NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226958564|ref|NP_001153007|]
View 

voltage-dependent L-type calcium channel subunit alpha-1C isoform 4 [Mus musculus]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1485 1.95e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 231.00  E-value: 1.95e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1296 VDIAITEPaehtqcspsmsaeeNSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1375
Cdd:pfam00520   81 ISLVLSSV--------------GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1376 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFI 1455
Cdd:pfam00520  147 GYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFV 208
                          250       260       270
                   ....*....|....*....|....*....|
gi 226958564  1456 SFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1485
Cdd:pfam00520  209 SFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 3.51e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 230.23  E-value: 3.51e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   283 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564   363 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 7.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 186.32  E-value: 7.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 226958564  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.45e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   523 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 226958564   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1557-1631 4.77e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.64  E-value: 4.77e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958564  1557 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1631
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1651-2086 1.66e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.98  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1651 AGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDifrragglfgnhvtyyqSDSRGNFPQTfatqrplhink 1730
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-----------------KAPIGSQPPS----------- 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1731 tgNNQADTESPSHEKLVDSTFTPSSYSSTGsnaninnanntalgrfphpaGYSSTVSTVeghGPPLSPAVRVQEAAWKLS 1810
Cdd:pfam16885   53 --RSRISVSLPVGDRLPDSLSLGPSDDDGG--------------------APNSRQPSV---PQTGSHTHRRSSGVLMFT 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1811 SKRCHSRESQGATVNQEIFPDETRSVRMS---EEAEYCSEPSLLSTdmfsyQEDEHRQLTCPEEDKREIQPSPKrsflrs 1887
Cdd:pfam16885  108 IPEEGSSQPKGTKGQDKQDEEEEVPDQLSyldEQAGTPSRPVLLPP-----HRPQHYPLREPVDRRRLLPPTPA------ 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1888 aslGRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRpLRPIP 1967
Cdd:pfam16885  177 ---GRKPSFNIQCLRRQ-------GSCEDLPIPGTYHRG----RNSGPS-RAQGSWA----------TPPQRGR-LLYAP 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1968 TLRLEGAESSEklnssfpsihcsSWSeettacsGSSSMARRARpVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQF 2047
Cdd:pfam16885  231 LLLVEEGAAGE------------GYL-------GKSPGPLRTF-TCLRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLF 290
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 226958564  2048 AQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2086
Cdd:pfam16885  291 AQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1494-1547 4.10e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 4.10e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564  1494 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1547
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1485 1.95e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 231.00  E-value: 1.95e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1296 VDIAITEPaehtqcspsmsaeeNSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1375
Cdd:pfam00520   81 ISLVLSSV--------------GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1376 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFI 1455
Cdd:pfam00520  147 GYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFV 208
                          250       260       270
                   ....*....|....*....|....*....|
gi 226958564  1456 SFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1485
Cdd:pfam00520  209 SFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 3.51e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 230.23  E-value: 3.51e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   283 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564   363 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 7.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 186.32  E-value: 7.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 226958564  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.45e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   523 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 226958564   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1557-1631 4.77e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.64  E-value: 4.77e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958564  1557 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1631
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1651-2086 1.66e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.98  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1651 AGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDifrragglfgnhvtyyqSDSRGNFPQTfatqrplhink 1730
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-----------------KAPIGSQPPS----------- 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1731 tgNNQADTESPSHEKLVDSTFTPSSYSSTGsnaninnanntalgrfphpaGYSSTVSTVeghGPPLSPAVRVQEAAWKLS 1810
Cdd:pfam16885   53 --RSRISVSLPVGDRLPDSLSLGPSDDDGG--------------------APNSRQPSV---PQTGSHTHRRSSGVLMFT 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1811 SKRCHSRESQGATVNQEIFPDETRSVRMS---EEAEYCSEPSLLSTdmfsyQEDEHRQLTCPEEDKREIQPSPKrsflrs 1887
Cdd:pfam16885  108 IPEEGSSQPKGTKGQDKQDEEEEVPDQLSyldEQAGTPSRPVLLPP-----HRPQHYPLREPVDRRRLLPPTPA------ 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1888 aslGRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRpLRPIP 1967
Cdd:pfam16885  177 ---GRKPSFNIQCLRRQ-------GSCEDLPIPGTYHRG----RNSGPS-RAQGSWA----------TPPQRGR-LLYAP 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1968 TLRLEGAESSEklnssfpsihcsSWSeettacsGSSSMARRARpVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQF 2047
Cdd:pfam16885  231 LLLVEEGAAGE------------GYL-------GKSPGPLRTF-TCLRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLF 290
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 226958564  2048 AQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2086
Cdd:pfam16885  291 AQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1494-1547 4.10e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 4.10e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564  1494 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1547
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1609-1639 3.32e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.32e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 226958564   1609 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1639
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1218-1485 1.95e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 231.00  E-value: 1.95e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1218 STYFEYLMFVLILLNTICLAMQHYGQS-CLFKIAMNILNMLFTGLFTVEMILKLIAFKP-KHYFCDAWNTFDALIVVGSI 1295
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1296 VDIAITEPaehtqcspsmsaeeNSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1375
Cdd:pfam00520   81 ISLVLSSV--------------GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAII 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1376 GMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKkcapesepsnstegetpcGSSFAVFYFI 1455
Cdd:pfam00520  147 GYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK------------------GEFWAYIYFV 208
                          250       260       270
                   ....*....|....*....|....*....|
gi 226958564  1456 SFYMLCAFLIINLFVAVIMDNFDYLTRDWS 1485
Cdd:pfam00520  209 SFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
123-416 3.51e-68

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 230.23  E-value: 3.51e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   123 WKPFEIIILLTIFANCVALAIYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHpnaYLRNGWNLLDFII 202
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   203 VVVGLFSAILEqatkadganalgGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   283 AIIGLELFMGKMHKtcynqegiidvpaeedpspcaletghgrqcqngtvckpgWDGPKHGITNFDNFAFAMLTVFQCITM 362
Cdd:pfam00520  144 AIIGYQLFGGKLKT---------------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTT 184
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564   363 EGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 416
Cdd:pfam00520  185 EGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
899-1176 7.20e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 186.32  E-value: 7.20e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   899 DTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHkgsFCRNYFNILDLLVVS 978
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   979 VSLISFGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYT 1057
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1058 CSDSskqteaeckgnyitykdgevdhpiiqprswENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYn 1137
Cdd:pfam00520  158 WENP------------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 226958564  1138 yrveisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1176
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
523-764 2.45e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.78  E-value: 2.45e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   523 SNVFYWLVIFLVFLNTLTIASEHYNQP-HWLTEVQDTANKALLALFTAEMLLKMYSLGL-QAYFVSLFNRFDCFIVCGGI 600
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   601 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF-NF 679
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLkTW 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564   680 DEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 759
Cdd:pfam00520  159 ENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233

                   ....*
gi 226958564   760 ESLTS 764
Cdd:pfam00520  234 TERTE 238
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1557-1631 4.77e-37

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 134.64  E-value: 4.77e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226958564  1557 NATLFALVRTALRIKTE--GNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1631
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
1651-2086 1.66e-33

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 133.98  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1651 AGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDifrragglfgnhvtyyqSDSRGNFPQTfatqrplhink 1730
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-----------------KAPIGSQPPS----------- 52
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1731 tgNNQADTESPSHEKLVDSTFTPSSYSSTGsnaninnanntalgrfphpaGYSSTVSTVeghGPPLSPAVRVQEAAWKLS 1810
Cdd:pfam16885   53 --RSRISVSLPVGDRLPDSLSLGPSDDDGG--------------------APNSRQPSV---PQTGSHTHRRSSGVLMFT 107
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1811 SKRCHSRESQGATVNQEIFPDETRSVRMS---EEAEYCSEPSLLSTdmfsyQEDEHRQLTCPEEDKREIQPSPKrsflrs 1887
Cdd:pfam16885  108 IPEEGSSQPKGTKGQDKQDEEEEVPDQLSyldEQAGTPSRPVLLPP-----HRPQHYPLREPVDRRRLLPPTPA------ 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1888 aslGRRASFHLECLKRQkdqggdiSQKTALPLHLVHHQAlavaGLSPLLqRSHSPTTfprpcptppvTPGSRGRpLRPIP 1967
Cdd:pfam16885  177 ---GRKPSFNIQCLRRQ-------GSCEDLPIPGTYHRG----RNSGPS-RAQGSWA----------TPPQRGR-LLYAP 230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1968 TLRLEGAESSEklnssfpsihcsSWSeettacsGSSSMARRARpVSLTVPSQAGAPGRQFHGSASSLVEAVLISEGLGQF 2047
Cdd:pfam16885  231 LLLVEEGAAGE------------GYL-------GKSPGPLRTF-TCLRVPGTHSDPSHGKRGSADSLVEAVLISEGLGLF 290
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 226958564  2048 AQDPKFIEVTTQELADACDMTIEEMENAADNILSGGAQQ 2086
Cdd:pfam16885  291 AQDPKFVALAKQEIADACHLTLDEMDSAASDLLAQGTSS 329
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1494-1547 4.10e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 116.98  E-value: 4.10e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 226958564  1494 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1547
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
1609-1639 3.32e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 65.32  E-value: 3.32e-13
                            10        20        30
                    ....*....|....*....|....*....|.
gi 226958564   1609 DEVTVGKFYATFLIQEYFRKFKKRKEQGLVG 1639
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1246-1478 6.59e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.36  E-value: 6.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1246 LFKIAMNILNMLFTGLFTVEMILKlIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEPAEHTQCSPSMSAEENSRISITF 1325
Cdd:pfam08016    8 LFILLCEIVFVVFFLYFVVEEILK-IRKHRPSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLADRLIKSVEASPVTFIDF 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1326 FRLFRV----------------MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGkialndtt 1389
Cdd:pfam08016   87 DRVAQLdnlyriilaflvfltwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-------- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226958564  1390 eiNRNNNFQTFPQAVLLLFR-CATGEAWQDIMlacmpgkkcapesepsnstegetPCGSSFAVFYFISFYMLCAFLIINL 1468
Cdd:pfam08016  159 --TQAPNFSNFVKSILTLFRtILGDFGYNEIF-----------------------SGNRVLGPLLFLTFVFLVIFILLNL 213
                          250
                   ....*....|
gi 226958564  1469 FVAVIMDNFD 1478
Cdd:pfam08016  214 FLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH