNLYCSIYFMTAMSFTRFL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDERLNATHC----QYNFPQVGRTALRVLQLVAGFLLP 274
Cdd:cd15158  101 AIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSP--FLMSGSHDTETNKTKCfeppQSNQQLTKLLVLNYISLVVGFIIP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLL----VSRGQR--RLRAMRLVVVVVVAFALCWTPYHLVVLVDiLMDLGALARNCgrESRVDVAKS 348
Cdd:cd15158  179 FLVILICYAMIIRTLLkntmKARKQQssRKKAIRMIIIVLLAFLVSFMPYHIQRTIH-LHFLSRKDSTC--EEVLYMQKS 255
                        250       260       270
                 ....*....|....*....|....*....|
gi 218563730 349 V--TSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15158  256 VviTLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
121-376 5.22e-29

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 114.62  E-value: 5.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLT-LPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd14993   21 VIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLeNVYRPWVFGEVLCKAVPYLQGVSVSASVLTLVAISIDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDER-----LNATHCQYNFP-QVGRTALRVLQLVAGFL 272
Cdd:cd14993  101 AICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtITIYICTEDWPsPELRKAYNVALFVVLYV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHI----------LAVLLVSRGQR------RLRAMRLVVVVVVAFALCWTPYHlvvLVDILMDLGALARN 336
Cdd:cd14993  181 LPLLIISVAYSLIgrrlwrrkppGDRGSANSTSSrrilrsKKKVARMLIVVVVLFALSWLPYY---VLSILLDFGPLSSE 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 337 CGRESRVDVaKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd14993  258 ESDENFLLI-LPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
120-383 8.06e-29

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 116.65  E-value: 8.06e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTAlSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:PHA02638 118 AIIMILFCKKIK-TITDIYIFNLAISDLIFVIDFPFIIYNEFDQWIFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFA 196
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVH--ATQLYRrgpPARVTLT-CLAVWGLCLLFALPDF--------IFLSAHHDERLNATHC-------QYNFPQVGrta 261
Cdd:PHA02638 197 ILYpiSFQKYR---TFNIGIIlCIISWILSLIITSPAYfifeasniIFSAQDSNETISNYQCtliedneKNNISFLG--- 270
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 262 lRVLQL---VAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGA----LA 334
Cdd:PHA02638 271 -RILQFeinILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATMYSFKGfnsiIS 349
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 218563730 335 RNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRL 383
Cdd:PHA02638 350 EHICGFIKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIFRNI 398
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
138-368 1.86e-28

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 112.97  E-value: 1.86e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWaVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15366   38 YLLNLSVSDLLYIATLPLW-IDYFLHrdnWIHGPESCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDfIFLSAHHDERLNATHCQYNFPQVGRTAL-RVLQLVAGFLLPLLVMAYCYAHILAVL---L 290
Cdd:cd15366  117 AVAVSAVVWAIEIGANSAP-LFHDELFRDRYNHTFCFEKYPMEDWVAWmNLYRVFVGFLFPWVLMLFSYRGILRAVrgnV 195
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218563730 291 VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15366  196 STEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYLGK-PCDCGFEERVFTAYHVSLALTSLNCVADPILYCLV 272
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
124-374 2.55e-28

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 112.43  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd15165   24 VFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLGRTLCSFLESLYFVNMYGSILIIVCISVDRYIAIRHP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 TQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsahHDERLNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCY 282
Cdd:cd15165  104 FLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSF----HDKPTNNTRCFHGFSnKTWSKKVIVVVEEFGFLIPMAVMVFCS 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 283 AHILAVLLVSRG-----QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMH 357
Cdd:cd15165  180 VQIIRTLLDMRRpeqpkVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN-DCSTKQSIRLFVQVSMCLANVN 258
                        250
                 ....*....|....*..
gi 218563730 358 CCLNPLLYAFVGVKFRE 374
Cdd:cd15165  259 CCLDAICYYFILKEFRE 275
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
138-376 2.85e-28

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 112.14  E-value: 2.85e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15119   37 WFLNLAIADFVFVLFLPLHITYVALdfHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHhDERLNATHCQYNFPQVGR-------TALRVLQLVAGFLLPLLVMAYCYAHILAV 288
Cdd:cd15119  117 LILCGIVWLSAAAISGPALYFRDTM-ELSINVTICFNNFHKHDGdlivmrhTILVWVRFFFGFLFPLLTMVVCYSLLAIK 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 289 LLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGResrvdVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15119  196 VKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSYLHNVLR-----AGIPLATSLAFINSCLNPILYVLI 270

                 ....*...
gi 218563730 369 GVKFRERM 376
Cdd:cd15119  271 GKKFKAHL 278
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
121-373 1.05e-27

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 111.02  E-value: 1.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL-TLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd14971   21 VILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLpGWVFGDFMCKFVHYFQQVSMHASIFTLVAMSLDRFL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG-RTALRVLQLVAGFLLPLLV 277
Cdd:cd14971  101 AVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAhRRAFALCTFLFGYLLPLLL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVL-------LVSRGQRRLRA--MRLVVVVVVAFALCWTPYHLVVLVdilmdlgaLARNCGRESRVDVAKS 348
Cdd:cd14971  181 ICVCYAAMLRHLwrvavrpVLSEGSRRAKRkvTRLVLVVVVLFAACWGPIHAILLL--------VALGPFPLTYATYALR 252
                        250       260
                 ....*....|....*....|....*.
gi 218563730 349 VTSG-LGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd14971  253 IWAHcLAYSNSAVNPVLYAFLSEHFR 278
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
124-376 1.12e-27

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 110.61  E-value: 1.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTdTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15372   24 VLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLgnNWPFGEGLCRVVTAFFYGNMYCSVLLLMCISLDRYLAVV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFP---QVGRTALRVLQLVA-GFLLPLLV 277
Cdd:cd15372  103 HPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPldeQDTYLFYYFACLAVlGFLLPLVV 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV---DILMDLGALarncgresrVDVAKSVTSGLG 354
Cdd:cd15372  183 ILFCYGSVLHTLLRS-GQRYGHAMKLTVLVLVSFVLCFTPSNLLLLLhysDPTLDDGGN---------LYIVYMVSLAIS 252
                        250       260
                 ....*....|....*....|..
gi 218563730 355 YMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15372  253 TLNSCVDPFIYYYVSEEFRDKV 274
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
113-374 2.10e-27

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 110.39  E-value: 2.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVdAAVQ--WVFGSGLCKVAGALFNINFYAGALLL 189
Cdd:cd15203   13 LGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLI-YTLTknWPFGSILCKLVPSLQGVSIFVSTLTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 190 ACISFDRYLNIVHATqlyRRGPPARVTLTCLA-VWGLCLLFALPDFIFLSAHHDERLNATHCQY----NFPQ-VGRTALR 263
Cdd:cd15203   92 TAIAIDRYQLIVYPT---RPRMSKRHALLIIAlIWILSLLLSLPLAIFQELSDVPIEILPYCGYfcteSWPSsSSRLIYT 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 264 VLQLVAGFLLPLLVMAYCYAHILAVL-----------------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHlvvLVDI 326
Cdd:cd15203  169 ISVLVLQFVIPLLIISFCYFRISLKLrkrvkkkrgkrtlssrrRRSELRRKRRTNRLLIAMVVVFAVCWLPLN---LFNL 245
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 327 LMDLGALARNCGRESRvdVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15203  246 LRDFEPLPQIDGRHFY--LIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
125-369 3.41e-27

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 109.52  E-value: 3.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTALSSTDTFLLHLAVADTLLVLTLPLWA-VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH- 202
Cdd:cd15121   25 VLCRMKKRSVTCILVLNLALADAAVLLTAPFFLhFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLITLMSMDRCLAVAKp 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 -ATQLYRRGPPARVTLtcLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFPQVGRTALRVL-QLVAGFLLPLLVMAY 280
Cdd:cd15121  105 fLSQKMRTKRSVRALL--LAIWIVAFLLSLP-MPFYRTVLKKNINMKLCIPYHPSVGHEAFQYLfETITGFLLPFTAIVT 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 281 CYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15121  182 CYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAAKLARPNVTALAFLSSSV 261

                 ....*....
gi 218563730 361 NPLLYAFVG 369
Cdd:cd15121  262 NPVLYAFAG 270
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
124-374 7.27e-27

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 108.69  E-value: 7.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15162   24 VLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYhiHGNNWIFGEALCRLVTVAFYGNMYCSILLLTCISIDRYLAIV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFP---QVGRTALRVLQL-VAGFLLPLLV 277
Cdd:cd15162  104 HPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPeqlLVGDWFYYFLSLaIVGFLIPFIL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSR----GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdlgalaRNCGRESRVDVAKSVTSGL 353
Cdd:cd15162  184 TASCYVATIRTLAALEdensEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSL------ISSSGTGHLYFAYLLALCL 257
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15162  258 STLNSCIDPFIYYFVSKEFRD 278
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
121-373 1.00e-26

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 108.08  E-value: 1.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15970   21 VIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLrHWPFGSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNFPQVGRTALRVLQLVA---GFLLPLL 276
Cdd:cd15970  101 VVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSD-GSVACNMQMPEPSQRWLAVFVVYTflmGFLLPVI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILA----VLLVSRGQRRLRAMR----LVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAks 348
Cdd:cd15970  180 AICLCYILIIVkmrvVALKAGWQQRKRSERkitlMVMMVVTVFVICWMPFYVVQLVSVFVG-----QHDATVSQLSVI-- 252
                        250       260
                 ....*....|....*....|....*
gi 218563730 349 vtsgLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15970  253 ----LGYANSCANPILYGFLSDNFK 273
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
102-376 1.10e-26

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 107.97  E-value: 1.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFN 179
Cdd:cd15921    2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLnsHWPFGDIACRIILYVLY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 180 INFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCqYNFPQVGR 259
Cdd:cd15921   82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDE--GSTRC-LELAHDAV 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 260 TALRVLQ---LVAGFLLPLLVMAYCYAHILAVLL-VSRGQRRLR-----AMRLVVVVVVAFALCWTPYHLVVLVDiLMDL 330
Cdd:cd15921  159 DKLLLINyvtLPVGFVVPFMTVIFCYIFIIKNLLkPSPALGRTRpsrrkACALIIISLGIFLVCFLPYHIVRTIH-LITE 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 218563730 331 GALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15921  238 RQIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
121-374 1.31e-26

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 107.77  E-value: 1.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVAD-TLLVLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15096   21 VILVVLSNQQMRSTTNILILNLAVADlLFVVFCVPFTATDyVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMSLDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQL---VAGFLLPL 275
Cdd:cd15096  101 AVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEVGTAAQTFFTsffLFSYLIPL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILAVLL--VSRGQRRL--------RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGalarncgrESRVDV 345
Cdd:cd15096  181 TLICVLYMLMLRRLRrqKSPGGRRSaesqrgkrRVTRLVVVVVVVFAICWLPIHIILLLKYYGVLP--------ETVLYV 252
                        250       260       270
                 ....*....|....*....|....*....|
gi 218563730 346 AKSVTSG-LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15096  253 VIQILSNcLAYGNSCVNPILYAFLSQNFRK 282
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
121-373 1.83e-26

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 107.25  E-value: 1.83e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15973   21 VIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQhWPFGSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15973  101 VVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKG-QAVACNLIWPhPAWSAAFVIYTFLLGFLLPVLAI 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHIL----AVLLVSRGQRRLRA----MRLVVVVVVAFALCWTPYHLVVLVDILMdlgalarncgreSRVDVA-KSV 349
Cdd:cd15973  180 GLCYILIIgkmrAVALKAGWQQRRKSekkiTRMVLMVVTVFVICWMPFYVVQLLNLFL------------PRLDATvNHA 247
                        250       260
                 ....*....|....*....|....
gi 218563730 350 TSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15973  248 SLILSYANSCANPILYGFLSDNFR 271
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
135-367 2.58e-26

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 107.24  E-value: 2.58e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPA 213
Cdd:cd15156   35 TTTYMINLAISDLLFVFTLPFRIFYFVQRnWPFGDLLCKISVTLFYTNMYGSILFLTCISVDRFLAIVYPFRSKTLRTKR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQ-VGRTALRVLQL---VAGFLLPLLVMAYCYAHILAVL 289
Cdd:cd15156  115 NAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFENFSSkTWKTYLSKIVIfieIVGFFIPLILNVTCSTMVLKTL 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 ----LVSRGQ-RRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYMHCCLNPLL 364
Cdd:cd15156  195 rrpnTLSRSKlNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQTF-KNCSVVAAVRTMYPITLCIAVSNCCFDPIV 273

                 ...
gi 218563730 365 YAF 367
Cdd:cd15156  274 YYF 276
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
120-373 4.38e-26

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 106.36  E-value: 4.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15087   20 AVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLqQWPFGELLCKLILSIDHYNIFSSIYFLTVMSVDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 nIVHATQLYRRGPPARVT---LTCLAVWGLCLLFALPDFIFLSAHHDErLNATHCQYNFPQVGR---TALRVLQLVAGFL 272
Cdd:cd15087  100 -VVLATVRSRRMPYRTYRaakIVSLCVWLLVTIIVLPFTVFAGVYSNE-LGRKSCVLSFPSPESlwfKASRIYTLVLGFA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVSRGQRRLRAM-----RLVVVVVVAFA---LCWTPYHLVVLVDILMDLGALARNCGresrvd 344
Cdd:cd15087  178 IPVSTICILYTMMLYKLRNMRLNSNAKALdkakkKVTLMVLVVLAvclFCWTPFHLSTVVALTTDLPQTPLVIG------ 251
                        250       260
                 ....*....|....*....|....*....
gi 218563730 345 VAKSVTSgLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15087  252 ISYFITS-LSYANSCLNPFLYAFLDDSFR 279
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
131-373 9.26e-26

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 105.58  E-value: 9.26e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 131 ALSSTDTFLLHLAVADTL-LVLTLPLWA-VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR 208
Cdd:cd15098   33 RRSTTNVFILNLSIADLFfLLFCVPFQAtIYSLPEWVFGAFMCKFVHYFFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSS 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 209 RGPPARVTLTCLAVWGLCLLFALPDFI-FLSAHHDERLNATHCQYNFPQ-VGRTALRVLQLVAGFLLPLLVMAYCYAHIL 286
Cdd:cd15098  113 LRTRRNALLGVLVIWVLSLAMASPVAVhQDLVHHWTASNQTFCWENWPEkQQKPVYVVCTFVFGYLLPLLLITFCYAKVL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVL---LVSRGQR----RLRAMRLVVVVVVAFALCWTPYHLVVLvdiLMDLGALARNcgreSRVDVAKSVTSGLGYMHCC 359
Cdd:cd15098  193 NHLhkkLKNMSKKsersKKKTAQTVLVVVVVFGISWLPHHIIHL---WVEFGDFPLT----QASFVLRITAHCLAYANSC 265
                        250
                 ....*....|....
gi 218563730 360 LNPLLYAFVGVKFR 373
Cdd:cd15098  266 VNPIIYAFLSENFR 279
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
124-376 1.01e-25

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 105.66  E-value: 1.01e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLP--LWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15374   24 LFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtlIYYYADHNHWPFGVVACKIVRFLFYANLYCSILFLTCISVHRYVGIC 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAhhDERLNATHCQ-----YNFPQVGRTALRVLQLVAGflLPLL 276
Cdd:cd15374  104 HPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTT--SRKDNITLCHdttrpEEFDHYVHYSSAVMVLLFG--IPCL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCY---AHILAVLLVSRGQR-----RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgaLARNCGRESRVDVAKS 348
Cdd:cd15374  180 VIVVCYglmARRLCKPRVGSSRQqgpssKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARL--LKADCDTLNIINVTYK 257
                        250       260
                 ....*....|....*....|....*...
gi 218563730 349 VTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15374  258 VTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
133-374 4.28e-25

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 103.85  E-value: 4.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15155   33 NETAIFMTNLAVSDLLFVFTLPFKIFyNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTCISVDRFLAIVYPFRSRTIRT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQ-VGRTALRVLQL---VAGFLLPLLVMAYCYAHILA 287
Cdd:cd15155  113 RRNSAIVCAGVWILVLSGGISASLFSTTNVSN--TSTTCFEGFSKsIWKTYLSKITIfieVVGFIIPLLLNLTCSSLVLR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 288 VL-----LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd15155  191 TLrkpatLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIA-NCGVERFARTMYPITLCLATLNCCFDP 269
                        250
                 ....*....|..
gi 218563730 363 LLYAFVGVKFRE 374
Cdd:cd15155  270 FVYYFTSESFQK 281
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
133-374 4.66e-25

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 103.34  E-value: 4.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR-RG 210
Cdd:cd15972   33 SVTNIYILNLALADELFMLGLPFLAAQNALSyWPFGSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKwRK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTClAVWGLCLLFALPDFIFLSAHHDerLNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCYahILAVL 289
Cdd:cd15972  113 PPVAKTVNA-TVWALSFLVVLPVVIFSGVPGG--MGTCHIAWPEPaQVWRAGFIIYTATLGFFCPLLVICLCY--LLIVV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 LVSRGQRRLRAM------------RLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVaksvtsgLGYMH 357
Cdd:cd15972  188 KVRSSGRRVRATstkrrgserkvtRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPSLFGLYFFVVV-------LSYAN 260
                        250
                 ....*....|....*..
gi 218563730 358 CCLNPLLYAFVGVKFRE 374
Cdd:cd15972  261 SCANPIIYGFLSDNFKQ 277
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
128-367 1.10e-24

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 102.57  E-value: 1.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSstdTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd15118   30 RRTVIS---IWILNLALSDLLATLSLPFFTYYLASghTWELGTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVW 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAhhDERLNATH-CQYNFPQVG-------------RTALRVLQLVAGF 271
Cdd:cd15118  107 AQNHRNVAAAKKICGVIWAMALINTIPYFVFRDV--IERKDGRKlCYYNFALFSpspdnnhpickqrQEGLAISKLLLAF 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAKSVTS 351
Cdd:cd15118  185 LIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAH-----NQHSLRPLVIQGLPFAT 259
                        250
                 ....*....|....*.
gi 218563730 352 GLGYMHCCLNPLLYAF 367
Cdd:cd15118  260 TLAFLNSVLNPVLYVF 275
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
102-375 1.33e-24

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 102.55  E-value: 1.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFN 179
Cdd:cd15968    2 LLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdrWLFGDFMCRLVRFLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 180 INFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHC-----QYNF 254
Cdd:cd15968   82 FNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIF--ARTGIIRNRTVCydlapPALF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 255 PQVgrTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG-------QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIL 327
Cdd:cd15968  160 PHY--VPYGMALTVSGFLLPFSIILWCYCLVVRTLCRTLGpaeppaqARRRKSIRTIVTVTLLFALCFLPFHITRTIYLA 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 328 MDLGALArNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15968  238 VRVTPGV-PCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKFGRR 284
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
133-374 2.10e-24

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 101.90  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15926   34 SSINLFVTSLAVTDFQFVLTLPFWAVENALdfTWLFGKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRR 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIF--LSAHHDERLnathCQYNFPQVGRTALRVLQL------VAGFLLPLLVMAYCY 282
Cdd:cd15926  114 GCCSAKWLCVLIWVLAILASLPNAIFstTATVSNEEL----CLVKFPDNRGNAQFWLGLyhaqkvLLGFLIPLGIISLCY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 283 AHILAVLL-----VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMH 357
Cdd:cd15926  190 LLLVRFITdknitGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILIKLNVVHFSYEYFTTQVYIFPITVCLAHSN 269
                        250
                 ....*....|....*..
gi 218563730 358 CCLNPLLYAFVGVKFRE 374
Cdd:cd15926  270 SCLNPILYCLMRREFRK 286
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
120-373 2.27e-24

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 101.41  E-value: 2.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15371   19 AIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYhlNGNNWVFGETMCRIITITFYGNMYCSILLLTCISINRY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATqLYRRGPPARVT-LTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQ-VGRTALR----VLQLVAGF 271
Cdd:cd15371   99 LAIVHPF-IYRSLPKKTYAvLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPEcEQNSNFQfyyfISMAVFGF 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHILAVlLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV----------DILMDLGALARnCgres 341
Cdd:cd15371  178 LIPLVITIFCYISIIRT-LNAYEHKWFWYVKITALVLIIFTICFAPSNVILIIhhfnyyyfnnDNLYSIYLIAL-C---- 251
                        250       260       270
                 ....*....|....*....|....*....|..
gi 218563730 342 rvdvaksvtsgLGYMHCCLNPLLYaFVGVKFR 373
Cdd:cd15371  252 -----------LGSLNSCLDPFLY-FLMSKWR 271
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
135-374 2.46e-24

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 101.46  E-value: 2.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAA-VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPA 213
Cdd:cd15971   35 TNIYILNLAIADELFMLGLPFLAIQVAlVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFP---QVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLL 290
Cdd:cd15971  115 TAKMINMAVWGVSLLVILPIMIYAGVQTKH--GRSSCTIIWPgesSAWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVK 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 VS--------RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVaksvtsgLGYMHCCLNP 362
Cdd:cd15971  193 SSgirvgsskRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLKGMFDFVVV-------LSYANSCANP 265
                        250
                 ....*....|..
gi 218563730 363 LLYAFVGVKFRE 374
Cdd:cd15971  266 ILYAFLSDNFKK 277
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
133-373 3.03e-24

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 101.40  E-value: 3.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15120   32 TVNTLWFLHLILSNLIFTLILPFMAVHVLMdnHWAFGTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNF----------PQVGRT----ALRVLQLVAGFLLPLL 276
Cdd:cd15120  112 TNRWASAIVLGVWISAILLSIPYLAFRETRLDEK-GKTICQNNYalstnwesaeVQASRQwihvAMFVFRFLLGFLLPFL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgalarncgRESRVDVAKSVTSGLGYM 356
Cdd:cd15120  191 IITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGLVLTRGR--------PPSLTDITLLLTVGTTCF 262
                        250
                 ....*....|....*..
gi 218563730 357 HCCLNPLLYAFVGVKFR 373
Cdd:cd15120  263 NTCFTPVLYLFVGENFK 279
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
121-375 3.56e-24

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 101.06  E-value: 3.56e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLL-SRRTALSSTDTFLLHLAVAD-TLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15097   21 VLAVLLrSGQSGHNTTNLFILNLSVADlCFILFCVPFQATIYSLEgWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdfiFLSAHHDERLNATH-CQYNFPQVGRTALRVLQLVAGFLLPLL 276
Cdd:cd15097  101 LAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGP---YLSYYDLIDYANSTvCMPGWEEARRKAMDTCTFAFGYLIPVL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVL---------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarncgreSRVDVAK 347
Cdd:cd15097  178 VVSLSYTRTIKYLwtavdpleaMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPF--------NQATYAF 249
                        250       260
                 ....*....|....*....|....*....
gi 218563730 348 SVTSG-LGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15097  250 RLLSHcMAYANSCLNPIVYALVSKHFRKG 278
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
128-375 5.69e-24

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 100.93  E-value: 5.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVAD---TLLVLtlPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd15195   28 RRRAKSHIQILIMHLALADlmvTFFNM--PMDAVwNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 tqLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSA--HHDERLNATHC---QYNFPQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15195  106 --LSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVlrKMPEQPGFHQCvdfGSAPTKKQERLYYFFTMILSFVIPLIIT 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHIL-----------AVLLVSRGQR--------RLRAMRLVVVVVVAFALCWTPYHLVVLVDiLMDLGALARNcgr 339
Cdd:cd15195  184 VTCYLLILfeiskmakrarDTPISNRRRSrtnsleraRMRTLRMTALIVLTFIVCWGPYYVLGLWY-WFDKESIKNL--- 259
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 340 ESRVDVAKSVtsgLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15195  260 PPALSHIMFL---LGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
122-375 5.78e-24

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 100.91  E-value: 5.78e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 122 AAVLLS----RRTALSSTDTFLLHLAVADtlLVLTLPLWAVDAA----VQWVFGSGLCKVAGALFNINFYAGALLLACIS 193
Cdd:cd15383   19 LAVLWSatrnRRRKLSHVRILILHLAAAD--LLVTFVVMPLDAAwnvtVQWYAGDLACRLLMFLKLFAMYSSAFVTVVIS 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 194 FDRYLNIVH---ATQLYRRGppaRVTLtcLAVWGLCLLFALPD-FIFLSAHHDERLNATHC--QYNFPQVGR-TALRVLQ 266
Cdd:cd15383   97 LDRHAAILNplaIGSARRRN---RIML--CAAWGLSALLALPQlFLFHTVTATPPVNFTQCatHGSFPAHWQeTLYNMFT 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAYCYAHILavLLVSRGQR----------------------RLRAMRLVVVVVVAFALCWTPYHLVVL- 323
Cdd:cd15383  172 FFCLFLLPLLIMIFCYTRIL--LEISRRMKekkdsaknevalrsssdnipkaRMRTLKMTIVIVSSFIVCWTPYYLLGLw 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 218563730 324 --VDILMDLGAlarncgresrvdVAKSVTSGL---GYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15383  250 ywFSPEMLEQT------------VPESLSHILflfGLLNACLDPLIYGLFTISFRRG 294
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
127-373 1.07e-23

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 100.08  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 127 SRRTALSSTDTFLLHLAVADtLLV--LTLPL---WAvdAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15382   28 NRRRKRSRVNILLMHLAIAD-LLVtfIMMPLeigWA--ATVAWLAGDFLCRLMLFFRAFGLYLSSFVLVCISLDRYFAIL 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HAtqLYRRGPPARVTLTCLAVWGLCLLFALPD-FIFLSAHHDERLNATHC-QYNF---PQVgRTALRVLQLVAGFLLPLL 276
Cdd:cd15382  105 KP--LRLSDARRRGRIMLAVAWVISFLCSIPQsFIFHVESHPCVTWFSQCvTFNFfpsHDH-ELAYNIFNMITMYALPLI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHIL------------AVLLVSRGQR------------RLRAMRLVVVVVVAFALCWTPYHLVVLVDIlmdlga 332
Cdd:cd15382  182 IIVFCYSLILceisrkskekkeDVSEKSSSVRlrrssvglleraRSRTLKMTIVIVLVFIICWTPYFIMSLWYW------ 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 218563730 333 larnCGRESRVDVAKSVTSGLGYMHC---CLNPLLYAFVGVKFR 373
Cdd:cd15382  256 ----FDRESASKVDPRIQKGLFLFAVsnsCMNPIVYGYFSIDLR 295
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
133-373 2.29e-23

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 98.87  E-value: 2.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15089   33 TATNIYIFNLALADALATSTLPFQSAKYLMEtWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFPQVG---RTALRVLQLVAGFLLPLLVMAYCYAHIL-- 286
Cdd:cd15089  113 PAKAKLINICIWVLSSGVGVP-IMVMAVTKTPRDGAVVCMLQFPSPSwywDTVTKICVFIFAFVVPILVITVCYGLMIlr 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 --AVLLVSRGQRRLRAMR----LVVVVVVAFALCWTPYHLVVLVDILMDLGAlarncgRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15089  192 lrSVRLLSGSKEKDRNLRritrMVLVVVAAFIICWTPIHIFVIVWTLVDIDR------RNPLVVAALHLCIALGYANSSL 265
                        250
                 ....*....|...
gi 218563730 361 NPLLYAFVGVKFR 373
Cdd:cd15089  266 NPVLYAFLDENFK 278
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
131-373 2.82e-23

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 98.67  E-value: 2.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 131 ALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR 208
Cdd:cd15147   33 KLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEgnWILPKFLCNVAGCLFFINTYCSVAFLGVISYNRYQAVTRPIKTAQ 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 209 RGPPARVTLTCLAVWGLCLLFALPdFIFLSAHHDERL---NATHCQYNFPQVGRTALRVLQ--LVAGFLLPLLVMAYCYA 283
Cdd:cd15147  113 STTRKRGIIISVAIWVIIVASASY-FLFMDSTNTVKIdsgNFTRCFEGYEKDNSKPVLIIHfiIIGLFFLVFLLILVCNL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVLLVS--RGQR----RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGA-LARNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd15147  192 VIARTLLSQpvQGQRnagvKRRALWMVCTVLAVFVICFVPHHVVQGPWTLAVLQQwRYWDCQFRQALNDAHQITLCLMST 271
                        250
                 ....*....|....*..
gi 218563730 357 HCCLNPLLYAFVGVKFR 373
Cdd:cd15147  272 NCVLDPVIYCFLTKKFR 288
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
128-374 3.54e-23

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 98.41  E-value: 3.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd15925   29 ARRAPPPIDVFVFNLALADFGFALTLPFWAVESALdfHWPFGGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAG 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQVGRTALRVLQ-LVAGFLLPLLVMAYCYAH 284
Cdd:cd15925  109 PGTHLSTFWAKIITLALWAAALLATVPTAIF--ATEGEVCGVELCLLKFPSNYWLGAYHLQrVVVAFVVPLGVITTSYLL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILAVL-----LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCC 359
Cdd:cd15925  187 LLSFLqqhkvNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFRAVPWNSTFYFIHTYVFPVTTCLAHSNSC 266
                        250
                 ....*....|....*
gi 218563730 360 LNPLLYAFVGVKFRE 374
Cdd:cd15925  267 LNPVLYCLMRREFRQ 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
133-373 6.50e-23

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 97.72  E-value: 6.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15091   33 TATNIYIFNLALADALVTTTMPFQSTVYLMNsWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVG----RTALRVLQLVAGFLLPLLVMAYCYAHIL- 286
Cdd:cd15091  113 PLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDyswwDTFMKICVFIFAFVIPVLIIIVCYTLMIl 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 ---AVLLVSRGQ---RRLRAM-RLVVVVVVAFALCWTPYHLVVLVDILMDLgalarncGRESRVDVAKSVTSGLGYMHCC 359
Cdd:cd15091  193 rlkSVRLLSGSRekdRNLRRItRLVLVVVAVFVVCWTPIHIFILVEALGSV-------SHSTAAVSSYYFCIALGYTNSS 265
                        250
                 ....*....|....
gi 218563730 360 LNPLLYAFVGVKFR 373
Cdd:cd15091  266 LNPILYAFLDENFK 279
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
135-376 6.76e-23

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 97.69  E-value: 6.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15207   35 TNYFILNLAVSDLLVgVFCMPFTLVDnILTGWPFGDVMCKLSPLVQGVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQ 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTclAVWGLCLLFALPDFIFL---SAHHDERLNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCYAHI--- 285
Cdd:cd15207  115 AFVIIV--AIWVLALAIMIPQALVLevkEYQFFRGQTVHICVEFWPsDEYRKAYTTSLFVLCYVAPLLIIAVLYVRIgyr 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 ------LAVLLVSRGQ------RRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmDLGALARNcGRESRVDVAKSVTSGL 353
Cdd:cd15207  193 lwfkpvPGGGSASREAqaavskKKVRVIKMLIVVVVLFALSWLPLHTVTMLD---DFGNLSPN-QREVLYVYIYPIAHWL 268
                        250       260
                 ....*....|....*....|...
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15207  269 AYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
138-368 8.63e-23

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 97.07  E-value: 8.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15376   39 FSFNLAVSDLLYALSLPLLAAYYYPpkNWRFGEAACKLERFLFTCNLYGSIFFITCISLNRYLGIVHPFFTRSHVRPKHA 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFlSAHHDERLNATHCqYNFPQVGRTA----LRVLQLVAGFLLPLLVMAYCYAHILAVLLV 291
Cdd:cd15376  119 KLVSLAVWLLVAALSAPVLSF-SHLEVERHNKTEC-LGTAVDSRLPtylpYSLFLAVVGCGLPFLLTLASYLAIVWAVLR 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SRG---QRRLRAMRLVVVVVVAFALCWTPYHlvVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15376  197 SPGittLEKRKVAALVAVVVALYAVSFVPYH--ILRNLNLYRRLQWLKAAASLRIYFAYQVTKGLVTLNMCIHPLLYMAV 274
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
120-373 1.50e-22

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 96.47  E-value: 1.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15092   20 LVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGfWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFP---QVGRTALRVLQLVAGFLLPL 275
Cdd:cd15092  100 AICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVED--EEIECLVEIPtpqDYWDPVFGICVFLFSFIIPV 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILA------VLLVSRGQRR--LRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESRVDVAK 347
Cdd:cd15092  178 LIISVCYSLMIRrlrgvrLLSGSKEKDRnlRRITRLVLVVVAVFVGCWTPIQIFVLAQ------GLGVQPSSETAVAILR 251
                        250       260
                 ....*....|....*....|....*.
gi 218563730 348 SVTSgLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15092  252 FCTA-LGYVNSSLNPVLYAFLDENFK 276
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
128-376 1.52e-22

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 96.38  E-value: 1.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ 205
Cdd:cd14988   28 RWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDytWLWGSFLCKFTHYFYFANMYSSIFFLTCLSVDRYLTLTSSSP 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRGPPARVTLTCLAVWGLCLLFALPDFIflsahHDERLNATH--CQYNFPQVGRT----ALRVLQLVAGFLLPLLVMA 279
Cdd:cd14988  108 FWQQHQHRIRRALCAGIWVLSAIIPLPEVV-----HMQLLDGVEpmCLFLAPFETYDewalAVSLLTLIIGFLIPFSIIA 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdILMDLGALARNCGRESRVDVAKSVTSGLGYMHCC 359
Cdd:cd14988  183 VFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLL-LTLHGSHISLHCNLVHFLYFFYDVIDCFSLLHCV 261
                        250
                 ....*....|....*..
gi 218563730 360 LNPLLYAFVGVKFRERM 376
Cdd:cd14988  262 ANPILYNFLSKSFRGKL 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
102-367 1.61e-22

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 96.46  E-value: 1.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWaVDAAVQ---WVFGSGLCKVAGALF 178
Cdd:cd15194    2 FLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLW-VDKEVVlgpWRSGSFLCKGSSYII 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 179 NINFYAGALLLACISFDRYLNIVHATQ--LYRRGPPARVTLTClaVWGLCLLFALPdfIFLSAHHDERLNATHCQYNFPQ 256
Cdd:cd15194   81 SVNMYCSVFLLTCMSLDRYLAIVLPLVsrKFRTKHNAKVCCTC--VWMLSCLLGLP--TLLSRELKKYEEKEYCNEDAGT 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 257 VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLV-----SRGQRRLR-AMRLVVVVVVAFALCWTPYHLVVLVDILMDL 330
Cdd:cd15194  157 PSKVIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHhyqksGKHQKKLRkSIKIVFIVVAAFVFSWMPFNLFKALAIASGL 236
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 331 GALaRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15194  237 QVE-VTCLPYTLAQLGMEVSAPLAFANSCANPFIYYF 272
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
138-376 1.71e-22

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 96.44  E-value: 1.71e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLY---RRGPPAr 214
Cdd:cd15171   38 YFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSVGLHSEALFNVLLTVQASRVFFHGRLASsarRVAPCG- 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 vTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQ--YNFPQVGRTALRVLQL---VAGFLLPLLVMAYCYAHiLAVL 289
Cdd:cd15171  117 -IIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSrpHFLPAEETFWKYFLTLkmnIVVLVFPLLVFIICCVQ-LRKT 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 LVSRGQRRLRaMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVG 369
Cdd:cd15171  195 QRFRERQRDL-SKLVFAIMVVFLLMWAPYNIALFLSAFKEHFSL-RDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLD 272

                 ....*..
gi 218563730 370 VKFRERM 376
Cdd:cd15171  273 PAFRRRL 279
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
133-376 2.84e-22

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 95.55  E-value: 2.84e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15157   33 TSVNIFMLNLAVSDLMFVSTLPFRADYYLMgsHWVFGDIACRIMSYSLYVNMYCSIYFLTVLSIVRFLAIVHPFKLWKVT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERlnaTHCQYnfPQVGRTA-LRVLQ---LVAGFLLPLLVMAYCYAHIL 286
Cdd:cd15157  113 SIKYARILCAVIWIFVMAASSPLLSKGTSKYNSQ---TKCLD--LHPSKIDkLLILNyivLVVGFILPFCTLSICYILII 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVLLVSR-GQRRLR-----AMRLVVVVVVAFALCWTPYHLVVLVDILMdlgalARNCGRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15157  188 KALLKPRvPQSKLRvshkkALLTIIITLILFLLCFLPYHILRTVHLMQ-----WSEGQCNLRLHKAVVITLCLAAANSCL 262
                        250
                 ....*....|....*.
gi 218563730 361 NPLLYAFVGVKFRERM 376
Cdd:cd15157  263 DPLLYYFAGENFKERL 278
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
121-374 2.92e-22

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 95.74  E-value: 2.92e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAV-DAAVQWVFGSGLCKVAGAlfnINFYAGA---LLLACISFD 195
Cdd:cd14969   21 VIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYsNLSGRWSFGDPGCVIYGF---AVTFLGLvsiSTLAALAFE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQlYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNaTHC--QYNFPQVGRTALRVLQLVAGFLL 273
Cdd:cd14969   98 RYLVIVRPLK-AFRLSKRRALILIAFIWLYGLFWALPPLFGWSSYVPEGGG-TSCsvDWYSKDPNSLSYIVSLFVFCFFL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVL-LVSRGQRRL--------------RAMRLVVVVVVAFALCWTPYHLVVLV----------DILM 328
Cdd:cd14969  176 PLAIIIFCYYKIYRTLrKMSKRAARRknsaitkrtkkaekKVAKMVLVMIVAFLIAWTPYAVVSLYvsfggestipPLLA 255
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 218563730 329 DLGALarncgresrvdVAKSVTsglgymhcCLNPLLYAFVGVKFRE 374
Cdd:cd14969  256 TIPAL-----------FAKSST--------IYNPIIYVFMNKQFRR 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
121-376 4.16e-22

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 95.27  E-value: 4.16e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSstDTFLLHLAVADTLLVLTLPL----WAVDAavQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15339   22 LFTIIRSRKKTVP--DIYVCNLAVADLVHIIVMPFlihqWARGG--EWVFGSPLCTIITSLDTCNQFACSAIMTAMSLDR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlSAHHDERLNATHCQYNFPQVGRTALRVL-QLVAGFLLPL 275
Cdd:cd15339   98 YIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVY-AKVIKFRDGLESCAFNLTSPDDVLWYTLyQTITTFFFPL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHIL------------AVLLVSR--GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgres 341
Cdd:cd15339  177 PLILICYILILcytwemyrknkkAGRYNTSipRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQPTLA------- 249
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 218563730 342 rVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15339  250 -FYVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
124-373 4.34e-22

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 95.25  E-value: 4.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAvdAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd15920   24 VFFLRQQRETSISVYMRNLALADLLLVLCLPFRV--AYQNTAGPLSFCKIVGAFFYLNMYASILFLSLISLDRYLKIIKP 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 TQLYRRGPPARVTLTCLAVWGLCLLFALPDFIflsahhdERLNATHCQY---NFPQVGRTALRV-LQLVAGFLLPLLVMA 279
Cdd:cd15920  102 LQQFKIHTVPWSSAASGGVWLLLLACMIPFLF-------ESRNEGPCDNkcfHFRSKGLTAGGInLTAVVIFYILSLLFL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAVLL-VSRG-------QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTS 351
Cdd:cd15920  175 YFYAKISHKLYkVSLGnaqqqikKASKRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVIS-SLPWKQTLHIANELVL 253
                        250       260
                 ....*....|....*....|..
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15920  254 CLSALNSCLDPIIYFFLSSSFR 275
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
135-374 4.47e-22

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 95.25  E-value: 4.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPA 213
Cdd:cd15974   35 TNIYILNLAVADELFMLGLPFLATQNAISyWPFGSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIFLSAHHDerlnATHCQYNFPQ---VGRTALRVLQLVAGFLLPLLVMAYCYAHI----- 285
Cdd:cd15974  115 VAKLINATVWTLSFLVVLPVIIFSDVQPD----LNTCNISWPEpvsVWSTAFIIYTAVLGFFGPLLVICLCYLLIvikvk 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 ---LAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVaksvtsgLGYMHCCLNP 362
Cdd:cd15974  191 ssgLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFVGVYFFVVV-------LSYANSCANP 263
                        250
                 ....*....|..
gi 218563730 363 LLYAFVGVKFRE 374
Cdd:cd15974  264 ILYGFLSDNFKQ 275
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
121-375 4.63e-22

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 95.52  E-value: 4.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL----VLTLPLWavDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd14986   21 VILVLRRKRKKRSRVNIFILNLAIADLVVafftVLTQIIW--EATGEWVAGDVLCRIVKYLQVVGLFASTYILVSMSLDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQlyRRGPPARVTLTCLAVWGLCLLFALPD-FIFLSAHHDerlNATH-CQYNFPQV-GRTALRVLQLVAGFLL 273
Cdd:cd14986   99 YQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQlVIFVERELG---DGVHqCWSSFYTPwQRKVYITWLATYVFVI 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVL--------------------LVSRGQRR--------LRAMRLVVVVVVAFALCWTPYHLVVLVD 325
Cdd:cd14986  174 PLIILSYCYGRILRTIwirsrqktdrpiaptamscrSVSCVSSRvslisrakIKTIKMTLVIILAFILCWTPYFIVQLLD 253
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 218563730 326 ILMDLGALArncgresrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd14986  254 VYAGMQQLE---------NDAYVVSETLASLNSALNPLIYGFFSSHLSFE 294
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
133-376 4.99e-22

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 95.36  E-value: 4.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLP--LWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15377   33 SGISVYMFNLALADFLYVLTLPalIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISVHRYTGVVHPLKSLGRL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWgLCLLFALPDFIFLSAHHDERLNATHCqynFPQVGRTALR------VLQLVAGFLLPLLVMAYCYAH 284
Cdd:cd15377  113 KKKNAICISVLVW-LIVVVAISPILFYSGTGVRKNKTITC---YDTTSDEYLRsyfiysMCTTVAMFCVPFILILGCYGL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILAVLL--------VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLG-ALARNCGRESRVDVAKSVTSGLGY 355
Cdd:cd15377  189 IVRALIykdmkyteENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDfQTPAMCAFNDRVYATYQVTRGLAS 268
                        250       260
                 ....*....|....*....|.
gi 218563730 356 MHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15377  269 LNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
133-374 7.14e-22

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 94.78  E-value: 7.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAV--DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15922   33 SSGTILQFNLALSDAIITPAAPLLIAyfSLGSHWPFGQFLCQLKVFLLSTHMYGSIYFLMLISIHRYVTVVHYNWKSLWK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFL------------SAHHDErLNATHCQYNFpqvgrtalrVLqLVAGFLLPLLVM 278
Cdd:cd15922  113 KKSFMKKLCLGVWLLLFVQGLPFFFVLktsvidgktkclSIHQSE-LSLLYFVWNF---------VL-LILGFLLPFGVS 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLL-----VSRGQR-RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgALARNCGRESRVDVAKSVTSG 352
Cdd:cd15922  182 LTCYALLGASIAkmnsnNARGRAmKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKL-FYPESCTLLHKVEVAYYISWV 260
                        250       260
                 ....*....|....*....|..
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15922  261 LTGVNCCLDPLLYCFASEKFRK 282
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
133-373 1.02e-21

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 94.29  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15090   33 TATNIYIFNLALADALATSTLPFQSVNYLMgTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVG---RTALRVLQLVAGFLLPLLVMAYCYAHILAV 288
Cdd:cd15090  113 PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQ--GSIDCTLTFSHPSwywENLLKICVFIFAFIMPVLIITVCYGLMILR 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 289 LLVSR-------GQRRLRAM-RLVVVVVVAFALCWTPYHLVVLVDILMdlgalarNCGRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15090  191 LKSVRmlsgskeKDRNLRRItRMVLVVVAVFIVCWTPIHIYVIIKALV-------TIPETTFQTVSWHFCIALGYTNSCL 263
                        250
                 ....*....|...
gi 218563730 361 NPLLYAFVGVKFR 373
Cdd:cd15090  264 NPVLYAFLDENFK 276
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
135-374 1.95e-21

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 93.31  E-value: 1.95e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPA 213
Cdd:cd15094   35 TNLYILNLAVADECFLIGLPFLIVTMILKyWPFGAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPF 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPdfIFLSAHHDERLNATHCQYNFPQV----GRTALRVLQLVAGFLLPLLVMAYCYAHILAVL 289
Cdd:cd15094  115 IAKVVCATTWSISFLVMLP--IILYASTVPDSGRYSCTIVWPDSsavnGQKAFTLYTFLLGFAIPLLLISVFYTLVILRL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 ------LVSRGQRR--LRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarNCGRESRVDVAKSVTSG-LGYMHCCL 360
Cdd:cd15094  193 rtvgpkNKSKEKRRshRKVTRLVLTVISVYIICWLPYWAFQVHLIFLP------PGTDMPKWEILMFLLLTvLSYANSMV 266
                        250
                 ....*....|....
gi 218563730 361 NPLLYAFVGVKFRE 374
Cdd:cd15094  267 NPLLYAFLSENFRK 280
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
138-368 2.09e-21

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 93.31  E-value: 2.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWaVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15365   38 YLFNLSLSDLLYIVILPLW-IDYLWNgdnWTLSGFVCIFSAFLLYTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRT 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFalpDFIFLSAH--HDERLNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLV 291
Cdd:cd15365  117 ALSVSVAIWLLEICF---NAVILTWEdsFHESSSHTLCYDKFPlEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRS 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SRG---QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGalarNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15365  194 NQAtedQEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPC----DCRNAKWLYTLYKITVALTSLNCIADPFLYCFV 269
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
121-376 2.26e-21

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 93.24  E-value: 2.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLS--RRTALSSTDTFLLHLAVADTLLVL-TLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15002   20 VIGILLNnaRKGKPSLIDSLILNLSAADLLLLLfSVPFRAAAYSKGsWPLGWFVCKTADWFGHACMAAKSFTIAVLAKAC 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRgPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQL-VAGFLLPL 275
Cdd:cd15002  100 YMYVVNPTKQVTI-KQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFMSAFVKLYpLFVFCLPL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHIL----------AVLLVSRGQRRLRAMRLvvVVVVAFALCWTPYHLVVLVDILMDLGALarncgreSRVDV 345
Cdd:cd15002  179 TFALFYFWRAYgqcqrrgtktQNLRNQIRSRKLTHMLL--SVVLAFTILWLPEWVAWLWLIHIKSSGS-------SPPQL 249
                        250       260       270
                 ....*....|....*....|....*....|.
gi 218563730 346 AKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15002  250 FNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
135-374 4.24e-21

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 92.13  E-value: 4.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15923   35 TNIYMTNLAVADLLLLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYVSIFTITAISVDRYVAIRYPLRARELRSPRK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDFIFlsahhDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLL---- 290
Cdd:cd15923  115 AAVVCAVIWVLVVTISIPYFLL-----DSSNEKTMCFQRTKQTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQkrld 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 -VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVG 369
Cdd:cd15923  190 dVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY---SCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFAT 266

                 ....*
gi 218563730 370 VKFRE 374
Cdd:cd15923  267 KEFRE 271
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
138-367 5.10e-21

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 92.14  E-value: 5.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15369   38 YMLNLACADLLFVLLLPFKIAYhfSGNDWLFGEAMCRVVTAAFYCNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQ-------------YNFPqvgrtalrVLQLVAgFLLPLLVMAYCY 282
Cdd:cd15369  118 SFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTCHdvlneqllmgyyvYYFS--------IFSCLF-FFVPLIITTVCY 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 283 AHILAVL----LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdlgaLARNCGRESRVdVAKSVTSGLGYMHC 358
Cdd:cd15369  189 VSIIRCLssssDVANSSKKTRALFMAVAVFCVFVICFGPTNVLLLAHYVR----FAYTSTNDASY-FAYLLCVCVGSISC 263

                 ....*....
gi 218563730 359 CLNPLLYAF 367
Cdd:cd15369  264 CLDPLIYYY 272
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
121-374 8.07e-21

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 91.65  E-value: 8.07e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPL--WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15392   21 VCYIVVSYPRMRTVTNYFIVNLALSDILMaVFCVPFsfIALLILQYWPFGEFMCPVVNYLQAVSVFVSAFTLVAISIDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHAtqLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHD--ERLNATHCQYNFPQVG-RTALRVLQLVAGFLLP 274
Cdd:cd15392  101 VAIMWP--LRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDsnASCGQYICTESWPSDTnRYIYSLVLMILQYFVP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLV---------SRGQRRLRA----MRLVVVVVVAFALCWTPYHlvvlvdILMDLGALARNCGRES 341
Cdd:cd15392  179 LAVLVFTYTRIGIVVWAkrtpgeaenNRDQRMAESkrklVKMMITVVAIFALCWLPLN------ILNLVGDHDESIYSWP 252
                        250       260       270
                 ....*....|....*....|....*....|...
gi 218563730 342 RVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15392  253 YIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
129-321 2.29e-20

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 90.40  E-value: 2.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQL 206
Cdd:cd15170   30 RRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGmiWPLPYFLCPLSSFIFFSTIYISTLFLTAISVERYLGVAFPIKY 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGPPARVTLTCLAVWGLCLLFALPDFI---FLSAHHDERLNATHCQYNFPQvgrTALRVLQLV------AGFLLPLLV 277
Cdd:cd15170  110 KLRRRPLYAVIASVFFWVLAFSHCSIVYIveyHIDSENTSVTNNSRCYDNFTP---EQLKILLPVrlelflVLFCIPFLI 186
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYA---HILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPY---HLV 321
Cdd:cd15170  187 TCFCYInfiRILSSLPHISRQRKQRAIGLAVATLLNFIVCFAPYnisHVV 236
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
133-374 6.04e-20

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 89.00  E-value: 6.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15378   33 KSSNIYLFNLSVSDLAFLCTLPMLVYSySNGQWLFGDFLCKSNRYLLHANLYSSILFLTFISIDRYLLIKYPFREHILQK 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSahHDERLNATHCQYNFPQVGRTALRVLQL---VAGFLLPLLVMAYCYAHIlAV 288
Cdd:cd15378  113 KRSAVAISLAIWVLVTLELLPILTFIG--PNLKDNVTKCKDYASSGDATNSLIYSLfltVTGFLIPLCVMCFFYYKI-AL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 289 LLVSRGQRRL------RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd15378  190 FLKNRNRQLAnatsfeKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSIGVSECTLIIIKSLYIVTRPIAFLNSVINP 269
                        250
                 ....*....|..
gi 218563730 363 LLYAFVGVKFRE 374
Cdd:cd15378  270 VFYFLMGDHFRE 281
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
124-376 6.13e-20

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 89.11  E-value: 6.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd14989   24 VNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQINMYSSIFFLTWMSFDRYIALAKV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 --TQLYRRGPPARvtLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVgrtalRVLQLVAGFLLPLLVMAYC 281
Cdd:cd14989  104 mkSSPLRTMQHAR--LSCGLIWMASISATLLPFTAVQAQHTG--EVHFCFADVREI-----QWLEVTLGFIIPFSIIGLC 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 282 YAHILAVLLVSRGQRRLR-----AMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVD--VAKSVTSGLG 354
Cdd:cd14989  175 YSLIVRVLVRAQKHRRLRprrqkALRMILVVVLVFFICWLPENVFISIQLLQGTQEPSESYDESFRHNhpLTGHIVNLAA 254
                        250       260
                 ....*....|....*....|..
gi 218563730 355 YMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd14989  255 FSNSCLNPLIYSFLGETFRDKL 276
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
133-374 6.83e-20

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 89.34  E-value: 6.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTL-LVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRR 209
Cdd:cd14979   33 TTTNYYLFSLAVSDLLiLLVGLPVELYNFWWQypWAFGDGGCKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPPARVTLTCLAVWGLCLLFALPdfiFLSAHHDERLNA---------THCQYNFPQVGRTALRVLQLVAGFLLPLLVMAY 280
Cdd:cd14979  113 VTKRRVKRFILAIWLVSILCAIP---ILFLMGIQYLNGplpgpvpdsAVCTLVVDRSTFKYVFQVSTFIFFVLPMFVISI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 281 CYAHILAVLLVSRG-------------------QRRLRAMRLVVVVVVAFALCWTPYHlvvlVDILMDLgALARNCGRES 341
Cdd:cd14979  190 LYFRIGVKLRSMRNikkgtraqgtrnvelslsqQARRQVVKMLGAVVIAFFVCWLPFH----AQRLMFS-YASKEDTFLF 264
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 342 RVDVAKSVTSG-LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd14979  265 DFYQYLYPISGiLFYLSSAINPILYNLMSSRFRV 298
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
113-375 9.22e-20

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 88.10  E-value: 9.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAV-AAVLLSRRTAlSSTDTFLLHLAVADTLLVLT-LPL-WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLL 189
Cdd:cd15001   12 LGLIGNSLViFVVARFRRMR-SVTNVFLASLATADLLLLVFcVPLkTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 190 ACISFDRYLNIVH---ATQLYRRGPPARVTltcLAVWGLCLLFALPD-FIFLSAHHDERLNAT--HCQYNFPQVG-RTAL 262
Cdd:cd15001   91 TAISIERYYVILHpmkAKSFCTIGRARKVA---LLIWILSAILASPVlFGQGLVRYESENGVTvyHCQKAWPSTLySRLY 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 263 RVLQLVAGFLLPLLVMAYCYAHIlavllvsrgqRRLRAMRLVVVVVVAFALCWTP---YHLVVLVDILMDLgalarNCGR 339
Cdd:cd15001  168 VVYLAIVIFFIPLIVMTFAYARD----------TRKQVIKMLISVVVLFAVCWGPlliDNLLVSFDVISTL-----HTQA 232
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 340 ESRVDVAKSVtsgLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15001  233 LKYMRIAFHL---LSYANSCINPIIYAFMSKNFRSS 265
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
124-373 1.94e-19

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 87.89  E-value: 1.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15373   24 VFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADEndWPFSEALCKIVRFLFYTNLYCSILFLLCISVHRFLGVC 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATH---CQYNFPQVgrTALRVLQLVAGFLLPLLVM 278
Cdd:cd15373  104 YPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHdtsSPELFDQF--VVYSSVMLVLLFCVPFVVI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLL------VSRGQRRLRAMRLVVVVVVAFALCWTPYHlvVLVDILMDLGALARNCGRESRVDVAKSVTSG 352
Cdd:cd15373  182 LVCYALMVRKLLkpsagtSTNSRSKKKSVKMIIIVLAVFILCFLPFH--VTRTLYYSFRSMDLSCGTLNAINLAYKVTRP 259
                        250       260
                 ....*....|....*....|.
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15373  260 LASANSCLDPILYFLAGQSFR 280
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
103-375 3.24e-19

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 87.24  E-value: 3.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 103 LPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNI 180
Cdd:cd15379    3 LPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKdyWPFGDFTCRLVRFQFYT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 181 NFYAGALLLACISFDRYLNIVHATQLYRRGPPARVT-LTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQVGR 259
Cdd:cd15379   83 NLHGSILFLTCISVQRYLGICHPLASWHKKKGKKLTwLVCGAVWLVVIAQCLPTFVF--ASTGTQRNRTVCYDLSPPARS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 260 TALR---VLQLVAGFLLPLLVMAYCYAHILAVLLV---------SRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdIL 327
Cdd:cd15379  161 TAYFpygITLTRTGFLLPFAARLACYCSMATILCRvviavavvaAPGEKRGKAARMIIVVAAVFLISFLPFHYTKTR-YL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 328 MDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15379  240 QVRSWDGGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
120-321 6.10e-19

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 85.75  E-value: 6.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15196   20 CVLLVLYRRRRKLSRMHLFILHLSVADLLVALfnVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMYASSYVLVATAIDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQlYRRGPPARVTLTCLAVWGLCLLFALPD-FIFlsAHHDERLNATHCQYNF-PQVGRTALRVLQLVAGFLLPL 275
Cdd:cd15196  100 IAICHPLS-SHRWTSRRVHLMVAIAWVLSLLLSIPQlFIF--SYQEVGSGVYDCWATFePPWGLRAYITWFTVAVFVVPL 176
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 218563730 276 LVMAYCYAHILAVLLvsrgQRRLRAMRLVVVVVVAFALCWTPYHLV 321
Cdd:cd15196  177 IILAFCYGRICYVVW----RAKIKTVKLTLVVVACYIVCWTPFFVV 218
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
124-373 1.16e-18

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 85.09  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLS--RRTAL-SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15053   21 VIMSvfRERSLqTATNYFIVSLAVADLLVAILVMPFAVYVEVNggkWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDERLNATHCQ-YNFPQVgrtalrVLQLVAGFLLPLL 276
Cdd:cd15053  101 IAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACP--LLFGLNNVPYRDPEECRfYNPDFI------IYSSISSFYIPCI 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLlvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVD-ILMDLGALARNCGresrvDVAKSVTSGLGY 355
Cdd:cd15053  173 VMLLLYYRIFRAL-----RREKKATKTLAIVLGVFLFCWLPFFTLNILNaICPKLQNQSCHVG-----PALFSLTTWLGY 242
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15053  243 VNSFLNPIIYTIFNIEFR 260
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
135-320 1.43e-18

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 85.42  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqLYRRGPP 212
Cdd:cd15390   35 TNYFLVNLAVADLLISAfnTVFNFTYLLYNDWPFGLFYCKFSNFVAITTVAASVFTLMAISIDRYIAIVHP--LRPRLSR 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIFLS--AHHDERL-NATHCQYNFPQVGRTALR----VLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15390  113 RTTKIAIAVIWLASFLLALPQLLYSTteTYYYYTGsERTVCFIAWPDGPNSLQDfvynIVLFVVTYFLPLIIMAVAYTRV 192
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 218563730 286 LAVLLVSRGQ--------RRLRAMR----LVVVVVVAFALCWTPYHL 320
Cdd:cd15390  193 GVELWGSKTIgentprqlESVRAKRkvvkMMIVVVVIFAICWLPYHL 239
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
102-374 1.98e-18

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 84.74  E-value: 1.98e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 102 FLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFN 179
Cdd:cd15375    2 YLPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGesWIFGEFMCKFIRFIFH 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 180 INFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAhhDERLNATHCQYNFPQVGR 259
Cdd:cd15375   82 FNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITT--KEKNNRTICLDFTSSDNL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 260 TALRVLQL---VAGFLLPLLVMAYCYAHILAVL---LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIlmDLGAL 333
Cdd:cd15375  160 NTIWWYNWiltVLGFLLPLVIVTLCYTRIIYTLakgPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRI--ETRLP 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 218563730 334 ARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15375  238 PVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
117-376 2.12e-18

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 84.81  E-value: 2.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 117 GNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISF 194
Cdd:cd16001   17 LNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMrdRWPFGDFLCKLVRFLFYTNLYGSILFLTCISV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 195 DRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQ--------YNFPQVGrtalrVLQ 266
Cdd:cd16001   97 HRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVY--ARTGSINNRTVCYdltspdnfGNYFPYG-----MVL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAYCYAHILAVLLVSRGQR------RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgALARNCGRE 340
Cdd:cd16001  170 TVTGFLIPFLIILLCYCLMIKSLIRSEEAAgvgkaaRAKSIRTILLVCGLFALCFVPFHITRTIYLFVRV-YLVQDCPLL 248
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 341 SRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd16001  249 QFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
124-376 2.93e-18

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 84.43  E-value: 2.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15368   24 LLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYhiQRNHWIFGKPLCNVVTVLFYANMYSSILTMTCISIERYLGVV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCqynFPQVGRTALRVLQLVAG---------FL 272
Cdd:cd15368  104 YPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTC---FDVLKWTMLPNIAAWAAflftlfillFL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVS-----RGQRRlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarncgrESRVDVAK 347
Cdd:cd15368  181 IPFIITVYCYVLIILKLVQTserygREQKR-RAIYLALIVLLVFITCFAPNNFILLAHMVSRLFY-------GKSLYHAY 252
                        250       260
                 ....*....|....*....|....*....
gi 218563730 348 SVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15368  253 KLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
129-375 4.28e-18

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 83.87  E-value: 4.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTAlssTDTFLLHLAVAD-TLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQL 206
Cdd:cd15095   32 RTV---TNYYIVNLAVTDlAFLVCCVPFTAALYATpSWVFGDFMCKFVNYMMQVTVQATCLTLTALSVDRYYAIVHPIRS 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL-NATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCYAH 284
Cdd:cd15095  109 LRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgPQTYCREVWPsKAFQKAYMIYTVLLTYVIPLAIIAVCYGL 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 IL--------------AVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLvdilmdLGALARNCGRESRVDVAKSVT 350
Cdd:cd15095  189 ILrrlwrrsvdgnnqsEQLSERALRQKRKVTRMVIVVVVLFAICWLPNHVLNL------WQRFDPNFPETYATYALKIAA 262
                        250       260
                 ....*....|....*....|....*
gi 218563730 351 SGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15095  263 LCLSYANSAVNPFVYAFMGENFRKY 287
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
138-368 5.50e-18

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 83.27  E-value: 5.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWA--VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15367   38 YLCNLTVADLLYIFSLPFWLqyVLQHDNWTYSELLCKICGILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVW----GLCLLFALPDFIFLSAHhderlNATHCQYNFP-QVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLL 290
Cdd:cd15367  118 TLVSTVIWlkelMTCVFFFLHGEISKDKE-----NHSVCFEHYPiKAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVR 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 VSRGQRR---LRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15367  193 KSHGTQKsqkIQIKRLVLSTVVIFLVCFGPYHILLLVRSVFE-----RDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF 267

                 .
gi 218563730 368 V 368
Cdd:cd15367  268 A 268
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
133-367 7.76e-18

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 83.18  E-value: 7.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTdTFLLHLAVADTLLVLTLPLWA--VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHatqlyrrg 210
Cdd:cd15201   34 SST-VYLFNLAVADFLLIICLPFRTdyYLRGKHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVH-------- 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTL--TCLAVWGLCLLFALP----DFIFLSAHHDERLNATHCQYNFPQVGRTALRV---LQLVAGFLLPLLVMAYC 281
Cdd:cd15201  105 PHHRINSisVRKAAIIACGLWLLTiamtVYLLTKKHLFPRGNATQCESFNICTGTDSSSNwheAMFLLEFFLPLAIILYC 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 282 YAHILAVL---LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdILMDLGALARNCGRESRVDVAKSVTSGLGYMHC 358
Cdd:cd15201  185 SVRIIWQLrgrQLDRHAKIKRAVQFIMVVAIVFIICFLPSNVTRIA-IWILKHTSNEDCQYYRSVDLAFYITISFTYFNS 263

                 ....*....
gi 218563730 359 CLNPLLYAF 367
Cdd:cd15201  264 MLDPVVYYF 272
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
121-374 1.04e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 82.72  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLT------LPLWAVDAavqWVFGSGLCKVAGALFNINFYAGALLLACISF 194
Cdd:cd14997   21 VGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVcmpvalVETWAREP---WLLGEFMCKLVPFVELTVAHASVLTILAISF 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 195 DRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDF---IFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGF 271
Cdd:cd14997   98 ERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLfitEFKEEDFNDGTPVAVCRTPADTFWKVAYILSTIVVFF 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHILAVLL--------------VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNC 337
Cdd:cd14997  178 VVPLAILSGLYSVICRRLVghpalesrradaanRHTLRSRRQVVYMLITVVVLFFVCLLPFRVVTLWIIFAPDEDLQ-AL 256
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 338 GRESRVDVAkSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd14997  257 GLEGYLNLL-VFCRVMVYLNSALNPILYNLMSTKFRS 292
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
121-373 1.08e-17

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 82.02  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15061   21 ILAVATTRRLR-TITNCYIVSLATADLLVgVLVLPLAIIRQLLgYWPLGSHLCDFWISLDVLLCTASILNLCCISLDRYF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQlYRRGPPARVTLTC-LAVWGLCLLFALPDfIFLSAHHDERLNAThCQYNFpqvgRTALRVLQLVAGFLLPLLV 277
Cdd:cd15061  100 AITYPLK-YRTKRSRRLAITMiLAVWVISLLITSPP-LVGPSWHGRRGLGS-CYYTY----DKGYRIYSSMGSFFLPLLL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLlvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarncgresrVDVAKSVTSGLGYMH 357
Cdd:cd15061  173 MLFVYLRIFRVI-----AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDCQF----------SEALSTAFTWLGYFN 237
                        250
                 ....*....|....*.
gi 218563730 358 CCLNPLLYAFVGVKFR 373
Cdd:cd15061  238 SVINPFIYAFYNKDFR 253
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
138-374 3.02e-17

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 81.38  E-value: 3.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15370   38 YMANLALADLLFVIWFPLKIAYhiNGNNWIYGEALCKVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIAI 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTcLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQ---VGRTALRVLQL-VAGFLLPLLVMAYCYAHILAVL-- 289
Cdd:cd15370  118 GIS-LAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEqllVGDMFNYFLSLaIGVFLFPAFLTAVAYVLMIRALks 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 ---LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIlmdlgALARNcGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15370  197 sinDESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHY-----FLLKN-QGQSSVYAFYITALCLSTLNSCIDPFVYY 270

                 ....*...
gi 218563730 367 FVGVKFRE 374
Cdd:cd15370  271 FVSHDFRD 278
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
138-376 3.33e-17

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 81.31  E-value: 3.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLY--RRGPPAR 214
Cdd:cd15152   38 FMINLAIADLLQVLSLPLRIFYYLNKsWPFGKFLCMFCFYLKYVNMYASIYFLVCISVRRCLYLIYPFRYNdcKRKCDVY 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VtltCLAVWGLCLLFALPdFIFLSAHHDErlNATHCQYNFP--QVGRTALRVLQLVA---GFLLPLLVMAYCYAHILAVL 289
Cdd:cd15152  118 I---SIAGWLVVCVGCLP-FPLLRQSQDT--NPTCCFADLPlrNVGLTTSVIMLTIAeltGFVTPLLIVLYCSWKTVMSL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 ------LVSRGQRRlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYMHCCLNPL 363
Cdd:cd15152  192 rektpvLQDLGEKK-KALKMILTCAVVFLICFAPYHISFPLDFLVKSNKI-KSCTARKVILIFHPVALCLASLNSCLDPV 269
                        250
                 ....*....|...
gi 218563730 364 LYAFVGVKFRERM 376
Cdd:cd15152  270 IYYFTTDEFKRRL 282
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
121-376 5.25e-17

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 80.57  E-value: 5.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15012   20 VILVVTSHRRMRTITNFFLANLAVADLCVGIfcVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVVISVERYI 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF-PQVGRTALRVLQL---VAGFLLP 274
Cdd:cd15012  100 AILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICvLDREMFNSKLYDTinfIVWYLIP 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLVS-RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAKSVTSGL 353
Cdd:cd15012  180 LLIMTVLYSKISIVLWKSsSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSE-----PYRCDSNWNALLTPLTFLV 254
                        250       260
                 ....*....|....*....|...
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15012  255 LYFNSAVNPLLYAFLSKRFRQSM 277
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
121-373 5.27e-17

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 80.63  E-value: 5.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15202   21 VCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNtWIFGLFMCHFSNFAQYCSVHVSAYTLTAIAVDRYQ 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHAtqLYRRGPPARVTLTCLAVWGLCLLFALPD------FIFLSAHHDERlnaTHCQYNFPQVGRTALRVLQLVA--- 269
Cdd:cd15202  101 AIMHP--LKPRISKTKAKFIIAVIWTLALAFALPHaicsklETFKYSEDIVR---SLCLEDWPERADLFWKYYDLALfil 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 270 GFLLPLLVMAYCYAHILAVLLVS---------RGQRRLRAMR----LVVVVVVAFALCWTPYHLVVLVdilmdlgalarn 336
Cdd:cd15202  176 QYFLPLLVISFAYARVGIKLWASnmpgdatteRYFALRRKKKkvikMLMVVVVLFALCWLPFNIYVLL------------ 243
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 218563730 337 cgRESRVDVAKS-------VTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15202  244 --LSSKPDYLIKtinavyfAFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
135-374 5.61e-17

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 80.84  E-value: 5.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVAD-TLLVLTLP--LWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15134   35 TNYYLFSLAVSDlLLLILGLPfeLYTIWQQYPWVFGEVFCKLRAFLSEMSSYASVLTITAFSVERYLAICHPLRSHTMSK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATH--------CQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYA 283
Cdd:cd15134  115 LSRAIRIIIAIWIIAFVCALPFAIQTRIVYLEYPPTSGealeesafCAMLNEIPPITPVFQLSTFLFFIIPMIAIIVLYV 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HI-----------LAVLLVSRGQRRLRA----MRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAKS 348
Cdd:cd15134  195 LIglqlrrstllrRGQRSVSGGRRSSQSrrtvLRMLVAVVVAFFICWAPFHAQRLLTVYAK-----NMTPPYLFINRILF 269
                        250       260
                 ....*....|....*....|....*..
gi 218563730 349 VTSG-LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15134  270 YISGvLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
121-373 1.44e-16

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 79.40  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd14992   21 VIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVslSWEYGHFLCKIVNYLRTVSVYASSLTLTAIAFDRYF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH----HDERLNATHCQYNFP--QVGRTALRVLQLVAGFL 272
Cdd:cd14992  101 AIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEvlfsVKNQEKIFCCQIPPVdnKTYEKVYFLLIFVVIFV 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVS-------------RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdlGALARNCGR 339
Cdd:cd14992  181 LPLIVMTLAYARISRELWFRkvpgfsikeverkRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLL------RDFFPLIMK 254
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 340 ESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd14992  255 EKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
121-373 2.33e-16

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 78.55  E-value: 2.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRtaLSSTDTFL-LHLAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15331   22 IAAILLERS--LQGVSNYLiLSLAVADLMVaVLVMPLSAVYeVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPpARVTLTCLAVWGLCLLFALPDFIFLS--AHHDERLNATHCQYNfPQVGRTalrVLQLVAGFLLPL 275
Cdd:cd15331  100 WAVTNIDYIRRRTA-KRILIMIAVVWFVSLIISIAPLFGWKdeDDLDRVLKTGVCLIS-QDYGYT---IFSTVGAFYVPL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTSGLGY 355
Cdd:cd15331  175 LLMIIIYWKIYQA-----AKRERKAARTLAIITGAFVVCWLPFFLVALVMPF---------CGAWQISRFLESFFLWLGY 240
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15331  241 FNSLLNPIIYTIFSPDFR 258
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
123-324 3.02e-16

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 78.47  E-value: 3.02e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLwAVDAAV----QWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15204   23 AVLARYKKLRTLTNLLIANLALSDFLVaVFCLPF-EMDYYVvrqrSWTHGDVLCAVVNYLRTVSLYVSTNALLVIAIDRY 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHatQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFP---QVGRTALRVLQLVAGFLLP 274
Cdd:cd15204  102 LVIVH--PLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQIWPvdqQAYYKAYYLFLFVLEFVLP 179
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218563730 275 LLVMAYCYAHIL------------AVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV 324
Cdd:cd15204  180 VLIMTLCYLRIVrkvwfrrvpgqqTEQIRRRLRRRRRKVRLLVVILTAFVLCWAPYYGYAIV 241
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
137-368 3.82e-16

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 78.25  E-value: 3.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 137 TFLLHLAVADTLL-VLTLPLWAVDAA-VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqLYRRGPPAR 214
Cdd:cd15384   37 SLLLHLAIADLLVtFFCIPSEAIWAYtVAWLAGNTMCKLVKYLQVFGLYLSTYITVLISLDRCVAILYP--MKRNQAPER 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPD-FIFLSAHHDERLNATHC-QYNFpqvgRTALRVLQLVAG------FLLPLLVMAYCYAHIL 286
Cdd:cd15384  115 VRRMVTVAWILSPIFSIPQaVIFHVERGPFVEDFHQCvTYGF----YTAEWQEQLYNMlslvfmFPIPLVIMVTCYVLIF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVL-------------LVSRGQRR--------LRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrvDV 345
Cdd:cd15384  191 ITLskssrdfqgleiyTRNRGPNRqrlfhkakVKSLRMSAVIVTAFILCWTPYYVIMIWFLFFNPYPLN---------DI 261
                        250       260
                 ....*....|....*....|....
gi 218563730 346 AKSVTSGLGYMHCCLNPLLY-AFV 368
Cdd:cd15384  262 LFDVIFFFGMSNSCVNPLIYgAFH 285
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
124-374 4.19e-16

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 78.00  E-value: 4.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH 202
Cdd:cd15079   24 IFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEgWALGPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVK 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 ATQLyRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNF---PQVGRTALRVLqLVAGFLLPLLVMA 279
Cdd:cd15079  104 PLNG-NPLTRGKALLLILFIWLYALPWALLPLLFGWGRYVPEGFLTSCSFDYltrDWNTRSFVATI-FVFAYVIPLIIII 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAV-------------------LLVSRGQRRLRA-MRLVVVVVVAFAL---CWTPYHLVVLVDILMD------- 329
Cdd:cd15079  182 YCYSFIVKAvfahekalreqakkmnvvsLRSNADANKQSAeIRIAKVALTNVFLwfiAWTPYAVVALIGAFGNqslltpl 261
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 330 ---LGALArncgresrvdvAKSVtsglgymhCCLNPLLYAFVGVKFRE 374
Cdd:cd15079  262 vsmIPALF-----------AKTA--------ACYNPIVYAISHPKYRL 290
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
133-374 5.80e-16

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 77.41  E-value: 5.80e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHatqlyRRG 210
Cdd:cd15213   33 SAINLLLANLAFSDIMLsLVCMPFAAVTiITGRWIFGDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQ-----RQD 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 P--PARVTLTCLAVWGLCLLFALPDFI---FLSAHHDerlnATHCQYNFPQ-VGRTALRVLQLVAGFLLPLLVMAYCYAH 284
Cdd:cd15213  108 KlnPHRAKILIAVSWVLSFCVSFPPLVgwgKYEFPPR----APQCVLGYTEsPADRIYVVLLLVAVFFIPFLIMLYSYFC 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILavllvsRGQRRL--RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGalarncgreSRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd15213  184 IL------NTVRSFktRAFTTILILFIGFSVCWLPYTVYSLLSVFSRYS---------SSFYVISTCLLWLSYLKSAFNP 248
                        250
                 ....*....|..
gi 218563730 363 LLYAFVGVKFRE 374
Cdd:cd15213  249 VIYCWRIKKFRE 260
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
137-375 6.81e-16

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 77.76  E-value: 6.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 137 TFLLHLAVADTLL-VLTLPLWAVDA-AVQWVFGSGLCKV---AGALFNINfyaGALLLACISFDRYLNIVH--ATQLYRR 209
Cdd:cd15083   37 YLIINLAISDFLMcILNCPLMVISSfSGRWIFGKTGCDMygfSGGLFGIM---SINTLAAIAVDRYLVITRpmKASVRIS 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPpaRVTLTCLAVWGLCLLFALPDFIFLSAHHDERLnATHCQYNFpqVGRTALR----VLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15083  114 HR--RALIVIAVVWLYSLLWVLPPLFGWSRYVLEGL-LTSCSFDY--LSRDDANrsyvICLLIFGFVLPLLIIIYCYSFI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSRGQRRLRAMRLVVVVVVA---------------------FALCWTPYHLVVLVDILMDLGALArncgresrvD 344
Cdd:cd15083  189 FRAVRRHEKAMKEMAKRFSKSELSSpkarrqaevktakialllvllFCLAWTPYAVVALIGQFGYLEVLT---------P 259
                        250       260       270
                 ....*....|....*....|....*....|.
gi 218563730 345 VAKSVTSGLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15083  260 LATAIPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
138-368 6.84e-16

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 77.51  E-value: 6.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQ---LYRRGPP 212
Cdd:cd15364   38 YLFSLSLCELLYLGTLPLWTIYVSNNhkWPWGSLACKITGYIFFCNIYISILLLCCISIDRFVAVVYALEsrgRRRQRIA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGL--CLLFALPDfiflsahhDERLNATHCQYNFPQVGRTA-LRVLQLVAGFLLPLLVMAYCYAHILAVL 289
Cdd:cd15364  118 AFISFLIFIVVGLvhSPVFIMRE--------GQTEGSHTCFETLQMDTQVAgFYYARFCIGFAIPLAILIFTNYRIFRSI 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 LVSRG---QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15364  190 QTSTSltpHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYPNGMCGFEERIYTPSVIFLCLSTVNSVADPIIYV 269

                 ..
gi 218563730 367 FV 368
Cdd:cd15364  270 LV 271
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
127-373 1.28e-15

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 76.72  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 127 SRRTALSSTDTFLLHLAVADTLLVLTLPL-WAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAT 204
Cdd:cd15167   27 QKRSSRKCINIYLINLLTADFLLTLALPVkIAVDLGIaPWKLKIFHCQVTACLIYINMYLSIIFLGFVSIDRYLQLTHSS 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 205 QLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThCQYNFPQVGRT--ALRVLQLVAGFL--------LP 274
Cdd:cd15167  107 KLYRIQEPGFAKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVG-CADFKTEFGRHwhVLTNFICMAIFLnfsaiiliSN 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHilavlLVSRGQRRLR-AMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGL 353
Cdd:cd15167  186 FLVIRKLYRN-----KDSEEYRNARqALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVIT-DCSLKRSLFLAKESTLLL 259
                        250       260
                 ....*....|....*....|
gi 218563730 354 GYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15167  260 AVLNLCFDPILYFHLSKAFR 279
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
121-376 1.32e-15

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 76.61  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLV-LTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15389   21 VCHVIFKNKRMHTATNLFIVNLAVSDILITlLNTPFTLVRFVNsTWVFGKIMCHLSRFAQYCSVYVSTLTLTAIALDRHR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLavWGLCLLFALPDFIF---LSAHHDERLNATHCQYNFPQVGRTALRVLQL---VAGFL 272
Cdd:cd15389  101 VILHPLKPRITPCQGVVVIAII--WIMASCLSLPHAIYqklVEFEYSNERTRSRCLPSFPEPSDLFWKYLDLatfILQYV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHIL-------AVLLVSRGQR------RLRAMRLVVVVVVAFALCWTPYHLVVlvdILMDLGALARNcgr 339
Cdd:cd15389  179 LPLLIIGVAYTRVAkklwlrnAIGDVTTEQYvaqrrkKKKTIKMLMLVVLLFAICWLPLNCYH---VLLSSHPIRSN--- 252
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 340 esrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15389  253 ----SALFFAFHWLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
121-374 2.12e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 75.38  E-value: 2.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15210   22 VLALLRSKKLR-TRTNAFIINLSISDLLFcAFNLPLAASTfLHQAWIHGETLCRVFPLLRYGLVAVSLLTLVLITLNRYI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHA---TQLYRRgppARVTLTCLAVWGLCLLFALPDF--IFLSAHHDERLNAthCQYNFPQVGRTALRVLqLVAGFLL 273
Cdd:cd15210  101 LIAHPslyPRIYTR---RGLALMIAGTWIFSFGSFLPLWlgIWGRFGLDPKVCS--CSILRDKKGRSPKTFL-FVFGFVL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAhilavllvSRGQRRLRAMRLvvVVVVAFALCWTPYHLVVLVDilmdlgalarncgRESRVDVAKSVTSGL 353
Cdd:cd15210  175 PCLVIIICYA--------RREDRRLTRMML--VIFLCFLVCYLPITLVNVFD-------------DEVAPPVLHIIAYVL 231
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15210  232 IWLSSCINPIIYVAMNRQYRQ 252
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
138-374 2.49e-15

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 75.46  E-value: 2.49e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15059   38 FLVSLAVADILVgLLIMPFSLVNELMgYWYFGSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNfPQVGrtalRVLQLVAG-FLLPLLVMAYCYAHIlavLLVSRG 294
Cdd:cd15059  118 KAMIAAVWIISAVISLPPLFGWKDEQPWHGAEPQCELS-DDPG----YVLFSSIGsFYIPLLIMIIVYARI---YRAAKR 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 QRRlRAMRLVVVVVVAFALCWTPYHLVVLvdilmdLGALARNCGREsrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15059  190 KER-RFTLVLGVVMGAFVLCWLPFFFTYP------LVVVCKTCGVP---ELLFKFFFWLGYCNSALNPVIYTIFNKDFRR 259
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
115-373 2.54e-15

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 75.77  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 115 LLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLT-LPlwaVDAAV----QWVFGSGLCKVAGALFNINFYAGALLL 189
Cdd:cd15927   15 VLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTcVP---FTSTIytldSWPFGEFLCKLSEFLKDTSIGVSVFTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 190 ACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQY----------NFPQVgR 259
Cdd:cd15927   92 TALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQIcypypqelgpNYPKI-M 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 260 TALRVLQLvagFLLPLLVMAYCYAHILAVLLVS---------RGQR-----RLRAMRLVVVVVVAFALCWTPYHlvvlvd 325
Cdd:cd15927  171 VLLRFLVY---YLIPLLIIGVFYVLMARHLIRStrnigsgqnQAAQrqieaRKKVAKTVLAFVVLFAVCWLPRH------ 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 218563730 326 ILMdlgaLARNCGRESRVD------VAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15927  242 VFM----LWFHFAPNGLVDynafwhVLKIVGFCLSFINSCVNPVALYLLSGSFR 291
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
124-365 2.68e-15

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 75.50  E-value: 2.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLP---LWAVDAAvQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15148   24 VFLFIHRKRNSVRIFLINVAIADLLLIICLPfriLYHVNNN-QWTLGPLLCKVVGNLFYMNMYISIILLGFISLDRYLKI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHderlNATHC-QYNFPQVGRT-ALRVLQLVAGFLLPLLVM 278
Cdd:cd15148  103 NRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTEKNE----ESTKCfQYKDRKNAKGkAIFNFLIVAMFWLVFLLL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLL-VSRGQRRL-------RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArnCGRESRVDVAKSVT 350
Cdd:cd15148  179 ILSYGKIAKKLLrISRDKPDFpnaakynRTARKSFFVLFIFTVCFVPYHAFRIFYITSQLQNNS--CYWKEILHKTNEIM 256
                        250
                 ....*....|....*
gi 218563730 351 SGLGYMHCCLNPLLY 365
Cdd:cd15148  257 LLLSAFNSCLDPVMY 271
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
135-367 3.12e-15

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 75.67  E-value: 3.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATqLYrrgpP 212
Cdd:cd15055   35 TNLLLLSLAVADFLVgLLVMPFSMIRSIETcWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPL-LY----P 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLT--CLAV---WGLCLLFALPdFIFLSAHHDERLNATHCQ------YNFPqvgrtaLRVLQLVAGFLLPLLVMAYC 281
Cdd:cd15055  110 TKITIRrvKICIclcWFVSALYSSV-LLYDNLNQPGLIRYNSCYgecvvvVNFI------WGVVDLVLTFILPCTVMIVL 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 282 YAHILavlLVSRGQ-RRLRAMRLVVVVVV----------------------AFALCWTPYHLVVLVDILMDLGALARNcg 338
Cdd:cd15055  183 YMRIF---VVARSQaRAIRSHTAQVSLEGsskkvskkserkaaktlgivvgVFLLCWLPYYIVSLVDPYISTPSSVFD-- 257
                        250       260
                 ....*....|....*....|....*....
gi 218563730 339 resrvdvaksVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15055  258 ----------VLIWLGYFNSCLNPLIYAL 276
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
136-376 6.59e-15

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 74.46  E-value: 6.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 136 DTFLLHLAVADTLLVLTLPLwAVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA-TQLYRRGP 211
Cdd:cd15338   39 DIFIFNLSIVDLLFLLGMPF-LIHQLLGngvWHFGETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPiRSTKIRTP 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLaVWGLCLLFALPDFIF--LSAHHDERLNATHCQYNfPQVGRTALRVLQLVAGFLLPLLVMAYCYAHIL--- 286
Cdd:cd15338  118 RVAVAVICL-VWILSLLSITPVWMYagLMPLPDGSVGCALLLPN-PETDTYWFTLYQFFLAFALPLVVICVVYFKILqnm 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVLLVSRGQRRLR-----AMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrVDVAKSVTSGLGYMHCCLN 361
Cdd:cd15338  196 ASTVAPLPQRSLRvrtkkVTRMAVAICLAFFICWAPFYILQLAHLSIDRPSLA--------FLYAYNVAISMGYANSCIN 267
                        250
                 ....*....|....*
gi 218563730 362 PLLYAFVGVKFRERM 376
Cdd:cd15338  268 PFLYIMLSETFKRQF 282
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
129-324 8.41e-15

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 74.01  E-value: 8.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTALSSTDTFLLHLAVADTLLVLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAT--Q 205
Cdd:cd14983   30 RLRLTPNVIYMINLCLSDLVFILSLPIKIVEAlSSAWTLPAVLCPLYNLAHFSTLYASTCFLTAISAGRYLGVAFPIkyQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 LYRRgpPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATH-----CQYNFPQVGRTALRVLQL---VAGFLLPLLV 277
Cdd:cd14983  110 LYKK--PLYSCLVCVAIWALVIFHVTLVFILETSGGTLDINTPVgnsstCYENFTPEQLALLAPVRLelsLVLFFLPLAI 187
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 218563730 278 MAYCYAHILAVLLVSR--GQRRLRAMRLVVVVVVAFALCWTPYHLVVLV 324
Cdd:cd14983  188 TAFCYVRCIRILVRSRlhERRKRRAVRVAVSTLLTFVVCFGPYNISHVV 236
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
121-373 1.13e-14

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 74.05  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15205   21 VIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNiSSNWLGGAFMCKMVPFVQSTAVVTSILTMTCIAVERHQ 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdFIF---LSAHHDERLNATH--CQYNF-PQVGRTALRVLQLVAGFL 272
Cdd:cd15205  101 GIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSP-MLFvqqLEVKYDFLYEKRHvcCLERWySPTQQKIYTTFILVILFL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVSR-------------------GQRRLRAMRLVVVVVVAFALCWTPYHLVVLvdiLMDLGAL 333
Cdd:cd15205  180 LPLTTMLFLYSRIGYELWIKKrvgdasvlqtihgiemskiSRKKKRAVKMMVTVVLLFAVCWAPFHVVHM---MIEYSNL 256
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 334 aRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15205  257 -ENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
116-376 1.25e-14

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 73.67  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 116 LGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISF 194
Cdd:cd15153   16 LANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHtWPFGRFLCLLCFYLKYLNMYASICFLTCISI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 195 DRY---LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFAlpdfifLSAHHDERLNATHCQYNFPQVGRTALRVLQLV--- 268
Cdd:cd15153   96 QRCfflLHPFKARDWKRRYDVGISAAVWIVVGLACLPFP------LLRSKSLSNNNRSCFADLGMKKLNFGAAIAMMtva 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 269 --AGFLLPLLVMAYCyAHILAVLLVSRGQR------RLRAMRLVVVVVVAFALCWTPYHLVVLVdILMDLGALARNCGRE 340
Cdd:cd15153  170 elFGFVIPLFIIAWC-TWKTENSLRQRNKQqqstseKQKALRMVRMCAAVFFICFAPYHINFLF-YLMVSESIITNCEVS 247
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 341 SRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15153  248 QVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
101-373 1.61e-14

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 73.25  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 101 AFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLwAVDAAVQ---WVFGSGLCKVAGAL 177
Cdd:cd14991    1 SILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPF-RIDYYLRgehWIFGEAWCRVNLFM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 178 FNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDERLNATHCQ----YN 253
Cdd:cd14991   80 LSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLP--LLLSTLLTVNSNKSSCHsfssYT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 254 FPQVG---RTALRVLQlvagFLLPLLVMAYCYAHILAVL----LVSRGQRRLRAMRLVVVVVVAFALCWTPyhlVVLVDI 326
Cdd:cd14991  158 KPSLSirwHNALFLLE----FFLPLGLIVFCSVRIACNLrirqSLGKQARVQRAIRLVFLVVIVFVLCFLP---SIIAGL 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 218563730 327 LMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd14991  231 LALVFKNLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
138-373 2.22e-14

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 72.90  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15199   38 YLLNLVLADVLLLICLPFKAYFYLNgnRWSLGGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQ--YNFPQVGRTALRVLQlvagFLLPLLVMAYCYAHILAVL---- 289
Cdd:cd15199  118 PYISFLVWLLLVGLTIPTLLASQPKNFTECNSFSPKddEDFSDTWQEAVFFLQ----FLLPFGLIVFCTVRIIRRLkkrl 193
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 -LVSRGQRRLRAMRLVVVVVVAFALCWTPyhlVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15199  194 rDVGKQPKLQRAMALVTSVVVVFGFCFLP---CFLARVLMLIFQNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFS 270

                 ....*
gi 218563730 369 GVKFR 373
Cdd:cd15199  271 SPTFR 275
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
121-374 2.38e-14

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 72.79  E-value: 2.38e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSsTDTFLLHLAVADTLLVL-TLPLWA-VDAAVQWVFGSGLCKVAGAlFNINFYAGALL-LACISFDRY 197
Cdd:cd15066   21 IISVMRHRKLRVI-TNYFVVSLAMADMLVALcAMTFNAsVEITGRWMFGYFMCDVWNS-LDVYFSTASILhLCCISVDRY 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFA-LPDFI--FLSAHHDERLNATHCQYNFpqVGRTALRVLQLVAGFLLP 274
Cdd:cd15066   99 YAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPIFLgwYTTEEHLQYRKTHPDQCEF--VVNKIYALISSSVSFWIP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRV-DVAKSVTSGL 353
Cdd:cd15066  177 CIVMIFTYYRIYLE-----AKREHKAAKTLGIIMGAFILCWLPFFLWYVTTTL---------CGDACPYpPILVSILFWI 242
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15066  243 GYFNSTLNPLIYAYFNRDFRE 263
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
121-373 2.40e-14

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 72.53  E-value: 2.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15063   22 IAAVLCSRKLR-TVTNLFIVSLACADLLVgTLVLPFSAVNEVLDvWIFGHTWCQIWLAVDVWMCTASILNLCAISLDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAG---FLLPL 275
Cdd:cd15063  101 AITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSLPCTCELTNGRGYVIYSAlgsFYIPM 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdlGALARNCGResrvDVAKSVTSGLGY 355
Cdd:cd15063  181 LVMLFFYFRIYRA-----ARMETKAAKTVAIIVGCFIFCWLPFFTVYLV------RAFCEDCIP----PLLFSVFFWLGY 245
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15063  246 CNSALNPCIYALFSRDFR 263
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
135-374 2.42e-14

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 73.19  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLT-LPL-WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqLYRRGPP 212
Cdd:cd15208   35 TNYFIVNLSLADFLVIIIcLPAtLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHP--LMFKSTA 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNA-----THCqynFPQVGRTALRVLQ----LVAGFLLPLLVMAYCYA 283
Cdd:cd15208  113 KRARVSILIIWIVSLLIMIPQAIVMECSRVVPLANktillTVC---DERWSDSIYQKVYhicfFLVTYLLPLCLMILAYF 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVL----------------------LVSRGQRRLRAMR----LVVVVVVAFALCWTPYHlvvLVDILMDLGALARNC 337
Cdd:cd15208  190 QIFRKLwcrqipgtssvvqrkwnkprksAVAAEEKQLRSRRktakMLIVVVIMFAICYLPVH---LLNILRYVFGLFTVD 266
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 338 GResRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15208  267 RE--TIYAWFLFSHWLVYANSAINPIIYNFMSGKFRE 301
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
123-373 2.81e-14

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 72.35  E-value: 2.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTAlSSTDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKV---AGALFNInfyAGALLLACISFDR 196
Cdd:cd15052   24 AISLEKRLQ-NVTNYFLMSLAIADLLvglLVMPLSILTELFGGVWPLPLVLCLLwvtLDVLFCT---ASIMHLCTISLDR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPqvgrtALRVLQLVAGFLLPLL 276
Cdd:cd15052  100 YMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGTCVLFNP-----NFVIYGSIVAFFIPLL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAhiLAVLLVSRGQrrlRAMRLVVVVVVAFALCWTPYhlvVLVDILMDLGAlARNCGRESRVdvaKSVTSGLGYM 356
Cdd:cd15052  175 IMVVTYA--LTIRLLSNEQ---KASKVLGIVFAVFVICWCPF---FITNILTGLCE-ECNCRISPWL---LSVFVWLGYV 242
                        250
                 ....*....|....*..
gi 218563730 357 HCCLNPLLYAFVGVKFR 373
Cdd:cd15052  243 SSTINPIIYTIFNKTFR 259
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
138-374 3.10e-14

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 72.74  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTL--LVLTLPLWAVDAAVQ-WVFGSGLCKV---AGALFNINFYAgalLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15337   38 FIINLAISDFGfsAVNGFPLKTISSFNKkWIWGKVACELygfAGGIFGFMSIT---TLAAISIDRYLVIAKPLEAMKKMT 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNaTHCQYNF-PQVGRTALRVLQL-VAGFLLPLLVMAYCYAHIlaVL 289
Cdd:cd15337  115 FKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQ-TSCTFDYlSRDLNNRLFILGLfIFGFLCPLLIIIFCYVNI--IR 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 LVSRGQRRLRAM-----------------------RLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVA 346
Cdd:cd15337  192 AVRNHEKEMTQTaksgmgkdtekndarkkaeiriaKVAIILISLFLLSWTPYAVVALLGQFGPAYWIT-PYVSELPVMFA 270
                        250       260
                 ....*....|....*....|....*...
gi 218563730 347 KsvTSGlgyMHcclNPLLYAFVGVKFRE 374
Cdd:cd15337  271 K--ASA---IY---NPIIYALSHPKFRA 290
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
121-367 3.92e-14

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 72.46  E-value: 3.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAV-DAAVQWVFGSgLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15057   22 IAAVLRFRHLRSKVTNYFIVSLAVSDLLVaILVMPWAAVnEVAGYWPFGS-FCDVWVSFDIMCSTASILNLCVISVDRYW 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFA-LPdfIFLSAHHDERLN------ATHCQYNFpQVGRTALRVLQLVAgF 271
Cdd:cd15057  101 AISSPFRYERRMTRRRAFIMIAVAWTLSALISfIP--VQLGWHRADDTSealalyADPCQCDS-SLNRTYAISSSLIS-F 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHILAVL-----------------------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILM 328
Cdd:cd15057  177 YIPVAIMIVTYTRIYRIArrqirriaaleraaqestnpdssLRSSLRRETKALKTLSIIMGVFVCCWLPFFILNCVLPFC 256
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 218563730 329 DLGALARNCGRESRVDvaksVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15057  257 DLRTAQFPCVPDTTFI----VFVWLGWANSSLNPIIYAF 291
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
121-376 5.02e-14

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 72.08  E-value: 5.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADT-LLVLTLPLWAV-DAAVQWVFGSGLCKVAGALfNINFYAGAL-LLACISFDRY 197
Cdd:cd15073   21 VLVTFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAAsDLHGSWKFGYAGCQWYAFL-NIFFGMASIgLLTVVAVDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHAtQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThCQYNFPQVGRTALRVLQ--LVAGFLLPL 275
Cdd:cd15073  100 LTICRP-DLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTGAT-CTINWRKNDSSFVSYTMsvIVVNFIVPL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHI-LAVLLVSRG------------QRRLRAMRLvvVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESR 342
Cdd:cd15073  178 AVMFYCYYNVsRFVKKVLASdclesvnidwtdQNDVTKMSV--IMIVMFLVAWSPYSIVCLWASFGEPKKIPPWMAIIPP 255
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 343 VdVAKSVTsglgymhcCLNPLLYAFVGVKFRERM 376
Cdd:cd15073  256 L-FAKSST--------FYNPCIYVIANKKFRRAI 280
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
117-367 5.35e-14

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 71.72  E-value: 5.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 117 GNGAVAAVLLSRRTALSSTDTFLLHLAVAD---TLLVLTLPLWAVDAAVQWVFGSGLCkVAGALFNINF-YAGALLLACI 192
Cdd:cd15212   17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDlltALLCLPFAFLTLFSRPGWLFGDRLC-LANGFFNACFgIVSTLTMTLI 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 193 SFDRYLNIVHATQlyRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH-HDERLNATHCQYNF---PQVGRTALRVLQLV 268
Cdd:cd15212   96 SFDRYYAIVRQPQ--GKIGRRRALQLLAAAWLTALGFSLPWYLLASAPeYYEKLGFYHCLYVLhsgPSRLGAAYSSVLIV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 269 AGFLLPLLVMAYCYAHILAVLLVSRGQRR-----LRAMRLVVVVVVA---------FALCWTPYHLVVLVdilmdlgALA 334
Cdd:cd15212  174 LCYLLPFALMCFCHYNICKTVRLSESRVRpvttyAHLLRFYSEMRTAttvlimivfIICCWGPYCLLGLV-------AAA 246
                        250       260       270
                 ....*....|....*....|....*....|...
gi 218563730 335 RNCGRESRVDVaksVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15212  247 GGYQFPPLMDT---VAIWMAWANGAINPLIYAI 276
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
123-374 5.67e-14

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 71.53  E-value: 5.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRtaLSSTDTFLL-HLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15329   24 AVCLVKK--LRTPSNYLIvSLAVSDLLVaLLVMPLAIIYELSgYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLV 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSahhDERLNATHCQY--NFpqvgrtALRVLQLVAGFLLPLLV 277
Cdd:cd15329  102 ITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWK---NKVNDPGVCQVsqDF------GYQIYATFGAFYIPLIV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTS---GLG 354
Cdd:cd15329  173 MLVLYYKIYRA-----AKSERKAIKTLGIIMGAFTLCWLPFFILALLRPF---------LKPIKCSCIPLWLSRlflWLG 238
                        250       260
                 ....*....|....*....|
gi 218563730 355 YMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15329  239 YANSFLNPIIYAKFNREFRT 258
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
142-373 6.10e-14

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 71.21  E-value: 6.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 142 LAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTC 219
Cdd:cd15064   42 LAVADLLVaVLVMPLSAVYELTGrWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMI 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 220 LAVWGLCLLFALPDFIFLSAHHDERLNAthCQYNfPQVGRTalrVLQLVAGFLLPLLVMAYCYAHILAVllvsrGQRRLR 299
Cdd:cd15064  122 ALVWTLSICISLPPLFGWRTPDSEDPSE--CLIS-QDIGYT---IFSTFGAFYIPLLLMLILYWKIYRA-----AARERK 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 218563730 300 AMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15064  191 AAKTLGIILGAFIVCWLPFFLVALIVPL---------CSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
121-374 1.19e-13

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 70.90  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLT-LPLWAVDAAVQ-WVFGSGLCKV---AGALFNInfyAGALLLACISFD 195
Cdd:cd15336   21 VIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKrWIFGEKGCELyafCGALFGI---TSMITLLAISLD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLnATHCQYNF--PQVGRTALRVLQLVAGFLL 273
Cdd:cd15336   98 RYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFGWSAYVPEGL-LTSCTWDYmtFTPSVRAYTMLLFCFVFFI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHI-LAVLLVSRGQRRL-------------------RAMRLVVVVVVAFALCWTPYHLVVLVdilmdlgAL 333
Cdd:cd15336  177 PLGIIIYCYLFIfLAIRSTGREVQKLgsqdrkekakqyqrmknewKMAKIAFVVILLFVLSWSPYACVALI-------AW 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 218563730 334 ArncGRESRVD-VAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15336  250 A---GYAHLLTpYMKSVPAVIAKASAIYNPIIYAITHPKYRE 288
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
138-373 1.30e-13

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 70.54  E-value: 1.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVAD-TLLVLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15060   38 FIVSLAVADlAVAIFVLPLNVAYFLLgKWLFGIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRV 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNfpqvGRTALRVLQLVAGFLLPLLVMAYCYAHILavllVSRGQ 295
Cdd:cd15060  118 LLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLT----EEKGYVIYSSSGSFFIPLLIMTIVYVKIF----IATSK 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 218563730 296 RRlRAMRLVVVVVVAFALCWTPYHLVVLvdILmdlgALARNCGRESRVdvaKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15060  190 ER-RAARTLGIIMGVFVVCWLPFFLMYV--IL----PFCETCSPSAKV---VNFITWLGYVNSALNPVIYTIFNLDFR 257
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
117-373 1.35e-13

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 70.77  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 117 GNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTL-PLWAVDA-AVQWVFGSGLCKVAGaLFNINFYAGALL-LACIS 193
Cdd:cd15074   17 GNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAfAHRWLFGDIGCVFYG-FCGFLFGCCSINtLTAIS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 194 FDRYLNIVH---ATQLYRRgppaRVTLTCLAVWGLCLLFALPDFIFLSAHHDERLnATHCQYNFPQVGRTALR----VLQ 266
Cdd:cd15074   96 IYRYLKICHppyGPKLSRR----HVCIVIVAIWLYALFWAVAPLVGWGSYGPEPF-GTSCSIDWTGASASVGGmsyiISI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAYCYAHILAVL---------LVSRGQRR----LRAMRLVVVVVVAFALCWTPYHLVVLVDILMD---- 329
Cdd:cd15074  171 FIFCYLLPVLIIVFSYVKIIRKVkssrkrvagFDSRSKRQhkieRKVTKVAVLICAGFLIAWTPYAVVSMWSAFGSpdsv 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 218563730 330 ---LGALARNCgresrvdvAKSvtsglgymHCCLNPLLYAFVGVKFR 373
Cdd:cd15074  251 pilASILPALF--------AKS--------SCMYNPIIYLLFSSKFR 281
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
113-374 1.86e-13

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 70.11  E-value: 1.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLA 190
Cdd:cd15206   13 LAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRnFIFGEVMCKLIPYFQAVSVSVSTFTLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 191 CISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFP-QVGRTALRVLQLVA 269
Cdd:cd15206   93 AISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREVWPnEIAEQAWYVFLDLM 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 270 GFLLPLLVMAYCYAHILAVLLVSrgqrRLRAMRLVVVVVVAFALCWTPYHlVVLVDILMDLGALARNCGresrvDVAKSV 349
Cdd:cd15206  173 LLVIPGLVMSVAYGLISWTLLEA----KKRVIRMLFVIVVEFFICWTPLY-VINTWKAFDPPSAARYVS-----STTISL 242
                        250       260
                 ....*....|....*....|....*
gi 218563730 350 TSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15206  243 IQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
138-373 2.64e-13

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 69.38  E-value: 2.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15050   38 YIVSLSVADLIVgAVVMPLNIVYlLESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPdfiFLSAHHDERLN-----ATHCQYNFPQVgrTALRVLQLVAGFLLPLLVMAYCYAHILAVLl 290
Cdd:cd15050  118 SLMISGAWLLSFLWVIP---ILGWHHFARGGervvlEDKCETDFHDV--TWFKVLTAILNFYIPSLLMLWFYAKIFKAV- 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 vsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESrvdvAKSVTSGLGYMHCCLNPLLYAFVGV 370
Cdd:cd15050  192 ----NRERKAAKQLGFIMAAFILCWIPYFILFMVI------AFCKNCCNEN----LHMFTIWLGYINSTLNPFIYPLCNE 257

                 ...
gi 218563730 371 KFR 373
Cdd:cd15050  258 NFK 260
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
121-374 2.73e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 69.61  E-value: 2.73e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADtLLVLTLPL-WAVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15310   21 VCMAVLRERALQTTTNYLVVSLAVAD-LLVATLVMpWVVYLEVTggvWNFSRICCDVFVTLDVMMCTASILNLCAISIDR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQL-YRRGPPA--RVTLTCLAVWGLCLLFALPDFIFLSAHHDerlnATHCQYNFPQvgrtaLRVLQLVAGFLL 273
Cdd:cd15310  100 YTAVVMPVHYqHGTGQSScrRVSLMITAVWVLAFAVSCPLLFGFNTTGD----PTVCSISNPD-----FVIYSSVVSFYL 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVLLvsrgqRRLRAMRLVVVVVVAFALCWTPYHLVVLvdilmdLGALARNCGRESRVdvaKSVTSGL 353
Cdd:cd15310  171 PFGVTLLVYVRIYVVLL-----REKKATQMLAIVLGAFIVCWLPFFLTHI------LNTHCQACHVPPEL---YSATTWL 236
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15310  237 GYVNSALNPVIYTTFNIEFRR 257
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
121-373 2.77e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 69.31  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSR--RTAlssTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFD 195
Cdd:cd15067   21 ILAVLRERylRTV---TNYFIVSLAVADLLVgSIVMPFSILHEMTGgyWLFGRDWCDVWHSFDVLASTASILNLCVISLD 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNfpqvGRTALRVLQLVAGFLLPL 275
Cdd:cd15067   98 RYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQCLFT----DDSGYLIFSSCVSFYIPL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHILAVLLVSRgqrrlRAMRLVVVVVVAFALCWTPYhlvVLVDILMdlGALARNCgrESRVDVAKSVTSGLGY 355
Cdd:cd15067  174 VVMLFTYYRIYRAAAKEQ-----KAAKTLGIVMGVFILCWLPF---FVTNILI--GFCPSNC--VSNPDILFPLVTWLGY 241
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15067  242 INSGMNPIIYACSSRDFR 259
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
138-374 2.79e-13

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 69.27  E-value: 2.79e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATqLYR-RGPPAR 214
Cdd:cd15049   38 FLLSLACADLIIgLVSMNLYTVYLVMgYWPLGPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPL-TYRaKRTPKR 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLVMAYCYAHIlavllvSR 293
Cdd:cd15049  117 AILMIALAWVISFVLWAPAILGWQYFVGERtVPDGQCYIQF--LDDPAITFGTAIAAFYLPVLVMTILYWRI------YR 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 294 GQRRLR-AMRLVVVVVVAFALCWTPYHLVVLVdilmdlGALARNCgresRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKF 372
Cdd:cd15049  189 ETARERkAARTLSAILLAFIITWTPYNILVLV------STFCAKC----IPDTLWSFGYWLCYINSTINPFCYALCNKTF 258

                 ..
gi 218563730 373 RE 374
Cdd:cd15049  259 RK 260
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
133-373 3.64e-13

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 69.44  E-value: 3.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLP--LWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15132   33 TTTNLYLSSMAVSDLLILLCLPfdLYRLWKSRPWIFGEFLCRLYHYISEGCTYATILHITALSIERYLAICFPLRAKVLV 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATH----CQYNFPQVGRTALRVLQLV--AGFLLPLLVMAYCYAH 284
Cdd:cd15132  113 TRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDfsreCKHTPYAVSSGLLGIMIWVttTYFFLPMLCLSFLYGF 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILAVLLVSRGQRRLRA-----------MRLVVVVVVAFALCWTPYHlvvlvdilmdLGALARNCGRESRVDVAKS----V 349
Cdd:cd15132  193 IGRKLWKSKNDLRGPNaaarershrqtVRILAVVVLAFIICWLPFH----------IGRILFANTEDYRTMMFSQyfniV 262
                        250       260
                 ....*....|....*....|....
gi 218563730 350 TSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15132  263 AMQLFYLSASINPILYNLISRKYR 286
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
121-374 4.38e-13

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 68.80  E-value: 4.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPL-WAVDAAVQWVFGSGLCKVAGALfNINFYAGALLLAC-ISFDRY 197
Cdd:cd15321   27 VIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFsLANELMGYWYFRKTWCEIYLAL-DVLFCTSSIVHLCaISLDRY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNfpqvgRTALRVL-QLVAGFLLPLL 276
Cdd:cd15321  106 WSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLN-----EEAWYILsSSIGSFFAPCL 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYahiLAVLLVSRgQRRLRAMRLVVVVVVAFALCWTPYHLvvlvdiLMDLGALarnCGRESRV-DVAKSVTSGLGY 355
Cdd:cd15321  181 IMILVY---LRIYLIAK-NREKRFTFVLAVVIGVFVLCWFPFFF------SYSLGAI---CPELCKVpHSLFQFFFWIGY 247
                        250
                 ....*....|....*....
gi 218563730 356 MHCCLNPLLYAFVGVKFRE 374
Cdd:cd15321  248 CNSSLNPVIYTIFNQDFRR 266
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-374 4.94e-13

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 69.01  E-value: 4.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVH 202
Cdd:cd14999   23 VMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKkWYFGDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVK 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 ATQLYRRgPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRV---LQLVAGFLLPLLVMA 279
Cdd:cd14999  103 PLDTVKR-SKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGGSKRICLPTWSEESYKVyltLLFSTSIVIPGLVIG 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 280 YCYAHILAVLLVS------RGQRRL---RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVdvaksVT 350
Cdd:cd14999  182 YLYIRLARKYWLSqaaasnSSRKRLpkqKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNY-----LL 256
                        250       260
                 ....*....|....*....|....
gi 218563730 351 SGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd14999  257 TCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
138-374 5.22e-13

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 68.84  E-value: 5.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd17790   38 FLLSLACADLIIgAFSMNLYTTYILMgHWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRg 294
Cdd:cd17790  118 AIMIGLAWLISFVLWAPAILFWQYLVGERtVLAGQCYIQF--LSQPIITFGTAIAAFYLPVTIMIILYWRIYRETIKEK- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 qrrlRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCgresrvdVAKSVTSgLGYMHC----CLNPLLYAFVGV 370
Cdd:cd17790  195 ----KAARTLSAILLAFILTWTPYNIMVLVS------TFCKDC-------VPKTLWE-LGYWLCyvnsTVNPMCYALCNK 256

                 ....
gi 218563730 371 KFRE 374
Cdd:cd17790  257 SFRD 260
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
133-376 6.74e-13

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 68.69  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAV-DAAVQWVFGSGLCKVAGALfnINFYAG-AL-LLACISFDRYLNIV---HATQL 206
Cdd:cd15166   33 TTVTVYMMNVALVDLIFILSLPFRMVyYAKDEWPFGDYFCRILGAL--TVFYPSiALwLLAFISADRYMAIVqpkHAKEL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGppaRVTLTCLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFPQVGRTALRVL---QLVAGFLLPLLVMAYCYA 283
Cdd:cd15166  111 KNTP---KAVLACVGVWIMTLASTFP-LLFLYEDPDKASNFTTCLKMLDIIHLKEVNVLnftRLIFFFLIPLFIMIGCYL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVLLVSRGQR-----RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarncgRESRVDVAKSVTSGLGYMHC 358
Cdd:cd15166  187 VIIHNLVHGRTSKlkpkvKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQN---------GDNSYNPWAAFTTFLMNLST 257
                        250
                 ....*....|....*...
gi 218563730 359 CLNPLLYAFVGVKFRERM 376
Cdd:cd15166  258 CLDVILYYIVSKQFQARV 275
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
120-367 7.07e-13

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 68.61  E-value: 7.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLL----VLTLPLWavDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFD 195
Cdd:cd15197   20 SVLFALWMRKAKKSRMNFFITQLAIADLCVglinVLTDIIW--RITVEWRAGDFACKVIRYLQVVVTYASTYVLVALSID 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVtLTCLAvWGLCLLFALPDFIfLSAHHDERLNATHCQYNFP-----QVGRTALRVLQlvag 270
Cdd:cd15197   98 RYDAICHPMNFSQSGRQARV-LICVA-WILSALFSIPMLI-IFEKTGLSNGEVQCWILWPepwywKVYMTIVAFLV---- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 271 FLLPLLVMAYCYAHILAVLLV----------------------SRG---QRRLRAMRLVVVVVVAFALCWTPYhlvVLVD 325
Cdd:cd15197  171 FFIPATIISICYIIIVRTIWKkskiqvtinkaglhdgssrrssSRGiipRAKIKTIKMTFVIVTVFIICWSPY---FVFD 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 218563730 326 ILMDLGALARNcgrESRVDVAKSVTSgLGYMHCCLNPLLYAF 367
Cdd:cd15197  248 LLDVFGLLPRS---KTKIAAATFIQS-LAPLNSAINPLIYCL 285
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
138-376 1.04e-12

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 68.24  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAV-DAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15924   37 YLKNTVVADLLMILTFPFKILsDAGLgPWQLRTFVCRVTSVLFYFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIfLSAHHDERLNATHCQYNFPQVGRTALRVLQLV--AGFLLPLLVMAYCYAHIL-----AV 288
Cdd:cd15924  117 KILSVVVWALMFLLSLPNMI-LTNQQPREKNVKKCSFLKSELGLKWHEIVNYIcqVIFWIVFLLMIVCYTAITkkvyrSY 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 289 LLVSRGQ--RRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15924  196 RRVFRSSssRRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQTRDVF-DCTAENILFYVKEATLFLSALNVCLDPIIYF 274
                        250
                 ....*....|
gi 218563730 367 FVGVKFRERM 376
Cdd:cd15924  275 FLCKSFRESL 284
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
121-373 1.86e-12

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 67.13  E-value: 1.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLT-LPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15062   21 VILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATlEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYI 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAthCQYNfpqvGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15062  101 GVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGWKEPAPADEQA--CGVN----EEPGYVLFSSLGSFYLPLAII 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVLLvsRGQRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALARNCGRESRVdvaKSVTSGLGYMHC 358
Cdd:cd15062  175 LVMYCRVYVVAF--KFSREKKAAKTLGIVVGAFVLCWFPFFVV------LPLGSLFSTLKPPEPV---FKVVFWLGYFNS 243
                        250
                 ....*....|....*
gi 218563730 359 CLNPLLYAFVGVKFR 373
Cdd:cd15062  244 CLNPIIYPCSSREFK 258
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
138-374 2.84e-12

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 66.94  E-value: 2.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15048   38 FLLNLAVADFLVgLVSMPFYIPyTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRT 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDERLNAT-HC----QYNFPQVGRTAlrVLQlvagFLLPLLVMAY----CYAHIL 286
Cdd:cd15048  118 VLLMALVWILAFLLYGPAIIGWDLWTGYSIVPTgDCevefFDHFYFTFITS--VLE----FFIPFISVSFfnllIYLNIR 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 A-----------------VLLVSRGQRR-------LRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESR 342
Cdd:cd15048  192 KrsrrrplrsvpilpasqNPSRARSQREqvklrrdRKAAKSLAILVLVFLICWAPYTILTIIRSF---------CSGSCV 262
                        250       260       270
                 ....*....|....*....|....*....|..
gi 218563730 343 VDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15048  263 DSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
123-374 4.02e-12

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 66.20  E-value: 4.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTAlSSTDTFLLHLAVADTLL-VLTLPLWA-VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15051   24 AVAVNRRLR-NLTNYFIVSLAVTDLLLgLLVLPFSAiYELRGEWPLGPVFCNIYISLDVMLCTASILNLFAISLDRYLAI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFAlpdfiFLSAH-----HDERL----NATHCQYnfpQVGRTALRVLQLVAgF 271
Cdd:cd15051  103 TAPLRYPSRVTPRRVAIALAAIWVVSLAVS-----FLPIHlgwntPDGRVqngdTPNQCRF---ELNPPYVLLVAIGT-F 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYahiLAVLLVSRGQ-RRLRAMRLVVVVVV---------------------AFALCWTPYHLVVlvdILMD 329
Cdd:cd15051  174 YLPLLIMCGVY---LRIFRIAREQaKRINALTPASTANSsksaatarehkatvtlaavlgAFIICWFPYFTYF---TYRG 247
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 218563730 330 LgalarnCGRESRVDVaKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15051  248 L------CGDNINETA-LSVVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
135-381 4.18e-12

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 66.13  E-value: 4.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15307   35 TNYFLMSLAITDLMVaVLVMPLGILTLVKgHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALP-DFIFLSAHHDERLNAThCQYNFPqvgrtALRVLQLVAGFLLPLLVMAYCYAhiLAVLLV 291
Cdd:cd15307  115 RRVTLKIVFVWLLSIAMSLPlSLMYSKDHASVLVNGT-CQIPDP-----VYKLVGSIVCFYIPLGVMLLTYC--LTVRLL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SRGQRR--------LRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgalarNCGRESRVDVAK---SVTSGLGYMHCCL 360
Cdd:cd15307  187 ARQRSRhgriirleQKATKVLGVVFFTFVILWSPFFVLNLLP----------TVCAECEERISHwvfDVVTWLGYASSMV 256
                        250       260
                 ....*....|....*....|.
gi 218563730 361 NPLLYAFVGVKFRERMWMLLL 381
Cdd:cd15307  257 NPIFYTIFNKVFRQAFKKVLL 277
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
113-373 4.89e-12

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 66.05  E-value: 4.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVL-TLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLA 190
Cdd:cd15978   13 LSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKdFIFGSAVCKTATYFMGISVSVSTFNLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 191 CISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLN---ATHCQYNFPQ-VGRTALRVLQ 266
Cdd:cd15978   93 AISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINnstGNMCRLLWPNdVTQQSWYIFL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAYCYAhiLAVLLVSRGQRRL----RAMRLVVVVVVAFALCWTPyhlvvlvdilmdlgALARNCGRESR 342
Cdd:cd15978  173 LLILFLIPGIVMMTAYG--LISLELYRGIKFLmakkRVIRMLIVIVILFFLCWTP--------------IFSANAWRAFD 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 218563730 343 VDVAKSVTSG--------LGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15978  237 TRSADRLLSGapisfihlLSYTSACVNPIIYCFMNKRFR 275
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
121-374 6.72e-12

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 65.51  E-value: 6.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15393   21 VIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFQFQAALLQrWVLPRFMCPFCPFVQVLSVNVSVFTLTVIAVDRYR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHAtqLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSA--HHDERLNAT--HCQYNFPQVG-RTALRVLQLVAGFLL 273
Cdd:cd15393  101 AVIHP--LKARCSKKSAKIIILIIWILALLVALPVALALRVeeLTDKTNNGVkpFCLPVGPSDDwWKIYNLYLVCVQYFV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVLLVS---------RGQRRLRA----MRLVVVVVVAFALCWTPYHLVVLVDILMDLgalarnCGRE 340
Cdd:cd15393  179 PLVIICYAYTRIAVKIWGTkapgnaqdvRDDEILKNkkkvIKMLIIVVALFALCWLPLQTYNLLNEIKPE------INKY 252
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 341 SRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15393  253 KYINIIWFCSHWLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
135-373 6.74e-12

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 65.30  E-value: 6.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLT-LPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15326   35 TNYFIVNLAIADLLLSFTvLPFSATLEILGyWVFGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIflsahhDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVM--AYCYAHILAVll 290
Cdd:cd15326  115 KRAILALLGVWVLSTVISIGPLL------GWKEPAPPDDKVCEITEEPFYALFSSLGSFYIPLIVIlvMYCRVYIVAL-- 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 vsRGQRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALARNCgreSRVDVAKSVTSGLGYMHCCLNPLLYAFVGV 370
Cdd:cd15326  187 --KFSREKKAAKTLGIVVGMFILCWLPFFIA------LPLGSLFSHL---KPPETLFKIIFWLGYFNSCLNPIIYPCSSK 255

                 ...
gi 218563730 371 KFR 373
Cdd:cd15326  256 EFK 258
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
133-374 8.43e-12

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 64.91  E-value: 8.43e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLT-LPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15325   33 TVTHYFIVNLAVADLLLTSTvLPFSAIfEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIM 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFAL-PDFIFLS-AHHDERLnathCQYNfpqvGRTALRVLQLVAGFLLPL---LVMaYCYAHI 285
Cdd:cd15325  113 TERRGLLALLCVWVLSLVISIgPLFGWKEpAPEDETI----CQIT----EEPGYALFSALGSFYLPLaiiLVM-YCRVYV 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVllvsRGQRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALARNCGREsrvDVAKSVTSGLGYMHCCLNPLLY 365
Cdd:cd15325  184 VAL----KFSREKKAAKTLGIVVGCFVLCWLPFFLV------MPIGSIFPAYKPS---DTVFKITFWLGYFNSCINPIIY 250

                 ....*....
gi 218563730 366 AFVGVKFRE 374
Cdd:cd15325  251 PCSSQEFKK 259
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
115-375 1.51e-11

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 64.41  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 115 LLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLwAVDAAVQ---WVFGSGLCKVAGALFNINFYAGALLLAC 191
Cdd:cd15200   15 LVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPF-RIDYYLRnevWRFGATACQVNLFMLSMNRTASIVFLTA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 192 ISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDErlNATHCQYNFPQVGRTALRVLQLVAG- 270
Cdd:cd15200   94 IALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIH--LLLLDHVQS--NSTCLSYDHGTDPSASDRWHRILFFl 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 271 -FLLPLLVMAYCYAHILAVLL---VSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIlmdlgaLARNCGRESRVDVA 346
Cdd:cd15200  170 eFFLPLGIILFCIFSIILTLKqrkLAKQAGPQRAVKVLAVIVLVYTVCFLPSILFALASL------VAFKVSQCRSLDLC 243
                        250       260       270
                 ....*....|....*....|....*....|..
gi 218563730 347 KSVTSG---LGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15200  244 TQLFHGslaFTYLNSALDPVLYCFSSPSFLNQ 275
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
121-367 1.51e-11

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 64.70  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSG--LCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15104   21 IVALLKLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQkvLCLLRMCFVITSCAASVLSLAAIAFDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQlYRRGPPARVTLTCLAV-WGLCLLFALPDFIFLSahhdERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLV 277
Cdd:cd15104  101 ALKQPLR-YKQIMTGKSAGALIAGlWLYSGLIGFLPLISPQ----FQQTSYKGKCSFFAAFHPRVLLVLSCMVFFPALLL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHIL-----------AVLLVSRGQRRLR-------AMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGR 339
Cdd:cd15104  176 FVFCYCDILkiarvhsraiyKVEHALARQIHPRrtlsdfkAARTVAVLIGCFLLSWLPFQITGLVQAL---------CDE 246
                        250       260
                 ....*....|....*....|....*...
gi 218563730 340 ESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15104  247 CKLYDVLEDYLWLLGLCNSLLNPWIYAF 274
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
138-376 1.59e-11

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 64.48  E-value: 1.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAV-DAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15149   37 YLKNIVFADLLMSLTFPFKILsDVELgPWQLNVIVCRYSAVIFYLNMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIfLSAHHDERLNATHCQYNFPQVGRTALRVLQ--LVAGFLLPLLVMAYCYAHILAVLLVS- 292
Cdd:cd15149  117 KALSVVVWMLMAVLSVPNII-LTNQSFHEANYTKCARLKSELGIQWHKASNyiCVSIFWVVFLLLIIFYVAISRKIYKSn 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 293 -RGQR-----RLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15149  196 qKFRRnstnmKAKSSRNIFSILFVFFVCFVPYHALRIPYTLSQTGA-DYSCQSKTILYYMKEFTLLLSAANVCLDPIIYF 274
                        250
                 ....*....|
gi 218563730 367 FVGVKFRERM 376
Cdd:cd15149  275 FLCQPFREML 284
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
121-373 2.17e-11

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 63.70  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15308   21 VCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGgvWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQvgrtaLRVLQLVAGFLLPLLV 277
Cdd:cd15308  101 IAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNR--DPAVCKLEDNN-----YVVYSSVCSFFIPCPV 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLlvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESRVdvaKSVTSGLGYMH 357
Cdd:cd15308  174 MLVLYCAMFRGL-----GRERKAMRVLPVVVGAFLFCWTPFFVVHITR------ALCESCSIPPQL---ISIVTWLGYVN 239
                        250
                 ....*....|....*.
gi 218563730 358 CCLNPLLYAFVGVKFR 373
Cdd:cd15308  240 SALNPVIYTVFNAEFR 255
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
134-376 2.19e-11

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 64.03  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 134 STDTFLLHLA---VADTLLVLTLPLWAV-DAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqlYR 208
Cdd:cd15151   30 STSTFIVYLKntlVADLIMTLMLPFKILsDSGLgPWQLRAFVCRFSAVVFYITMYISIILLGLISFDRYLKIVRP---FG 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 209 RGPPARVTLT---CLAVWGLCLLFALPDFIfLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLL--PLLVMAYCYA 283
Cdd:cd15151  107 KSWVQRVRFAkilSGAVWLVMFLLSVPNMI-LSNKPATPISVKKCASLKSPLGLKWHEVVNYICQFIFwgVFALMVLFYT 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVLLVS------RGQRRLRAMRLVVVVVVA-FALCWTPYHLVVLVDILMDLGALaRNCGRESRVDVAKSVTSGLGYM 356
Cdd:cd15151  186 IISKKVYESykksrsKDNKASKKTKAKVFIIVAvFFVCFAPFHFVRVPYTLSQTGKI-TDCQLQNLLYIAKEITLWLAAT 264
                        250       260
                 ....*....|....*....|
gi 218563730 357 HCCLNPLLYAFVGVKFRERM 376
Cdd:cd15151  265 NVCLDPLIYIFLCKSFRQRL 284
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
133-376 2.34e-11

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 63.98  E-value: 2.34e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLT-LPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd14977   33 SVPNILIASLALGDLLLLLLcVPLNAYNLlTKDWLFGDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIG 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL---NATHC----QYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYA 283
Cdd:cd14977  113 ACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLdnsSLTVCimkpSTPFAETYPKARSWWLFGCYFCLPLAFTAVCYL 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVLLVS----------RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGAlarNCGRESRVDVAKSVTSGL 353
Cdd:cd14977  193 LMARTLIRAakeytrgtkkHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRATLYNEV---LIDTRSTLDILDLIGQFL 269
                        250       260
                 ....*....|....*....|...
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd14977  270 SFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
135-374 3.07e-11

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 63.43  E-value: 3.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPlwaVDAAVQW--VFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15164   35 TRVYMINLAVADCCLLFSLP---FVLYFLKhsWPDDELCLVLQSIYFINRYMSIYIITAIAVDRYIAIKYPLKAKSLRSP 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALpdFIFLSAHHDErlnaTHCQYNFPQVGRTALRVLQLVaGFLLPLLVMAYCYAHILAVLL-- 290
Cdd:cd15164  112 RKAALTCGLLWVLVIISVS--LRLAWEEQEE----NFCFGKTSTRPSKRTLIFSLL-GFFIPLIILSFCSIQVIRSLKkk 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 --VSRGQRRL--RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArnCGRESRVDVAKSVTSGLGYMHCCLNPLLYA 366
Cdd:cd15164  185 kkTNPHEEKLiqKAIYIVSANLIVFIVCFLPLHIGLLVRFVMESNKAS--CSLIQNIRNFIYVASCLANANCCLDAICYY 262

                 ....*...
gi 218563730 367 FVGVKFRE 374
Cdd:cd15164  263 FVAKEFQE 270
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
124-373 3.23e-11

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 63.82  E-value: 3.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLT-LPlwaVDAAV----QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15125   24 IFITNSAMRSVPNIFISSLAAGDLLLLVTcVP---VDASRyfyeEWMFGTVGCKLIPVIQLTSVGVSVFTLTALSADRYK 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHH---DERLNATHCqYNFPQVGRTALR---VLQLVAGFL 272
Cdd:cd15125  101 AIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHimpDDNTTFTAC-IPYPQTDEMHPKihsVLIFLVYFL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVLLVS--------------RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV------DILMDLGA 332
Cdd:cd15125  180 IPLAIISIYYYHIAKTLIKSahnipgeysehskrQMETRKRLAKIVLVFVGLFAFCWFPNHVLYMYrsfnynEIDSSLGH 259
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 218563730 333 LarncgresrvdVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15125  260 M-----------IVTLVARVLSFCNSCVNPFALYLLSESFR 289
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
138-376 3.63e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 63.27  E-value: 3.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAA--VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA---TQLYrrgpp 212
Cdd:cd15969   37 YLKNIVIADLLMTLTFPFKIIQDSglGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPfgdSRMY----- 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 aRVTLT---CLAVWGLCLLFALPDFIFLSAHHDERlNATHCQY---NFPQVGRTALRVLQLVAgFLLPLLVMAYCYAHIL 286
Cdd:cd15969  112 -SITFTkvlSACVWLIMAFLSLPNIILTNGQPTED-NIHDCSKlksPLGVKWHTAVSYINICI-FVAVLVILIVCYISIS 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVL------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArNCGRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15969  189 RYIyksskqFISSSSRTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQLDKIL-DCTIKTILYYCKEATLFLSACNVCL 267
                        250
                 ....*....|....*.
gi 218563730 361 NPLLYAFVGVKFRERM 376
Cdd:cd15969  268 DPIIYFFMCRSFSQRL 283
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
121-374 3.77e-11

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 63.32  E-value: 3.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLL-HLAVADTLL-VLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15404   20 VVCLMVYQKAAMRSAINILLaSLAFADMMLaVLNMPFALVTIiTTRWIFGDAFCRVSAMFFWLFVMEGVAILLIISIDRF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVhatQLYRRGPPARVTLTCLAVWGLCLLFALPdFIFLSAHHDERLNATHCQYNFP-QVGRTALRVLQLVAGFLLPLL 276
Cdd:cd15404  100 LIIV---QKQDKLNPYRAKVLIAVSWAVSFCVAFP-LAVGSPDLQIPSRAPQCVFGYTtNPGYQAYVILIMLIFFFIPFM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAKSVTsGLGYM 356
Cdd:cd15404  176 VMLYSFMGILNTVR----SFKTRAFTTILILFIVFTVCWAPFTTYSLVATFNS-----HFYHKHNFFEISTWLL-WLCYL 245
                        250
                 ....*....|....*...
gi 218563730 357 HCCLNPLLYAFVGVKFRE 374
Cdd:cd15404  246 KSALNPLIYYWRIKKFRD 263
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
121-374 7.00e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.56  E-value: 7.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADtLLVLTLPLWAVDAAV---QWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15400   21 VIISVFRNRKLRNSGNVFVVSLALAD-LVVALYPYPLVLVAIfhnGWALGEMHCKVSGFVMGLSVIGSIFNITGIAINRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThcqyNFPQVGRTALRVLQLVAGFLLPLLV 277
Cdd:cd15400  100 CYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSC----TFVQTASSSYTIAVVVIHFIVPITV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQRR-----------LRAMRLVVVVVVAFALCWTPYHLVVLvdilmdlgALARNcgresRVDVA 346
Cdd:cd15400  176 VSFCYLRIWVLVIQVRRKVKseskprlkpsdFRNFLTMFVVFVIFAICWAPLNLIGL--------AVAIN-----PQEMA 242
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 218563730 347 KSVTSGL-------GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15400  243 PKVPEWLfvvsyfmAYFNSCLNAIIYGLLNQNFRK 277
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
133-374 8.37e-11

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 62.45  E-value: 8.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLT-LPLWAVDA--AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqLYRR 209
Cdd:cd15394   33 NVTNFLIGNLAFSDMLMCATcVPLTLAYAfePRGWVFGRFMCYFVFLMQPVTVYVSVFTLTAIAVDRYYVTVYP--LRRR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPPARVTLTCLAVWGLCLLFALPdfIFLSAHHDE--RLNATHCQ--YNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15394  111 ISRRTCAYIVAAIWLLSCGLALP--AAAHTYYVEfkGLDFSICEefWFGQEKQRLAYACSTLLITYVLPLLAISLSYLRI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVL-------LVSRGQ------RRLRAMRLVVVVVVAFALCWTPYHLV-VLVDILMDLGAlarncgrESRVDVAKSVTS 351
Cdd:cd15394  189 SVKLrnrvvpgSMTQSQaewdraRRRKTFRLLVVVVVAFAICWLPLHIFnVIRDIDIDLID-------KQYFNLIQLLCH 261
                        250       260
                 ....*....|....*....|...
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15394  262 WLAMSSACYNPFLYAWLHDSFRG 284
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
121-373 9.88e-11

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 61.92  E-value: 9.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRrtALSSTDTFLL-HLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15330   22 VAAIALER--SLQNVANYLIgSLAVTDLMVsVLVLPMAALYQVLnKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDeRLNATHCQYNfPQVGRTalrVLQLVAGFLLPLLV 277
Cdd:cd15330  100 WAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPED-RSDPDACTIS-KDPGYT---IYSTFGAFYIPLIL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdLGALARNCGRESRVDvakSVTSGLGYMH 357
Cdd:cd15330  175 MLVLYGRIFKA-----AARERKTVKTLGIIMGTFILCWLPFFIVALV-----LPFCESTCHMPELLG---AIINWLGYSN 241
                        250
                 ....*....|....*.
gi 218563730 358 CCLNPLLYAFVGVKFR 373
Cdd:cd15330  242 SLLNPIIYAYFNKDFQ 257
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
114-373 1.30e-10

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 61.74  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 114 GLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLP--LWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLAC 191
Cdd:cd15928   14 GASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPldLYRLWRYRPWRFGDLLCRLMYFFSETCTYASILHITA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 192 ISFDRYLNIVH---ATQLYRRGppaRVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATH-CQYNFPQVGRTALRVLQL 267
Cdd:cd15928   94 LSVERYLAICHplrAKVLVTRG---RVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRgFECTVVNVSSGLLSVMLW 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 268 VAG--FLLPLLVMAYCYAHILAVLLVSRGQRRLRA-----------MRLVVVVVVAFALCWTPYHlvvlvdilmdLGALA 334
Cdd:cd15928  171 VSTsfFFVPMVCLSLLYGLIGRALWDRRQRSRTAGasrrdnnhrqtVRMLAVIVLAFVLCWLPFH----------VGRVI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 218563730 335 RNCGRESRVDVAKS------VTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15928  241 FNHSRASTKHLHYVsqyfnlVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
121-373 1.68e-10

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 61.25  E-value: 1.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVD----AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd14995   21 VVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIesllGPDSWIYGYAGCLLITYLQYLGINASSLSITAFTIER 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH--HDERLNATHCQYNFPQVGRTALRVLQLVAGFLLP 274
Cdd:cd14995  101 YIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSikHYGDDIVVRCGYKVSRHYYLPIYLADFVLFYVIP 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLVSRGQrrlrAMRLVVVVVVAFALCWTPYHLVVLVDILMDLG-------ALARNCgresrvdvak 347
Cdd:cd14995  181 LLLAIVLYGLIGRILFSSRKQ----VTKMLAVVVVLFALLWMPYRTLVVYNSFASPPyldlwflLFCRTC---------- 246
                        250       260
                 ....*....|....*....|....*.
gi 218563730 348 svtsglGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd14995  247 ------IYLNSAINPILYNLMSQKFR 266
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
126-374 1.69e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 61.60  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 126 LSRRTALsstdtFLLHLAVADTLLVLTLPLWAV--DAAVQWVFGSGLCKVAGAlFNINFYAGALLLAC-ISFDRYLNIVH 202
Cdd:cd15065   30 LRKKSNL-----FIVSLAVADLLVALLVMTFAVvnDLLGYWLFGETFCNIWIS-FDVMCSTASILNLCaISLDRYIHIKK 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 ATQLYRRGPPARVTLTCLAVWGLCLLFA-LPdfIFLSAH---HDERLNATHCQYNFPQVgrtALRVLQLVA------GFL 272
Cdd:cd15065  104 PLKYERWMTTRRALVVIASVWILSALISfLP--IHLGWHrlsQDEIKGLNHASNPKPSC---ALDLNPTYAvvssliSFY 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILavLLVSRGQRRLRAMRLVVVVVVA------------------------------FALCWTPYHLVV 322
Cdd:cd15065  179 IPCLVMLLIYSRLY--LYARKHVVNIKSQKLPSESGSKfqvpslsskhnnqgvsdhkaavtlgiimgvFLICWLPFFIIN 256
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 218563730 323 LVdilmdlGALARNCGREsrvDVAKSVTsGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15065  257 II------AAFCKTCIPP---KCFKILT-WLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
129-373 1.81e-10

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 61.44  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTALSSTDTFLLHLAVADTLLVLTLP-----LWAVDAavqWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd15131   29 RDMRTTTNLYLSSMAFSDLLIFLCMPldlyrLWQYRP---WNFGDLLCKLFQFVSESCTYSTILNITALSVERYFAICFP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 TQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLN---ATHCQYNFPQVGRTALRVLQLVAG--FLLPLLVM 278
Cdd:cd15131  106 LRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNpidTNECKATEYAVRSGLLTIMVWVSSvfFFLPVFCL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL-----------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLV-VLVDILMDLGAL-----ARNCGRES 341
Cdd:cd15131  186 TVLYSLIGRKLwrrrrenigpnASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGrYLFSKSFEAGSLeialiSQYCNLVS 265
                        250       260       270
                 ....*....|....*....|....*....|..
gi 218563730 342 RVdvaksvtsgLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15131  266 FV---------LFYLSAAINPILYNIMSKKYR 288
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
136-374 1.86e-10

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 61.46  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 136 DTFLLHLAVADtLLVLTLPLWAVDAAV---QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQlYRRGPP 212
Cdd:cd15401   36 NIFVVSLSVAD-LVVAVYPYPLILLAIfhnGWTLGNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLR-YDKLYN 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAV-WGLCLLFALPDFIFLSAHHDERLNAThcqyNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLV 291
Cdd:cd15401  114 MKKTCCYVCLtWVLTLAAIVPNFFVGSLQYDPRIYSC----TFAQTVSSSYTITVVVVHFIVPLSIVTFCYLRIWVLVIQ 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SR------GQRRLRAMRL-----VVVVVVAFALCWTPYHLVVLvdilmdlgALARNCGR-ESRVDVAKSVTSG-LGYMHC 358
Cdd:cd15401  190 VKhrvrqdSKQKLKANDIrnfltMFVVFVLFAVCWGPLNFIGL--------AVAINPLKvAPKIPEWLFVLSYfMAYFNS 261
                        250
                 ....*....|....*.
gi 218563730 359 CLNPLLYAFVGVKFRE 374
Cdd:cd15401  262 CLNAVIYGVLNQNFRK 277
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
121-373 1.95e-10

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 61.10  E-value: 1.95e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd16003   21 VIWIILAHKRMRTVTNYFLVNLAFSDASMAAfnTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIYSMTAIAVDRYM 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTClaVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQVGRTAL--RVLQLVAGFLLPLL 276
Cdd:cd16003  101 AIIDPLKPRLSATATKVVIGS--IWILAFLLAFPQCLYSKTKVMP--GRTLCFVAWPGGPDQHFtyHIIVIVLVYCLPLL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAhILAVLL---------VSRGQRRLRAMR----LVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESRV 343
Cdd:cd16003  177 VMGITYT-IVGITLwggeipgdtSDKYHEQLRAKRkvvkMMIIVVLTFAICWLPYHIYFIVT------GLYQQLNRWKYI 249
                        250       260       270
                 ....*....|....*....|....*....|
gi 218563730 344 DVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd16003  250 QQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
125-376 2.24e-10

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 62.14  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTALSSTDT-FLLHLAVADTLLVLTLPLWAVDAavQWVFGS--GLCKVAGALFNINFYAGALLLACISFDRYlNIV 201
Cdd:PHA03235  58 LLANRVHGFSTPTlYMTNLYLANLLTVFVLPFIMLSN--QGLLSGsvAGCKFASLLYYASCTVGFATVALIAADRY-RVI 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 HATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIF--LSAHHDERLNATHCQ-----YNFPQVgRTAL---RVLQLVAGF 271
Cdd:PHA03235 135 HQRTRARSSAYRSTYKILGLTWFASLICSGPAPVYttVVAHDDVDPEAPGYEtcviyFRADQV-KTVLstfKVLLTLVWG 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdLGALARNCGRESRVDVAKSVTS 351
Cdd:PHA03235 214 IAPVVMMTWFYTFFYRTLKRASYKKRSRTLTFVCILLLSFLCLQTPFVAIMIFDSYA-TLIWPSDCEHINLRDAVSTLSR 292
                        250       260
                 ....*....|....*....|....*
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:PHA03235 293 LVPNLHCLLNPILYAFLGNDFLKRF 317
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
138-367 2.53e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 60.77  E-value: 2.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTL--------LVLTLPLWAVDAAVQWVFGSGLCKVAGALfninfYAGALLLacISFDRYLNIVHATQLYRR 209
Cdd:cd14972   36 LIANLAAADLLagiafvftFLSVLLVSLTPSPATWLLRKGSLVLSLLA-----SAYSLLA--IAVDRYISIVHGLTYVNN 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPPARVTLTCLAVWGLCLLFALpdfIFLSAHHDERLNATHCQYNFPQVGRTALrVLQLVAgFLLPLLVMAYCYAHILAVL 289
Cdd:cd14972  109 VTNKRVKVLIALVWVWSVLLAL---LPVLGWNCVLCDQESCSPLGPGLPKSYL-VLILVF-FFIALVIIVFLYVRIFWCL 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 -----LVSRGQRRLRAMRLVVVVVVA---------FALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTSGLGY 355
Cdd:cd14972  184 wrhanAIAARQEAAVPAQPSTSRKLAktvvivlgvFLVCWLPLLILLVLDVL---------CPSVCDIQAVFYYFLVLAL 254
                        250
                 ....*....|..
gi 218563730 356 MHCCLNPLLYAF 367
Cdd:cd14972  255 LNSAINPIIYAF 266
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
138-373 3.50e-10

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 60.22  E-value: 3.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15301   38 FLFSLAVADFAIgVISMPLFTVYTALGyWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFaLPDFIFLSAHHDERLN--ATHCQYNFPQVGRTaLRVLQLVAGFLLPLLVMAYCYAHILAVLLVSR 293
Cdd:cd15301  118 AVMIASAWIISLLL-WPPWIYSWPYIEGKRTvpAGTCYIQFLETNPY-VTFGTALAAFYVPVTIMCILYWRIWRETKKRQ 195
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 294 GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNcgresrvdVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15301  196 KKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFFPCSDTIPT--------ELWDFSYYLCYINSTINPLCYALCNAAFR 267
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
121-368 4.36e-10

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 59.86  E-value: 4.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15215   20 LLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPlfWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYL 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPD-FIFLSAHHDERLNATHCQYNfpqvGRTALRVLQLVAGFLLPLLV 277
Cdd:cd15215  100 AIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPlYGWGQAAFDERNALCSVIWG----SSYSYTILSVVSSFVLPVII 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAhilAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarncgresrVDVAKSVTSG---LG 354
Cdd:cd15215  176 MLACYS---MVFRAARRCYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVD-------------TQVPQWVISIilwLF 239
                        250
                 ....*....|....
gi 218563730 355 YMHCCLNPLLYAFV 368
Cdd:cd15215  240 FLQCCIHPYIYGYM 253
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
138-373 4.48e-10

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 59.84  E-value: 4.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLW-AVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATqLYRRGPPA-- 213
Cdd:cd15295   38 FFLNLAISDFFVgAISIPLYiPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAV-SYRNQQTAtl 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIFLSAHHDERlnaTHC--QYNFPQVGRTALRVLQlvagFLLPLLVMAYCYAHILAVLlv 291
Cdd:cd15295  117 RIVTQMVAVWVLAFLVHGPAILVSDSWKTED---GECepEFFSNWYILAITSVLE----FLVPVILVAYFNTQIYWSL-- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 srgQRRLRAMRLVVVVV---VAFALCWTPYHLVVLVdilmdlgalaRNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15295  188 ---WKRLRDRKLAKSLAiilGTFAICWAPYSLFTII----------RAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLC 254

                 ....*
gi 218563730 369 GVKFR 373
Cdd:cd15295  255 HKRFR 259
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
121-373 8.04e-10

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 59.18  E-value: 8.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRrtALSS-TDTFLLHLAVADTLL-VLTLPL-WAVDAAVQWVFGSGLCKVAGALfNINFYAGALLLAC-ISFDR 196
Cdd:cd15323   22 VIAVLTSR--ALRApQNLFLVSLASADILVaTLVMPFsLANELMGYWYFGQVWCNIYLAL-DVLFCTSSIVHLCaISLDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAtHCQYNfpqvGRTALRVLQLVAGFLLPLL 276
Cdd:cd15323   99 YWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVYP-QCKLN----DETWYILSSCIGSFFAPCL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVllvsRGQRRLRAMRLVVVVVVAFALCWTPYHLVVlvdilmdlgALARNCGRESRV-DVAKSVTSGLGY 355
Cdd:cd15323  174 IMILVYIRIYRV----AKAREKRFTFVLAVVMGVFVVCWFPFFFSY---------SLYGICREACEVpEPLFKFFFWIGY 240
                        250
                 ....*....|....*...
gi 218563730 356 MHCCLNPLLYAFVGVKFR 373
Cdd:cd15323  241 CNSSLNPVIYTIFNQDFR 258
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
138-373 8.31e-10

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 59.41  E-value: 8.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADtLLVLTLPLWAVDAAV---QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15209   38 FVVSLSVAD-LVVAIYPYPLILHAIfhnGWTLGQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRN 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThcqyNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG 294
Cdd:cd15209  117 TCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSC----TFAQTVSTVYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQ 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 QRR-----------LRAMRLVVVVVVAFALCWTPYHLVVLvdilmdlgALARNcgresRVDVAKSVTSGL-------GYM 356
Cdd:cd15209  193 RVKpdqrpklkpadVRNFLTMFVVFVLFAVCWAPLNFIGL--------AVAIN-----PKEMAPKIPEWLfvasyfmAYF 259
                        250
                 ....*....|....*..
gi 218563730 357 HCCLNPLLYAFVGVKFR 373
Cdd:cd15209  260 NSCLNAIIYGLLNQNFR 276
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
120-365 1.06e-09

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 58.78  E-value: 1.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15335   20 AVIAAICTTKKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVMdTWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDfIFLSAHHDERLnATHCQYNFPQVGRTalrVLQLVAGFLLPLLV 277
Cdd:cd15335  100 WAITDAIEYARKRTAKRAGLMILTVWTISIFISIPP-LFWRNHHDANI-PSQCIIQHDHVIYT---IYSTFGAFYIPLTL 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILavllvSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdLGALARNCGREsrvdVAKSVTsGLGYMH 357
Cdd:cd15335  175 ILILYYRIY-----HAASRERKAARILGLILGAFILSWLPFFIKELI-----VGLSVMTVSPE----VADFLT-WLGYVN 239

                 ....*...
gi 218563730 358 CCLNPLLY 365
Cdd:cd15335  240 SLVNPLLY 247
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
138-381 1.59e-09

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 58.42  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15299   41 FLLSLACADLIIgVISMNLFTTYIIMnRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRA 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRg 294
Cdd:cd15299  121 GVMIGLAWVISFVLWAPAILFWQYFVGKRtVPPDECFIQF--LSEPIITFGTAIAAFYLPVTIMTILYWRIYKETIKEK- 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 qrrlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarncgrESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15299  198 ----KAAQTLSAILLAFIITWTPYNIMVLVNTFCD----------SCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRT 263

                 ....*..
gi 218563730 375 RMWMLLL 381
Cdd:cd15299  264 TFKMLLL 270
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
121-323 1.62e-09

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 58.63  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15388   21 VLLVLWRRRKQLARMHVFMLHLCIADLVVAFfqVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMFASSYMIVAMTFDRHQ 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPpARVTLTCLAVWGLCLLFALPDfIFLSAHHDERLNATHCQYNFPQV-GRTALRVLQLVAGFLLPLLV 277
Cdd:cd15388  101 AICRPMVTFQKGR-ARWNGPVCVAWAISLILSLPQ-VFIFSKVEVAPGVYECWACFIEPwGLKAYVTWITLVVFVLPTLI 178
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 218563730 278 MAYCYA---------------HILAV-----LLVSRGQR-------RLRAMRLVVVVVVAFALCWTPYHLVVL 323
Cdd:cd15388  179 ITVCQVlifkeihiniylksqIIVAVvkkkqLLSSRASSvaevskaMIKTVKMTLVIVLVYVLCWAPFFLVQL 251
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
136-373 1.66e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 58.38  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 136 DTFLLHLAVADtLLVLTLPLWAVDAAV---QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15402   36 NIFVVSLAVAD-LVVAIYPYPLVLTSIfhnGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSD 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThcqyNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILavLLVS 292
Cdd:cd15402  115 KNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSC----TFAQSVSSAYTIAVVFFHFILPIIIVTFCYLRIW--ILVI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 293 RGQRRL-------------RAMRLVVVVVVAFALCWTPYHLVVLvdilmdlgALARNCGRE-SRVDVAKSVTSG-LGYMH 357
Cdd:cd15402  189 QVRRRVkpdnkpklkphdfRNFVTMFVVFVLFAVCWAPLNFIGL--------AVAVDPETIvPRIPEWLFVASYyMAYFN 260
                        250
                 ....*....|....*.
gi 218563730 358 CCLNPLLYAFVGVKFR 373
Cdd:cd15402  261 SCLNAIIYGLLNQNFR 276
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
113-374 1.79e-09

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 58.29  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLA 190
Cdd:cd15979   13 LSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGtFIFGEVICKAVAYLMGVSVSVSTFSLV 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 191 CISFDRYLNIVHATQ---LYRRGPPARVTltcLAVWGLCLLFALPDFIFLSAHH---DERLNATHCQYNFPQVG-RTALR 263
Cdd:cd15979   93 AIAIERYSAICNPLQsrvWQTRSHAYRVI---AATWLLSGLIMIPYPVYSVTVPvpvGDRPRGHQCRHAWPSAQvRQAWY 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 264 VLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGresrv 343
Cdd:cd15979  170 VLLLLILFFIPGVVMIVAYGLISRELYRGLLAKK-RVIRMLVVIVAMFFLCWLPIFSANTWRAFDPLSAHRALSG----- 243
                        250       260       270
                 ....*....|....*....|....*....|.
gi 218563730 344 dVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15979  244 -APISFIHLLSYTSACVNPLVYCFMNRRFRK 273
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
120-374 1.82e-09

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 58.42  E-value: 1.82e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLH----LAVADTLLVLT---LPLWA-VDAAVQWVFGSGLCKVAGALFNINFYAGALLLAC 191
Cdd:cd15130   19 SVTLFTLARKKSLQSLQSTVRYhlgsLALSDLLILLLampVELYNfIWVHHPWAFGDAGCRGYYFLRDACTYATALNVAS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 192 ISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPdFIFLSAHHDERLNATH--CQYNFPQVGRTALRV---LQ 266
Cdd:cd15130   99 LSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIP-MLFTMGLQNESDDGTHpgGLVCTPIVDTATLKVviqVN 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAycyahILAVLLVSRGQRRLR-AMRLVVVVVVAFALCWTPYHLVVLV----------DILMDLgalar 335
Cdd:cd15130  178 TFMSFLFPMLVTS-----ILNTVIANKLVQALRrGVLVLRAVVIAFVVCWLPYHVRRLMfcyisdeqwtTFLFDF----- 247
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 218563730 336 ncgresrVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15130  248 -------YHYFYMLTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
123-376 1.89e-09

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 58.41  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTALSSTDTFLLHLAVADTL-LVLTLPLWAVDAAVQWVFGSG------LCKVAGALFNINFYAGALLLACISFD 195
Cdd:cd14978   22 LVVLTRKSMRSSTNVYLAALAVSDILvLLSALPLFLLPYIADYSSSFLsyfyayFLPYIYPLANTFQTASVWLTVALTVE 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQY----NFPQVGRTALRV---LQLV 268
Cdd:cd14978  102 RYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYviptLLRQNETYLLKYyfwLYAI 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 269 AGFLLPLLVMAYCYAHILAVL----------------LVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlga 332
Cdd:cd14978  182 FVVLLPFILLLILNILLIRALrkskkrrrllrrrrrlLSRSQRRERRTTIMLIAVVIVFLICNLPAGILNILEAIFG--- 258
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 218563730 333 larNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd14978  259 ---ESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
121-324 3.54e-09

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 57.11  E-value: 3.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRtaLSSTDTFLL-HLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVaGALFNINFYAGALLLAC-ISFDR 196
Cdd:cd15333   26 IATIYLTRK--LHTPANYLIaSLAVTDLLVsILVMPISIVYTVTGtWTLGQVVCDI-WLSSDITCCTASILHLCvIALDR 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLnaTHCQYNFPQVGRTalrVLQLVAGFLLPLL 276
Cdd:cd15333  103 YWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEV--SECVVNTDHILYT---VYSTVGAFYIPTL 177
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 277 VMAYCYAHIlavlLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV 324
Cdd:cd15333  178 LLIALYGRI----YVEARARERKATKTLGIILGAFIVCWLPFFIISLV 221
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
121-374 3.77e-09

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 57.54  E-value: 3.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLT---LPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15133   21 TCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgmpLELYELWQNYPFLLGSGGCYFKTFLFETVCLASILNVTALSVERY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALP-----DFIFLSAHHDERLNATHCQ----YNFpQVGRTALRVlqlv 268
Cdd:cd15133  101 IAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPntslhGIKFLGSGVPASAQCTVRKpqaiYNM-IPQHTGHLF---- 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 269 agFLLPLLVMAYCY---AHILAV--LLVSRG--------------QRRLRAM--RLVVVVVVAFALCWTPYHlvvlVDIL 327
Cdd:cd15133  176 --FVLPMAVISVLYllmALRLARerGLDATGagskigtrtgqllqHPRTRAQvtKMLFILVVVFAICWAPFH----IDRL 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 218563730 328 MDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15133  250 MWSFISDWTDNLHEVFQYVHIISGVFFYLSSAVNPILYNLMSTRFRE 296
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
124-376 5.94e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 56.66  E-value: 5.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAV--DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV 201
Cdd:cd15000   23 ILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLvhDFFQNYVLGSVGCKLEGFLEGSLLLASVLALCAVSYDRLTAIV 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 202 --HATQLYRRGPPARVTLTclavWGLCLLFALPDFIFLSAHHDERLN--ATHCQYNfPQVGRTALRVLqLVAGFLLPLLV 277
Cdd:cd15000  103 lpSEARLTKRGAKIVIVIT----WIVGLLLALPLAIYRSYRERQWKNflETYCAEN-TQVLPIYWHVI-ITVLVWLPLGI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVL------LVSRGQRRL-----RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGrESRVDVA 346
Cdd:cd15000  177 MLICYSAIFWKLdkyerrVLRREHPSVvrykkKAAKTLFIVLITFVVCRIPFTALIFYRYKLVPNDNTQNSV-SGSFHIL 255
                        250       260       270
                 ....*....|....*....|....*....|
gi 218563730 347 KSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15000  256 WFASKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
121-373 7.04e-09

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 56.45  E-value: 7.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15305   22 IMAVSLEKKLQ-NATNFFLMSLAVADMLvgiLVMPVSLIAILYDYAWPLPRYLCPIWISLDVLFSTASIMHLCAISLDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVgrtaLRVLQLVAgFLLPLLV 277
Cdd:cd15305  101 VAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKVFVNGTCVLNDENF----VLIGSFVA-FFIPLII 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAhiLAVLLVSRGQ---RRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGRESRVDVAkSVTSGLG 354
Cdd:cd15305  176 MVITYC--LTIQVLQRQQainNERRASKVLGIVFFLFLIMWCPFFITNILSVLCK-----EACDQKLMEELL-NVFVWVG 247
                        250
                 ....*....|....*....
gi 218563730 355 YMHCCLNPLLYAFVGVKFR 373
Cdd:cd15305  248 YVSSGINPLVYTLFNKTYR 266
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
123-367 7.17e-09

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 56.73  E-value: 7.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLS---RRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15386   20 AVLLAmyrMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRFQGPDLLCRAVKYLQVLSMFASTYMLIMMTVDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRgPPARVTLTCLAVWGLCLLFALPD-FIFLSAHHDERLNATHC--QYNFPQvGRTALRVLQLVAGFLLP 274
Cdd:cd15386  100 IAVCHPLRTLQQ-PSRQAYLMIGATWLLSCILSLPQvFIFSLREVDQGSGVLDCwaDFGFPW-GAKAYITWTTLSIFVLP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHI----------------------LAVLLVSR-------GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVD 325
Cdd:cd15386  178 VAILIVCYSLIcyeicknlkgktqtsrsegggwRTQGMPSRvssvrtiSRAKIRTVKMTFVIVLAYIACWAPFFSVQMWS 257
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 218563730 326 IlmdlgaLARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15386  258 V------WDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMF 293
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
135-374 7.85e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 56.48  E-value: 7.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVdAAVQ--WVFGSGLCKVAGAlFNINFYAGALL-LACISFDRYLNIVHATQlYRRG 210
Cdd:cd15314   35 TNYLILSLAVADLLVgGLVMPPSMV-RSVEtcWYFGDLFCKIHSS-FDITLCTASILnLCFISIDRYYAVCQPLL-YRSK 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAV-WGLCLLFALpDFIFLSAHHDERLNA-THCQYN-FPQVGRTALrVLQLVAGFLLPLLVMAYCYAHILA 287
Cdd:cd15314  112 ITVRVVLVMILIsWSVSALVGF-GIIFLELNIKGIYYNhVACEGGcLVFFSKVSS-VVGSVFSFYIPAVIMLCIYLKIFL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 288 VllvsrGQRRLRAMRLVVVVVVA-------------------FALCWTPYHLVVLVDILMdlgalarncgRESRVDVAKS 348
Cdd:cd15314  190 V-----AQRQARSIQSARTKSGAssskmerkatktlaivmgvFLLCWTPFFLCNIIDPFI----------NYSIPPVLIE 254
                        250       260
                 ....*....|....*....|....*.
gi 218563730 349 VTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15314  255 VLNWLGYSNSTLNPFIYAFFYSWFRK 280
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
121-320 7.93e-09

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 56.39  E-value: 7.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGaLFNIN-FYAGALLLACISFDRY 197
Cdd:cd16004   21 VIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHndWYFGLEFCRFQN-FFPITaMFVSIYSMTAIAADRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTclAVWGLCLLFALPDFIFLSAHHDErlNATHCQYNFPQ-VGRTALRVLQL---VAGFLL 273
Cdd:cd16004  100 MAIIHPFKPRLSAGSTKVVIA--GIWLVALALAFPQCFYSTVTMDQ--GRTKCIVAWPGdSGGKHQLTYHLaviVLIYLL 175
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVLLVS---------RGQRRLRAMR----LVVVVVVAFALCWTPYHL 320
Cdd:cd16004  176 PLAVMFVTYSIIGITLWRSavpghqahgAYHRQLQAKKkfvkTMVVVVVTFAICWLPYHL 235
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
124-374 1.24e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 55.74  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLS---RRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15297   21 VMVSikvNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIgYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLV 277
Cdd:cd15297  101 CVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRtVPEGECYIQF--FSNAAVTFGTAIAAFYLPVII 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHIlavllvSRGQ-RRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCgresrvdVAKSV-TSG--L 353
Cdd:cd15297  179 MTVLYWQI------SRASsREKKVTRTILAILLAFIITWTPYNVMVLIN------TFCASC-------IPNTVwTIGywL 239
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15297  240 CYINSTINPACYALCNATFKK 260
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
121-367 1.34e-08

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 55.33  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15214   20 IVVTLYKKSYLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIRrEWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVagfLLPLLVM 278
Cdd:cd15214  100 AVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFKWMCVAAWHKEAGYTAFWQVWCA---LLPFVVM 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAvllVSRGQrRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdlgalarncGRESRVDVAKSVTSGLGYMHC 358
Cdd:cd15214  177 LVCYGFIFR---VARAN-QCKAFITILVVLGAFVTTWGPYMVVISTEALW---------GKNSVSPQLETLATWLSFTSA 243

                 ....*....
gi 218563730 359 CLNPLLYAF 367
Cdd:cd15214  244 VCHPLIYGL 252
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
120-374 1.36e-08

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 56.01  E-value: 1.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLH-LAVADTLL-VLTLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15403   19 AIVCLIVYQKPAMRSAINLLLAtLAFSDIMLsLLCMPFTAVTiITVDWHFGAHFCRISAMLYWFFVLEGVAILLIISVDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVhatQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAhHDERLNATHCQYNFPQ-VGRTALRVLQLVAGFLLPL 275
Cdd:cd15403   99 FLIIV---QRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTL-VEVPARAPQCVLGYTEsPADRVYAVLLVVAVFFVPF 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 276 LVMAYCYAHIL-----------------AVLLVSR-GQRRL--------------RAMRLVVVVVVAFALCWTPYHLVVL 323
Cdd:cd15403  175 SIMLYSYLCILntvrrnavrihnhadslCLSQVSKlGLMGLqrphqmnvdmsfktRAFTTILILFVGFSLCWLPHTVFSL 254
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 218563730 324 vdilmdLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15403  255 ------LSVFSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFRE 299
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
138-373 1.37e-08

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 55.44  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAAV-QWVFGSGLCKVAG------ALFNINFyagallLACISFDRYLNIVHATQLYRRg 210
Cdd:cd15072   38 LVLSLAVADMGISLNALVAASSSLLrRWPYGSEGCQAHGfqgfftALASICS------SAAIAWDRYHHYCTRSKLQWS- 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 ppARVTLTCLaVWGLCLLFA-LPDFIFlsAHHDERLNATHCQYNFPQVGRTALRVLQLVA--GFLLPLLVMAYCYAHILA 287
Cdd:cd15072  111 --TAISLVLF-VWLFSAFWAaMPLLGW--GEYDYEPLGTCCTLDYSKGDRNYVSYLFTMAffNFILPLFILLTSYSSIEQ 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 288 VLLvSRGQRRLramrLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVdVAKSVtsglgymhCCLNPLLYAF 367
Cdd:cd15072  186 KLK-KEGHLRF----NTGLPLLTLLICWGPYAILALYAAITDVTSISPKLRMVPAL-LAKTS--------PTINAILYAL 251

                 ....*.
gi 218563730 368 VGVKFR 373
Cdd:cd15072  252 GNENYR 257
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
126-374 1.39e-08

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 55.43  E-value: 1.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 126 LSRRTALSSTDTFLL-HLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYlNIVH 202
Cdd:cd15309   25 VSREKALQTTTNYLIvSLAVADLLVATLVMPWVVYLEVvgEWRFSRIHCDIFVTLDVMMCTASILNLCAISIDRY-TAVA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 203 ATQLY--RRGPPARVTLTCLAVWGLCLLFALPdFIFLSAHHDERLnathCQYNFPqvgrtALRVLQLVAGFLLPLLVMAY 280
Cdd:cd15309  104 MPMLYntRYSSKRRVTVMISVVWVLSFAISCP-LLFGLNNTDQNE----CIIANP-----AFVVYSSIVSFYVPFIVTLL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 281 CYAHILAVLlvsrgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrvdVAKSVTSGLGYMHCCL 360
Cdd:cd15309  174 VYVQIYIVL-----QKEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNIPP----------ALYSAFTWLGYVNSAV 238
                        250
                 ....*....|....
gi 218563730 361 NPLLYAFVGVKFRE 374
Cdd:cd15309  239 NPIIYTTFNIEFRK 252
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
124-376 1.57e-08

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 55.18  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVdaavqWVFGSGLCKVAGAL----FNINFYAGALLLACISFDRYLN 199
Cdd:cd15163   24 VFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIV-----MYYSAGNCLTCSFVhifsYFVNMYCSILFLTCICVDRYLA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQLYRRGPPARVTLTCLAVWglclLFALP-DFIFLSAhhderlnathcQYNFPQVGRTALRVLqLVAGFLLPLLVM 278
Cdd:cd15163   99 IVQVEASRRWRNPNYAKGICVFIW----LFAIVvTFSILTT-----------AIKFASCCLSKLFAL-TVFEFFLPLLII 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVL----LVSRG-QRRLRAMRLVVVVVVAFALCWTPYHL-VVLVDILMDLgalarncGRESRVdVAKSVTSG 352
Cdd:cd15163  163 TFFTIRIMCALsrpgLMHQSrERRMRAVQLLITVLIIFMICFTPFHVrQVAVAFNPDI-------PHHTSL-IVYHVTVT 234
                        250       260
                 ....*....|....*....|....
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15163  235 LSSLNSCMDPIVYCFVTNNFQSTM 258
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
121-373 2.36e-08

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 54.94  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTLL---VLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15304   22 IMAVSLEKKLQ-NATNYFLMSLAIADMLLgflVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQY---NFPQVGRtalrvlqlVAGFLLP 274
Cdd:cd15304  101 IAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLadeNFVLIGS--------FVAFFIP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLVSRGQRRlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalaRNCGrESRVDVAKSVTSGLG 354
Cdd:cd15304  173 LTIMVITYFLTIKSLQQSISNEQ-KASKVLGIVFFLFVVMWCPFFITNVMAVICK-----ESCN-EVVIGGLLNVFVWIG 245
                        250
                 ....*....|....*....
gi 218563730 355 YMHCCLNPLLYAFVGVKFR 373
Cdd:cd15304  246 YLSSAVNPLVYTLFNKTYR 264
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
121-374 3.22e-08

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 54.11  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPL-WAVDAAVQWVFGSGLCKVAGALfNINFYAGALLLAC-ISFDRY 197
Cdd:cd15324   21 VVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFsLANEVMGYWYFGSTWCAFYLAL-DVLFCTSSIVHLCaISLDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDfiFLSAHHDERlnatHCQYNfpqvGRTALRVLQLVAGFLLPLLV 277
Cdd:cd15324  100 WSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPP--LLMTKHDEW----ECLLN----DETWYILSSCTVSFFAPGLI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVsrgqRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALAR-NCGREsrvDVAKSVTSGLGYM 356
Cdd:cd15324  170 MILVYCKIYRVAKM----REKRFTFVLAVVMGVFVLCWFPFFFT------YSLHAVCRkRCGIP---DALFNLFFWIGYC 236
                        250
                 ....*....|....*...
gi 218563730 357 HCCLNPLLYAFVGVKFRE 374
Cdd:cd15324  237 NSSVNPIIYTIFNRDFRK 254
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
139-374 3.27e-08

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 54.49  E-value: 3.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 139 LLHLAVADTL-LVLTLPLWA---VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15356   42 LVSLALSDLLiLLISVPIELynfVWFHYPWVFGDLVCRGYYFVRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALP-DFIFLSAHHDERLNAT---HCQYNFPQVGRTALRVLQLV---AGFLLPLLVMAYCYAHILA 287
Cdd:cd15356  122 TKWLLALIWASSLGFALPmAFIMGQKYELETADGEpepSSRVCTVLVSRATLKVFIQVnafVSFVLPLALIAFLNGVTVS 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 288 VLLVSRGQRRLRAMRlvvVVVVAFALCWTPYHLVVLVDILMDLGALARNCgrESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15356  202 HLRIQSLQHSVQVLR---AIVIAYVICWLPYHARRLMFCYVPDDAWTDSL--YNFYHYFYMLTNTLFYVSSAVNPLLYNV 276

                 ....*..
gi 218563730 368 VGVKFRE 374
Cdd:cd15356  277 VSSSFRK 283
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
138-374 3.62e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 3.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15300   38 YLLSLACADLIIgIFSMNLYTSYILMgYWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRg 294
Cdd:cd15300  118 GIMIGLAWLISFILWAPPILCWQYFVGKRtVPERECQIQF--LSEPTITFGTAIAAFYIPVSVMTILYCRIYKETIKER- 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 qrrlRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarncgresrvDVAKSVTSGLGYMHC----CLNPLLYAFVGV 370
Cdd:cd15300  195 ----KAAQTLSAILLAFIITWTPYNIMVLVSTFCS--------------DCIPLTLWHLGYWLCyvnsTVNPMCYALCNK 256

                 ....
gi 218563730 371 KFRE 374
Cdd:cd15300  257 TFRK 260
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
138-374 3.70e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 3.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15298   38 FLFSLACADLIIgAFSMNLYTVYIIKgYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVllvsrG 294
Cdd:cd15298  118 GLMIAAAWVLSFVLWAPAILFWQFVVGKRtVPDNQCFIQF--LSNPAVTFGTAIAAFYLPVVIMTVLYIHISLA-----S 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 295 QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDilmdlgALARNCGRESrvdvAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15298  191 ARERKVTRTIFAILLAFILTWTPYNVMVLVN------TFCQSCIPDT----VWSIGYWLCYVNSTINPACYALCNATFKK 260
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
133-367 4.03e-08

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 54.43  E-value: 4.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLtlplWAVDAAV-------QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYlNIVHATQ 205
Cdd:cd15198   33 SRMNFLLLQLALADLLVIG----GTALSQIiwellgdRWMAGDVACRLLKLLQASARGASANLVVLLALDRH-QAIRAPL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 206 lyrrGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL-----NATHCQYNFPQVGRTALRVLQL---VAGFLLPLLV 277
Cdd:cd15198  108 ----GQPLRAWKLAALGWLLALLLALPQAYVFRVDFPDDPasawpGHTLCRGIFAPLPRWHLQVYATyeaVVGFVAPVVI 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVLLVSRGQRRLRAM--------------------------RLVVVVVVAFALCWTPYHLVVLvdilmdlg 331
Cdd:cd15198  184 LGVCYGRLLLKWWERANQAPGAKKpwkkpskshlratapsalprakvktlKMTLVIALLFVGCSLPYFIAEL-------- 255
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 332 ALARNCGRESRVDVAkSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15198  256 AAAFGSGDWEPEKVA-AALGVMAVANSATNPFVFLF 290
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
122-373 4.55e-08

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 53.98  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 122 AAVLLS---RRTALSSTDTFLLHLAVADTLL-VLTLPLWAVD--AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFD 195
Cdd:cd15302   19 ILVLLSfyvDRNIRQPSNYFIASLAVSDLLIgLESMPFYTVYvlNGDYWPLGWVLCDLWLSVDYTVCLVSIYTVLLITID 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVTLTCLAVWGL-CLLFALPDFIFLSAHHDER-LNATHCQYNFpqVGRTALRVLQLVAGFLL 273
Cdd:cd15302   99 RYCSVKIPAKYRNWRTPRKVLLIIAITWIIpALLFFISIFGWQYFTGQGRsLPEGECYVQF--MTDPYFNMGMYIGYYWT 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRV-DVAKSVTSG 352
Cdd:cd15302  177 TLIVMLILYAGIYRA-----ANRARKALRTITFILGAFVICWTPYHILATIYGF---------CEAPPCVnETLYTISYY 242
                        250       260
                 ....*....|....*....|.
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15302  243 LCYMNSPINPFCYALANQQFK 263
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
135-373 4.71e-08

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 53.76  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLT-LPLWA-VDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15327   35 TNYFIVNLAIADLLLSTTvLPFSAtLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTE 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIFLS--AHHDERLNATHCQYNFPqvgrtalrVLQLVAGFLLPLLVMAYCYAHILAVLL 290
Cdd:cd15327  115 RKAGVILVLLWVSSMVISIGPLLGWKepPPPDESICSITEEPGYA--------LFSSLFSFYLPLMVILVMYFRVYVVAL 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 291 vsRGQRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALARNCgreSRVDVAKSVTSGLGYMHCCLNPLLYAFVGV 370
Cdd:cd15327  187 --KFSREKKAAKTLAIVVGVFILCWFPFFFV------LPLGSFFPAL---KPSEMVFKVIFWLGYFNSCVNPIIYPCSSK 255

                 ...
gi 218563730 371 KFR 373
Cdd:cd15327  256 EFK 258
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
138-367 4.89e-08

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 54.06  E-value: 4.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRgPPARV 215
Cdd:cd15385   38 FIKHLSLADLVVAFfqVLPQLCWDITYRFYGPDFLCRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLKTLQQ-PTKRS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPD-FIFLSAHHDERLNATHCQYNFPQV-GRTALRVLQLVAGFLLPLLVMAYCYAHIL------- 286
Cdd:cd15385  117 YLMIGSAWALSFILSTPQyFIFSLSEIENGSGVYDCWANFIVPwGIKAYITWITISIFVVPVIILLTCYGFICyniwrni 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 -----------------------AVLLVSRGqrRLRAMRLVVVVVVAFALCWTPYHLVVLvdilmdLGALARNCGRESRV 343
Cdd:cd15385  197 kcktrrglsdnalknillavcvsSVKTISRA--KIRTVKMTFVIVLAYIVCWAPFFTIQM------WSVWDQNFPWDESE 268
                        250       260
                 ....*....|....*....|....
gi 218563730 344 DVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15385  269 NTAVTITALLASLNSCCNPWIYMF 292
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
121-373 6.64e-08

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 53.61  E-value: 6.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLH-LAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15317   20 VVIISISHFKQLHSPTNMLVLsLATADFLLGLCVMPFSMIRTVEtcWYFGDLFCKFHTGLDLLLCTTSIFHLCFIAIDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATqLYRRGPPARVTLTCLAV-WGLCLLFalpDFIFLSAH-HDERLNAT--------HCQYNFPQvgrtaLRVLQL 267
Cdd:cd15317  100 YAVCDPL-RYPSKITVQVAWRFIAIgWLVPGIY---TFGLIYTGaNDEGLEEYsseiscvgGCQLLFNK-----IWVLLD 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 268 VAGFLLPLLVMAYCYAHILavlLVSRGQ------------------------RRLRAMRLVVVVVVAFALCWTPYHLVVL 323
Cdd:cd15317  171 FLTFFIPCLIMIGLYAKIF---LVARRQarkiqnmedkfrsseensskasasRERKAAKTLAIVMGIFLFCWLPYFIDTI 247
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 218563730 324 VDILMDLGALArncgresrvdVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15317  248 VDEYSNFITPA----------IVFDAVIWLGYFNSAFNPFIYAFFYPWFR 287
7tmA_ACKR1_DARC cd15010
Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G ...
139-369 8.60e-08

Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors; Atypical chemokine receptor 1 (ACKR1), also known as DARC (Duffy antigen receptor for chemokines) or Fy glycoprotein (GpFy), was originally identified on erythrocytes. ACKR1 is also ubiquitously expressed by endothelial cells of venules and is highly promiscuous among all chemokine receptor. It binds many proinflammatory chemokines from both the CC and CXC subfamilies, including CCL2, CCL5, CCL7, CCL11, CXCL1, CXCL2, CXCL3, and CXCL5. Erythrocyte ACKR1 is thought to act as a chemokine sink, limiting the levels of circulating chemokines, thereby controlling leukocyte activation. ACKR1-deficient erythrocytes are shown to confer resistance to the malarial parasite, Plasmodium vivax. On the other hand, ACKR1-expressing endothelial cells can internalize chemokines. ACKR1-internalized chemokines can be moved intact across the endothelium and promotes neutrophil transmigration. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 410631  Cd Length: 257  Bit Score: 52.87  E-value: 8.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 139 LLHLAVADTLLVLTLPLWAVDAAVQWvfGSGLCKVAGALFNINFYAGALLLACisfdrylnivHA--TQLYRRGPPARVT 216
Cdd:cd15010   40 LAQLAVGSALFSIVVPILAPGLSQGW--GTGLCKLAYLVWYGSAFAQALLVGC----------HAclGPWLGWGQVPGLT 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 217 LtCLAV--WGLCLLFALPDFIFLSAhhderlnathcqYNFPQVGRT-----ALRVLQLVAGF----LLPLlvmaycyahi 285
Cdd:cd15010  108 L-GLAVglWGAAALLALPVALASGT------------SGGPCTLRSsrdleALYLTHLAACLaifvLLPL---------- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 laVLLVSRGQRRLRAM--RLVVVVVVAFALCWTPYHLVVLVDILMDLGAL-ARNCGRESRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd15010  165 --GLLGAKGLKTALRVgpGPWVGVLWLWFIFWWPYGVVLGLDFLVRSKLLlLSTCGAQEALDYMLGLSEALGILHCVATP 242

                 ....*..
gi 218563730 363 LLYAFVG 369
Cdd:cd15010  243 LLLALVC 249
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
121-374 9.16e-08

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 53.03  E-value: 9.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRtaLSSTDTFLL-HLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15334   22 ITAIIVTRK--LHHPANYLIcSLAVTDFLVaVLVMPFSIMYIVKEtWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRY 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFlsaHHDERLNATHCQYNFPQVGRTalrVLQLVAGFLLPLLV 277
Cdd:cd15334  100 RAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFW---RHQTTSREDECIIKHDHIVFT---IYSTFGAFYIPLAL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 278 MAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdlgalARNCGRESRVDVAKSVTSGLGYMH 357
Cdd:cd15334  174 ILILYYKIYRA-----ATRERKAATTLGLILGAFVICWLPFFVKEVI---------VNTCDSCYISEEMSNFLTWLGYIN 239
                        250
                 ....*....|....*..
gi 218563730 358 CCLNPLLYAFVGVKFRE 374
Cdd:cd15334  240 SLINPLIYTIFNEDFKK 256
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
120-376 1.10e-07

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 52.99  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWA-VDA---------AVQWVFGSGlCKVAGALFNINFYAGALLL 189
Cdd:cd15136   20 IVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAiVDAktlgeyynyAIDWQTGAG-CKTAGFLAVFSSELSVFTL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 190 ACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHderlNATHCqynFPQVGRTALRVLQLVA 269
Cdd:cd15136   99 TVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPLVGVSSYS----KTSIC---LPFETETPVSKAYVIF 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 270 GFL---LPLLVMAYCYAHILAVL-----LVSRGQRRLrAMRLVVVVVVAFaLCWTPYhlvvlvdILMDLGALARNcgRES 341
Cdd:cd15136  172 LLLfngLAFLIICGCYIKIYLSVrgsgrAANSNDTRI-AKRMALLVFTDF-LCWAPI-------AFFGLTAAFGL--PLI 240
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 218563730 342 RVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15136  241 SVSNAKILLVFFYPLNSCANPFLYAIFTKQFRRDC 275
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
138-374 1.38e-07

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 52.62  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLT-LPlwaVDA----AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15123   38 FITSLAFGDLLLLLTcVP---VDAtryiADTWLFGRIGCKLLSFIQLTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAV 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFALPDFIF--LSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFL----LPLLVMAYCYAHIL 286
Cdd:cd15123  115 LKTCCKAGCVWIVSMLFAIPEAVFsdLYSFRDPEKNTTFEACAPYPVSEKILQEIHSLLCFLvfyiIPLSIISVYYFLIA 194
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVLLVS------------RGQ--RRLRAMRLVVVVVVAFALCWTPYHLVVLVdilmdlgalaRNCGRESRVD------VA 346
Cdd:cd15123  195 RTLYKStfnmpaeehshaRKQieSRKRVAKTVLVLVALFAFCWLPNHILYLY----------RSFTYHTSVDssafhlIA 264
                        250       260
                 ....*....|....*....|....*...
gi 218563730 347 KSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15123  265 TIFSRVLAFSNSCVNPFALYWLSKSFRQ 292
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
121-373 1.43e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 52.56  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL-LVLTLPL--WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15357   21 VCLVILKHQNMKTPTNYYLFSLAVSDLLvLLFGMPLevYEMWSNYPFLFGPVGCYFKTALFETVCFASILSVTTVSVERY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDF----IFLSAHHDERL--NATHCQ-------YNFpqvgrtalrV 264
Cdd:cd15357  101 VAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTsihgIKLQYFPNGTLipDSATCTvvkplwiYNL---------I 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 265 LQLVA--GFLLPLLVMAYCYaHILAVLLvsRGQRRLRA---------------MRLVVVVVVAFALCWTPYHlvvlVDIL 327
Cdd:cd15357  172 IQITSllFYVLPMGVISVLY-YLMGLKL--RGDKSLEAdemnvniqrpsrksvTKMLFVLVLVFAICWAPFH----VDRL 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 218563730 328 MDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15357  245 FFSFVVEWTEPLANVFNLIHVVSGVFFYLSSAVNPIIYNLLSRRFR 290
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
121-373 1.51e-07

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 52.49  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTAlSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15056   22 IVAVCTDRQLR-KKTNYFVVSLAVADLLVaVLVMPFGAIELVNnRWIYGETFCLVRTSLDVLLTTASIMHLCCIALDRYY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRgPPARVTLTCLAVWglcllfALPDFI-FLS-------------AHHDERLNATHCQYnfpqVGRTALRV 264
Cdd:cd15056  101 AICCQPLVYKM-TPLRVAVMLGGCW------VIPTFIsFLPimqgwnhigiedlIAFNCASGSTSCVF----MVNKPFAI 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 265 LQLVAGFLLPLLVMAYCY----------AHILAVLLV-------------SRGQRRLRAMRLVVVVVVAFALCWTPYHLV 321
Cdd:cd15056  170 ICSTVAFYIPALLMVLAYyriyvaareqAHQIRSLQRagssnheadqhrnSRMRTETKAAKTLGIIMGCFCVCWAPFFVT 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 218563730 322 VLVDILMDlgalARNCgresrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15056  250 NIVDPFIG----YRVP------YLLWTAFLWLGYINSGLNPFLYAFFNKSFR 291
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
135-365 1.73e-07

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 52.60  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAV-DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15958   35 TNLFITSLACADLVMgLLVVPFGATlVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTR 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCLLFA-LPdfIFLSAHHDERLNATHCqYNFPQ----VGRTALRVLQLVAGFLLPLLVMAYCYAHIL- 286
Cdd:cd15958  115 ARAKGIVCTVWAISALVSfLP--IMMHWWRDEDDQALKC-YEDPGccdfVTNRAYAIASSIISFYIPLLIMIFVYLRVYr 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 -------------------AVLLVSRGQRRL---------RAMRLVVVVVVAFALCWTPYHLVVLVDILMdlgalarncg 338
Cdd:cd15958  192 eakkqikkidkcegrfhntLTGLGRKCKRRPsrilalreqKALKTLGIIMGVFTLCWLPFFLVNVVNVFN---------- 261
                        250       260
                 ....*....|....*....|....*..
gi 218563730 339 RESRVDVAKSVTSGLGYMHCCLNPLLY 365
Cdd:cd15958  262 RELVPDWLFVFFNWLGYANSAFNPIIY 288
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
120-369 2.40e-07

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 51.93  E-value: 2.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15169   21 AIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASgaWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVH--ATQLYRRgpPARVTLTCLAVWGLCLLFAlpDFIFLSAHHDERLNATHCQYNF---------------PQVGRT 260
Cdd:cd15169  101 LGAAFplGYQAFRR--PCYSWGVCAAIWALVLCHL--GLVFGLEAPGGWLDHSNTSLGIntpvngspvcleawdPASAGP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 261 ALRVLQLVAgFLLPLLVMAYCYAHILAVLLVS--RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILM-DLGALARNC 337
Cdd:cd15169  177 ARFSLSLLL-FFLPLAITAFCYVGCLRALARSglTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYpNLGGSWRKL 255
                        250       260       270
                 ....*....|....*....|....*....|..
gi 218563730 338 GRESrvdvaksvtsglGYMHCCLNPLLYAFVG 369
Cdd:cd15169  256 GLIT------------GAWSVVLNPLVTGYLG 275
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
121-324 3.64e-07

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 51.40  E-value: 3.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAV--QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd16002   21 VMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIhnEWYYGLEYCKFHNFFPIAAVFASIYSMTAIALDRYM 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQlyRRGPPARVTLTCLAVWGLCLLFALPDFIFlsAHHDERLNATHCQYNFPQ----VGRTALRVLQLVAGFLLP 274
Cdd:cd16002  101 AIIHPLQ--PRLSATATKVVICVIWVLAFLLAFPQGYY--SDTEEMPGRVVCYVEWPEheerKYETVYHVCVTVLIYFLP 176
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 218563730 275 LLVMAYCYAHILAVLLVSR----GQRR--------LRAMRLVVVVVVAFALCWTPYHLVVLV 324
Cdd:cd16002  177 LLVIGCAYTVVGITLWASEipgdSSDRyheqvsakRKVVKMMIVVVCTFAICWLPYHIYFLL 238
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
121-373 3.66e-07

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 51.10  E-value: 3.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPL-WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15322   21 VIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFsLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYW 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAThCQYNfpqvGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15322  101 SITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI-CKIN----DEKWYIISSCIGSFFAPCLIM 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHILAVllvsRGQRRLRAMRLVVVVVVAFALCWTPYHLVvlvdilMDLGALARNCGRESRVdvakSVTSGLGYMHC 358
Cdd:cd15322  176 VLVYIRIYQI----AKNREKRFTFVLAVVIGVFVICWFPFFFT------YTLTAVCDCSVPETLF----KFFFWFGYCNS 241
                        250
                 ....*....|....*
gi 218563730 359 CLNPLLYAFVGVKFR 373
Cdd:cd15322  242 SLNPVIYTIFNHDFR 256
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
121-373 3.99e-07

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 51.40  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15084   31 VIVVSIKYKKLRSPLNYILVNLAVADLLVTLfgSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFERYL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NI---VHATQLYRRgppaRVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNaTHCQYNFPQVG--RTALRVLQLVAGFLL 273
Cdd:cd15084  111 VIckpMGDFRFQQR----HAVSGCAFTWGWSLLWTSPPLFGWSSYVPEGLR-TSCGPNWYTGGtnNNSYILALFVTCFAL 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVLLVSRGQRR-----LRA----MRLVVVVVVAFALCWTPYHLVVLVdilmdlgaLARNCGRESRVD 344
Cdd:cd15084  186 PLSTIIFSYSNLLLTLRAVAAQQKesettQRAekevTRMVIAMVMAFLICWLPYATFAMV--------VATNKDVVIQPT 257
                        250       260
                 ....*....|....*....|....*....
gi 218563730 345 VAkSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15084  258 LA-SLPSYFSKTATVYNPIIYVFMNKQFR 285
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
138-376 6.12e-07

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 50.66  E-value: 6.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWA-VDA---------AVQWVfGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqLY 207
Cdd:cd15137   38 LIKNLAIADFLMGVYLLIIAsVDLyyrgvyikhDEEWR-SSWLCTFAGFLATLSSEVSVLILTLITLDRFICIVFP--FS 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 208 RRGPPARVTLTCLA-VWGLCLLFAL---------PDF-----IFLSAH-HDERlnATHCQYNfpqvgrtalrvlqlVAGF 271
Cdd:cd15137  115 GRRLGLRRAIIVLAcIWLIGLLLAVlpllpwdyfGNFygrsgVCLPLHiTDER--PAGWEYS--------------VFVF 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 L----LPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAF-------ALCWTPYhlvvlvdILMDLGALarncgre 340
Cdd:cd15137  179 LglnfLAFVFILLSYIAMFISIRRTRKAAASRKSKRDMAVAKRFflivltdFLCWIPI-------IVIGILAL------- 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 218563730 341 SRVDVAKSVTSGLGY----MHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15137  245 SGVPIPGEVYAWVAVfvlpINSALNPILYTLSTPKFRKKL 284
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
120-317 6.30e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 50.71  E-value: 6.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLL---HLAVAD---TLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACIS 193
Cdd:cd14981   19 LLALIVLARSSKSHKWSVFYRlvaGLAITDllgILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFGLSSLLIVCAMA 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 194 FDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFAL-------------PD---FI-FLSAHHDERLNAthcqYNFpq 256
Cdd:cd14981   99 VERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASlpllglgsyvlqyPGtwcFLdFYSKNTGDAAYA----YLY-- 172
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218563730 257 vgrTALRVLQLVAGFLLPLLVMAY-CYAHILAVLLVSRGQRRLRAMR-------LVVVVVVAFALCWTP 317
Cdd:cd14981  173 ---SILGLLILLVTLLCNLLVIITlLRMRRRKKRHRRSRRSARRQKRneiqmvvLLLAITVVFSVCWLP 238
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
121-373 8.26e-07

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 50.21  E-value: 8.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVAD-TLLVLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15391   21 VIVVFYDGRRSRTDLNYYLINLAVSDlIMALFCMPFTFTQIMLGhWVFPAPMCPIVLYVQLVSVTASVLTNTAIGIDRFF 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHAtqLYRRGPPARVTLTCLAVWGLCllFALPDFIFLSAHHDERLNATH----CQYNFPQ--VGRTALRVLQLVAGFL 272
Cdd:cd15391  101 AVIFP--LRSRHTKSRTKCIIASIWAIS--FSLSSVQLFAGRTQRYGQYSEgrvlCGESWPGpdTSRSAYTVFVMLLTYI 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVL---------LVSRGQRRLRAMR----LVVVVVVAFALCWTPYHLVVLVdilMDLGALARNCGR 339
Cdd:cd15391  177 IPLLILTSTYGYVGFRLwnrtapgnaDKGRDDMQIKSKRkvikMLVFVVLMFGICWLPLHLFNLV---QDFSTVFRNMPQ 253
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 340 esrvDVAKSVTSGLGYM---HCCLNPLLYAFVGVKFR 373
Cdd:cd15391  254 ----HTTRLIYGACHWIamsNSFVNPIIYLFMNDSFR 286
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
120-374 1.04e-06

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 49.76  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLsrRTALSSTDTFLLHLAVADTLLVLTL-PLWAVDAA---VQWVFGSGLCKVAGALFNINFYAGALLLACISFD 195
Cdd:cd15220   19 AVMVVIA--KTPHLRKFAFVCHLCVVDLLAALLLmPLGILSSSpffLGVVFGEAECRVYIFLSVCLVSASILTISAISVE 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 196 RYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLF-ALPDFIFLSAHHDERLNATHCQ-YNFPQVGRTALRVLQLVAGFLL 273
Cdd:cd15220   97 RYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLgLLPVLGWPSYGGPAPIAARHCSlHWSHSGHRGVFVVLFALVCFLL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAVLLVSrgqrrlRAMRLVVVVVVAFALCWTPYHLVVLVDILmdlgalarnCGRESRVDVAKSVTSGL 353
Cdd:cd15220  177 PLLLILVVYCGVFKVFGGG------KAALTLAAIVGQFLCCWLPYFAFHLYSAL---------AASPVSGGEAEEVVTWL 241
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15220  242 AYSCFAVNPFFYGLLNRQIRE 262
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
138-373 1.23e-06

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 49.81  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAVDAA--VQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV------HATQLYRR 209
Cdd:cd15150   37 FLKNTVISDLLMILTFPFKILSDAklGSWPLRGFVCQVTSVIFYFTMYISILFLGLITIDRYQKTTrpfktsNPKNLLGA 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 gpparvTLTCLAVWGLCLLFALPDFIFLSAHHDERlNATHCQYNFPQVGRTALRVLQLVAG--FLLPLLVMAYCYAHILA 287
Cdd:cd15150  117 ------KILSTVIWASMFALSLPNMILTNRQPTPK-NVKKCSLLKSEFGLVWHEIVNYICQviFWVNFLIVIVCYTLITK 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 288 VLLVS------RGQRRLRAMRLVVVVVVA-FALCWTPYHLVVLVDILMDLGALARnCGRESRVDVAKSVTSGLGYMHCCL 360
Cdd:cd15150  190 ELYKSykrtrgVGKVSRKKVNVKVFIIIAvFFICFVPFHFARIPYTLSQTRDVFD-CTAKNTLFYVKESTLWLTSLNACL 268
                        250
                 ....*....|...
gi 218563730 361 NPLLYAFVGVKFR 373
Cdd:cd15150  269 DPFIYFFLCKSFR 281
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
129-372 1.38e-06

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 49.35  E-value: 1.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 129 RTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCK---VAGALFNInfyAGALLLACISFDRYLNIVHA 203
Cdd:cd15086   29 KVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQgrWLIGEHGCRwygFANSLFGI---VSLISLAVLSYERYCTLLRP 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 TQL----YRRgpparVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNAT-HCQYNFPQVGRTALRVLQLVAGFLLPLLVM 278
Cdd:cd15086  106 TEAdvsdYRK-----AWLGVGGSWLYSLLWTLPPLLGWSSYGPEGPGTTcSVQWTSRSANSISYIICLFIFCLLLPFLVM 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 279 AYCYAHIL-AVLLVSR------GQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrvDVAKSVTS 351
Cdd:cd15086  181 VYCYGRLLyAIKQVGKinkstaRKREQHVLLMVVTMVICYLLCWLPYGVMALLATFGKPGLVT---------PVASIVPS 251
                        250       260
                 ....*....|....*....|.
gi 218563730 352 GLGYMHCCLNPLLYAFVGVKF 372
Cdd:cd15086  252 ILAKSSTVVNPIIYVFMNKQF 272
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
121-324 1.68e-06

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 49.43  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15399   21 VIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLdEWKFGAVLCHLVPYAQALAVHVSTVTLTVIALDRHR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHatQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDE---RLNATHCQYNFPQVGR---TALRVLQLVAGFL 272
Cdd:cd15399  101 CIVY--HLESKISKKISFLIIGLTWAASALLASPLAIFREYSVIEispDFKIQACSEKWPNGTLndgTIYSVSMLLIQYV 178
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 218563730 273 LPLLVMAYCYAHILAVLL--VSRG-------QRRLRAMRLVVVVVVAFALCWTPYHLVVLV 324
Cdd:cd15399  179 LPLAIISYAYIRIWTKLKnhVSPGggndhyhQRRRKTTKMLVCVVVVFAVSWLPFHAFQLA 239
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
121-325 2.06e-06

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 49.05  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15981   21 VCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITgWPFDNAMCKMSGLVQGMSVSASVFTLVAIAVERFR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHAtqlYRRGPPARVTL-TCLAVWGLCLLFALPDFIFLSA----HH---DERLNAT---HCQYNFPQVGRTALRVLQL 267
Cdd:cd15981  101 CIVHP---FRQKLTLRKAIvTIVIIWVLALIIMCPSAVTLTVtreeHHfmvDDYNNSYplySCWEAWPDTEMRKIYTTVL 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218563730 268 VAG-FLLPLLVMAYCYAHILAVLLVSRG----------------QRRLRAMRLVVVVVVAFALCWTP-YHLVVLVD 325
Cdd:cd15981  178 FSHiYLAPLTLIVIMYARIAFKLFKSSApirgsqgeeeegrrvsKRKIKVINMLIIVALFFTLSWLPlWTLMLLTD 253
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
121-365 2.29e-06

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 48.79  E-value: 2.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15328   21 VLVTILRVRTFHRVPHNLVASMAVSDVLvaaLVMPLSLVHELSGRRWQLGRSLCQVWISFDVLCCTASIWNVTAIALDRY 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIF-LSAHHDERLNAthCQYNfpqvGRTALRVLQLVAGFLLPLL 276
Cdd:cd15328  101 WSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFgWGETYSEDSEE--CQVS----QEPSYTVFSTFGAFYLPLC 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALArncgresrvdVAKSVTSGLGYM 356
Cdd:cd15328  175 VVLFVYWKIYKA-----AQKEKRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPP----------IWKSIFLWLGYS 239

                 ....*....
gi 218563730 357 HCCLNPLLY 365
Cdd:cd15328  240 NSFFNPLIY 248
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
135-365 2.56e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.99  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIV----HATQLYR 208
Cdd:cd15058   35 TNIFITSLACADLVMgLLVVPLGATIVvTGKWQLGNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITrplrYQVLLTK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 209 RgppaRVTLTCLAVWglcLLFALPDF--IFLSAHHDERLNATHCqYNFPQ----VGRTALRVLQLVAGFLLPLLVMAYCY 282
Cdd:cd15058  115 R----RARVIVCVVW---IVSALVSFvpIMNQWWRANDPEANDC-YQDPTccdfRTNMAYAIASSVVSFYIPLLIMIFVY 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 283 AHilaVLLVSRGQRRL---------------------------------------RAMRLVVVVVVAFALCWTPYHLVVL 323
Cdd:cd15058  187 AR---VFLIATRQLQLidkrrlrfqsecpapqttspegkrssgrrpsrltvvkehKALKTLGIIMGTFTLCWLPFFIANI 263
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 218563730 324 V-----DILMDLGALARNCgresrvdvaksvtsgLGYMHCCLNPLLY 365
Cdd:cd15058  264 InvfnrNLPPGEVFLLLNW---------------LGYINSGLNPIIY 295
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
115-373 2.75e-06

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 48.73  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 115 LLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAVQ-WVFGSGLCKVAGALFNINFYAGALLLACI 192
Cdd:cd15980   15 MMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAgWPFGSTVCKMSGMVQGISVSASVFTLVAI 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 193 SFDRYLNIVHATQlyRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL-------NATH----CQYNFPQVGRTA 261
Cdd:cd15980   95 AVDRFRCIVYPFK--QKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYrvvlgsqNKTSpvywCREDWPNQEMRK 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 262 LRVLQLVAG-FLLPLLVMAYCYAHILAVLL-----------------VSRgqRRLRAMRLVVVVVVAFALCWTPYHLVVL 323
Cdd:cd15980  173 IYTTVLFANiYLAPLSLIVIMYARIGITLFktamphtgkhnqeqrhvVSR--KKQKVIKMLLIVALLFILSWLPLWTLMM 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 218563730 324 vdiLMDLGALARNCGRESRVDVAkSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15980  251 ---LSDYANLSPNQLQIINIYIY-PFAHWLAFFNSSVNPIIYGFFNENFR 296
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
128-380 3.22e-06

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 48.40  E-value: 3.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSstdTFLLHLAVADTL-LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATqL 206
Cdd:cd14973   30 KRNPFS---VYILNLAAADFLfLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLSLLAAISTERCLSVLFPI-W 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGPPARVTLT-CLAVWGLCLLFALPDFIFLSaHHDERLNATHCQYnfpqvgrtalRVLQLVAGFLLPLLVMayCYAHI 285
Cdd:cd14973  106 YRCHRPKHLSAVvCALLWALSLLLSVLESYFCG-FLFWKFNESACRT----------FNFLSALLFLLLFLVM--CVSSL 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSRGQRRLRAMRLVV---VVVVAFALCWTPYHLVVLVDILMDLGalarncgresRVDVAKSVTSGLGYMHCCLNP 362
Cdd:cd14973  173 TLLIRVQCSSQRRPPTRLYVvilLTVLVFLLCGLPLGIYWFLLLWFSNY----------LFHTFHPISDLLSCVNSSANP 242
                        250
                 ....*....|....*...
gi 218563730 363 LLYAFVGVKFRERMWMLL 380
Cdd:cd14973  243 IIYFFVGSLRGRRLREPL 260
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
120-374 3.49e-06

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 48.30  E-value: 3.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTAL----SSTDTFLLHLAVADTL-LVLTLP------LWAVDAavqWVFGSGLCKVAGALFNINFYAGALL 188
Cdd:cd15355   19 SITLYTLARKKSLqhlqSTVHYHLASLALSDLLiLLLAMPvelynfIWVHHP---WAFGDAACRGYYFLRDACTYATALN 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 189 LACISFDRYLNIVH---ATQLYRRGPPARVTLtclAVWGLCLLFALPdFIF-------LSAHHDERLNATHCQYNFPQVg 258
Cdd:cd15355   96 VASLSVERYLAICHpfkAKSLMSRSRTKKFIS---AIWLASALLAIP-MLFtmgeqnrSGTHPGGLICTPIVDTSTLKV- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 259 rtalrVLQLVA--GFLLPLLVMA-----------------------YCYAHILAVLLVSRGQRRLRAMR----LVVVVVV 309
Cdd:cd15355  171 -----VIQVNAflSFLFPMLVISvlntlianqltvmvnqaeqenqvCTIGGQRTVLSVSMEPGRVQSLRhgvlVLRAVVI 245
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218563730 310 AFALCWTPYHLVVLV----------DILMDLgalarncgresrVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15355  246 AFVVCWLPYHVRRLMfcyvsdeqwtTFLYDF------------YHYFYMLTNVLFYVSSAINPILYNLVSANFRQ 308
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
123-330 5.17e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 47.93  E-value: 5.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTAL-SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15318   22 VVTVSHFKALhTPTNFLLLSLALADMLLGLTVLPFSTIRSVEscWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATqLYRRGPPARVTLTCLAV-WGLCLLFAlpDFIFLSAHHDERLnaTHCQYNFPQVGRTALRVLQL-----VAGFLL 273
Cdd:cd15318  102 ICDPL-LYPSKFTIRVACIFIAAgWLVPTVYT--SVFLYTKAVEEGL--AELLTSVPCVGSCQLLYNKLwgwlnFPVFFI 176
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 274 PLLVMAYCYAHILAV-------------LLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDL 330
Cdd:cd15318  177 PCLIMIGLYVKIFIVakrqaraiasllsDTNGASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNF 246
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
135-374 5.51e-06

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 47.91  E-value: 5.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHAtqlyrRGPP 212
Cdd:cd15396   35 TNILIANLSLSDVLVcVMCIPFTAVYTLMdHWIFGETMCKLTSFVQSVSVSVSIFSLVLIAIERYQLIVNP-----RGWK 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTC---LAVWGLCLLFALPDFIF----------LSAHHDERLNATHCQYNFPQVGR-----TALRVLQlvagFLLP 274
Cdd:cd15396  110 PSASHAYwgiVLIWLFSLMISIPFLIFhqltdepfrnLSSHSDFYKDKVVCIEAWPSETErliftTSLLVFQ----YFVP 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLLV------------SRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLV-----DILMdlgalarNC 337
Cdd:cd15396  186 LGFIFICYLKIFVCLKKrnskidrmreneSRLSENKRINTMLISIVVTFAACWLPLNIFNVVfdwnhEVLM-------SC 258
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 338 GResrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15396  259 HH----NLVFTLCHLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
123-373 5.62e-06

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 47.81  E-value: 5.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 123 AVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15397   23 CVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMdYWIFGEVLCKMTPFIQCMSVTVSILSLVLIALERHQLI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLyrRGPPARVTLTCLAVWGLCLLFALPDFIF----------LSAHHDERLNATHCQYNFPQVG-RTALRVLQLVA 269
Cdd:cd15397  103 INPTGW--KPSVSQAYLAVVVIWMLACFISLPFLAFhiltdepyknLSHFFAPLADKAVCTESWPSEHhKLAYTTWLLLF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 270 GFLLPLLVMAYCYAHILAVL-----LVSRG---QRRLRAMR----LVVVVVVAFALCWTPYHLV-VLVDilMDLGALARN 336
Cdd:cd15397  181 QYCLPLLFILVCYLRIYLRLrrrkdMLERRgeyNRRAGHSKrinvMLVSLVAAFALCWLPLNVFnAIAD--WNHEAIPHC 258
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 337 cgresRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15397  259 -----QHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
134-374 7.99e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 47.13  E-value: 7.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 134 STDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15306   34 ATNYFLMSLAVADLLvglFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYN 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALP-------DFIFLSAHHDERLNATHCQYnFPQVGRtalrvlqlVAGFLLPLLVMAYCYA 283
Cdd:cd15306  114 SRATAFIKITVVWLISIGIAIPvpikgieTDVDNPNNITCVLTKERFGD-FILFGS--------LAAFFTPLAIMIVTYF 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarNCGRESrVDVAKSVTSGLGYMHCCLNPL 363
Cdd:cd15306  185 LTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCD------SCNQTT-LQMLMEIFVWIGYVSSGVNPL 257
                        250
                 ....*....|.
gi 218563730 364 LYAFVGVKFRE 374
Cdd:cd15306  258 VYTLFNKTFRD 268
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
125-250 1.47e-05

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 46.33  E-value: 1.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 125 LLSRRTALSSTDTFLLHLAVADTLLVLTLPL-WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHA 203
Cdd:cd14994   25 LLVKMNTRSVTTTAVINLIVVHSLFLLTVPFrIYYYASKTWKFGMPLCKMVSAMIHIHMHLTFLFYVIILVIRYLIFFQR 104
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 T---QLYRRgppARVTLTCLAVWGLCLLFALPDFIFLSAHHDErLNATHC 250
Cdd:cd14994  105 KdkmEFYRK---LHAVAASAVVWVLVLLIVVPVFVKEYGSSSS-YNSDQC 150
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
124-374 1.50e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 46.69  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTL-LVLTLPL--WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNI 200
Cdd:cd15358   24 VILRHKVMRTPTNYYLFSLAVSDLLvLLLGMPLelYEMWSNYPFLLGAGGCYFKTLLFETVCFASILNVTALSVERYIAV 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 201 VHATQLYRRGPPARVTLTCLAVWGLCLLFALPDfifLSAHHDERL---------NATHCQYNFPQVGRTALRVLQLVAGF 271
Cdd:cd15358  104 VHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPN---TSLHGIFQLtvpcrgpvpDSATCMLVKPRWMYNLIIQITTLLFF 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 272 LLPLLVMAYCYAHI---------LAVLLVSRGQ---------------RRLRAMRLVVVVVVAFALCWTPYHLVVLVDIL 327
Cdd:cd15358  181 FLPMGTISVLYLLIglqlkrekmLLVLEAKGSKagdsyqhrriqqekrRRRQVTKMLFVLVVVFGICWAPFHTDRLMWSF 260
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 328 MDlgalaRNCGRESRVDVAKSVTSG-LGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15358  261 IS-----QWTGELHLAFQYVHIISGvFFYLSSAANPVLYNLMSTRFRE 303
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
138-232 1.88e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 46.30  E-value: 1.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVAD---TLLVLTLPLWAVDAAVQWVFGSGLCKVAgALFNINF-YAGALLLACISFDRYLNIVHAtQLYRRgppa 213
Cdd:cd15005   38 FLLDLCLADglrSLACFPFVMASVRHGSGWIYGALSCKVI-AFLAVLFcFHSAFTLFCIAVTRYMAIAHH-RFYAK---- 111
                         90       100
                 ....*....|....*....|....
gi 218563730 214 RVTL-TCLAV----WGLCLLFALP 232
Cdd:cd15005  112 RMTFwTCLAVicmaWTLSVAMAFP 135
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
103-375 2.02e-05

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 46.05  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 103 LPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPlwAVDA----AVQWVFGSGLCKVAGALF 178
Cdd:cd15124    3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCA--PVDAsrylADEWLFGRVGCKLIPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 179 NINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAH--HDERLNAT-------- 248
Cdd:cd15124   81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHpfYDKSTNKTfvscapyp 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 249 HCQYNFPQVGRTAlrvlQLVAGFLLPLLVMAYCYAHILAVLLVS--------------RGQRRLRAMRLVVVVVVAFALC 314
Cdd:cd15124  161 HSNELHPKIHSMA----SFLIFYVIPLSIISVYYYFIAKNLIRSaynlpvegnvhvrrQIESRKRLAKTVLVFVGLFAFC 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 218563730 315 WTPYHLVVL--------VDILMdLGALARNCGREsrvdvaksvtsgLGYMHCCLNPLLYAFVGVKFRER 375
Cdd:cd15124  237 WLPNHIIYLyrsyhyseVDTSM-LHFVSSICARI------------LAFTNSCVNPFALYLLSKSFRKQ 292
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
139-318 3.69e-05

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 45.17  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 139 LLHLAVADTLLVLTLPLWAVDAAVQWVF--GSGLCKVAGalFNINFYAGALL--LACISFDRYLNIVHATQLYR-RGPPA 213
Cdd:cd15082   52 IVNLSVADFLVSLTGGTISFLTNARGYFflGVWACVLEG--FAVTFFGIVALwsLAVLAFERFFVICRPLGNIRlQGKHA 129
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 214 RVTLtcLAVWGLCLLFALPDFIFLSAHHDERLNAThCQYNF--PQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLL- 290
Cdd:cd15082  130 ALGL--LFVWTFSFIWTIPPVLGWSSYTVSKIGTT-CEPNWysGNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLRk 206
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 218563730 291 VSRGQRRLRA--------MRLVVVVVVAFALCWTPY 318
Cdd:cd15082  207 VSNTQGRLGNarkperqvTRMVVVMIVAFMVCWTPY 242
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
133-373 3.91e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 45.04  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRG 210
Cdd:cd15312   33 SPTNFLILSLAITDFLLGFLVMPYSMVRSVEscWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKI 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 211 PPARVTLTCLAVWGLCLLFALPdfIFLSAHH----DERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHIL 286
Cdd:cd15312  113 TTPVIKVFLVISWSVPCLFAFG--VVFSEVNlegiEDYVALVSCTGSCVLIFNKLWGVIASLIAFFIPGTVMIGIYIKIF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 avlLVSRGQRRL----------------------RAMRLVVVVVVAFALCWTPYHLVVLVDILMDLgalarncgrESRVD 344
Cdd:cd15312  191 ---FVARKHAKVinnrpsvtkgdsknklskkkerKAAKTLSIVMGVFLLCWLPFFVATLIDPFLNF---------STPVD 258
                        250       260
                 ....*....|....*....|....*....
gi 218563730 345 VAKSVTsGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15312  259 LFDALV-WLGYFNSTCNPLIYGFFYPWFQ 286
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
121-374 5.16e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 44.55  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSR--RTAlssTDTFLLHLAVADTLL-VLTLPLwAVDAAVQwvfgsglckvagalFNINFYaGALLLAC------ 191
Cdd:cd14968   22 IWAVKLNRalRTV---TNYFIVSLAVADILVgALAIPL-AILISLG--------------LPTNFH-GCLFMAClvlvlt 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 192 ---------ISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFAL-PDFIFLSAHHDERLNATH---CQynFPQVG 258
Cdd:cd14968   83 qssifsllaIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLtPMFGWNNGAPLESGCGEGgiqCL--FEEVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 259 RTALRV-LQLVAGFLLPLLVMAYCYAHILAV----------LLVSRG-----QRRLRAMRLVVVVVVAFALCWTPYHLVV 322
Cdd:cd14968  161 PMDYMVyFNFFACVLVPLLIMLVIYLRIFRVirkqlrqiesLLRSRRsrstlQKEVKAAKSLAIILFLFALCWLPLHIIN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 218563730 323 LVDILmdlgalarnCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd14968  241 CITLF---------CPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
135-365 6.05e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 44.51  E-value: 6.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15959   35 TNVFVTSLACADLVMgLLVVPPGATILLTgHWPLGTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCllfALPDFIFLSAH-----HDERlnATHCqYNFPQ----VGRTALRVLQLVAGFLLPLLVMAYCYA 283
Cdd:cd15959  115 RRARTAVCLVWAIS---AAISFLPIMNQwwrdgADEE--AQRC-YDNPRccdfVTNMPYAIVSSTVSFYVPLLVMIFVYV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HILAV---------------------LLVSRGQRRLRAMRLVVVV-----------VVAFALCWTPYHLVVLVDILmdlg 331
Cdd:cd15959  189 RVFVVatrqvrlirkdkvrfppeespPAESRPACGRRPSRLLAIKehkalktlgiiMGTFTLCWLPFFVANIIKVF---- 264
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 332 alarncGRESRVDVAKSVTSGLGYMHCCLNPLLY 365
Cdd:cd15959  265 ------CRSLVPDPAFLFLNWLGYANSAFNPIIY 292
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
121-373 7.25e-05

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 44.40  E-value: 7.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL-LVLTLPL---WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15135   24 VTQVLQKKGYLQKSVTDHMVSLACSDLLvLLLGMPVelySAIWDPFATPSGNIACKIYNFLFEACSYATILNVATLSFER 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQlYRRGPPARVTLTCLAVWGLCLLFALPDFI------FLSAHHDERLNATHCQ---YNF----PQVGRTALR 263
Cdd:cd15135  104 YIAICHPFK-YKALSGSRVRLLICFVWLTSALVALPLLFamgtedPLEAFPSYRGTRHHCQdqkSNLtictSLSSKWTVF 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 264 VLQLVAGFLLPLLVMA----YCYAHILAVLLVSRG-----------------------QRRLRAMRLVVVVVVAFALCWT 316
Cdd:cd15135  183 QASIFSAFVLYLLVLAsvafMCRRMMRALMGSKKGavavkgpggsvqllrkhesaegkTARKQTILFLGLIVGTLAVCWM 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 218563730 317 PYHLVVLVDILMDLGALARNCGREsrVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15135  263 PNQIRRIMAAAKPKDDWTRSYFRA--YIILLPIADTFFYLSSVLNPLLYNLSSQQFR 317
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
142-373 8.03e-05

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 44.13  E-value: 8.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 142 LAVADTLLVL-TLPLWAVD-AAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTC 219
Cdd:cd15977   42 LALGDLLYILiAIPINVIKlIAEDWPFGVHVCKLYPFIQKASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEV 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 220 LAVWGLCLLFALPDFI-FLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAG-------FLLPLLVMAYCYAHILAVLLV 291
Cdd:cd15977  122 TLIWAVAIIVAVPEAIaFDMVEIDYRGQTLLVCMLPMEQTSSFMRFYQDVKDwwlfgfyFCLPLACTGVFYTLMSCEMLS 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 292 SRG----------QRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLN 361
Cdd:cd15977  202 IKNgmrialndhmKQRREVAKTVFCLVVIFALCWLPLHLSRILKKTIYDVKDPQRCELLSFLLVMDYTGINMASLNSCIN 281
                        250
                 ....*....|..
gi 218563730 362 PLLYAFVGVKFR 373
Cdd:cd15977  282 PVALYFVSRKFK 293
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
133-376 8.40e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 44.08  E-value: 8.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLCKVAgALFNINF-YAGALLLACISFDRYLnIVHATQLYRR 209
Cdd:cd15316   33 SPTNFLIASLACADFLVGVTVMPFSTVRSVEscWYFGESFCTFH-TCCDVSFcYASLFHLCFISVDRYI-AVTDPLVYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPPARVTLTCLAV-WGLCLLFALPdfIFLSAHHDERL----NATHCQYNFpQVGRTALRVLQLVAGFLLPLLVMAYCYAH 284
Cdd:cd15316  111 KFTVSVSGICISVsWIFSLTYSFS--VFYTGVNDDGLeelvNALNCVGGC-QIILNQNWVLVDFLLFFIPTFAMIILYGK 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 285 ILAV---------------------LLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdlGALARNCGRESRV 343
Cdd:cd15316  188 IFLVakqqarkiemtsskaesssesYKDRVARRERKAAKTLGITVIAFLVSWLPYLIDVLIDAFM--NFITPPYIYEICC 265
                        250       260       270
                 ....*....|....*....|....*....|...
gi 218563730 344 DVAksvtsglgYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15316  266 WCA--------YYNSAMNPLIYALFYPWFRKAI 290
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
121-376 1.44e-04

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 43.25  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL--LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYL 198
Cdd:cd15054   21 LILLIFTQRSLRNTSNYFLVSLFMSDLMvgLVVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASILNLCVISLDRYL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 199 NIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDfIFLSAHHDERLNATHCQYNFPQVGRTALRV---LQLVAG---FL 272
Cdd:cd15054  101 LIISPLRYKLRMTPPRALALILAAWTLAALASFLP-IELGWHELGHERTLPNLTSGTVEGQCRLLVslpYALVAScltFF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 273 LPLLVMAYCYAHILAVllvsrGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDlgalarnCGRESRVDvaksVTSG 352
Cdd:cd15054  180 LPSGAICFTYCRILLA-----ARKALKASLTLGILLGMFFVTWLPFFVANVVQAVCD-------CVSPGLFD----VLTW 243
                        250       260
                 ....*....|....*....|....
gi 218563730 353 LGYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15054  244 LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
166-373 2.06e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 42.89  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 166 FGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL 245
Cdd:cd15128   73 FGQFLCKLVPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYK 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 246 NATH--CQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG-----------QRRLRAMRLVVVVV 308
Cdd:cd15128  153 GVTLrtCLLRpetsFMKFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKRNgmlrialnehlKQRREVAKTVFCLV 232
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 218563730 309 VAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15128  233 VIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
166-373 2.45e-04

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 42.54  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 166 FGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERL 245
Cdd:cd15975   73 FGVFLCKLVPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYN 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 246 NATH--CQYN----FPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG------------QRRLRAmRLVVVV 307
Cdd:cd15975  153 GEQYrtCMLNattkFMNFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNRRKgslrialsehlkQRREVA-KTVFCL 231
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 218563730 308 VVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15975  232 VVIFALCWFPLHLSRILKKTVYNENDPRRCELLSFLLVMDYISINLATMNSCINPIALYFVSKKFK 297
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
124-377 2.54e-04

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 43.00  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 124 VLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYlnivha 203
Cdd:PHA03234  58 IIYHKVAKHNATSFYLITLFASDFLHMLCVFFLTLNREALFNFNQAFCQCVLFIYHASCSYSICMLAIIATIRY------ 131
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 204 TQLYRRGPPARVTLTCLAVWGLCLLF----ALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFL---LPLL 276
Cdd:PHA03234 132 KTLHRRKKNDKKNNHIGRNIGILFLAsamcAIPAALFVKTEGKKGNYGKCNIHISSKKAYDLFIAIKIVFCFIwgiFPTM 211
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 277 VMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMdLGALARNCGRESRVDVAKSVTSGLGYM 356
Cdd:PHA03234 212 IFSFFYVIFCKALHALTEKKHKKTLFFIRILILSFLCIQIPNIAILICEIAF-LYIANNSCFGLAQREILQIIIRLMPEI 290
                        250       260
                 ....*....|....*....|.
gi 218563730 357 HCCLNPLLYAFVGVKFRERMW 377
Cdd:PHA03234 291 HCFSNPLVYAFTGGDFRLRFT 311
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
121-374 2.55e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 42.53  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGalFNINFYAGALL--LACISFDR 196
Cdd:cd15085   21 VIAVTLKNPQLRNPINIFILNLSFSDLMMALcgTTIVTVTNYEGYFYLGDAFCIFQG--FAVNYFGIVSLwsLTLLAYER 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YlNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNaTHCQYNFPQVGRT--ALRVLQLVAGFLLP 274
Cdd:cd15085   99 Y-NVVCKPMGGLKLSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQ-TSCSIGWEERSWSnySYLILYFLMCFVIP 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCYAHILAVLL-----------VSRGQRRLRAMRLVVVVVVAFALCWTPY---HLVVLVDILMDLGALArncgre 340
Cdd:cd15085  177 VAIIGFSYGNVLRSLHklnkkieqqggKNCPEEEERAVIMVLAMVIAFLICWLPYtvfALIVVVNPELSISPLA------ 250
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 341 SRVDVAKSVTSGLgymhccLNPLLYAFVGVKFRE 374
Cdd:cd15085  251 ATMPTYFAKTSPV------YNPIIYIFLNKQFRE 278
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
113-368 3.86e-04

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 42.06  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 113 LGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVL-----TLPLWAVDaavQWVFGSGLCKVAGALFNINFYAGAL 187
Cdd:cd15398   13 LGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLfcspfTLTCVLLD---QWIFGEVMCHIVPFLQCVSVMVSTL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 188 LLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDF---IFLSA--HHDERLNATHCQYNFPQVG-RTA 261
Cdd:cd15398   90 MLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWTLGFTICSPLPVFhkiVDLSEtfNLESLKNKYLCIESWPSDSyRIA 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 262 LRVLQLVAGFLLPLLVMAYCYAHilavllVSRGQRRLRAM--RLvVVVVVAFALCWTPYHLVVLVdilMDLGAlarNCGR 339
Cdd:cd15398  170 FTISLLFVQYILPLVCLTVSHTS------VCRSVKRSRSVfyRL-TIVILAFAVSWMPLHLFHLV---TDFNA---NLIS 236
                        250       260
                 ....*....|....*....|....*....
gi 218563730 340 ESRVDVAKSVTSGLGYMHCCLNPLLYAFV 368
Cdd:cd15398  237 NRHFKLVYCICHLLGMLSCCLNPILYGFL 265
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
135-365 4.19e-04

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 42.16  E-value: 4.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTL-PLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPP 212
Cdd:cd15957   35 TNYFITSLACADLVMGLAVvPFGAAHILLkTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTK 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 213 ARVTLTCLAVWGLCllfALPDFIFLSAH-----HDERLN----ATHCQYNFPQvgrtALRVLQLVAGFLLPLLVMAYCYA 283
Cdd:cd15957  115 NKARVIILMVWIVS---GLTSFLPIQMHwyratHQEAINcyaeETCCDFFTNQ----AYAIASSIVSFYVPLVIMVFVYS 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 284 HI-------LAVLLVSRGQRRLR-------------------------AMRLVVVVVVAFALCWTPYHLVVLVDILMDlg 331
Cdd:cd15957  188 RVfqeakrqLQKIDKSEGRFHNQnidqngsgggggnrrrskfclkehkALKTLGIIMGTFTLCWLPFFIVNIVHVIQD-- 265
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 218563730 332 alarncgresrVDVAKSV---TSGLGYMHCCLNPLLY 365
Cdd:cd15957  266 -----------NLIRKEVyilLNWIGYVNSGFNPLIY 291
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
122-367 5.10e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 41.87  E-value: 5.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 122 AAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAV-DAAVQWVFGSgLCKVAGALFNINFYAGALLLACISFDRYLN 199
Cdd:cd15319   23 AAVVRFRHLRSKVTNIFIVSLAVSDLFVaLLVMPWKAVaEVAGYWPFGA-FCDVWVAFDIMCSTASILNLCVISVDRYWA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 200 IVHATQlYRRGPPARVTLTCLAV-WGLCLLFAL------------PDFIFLSAHHDERLNATHCQynfPQVGRTALRVLQ 266
Cdd:cd15319  102 ISSPFR-YERKMTQRVALVMISVaWTLSVLISFipvqlnwhkdsgDDWVGLHNSSISRQVEENCD---SSLNRTYAISSS 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAgFLLPLLVMAYCYAHILAVL--------------------------------LVSRGQRRLRAMRLVVVVVVAFALC 314
Cdd:cd15319  178 LIS-FYIPVAIMIVTYTRIYRIAqiqirrissleraaehaqscrsnridchhhtsLRTSIKKETKVLKTLSVIMGVFVCC 256
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 218563730 315 WTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15319  257 WLPFFILNCMVPFCDRPPADPDAGLPCVSETTFDVFVWFGWANSSLNPIIYAF 309
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
121-232 6.20e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 41.47  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15217   21 VSLLVLKDRALHKAPYYFLLDLCLADTIrsaVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLFCISVTRY 100
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHatqlyRRGPPARVTL-TCLAV----WGLCLLFALP 232
Cdd:cd15217  101 MAIAH-----HRFYSKRMTFwTCIAVicmvWTLSVAMAFP 135
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
114-367 6.26e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 41.26  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 114 GLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLtlpLWAVDAAVQWV-----FGSGLCKVAGALFNINFYAGALL 188
Cdd:cd14964   12 GLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASL---VVLVLFFLLGLteassRPQALCYLIYLLWYGANLASIWT 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 189 LACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDeRLNATHCQYNFPqvGRTALRVLQLV 268
Cdd:cd14964   89 TLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPR-YNTLTGSCYLIC--TTIYLTWGFLL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 269 AGFLLPLLVMAYCYahilaVLLVSRGQRRLRAMRLVVVVVVA---------------FALCWTPYHLVVLVDILmdlgaL 333
Cdd:cd14964  166 VSFLLPLVAFLVIF-----SRIVLRLRRRVRAIRSAASLNTDknlkatksllilvitFLLCWLPFSIVFILHAL-----V 235
                        250       260       270
                 ....*....|....*....|....*....|....
gi 218563730 334 ARNCGRESRVDVAKSvtsgLGYMHCCLNPLLYAF 367
Cdd:cd14964  236 AAGQGLNLLSILANL----LAVLASTLNPFIYCL 265
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
122-367 7.98e-04

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 40.96  E-value: 7.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 122 AAVLLSRRTAL---SSTDTFLLHLAVADTLLVL--TLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDR 196
Cdd:cd15387   19 ICVLLAIHTTRhkhSRMYFFMKHLSIADLVVAVfqVLPQLIWDITFRFYGPDFLCRLVKYLQVVGMFASTYMLLLMSIDR 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 197 YLNIVHATQ-LYRRGPPARVTLTclavWGLCLLFALPDfIFLSAHHDERLNATHCQYNFPQV-GRTALRVLQLVAGFLLP 274
Cdd:cd15387   99 CLAICQPLRsLHRRSDRVYVLFS----WLLSLVFSIPQ-VHIFSLREVGNGVYDCWADFIQPwGPKAYITWITLSVYIIP 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 275 LLVMAYCY---------------------------------AHILAVLLVSRGqrRLRAMRLVVVVVVAFALCWTPYHLV 321
Cdd:cd15387  174 VLILSVCYglisfkiwqnvklktrretktplssaasggaalARVSSVKLISKA--KIRTVKMTFVIVLAYIVCWTPFFFV 251
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 218563730 322 VLvdilmdLGALARNCGREsrvDVAKSVTSGLGYMHCCLNPLLYAF 367
Cdd:cd15387  252 QM------WSVWDPNAPKE---ASPFIIAMLLASLNSCCNPWIYMF 288
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
121-375 1.04e-03

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 40.69  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLL-HLAVADTLLVLTLPLWA-VDAA--------VQWVFGSGLCKVAGALFNINFYAGALLLA 190
Cdd:cd14980   21 VIIWHISSKKKKKKVPKLLIiNLAIADFLMGIYLLIIAiADQYyrgryaqySEEWLRSPPCLLACFLVSLSSLMSVLMML 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 191 CISFDRYLNIVHATQLYRRgPPARVTLTCLAVWGLCLLFALPDFIF-LSAHHDERLNAT-------HCQYNFPQVGRTAL 262
Cdd:cd14980  101 LITLDRYICIVYPFSNKRL-SYKSAKIILILGWLFSIIFAAIPILYsINQPGDNRLYGYssicmpsNVSNPYYRGWLIAY 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 263 RVLQLVAgfllpLLVMAYCYAHILAVLLVSRGQRRLR--------AMRLVVVVVVAFaLCWTPYHLVVLVDILmdlgala 334
Cdd:cd14980  180 LLLTFIA-----WIIICILYILIFISVRKSRKSARRSsskrdkriAIRLALILITDL-ICWLPYYIVIFSGLL------- 246
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 218563730 335 rncgRESRVDVAKsvtsgLGY-------MHCCLNPLLYAFVGVKFRER 375
Cdd:cd14980  247 ----TSTEIDIHV-----LQFiailalpLNSAINPYLYTLTTPTFKRD 285
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
133-374 1.09e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 40.53  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLL-VLTLPLwAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGP 211
Cdd:cd15070   33 TTTFYFIVSLALADIAVgVLVIPL-AIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTT 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 212 PARVTLTCLAVWGLCLLFAL-PDFIFLSAHHDERLNATHCQYNFPQVGRTALRV-LQLVAGFLLPLLVMAYCYAHILAVL 289
Cdd:cd15070  112 QRRIWLALGLCWLVSFLVGLtPMFGWNRKPSLESVNTTPLQCQFTSVMRMDYMVyFSFFTWILIPLVIMCALYVDIFYII 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 290 LVSRGQ-------------RRLRAMRLVVVVVVAFALCWTPYHLVvlvdilmdlgalarNCGRESRVDVAKSVTSG---L 353
Cdd:cd15070  192 RNKLSQnatgfretgafygREFKTAKSLALVLFLFAVCWLPLSII--------------NCVVYFNPKVPKIALYLgilL 257
                        250       260
                 ....*....|....*....|.
gi 218563730 354 GYMHCCLNPLLYAFVGVKFRE 374
Cdd:cd15070  258 SHANSMMNPIVYACKIKKFKE 278
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
138-327 1.14e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 40.52  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPL-WAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15219   38 FLLNLSFCNLLLtVLNMPFtLLGVVRNRQPFGDGFCQAVGFLETFLTSNAMLSMAALSIDRWIAVVFPLSYTSKMRYRDA 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALPDfIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLV---AGFLLPLLVMAYCYAHILAVllvs 292
Cdd:cd15219  118 ALMVGYSWLHSLTFSLVA-LFLSWLGYSSLYASCTLHLPREEERRRFAVFTAFfhaFTFLLSLLVLCVTYLKVLKV---- 192
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 218563730 293 rgQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIL 327
Cdd:cd15219  193 --RRRQRATKKISIFIGTFVLCFAPYVITRLVELL 225
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
142-373 1.16e-03

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 40.61  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 142 LAVADTL-LVLTLPLWAVDA-AVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTC 219
Cdd:cd15976   42 LALGDLLhIIIDIPINVYKLlAEDWPFGVEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEI 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 220 LAVWGLCLLFALPDFIFLS------AHHDERLNATHC--QYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHI------ 285
Cdd:cd15976  122 VLIWVVSIILAVPEAIGFDmitmdyKGELLRICLLHPiqKTAFMQFYKTAKDWWLFSFYFCLPLACTAVFYTLMtcemlr 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 ----LAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLN 361
Cdd:cd15976  202 kkngMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTIYDEKDPNRCELLSFFLVLDYIGINMASLNSCIN 281
                        250
                 ....*....|..
gi 218563730 362 PLLYAFVGVKFR 373
Cdd:cd15976  282 PIALYLVSKRFK 293
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
121-232 1.54e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.40  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 121 VAAVLLSRRTALSSTDTFLLHLAVADTL---LVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15218   21 ISILLVKDKTLHRAPYYFLLDLCCSDILrsaICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLFCISVTRY 100
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHatqlyRRGPPARVTL-TCLA----VWGLCLLFALP 232
Cdd:cd15218  101 LAIAH-----HRFYTKRLTFwTCLAvicmVWTLSVAMAFP 135
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
120-373 1.59e-03

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 40.18  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 120 AVAAVLLSRRTALSSTDTFLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRY 197
Cdd:cd15395   20 ALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMdHWVFGEAMCKLNSMVQCISITVSIFSLVLIAIERH 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 198 LNIVHATQLYRRGPPARVTLTclAVWGLCLLFALPDFIF----------LSAHHDERLNATHCQYNFP-QVGRTALRVLQ 266
Cdd:cd15395  100 QLIINPRGWRPNNRHAYVGIA--VIWVLAVLTSLPFLIFqvltdepfknVNVSLDAYKGKYVCLDQFPsDTIRLSYTTCL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 267 LVAGFLLPLLVMAYCYAHILAVL--------------LVSRGQRRLRAMRLVVVVvvAFALCWTPYHLVVLVdilMDLG- 331
Cdd:cd15395  178 LVLQYFGPLCFIFICYLKIYIRLkrrnnmmdkmrdnkYRSSETKRINIMLISIVV--AFAVCWLPLNIFNAV---FDWNh 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 218563730 332 ALARNCGResrvDVAKSVTSGLGYMHCCLNPLLYAFVGVKFR 373
Cdd:cd15395  253 EAIATCNH----NLLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
138-303 2.06e-03

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 39.89  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLLVLTLPLWAV--DAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARV 215
Cdd:cd15109   37 YFLHLASADVGYLFSKAVFSIlnTGGFLGTFADYIRSVSRILGLCTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLS 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 216 TLTCLAVWGLCLLFALpdfiflsahhderLNATHCQYNFPQVGRTALRVLQLVAGFLL-----PLLVMAyCYAHILAVll 290
Cdd:cd15109  117 AVVCALLWMLSLLVTC-------------IHNYFCVFLGREAPGAACRHMDIFLGILLfllfcPLMVLP-CLALILHV-- 180
                        170
                 ....*....|...
gi 218563730 291 VSRGQRRLRAMRL 303
Cdd:cd15109  181 ECRARRRQRSAKL 193
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
138-236 2.41e-03

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 39.39  E-value: 2.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLLHLAVADTLL-VLTLPLWAVDAAV-QWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQlYR--RGPPA 213
Cdd:cd15296   38 FFLNLAISDFLVgGFCIPLYIPYVLTgRWKFGRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVS-YRaqKGMTR 116
                         90       100
                 ....*....|....*....|...
gi 218563730 214 RVTLTCLAVWGLCLLFALPDFIF 236
Cdd:cd15296  117 QAVLKMVLVWVLAFLLYGPAIIS 139
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
135-376 2.46e-03

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 39.43  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 135 TDTFLLHLAVADTLLVLTLPLWAVDAAVQ--WVFGSGLC---KVAGALFNInfyAGALLLACISFDRYLNIVHATqlYRR 209
Cdd:cd15078   35 TNLLLVNISLSDLLVSLLGVTFTFMSCVRgrWVFDVAGCvwdGFSNSLFGI---VSIMTLTVLAYERYIRVVHAK--VVN 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 210 GPPARVTLTCLAVWGLCL----LFALPDFIFLSAHHDERLNATHCQYNfpqvgRTALRVLQLVAGFLLPLLVMAYCYAHI 285
Cdd:cd15078  110 FSWSWRAITYIWLYSLAWtgapLLGWNRYTLEVHGLGCSFDWKSKDPN-----DTSFVLLFFLGCLVVPLGIMAYCYGHI 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 286 LAVLLVSRGQRRLRAM-------------RLVVVVVVAFALCWTPYHLVVLVDILmdlgalarncGRESRVDVAKSVTSG 352
Cdd:cd15078  185 LYEIRMLRSVEDLQTFqvikilkyekkvaKMCLLMISTFLICWMPYAVVSLLVTS----------GYSKLVTPTIAIIPS 254
                        250       260
                 ....*....|....*....|....*
gi 218563730 353 L-GYMHCCLNPLLYAFVGVKFRERM 376
Cdd:cd15078  255 LfAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_MrgprE cd15112
mas-related G protein-coupled receptor subtype E, member of the class A family of ...
182-299 2.57e-03

mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320240  Cd Length: 272  Bit Score: 39.43  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 182 FYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALpdfiflsahhderLNATHCQYNFPQVGRTA 261
Cdd:cd15112   83 YIVGLSLLAAISAEQCLATLFPAWYQCRRPRHLTTCVCALLWALCLLLHL-------------LLSGACTQFFGGPSGHL 149
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 218563730 262 LRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLR 299
Cdd:cd15112  150 CGRLWLVRAVLLALLCCTMCVSSLVLLLRVERGPPRQR 187
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
133-327 2.62e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 39.35  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 133 SSTDTFLLHLAVADTLLVLTLP----LWAVDAavqwvFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYR 208
Cdd:cd15905   31 NTANYFFLSLLLADLLTGVALPfipgMSNESR-----RGYHSCLFVYVAPNFLFLSFLANLLMVHYERYLCIVYPLQYHN 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 209 RGPPARVTLTCLAVWGLCLLFA-LPdfIFLSAHHDERLNATHcQYNFPqvgrTALRVLQlVAGFLLP-LLVMAYCYAHIL 286
Cdd:cd15905  106 FWVHRWVPLALLLTWALPLLFAcLP--ALGWNNWTPGSNCSY-KQVFP----AAYIYLE-VYGLVLPsILAIAFMSVRVL 177
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AV----------LLVS---------RGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDIL 327
Cdd:cd15905  178 AVarrqlqdickLLRAvqrdgpselEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLMSVL 237
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
138-324 4.78e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 38.61  E-value: 4.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 138 FLL--HLAVADTLLVLTLPLwavDAAVQWVFGSGLCKVAGA-LFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPAR 214
Cdd:cd15100   36 FLLigSLALADLLAGLGLIL---HFVFRYCVYSEALSLVSVgLLVAAFSASVCSLLAITVDRYLSLYNALTYYSERTLTF 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 215 VTLTCLAVWGLCLLFALPDFIFLSAHHDErlnaTHCQYNFPQvgrTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRG 294
Cdd:cd15100  113 TYVMLALLWTLALGLGLLPVLGWNCLREG----SSCSVVRPL---TKNHLAVLAVAFLLVFALMLQLYAQICRIVLRHAH 185
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 218563730 295 QRRLRAMRLVVVVVVA--------------FALCWTPYHLVVLV 324
Cdd:cd15100  186 QIALQRHFLAPSHYVAtrkgvstlalilgtFAACWIPFAVYCLL 229
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
128-395 6.60e-03

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 38.15  E-value: 6.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 128 RRTALSstdTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGS-GLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQL 206
Cdd:cd15107   30 HRNAFS---VYILNLAGADFLFLCTQIVFSLEIVLQFHSIDiHIPLFLLTVTMFAYLAGLSMITAISIERCLSVMWPIWY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 207 YRRGPPARVTLTCLAVWGLCLLFALpdfiflsahhderLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHIL 286
Cdd:cd15107  107 HCQRPRHTSAVICTLLWVLSLLLSL-------------LEGKGCGFLFSTYDYYWCWTLDLITTAWLIVLFVVLSGSSLA 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 218563730 287 AVLLVSRGQRRLRAMRLV---VVVVVAFALCWTPYHLVVLVDILMDLGALARNCGresrvdvAKSVTSGLGYMHCCLNPL 363
Cdd:cd15107  174 LLVRIFCGSHRIPVTRLYvtiALTVLVFLIFGLPFGIYWFLLKWIEEFYIVPCCG-------FYEVILFLSCVNSCANPI 246
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 218563730 364 LYAFVGV----KFRERMWMLLLrlgcpnQRGLQRQP 395
Cdd:cd15107  247 IYFLVGSirhhRFQRKTLKLLL------QRAMQDTP 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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