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Conserved domains on  [gi|608601785|ref|NP_001139816|]
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PRAME family member 11 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 269-393 6.24e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 269 LRCLQKLYM--NSVSFLEGhLDQLlsclkTSLKVLTITNCVL-----LESD---LKHLSQCpsisqLKTLDLSGIRLTny 338
Cdd:cd21340   67 LVNLKKLYLggNRISVVEG-LENL-----TNLEELHIENQRLppgekLTFDprsLAALSNS-----LRVLNISGNNID-- 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 608601785 339 SLVPLQILlekvaATLEYLDLDDCGIidSQVNAILPALSRCFELNTFSFCGNPIC 393
Cdd:cd21340  134 SLEPLAPL-----RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPVC 181
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 269-393 6.24e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 269 LRCLQKLYM--NSVSFLEGhLDQLlsclkTSLKVLTITNCVL-----LESD---LKHLSQCpsisqLKTLDLSGIRLTny 338
Cdd:cd21340   67 LVNLKKLYLggNRISVVEG-LENL-----TNLEELHIENQRLppgekLTFDprsLAALSNS-----LRVLNISGNNID-- 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 608601785 339 SLVPLQILlekvaATLEYLDLDDCGIidSQVNAILPALSRCFELNTFSFCGNPIC 393
Cdd:cd21340  134 SLEPLAPL-----RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
223-392 1.56e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 223 LTQFTPYLGHLRNLQKLVLSHMDvsryvspeqkkeiVTQFTTQFLKLRCLQKLYM--NSVSFLEGHLDQLlsclkTSLKV 300
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSNNQ-------------LTDLPEPLGNLTNLKSLDLsnNQLTDLPEELGNL-----TNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 301 LTITNCVLleSDL-KHLSQCPSisqLKTLDLSGIRLTN--YSLVPLQillekvaaTLEYLDLDDCGIIDsqvnaiLPALS 377
Cdd:COG4886  187 LDLSNNQI--TDLpEPLGNLTN---LEELDLSGNQLTDlpEPLANLT--------NLETLDLSNNQLTD------LPELG 247

                        170
                 ....*....|....*
gi 608601785 378 RCFELNTFSFCGNPI 392
Cdd:COG4886  248 NLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 269-393 6.24e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 6.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 269 LRCLQKLYM--NSVSFLEGhLDQLlsclkTSLKVLTITNCVL-----LESD---LKHLSQCpsisqLKTLDLSGIRLTny 338
Cdd:cd21340   67 LVNLKKLYLggNRISVVEG-LENL-----TNLEELHIENQRLppgekLTFDprsLAALSNS-----LRVLNISGNNID-- 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 608601785 339 SLVPLQILlekvaATLEYLDLDDCGIidSQVNAILPALSRCFELNTFSFCGNPIC 393
Cdd:cd21340  134 SLEPLAPL-----RNLEQLDASNNQI--SDLEELLDLLSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
223-392 1.56e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 223 LTQFTPYLGHLRNLQKLVLSHMDvsryvspeqkkeiVTQFTTQFLKLRCLQKLYM--NSVSFLEGHLDQLlsclkTSLKV 300
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSNNQ-------------LTDLPEPLGNLTNLKSLDLsnNQLTDLPEELGNL-----TNLKE 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 301 LTITNCVLleSDL-KHLSQCPSisqLKTLDLSGIRLTN--YSLVPLQillekvaaTLEYLDLDDCGIIDsqvnaiLPALS 377
Cdd:COG4886  187 LDLSNNQI--TDLpEPLGNLTN---LEELDLSGNQLTDlpEPLANLT--------NLETLDLSNNQLTD------LPELG 247

                        170
                 ....*....|....*
gi 608601785 378 RCFELNTFSFCGNPI 392
Cdd:COG4886  248 NLTNLEELDLSNNQL 262
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 323-392 3.42e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.77  E-value: 3.42e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608601785 323 SQLKTLDLSGIRLTNYSLVPLQILLEKvAATLEYLDLDDCGIIDSQVNAILPALSRCFELNTFSFCGNPI 392
Cdd:COG5238  292 TTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQI 360
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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