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Conserved domains on  [gi|239937471|ref|NP_001155246|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-361 1.49e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467709  Cd Length: 207  Bit Score: 458.62  E-value: 1.49e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 315
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 239937471 316 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-361 1.49e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 458.62  E-value: 1.49e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 315
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 239937471 316 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-366 8.65e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 265.62  E-value: 8.65e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  115 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 194
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  195 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 264
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  265 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIK 344
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 239937471  345 ESWTHNIQREKEFLRKLVKARV 366
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 156-361 1.49e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 458.62  E-value: 1.49e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 315
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 239937471 316 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 156-361 2.06e-128

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 367.00  E-value: 2.06e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglMGRGNIPTLGSVAVTMALHGCDE 315
Cdd:cd23967   82 LWLQAVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCDE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 239937471 316 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23967  160 VDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 155-361 6.03e-90

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 269.30  E-value: 6.03e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 234
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 235 FKWLKYIVYKERVSASDG--FWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL--PFNNGLMGRGNIPTLGSVAVTMAL 310
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRlfFWKEVADSIPLKPSQFRILNPLIIKETALDILQYpePQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 239937471 311 HGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 115-366 8.65e-88

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 265.62  E-value: 8.65e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  115 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 194
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  195 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 264
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471  265 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIK 344
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 239937471  345 ESWTHNIQREKEFLRKLVKARV 366
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 156-361 8.48e-77

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 235.80  E-value: 8.48e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASdGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 315
Cdd:cd23984   82 RWLLDLLMGKKVSAK-GFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 239937471 316 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23984  161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 156-361 1.57e-73

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 227.24  E-value: 1.57e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQD 234
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 235 FKWLKYIVYKERVSAsDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPfnnGLMGRGNIPTLGSVAVTMALHGCD 314
Cdd:cd23982   82 FYWLYEILSNEKRVR-KGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVP---GQRKKKQKPTTGLLAITLALHLCD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 239937471 315 EVAVAGFGY-DMNTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKL 361
Cdd:cd23982  158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 159-361 8.36e-52

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 171.01  E-value: 8.36e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 159 CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 229
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 230 FKWQDFKWLKYIVYkervsasdgfwksvatRVPKEPPEIRILNPYFIQEAAFTLIGLpfNNGLMGRGNIPTLGSVAVTMA 309
Cdd:cd19952   81 AAAADFKRLKRRKK----------------RHDNAVLLLTDPAPDLLSYVRKRLEKL--GLKSFFGGNAPSSGLLAVLLA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 239937471 310 LHGCDEVAVAGFGYDM-NTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 361
Cdd:cd19952  143 LQLCDSVDLYGFGVDSgHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 106-368 2.56e-42

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 149.33  E-value: 2.56e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 106 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTKeYRLTPALDSLH-----CRRCIIVGNGGVLANKSLGSR 176
Cdd:cd23964   24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLN-LTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 177 IDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGF 253
Cdd:cd23964  103 IDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 254 WKSV-ATRVPKEPPE-IRILNPYFIQEAaftliglpFNNGL-MGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmntPNA 330
Cdd:cd23964  183 GKRPpPLFGPKLNATnVRLLHPDFIRYL--------FNRWLnSSTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRF 251

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 239937471 331 PLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVIT 368
Cdd:cd23964  252 SLHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 155-368 7.83e-40

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 142.42  E-value: 7.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 233
Cdd:cd23966   76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 234 DFKWLKyivykervSA-SDGFWKSVATRVPK----EPPEIRILNPYFIQEAAFTLIGlpfnnglmGRGNIPTLGSVAVTM 308
Cdd:cd23966  151 DLQWLI--------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIF 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 239937471 309 ALHGCDEVAVAGFGYDMNtpNAPLHYYETVRmAAIKESWT--HNIQREKEFLRKLVKARVIT 368
Cdd:cd23966  215 ALHICDEVSVFGFGADSK--GNWHHYWEKNR-SAGAFRKTgvHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 110-336 7.80e-29

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 113.05  E-value: 7.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 110 DDSFRKWARIREFVPPfgiKGQDNLIKAILSVTK-EYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNS 188
Cdd:cd23980   37 EDTYKWWLRLQREKKP---KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 189 APVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWLKYIVYKERVSASdgfWKSVATRVPKEPPEI 268
Cdd:cd23980  114 APTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVISATTTGTISHT---YVPVPRKIKVKKEKI 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 239937471 269 RILNPYFIQEAaftliglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmnTPNAPLHYYE 336
Cdd:cd23980  187 LIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGAD--SKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 152-367 1.12e-26

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 107.26  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 152 DSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 231
Cdd:cd23979   76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 232 WQDFKWLKYIVYKERVSASDGFWKSVaTRVPKEppEIRILNPYFiqeaaFTLIglpFNNGLMGRGNIPTLGSVAVTMALH 311
Cdd:cd23979  152 TLDLLWITSALSTGQIRFTYAPVKQF-LRVDKD--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALH 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 239937471 312 GCDEVAVAGFGYDmNTPNAPlHYYETVRMAA-IKESWTHNIQREKEFLRKLVKARVI 367
Cdd:cd23979  221 VCDEVNVYGFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLAKAGKI 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 157-361 1.33e-22

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 95.80  E-value: 1.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFV--- 226
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVwdp 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 227 -------LAGFKWQDFKWL-KYIVYKErvsasdgfwksvatRVPKEPPEirILNPYF-------IQEAAFTliglpfnng 291
Cdd:cd23968  125 ssynvnlEKWYKKPDFDFFpNYIKYRR--------------RHPEEPFY--LIDPRFlwrlwdiLQEYTPE--------- 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 239937471 292 lMGRGNIPTLGSVAVTMALHGCDEVAVagfgYDMNTPNAP---LHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23968  180 -KIKPNPPSSGFIGIVLMLHLCDWVDV----YEYVPSVRQtdrCHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 157-361 1.94e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 92.71  E-value: 1.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTL------RITYPEGAMQRPEQYERdslFVlagf 230
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsILKRRYNSLKKNRDRDK---FL---- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 231 kwQDFKWLK--YIVY-KERVSASDGFWKSVATRVPKEPPEIRIL--NP-YFIQEAAFtliglpfnNGLMGRGNIPTLGSV 304
Cdd:cd23963  137 --NRLKEYNgsILWYpKFSFKSSTNLLLKAARALKKNGLNLTVVysNPeHFLAVQKF--------WKRRGLEKRPSTGLY 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 305 AVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYEtvRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23963  207 LVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEEFKLLREL 264
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 107-367 1.94e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 93.28  E-value: 1.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 107 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLHCRRCIIVGNGGVLANKSLGSRI 177
Cdd:cd23973   25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 178 DDYDIVIRLNSAPVKGFERDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKYIVYKE 245
Cdd:cd23973  105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEALLKNK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 246 RVsaSDGFWKSvatRVPKE-------PPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAV 318
Cdd:cd23973  183 TI--PSGAYYG---RRPRSyfsgdftEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSA 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 239937471 319 AGF---GYDmntpNAPLHYYETvrmaaikeSWT-------HNIQREKEFLRKLVKARVI 367
Cdd:cd23973  258 YGFiteDYR----KYPDHYYDK--------KKTklvfyinHDFRLEKKLWKRLHDEKII 304
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 116-367 2.63e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 87.19  E-value: 2.63e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 116 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDSLH-CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAP 190
Cdd:cd23972   37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTPGkCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 191 VKGFERDVGSKTTLR-----------ITYPEGAMQRPEQyERDSLFVLAGFKWQDFKWLKYIVYKERV-SASDGFWKSVA 258
Cdd:cd23972  117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAILGVPVpEGLDKGDRPHK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 259 TRVPKEPPE-IRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmNTPNAPLHYYET 337
Cdd:cd23972  196 YFGPEASAKkFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSDHYYER 274

                        250       260       270
                 ....*....|....*....|....*....|
gi 239937471 338 VRMAAIKESwTHNIQREKEFLRKLVKARVI 367
Cdd:cd23972  275 KKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 156-337 2.85e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 85.37  E-value: 2.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI----TYPEGAMQRPEQYERDS---LFVLa 228
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 229 gfkwqdfkWLKYIVYKERVSASDGFWKSVATRVPKeppeiriLNPYFiqeaaftliglpFNNGLMGRGN--------IPT 300
Cdd:cd23965   80 --------WGPETKMNKDGAGKYNLLRSLSKKYPD-------VEFYS------------LTPEKMDYADelfeketgKSR 132

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 239937471 301 LGS--------VAVTMALHGCDEVAVagfgYDMNTPN---------APLHYYET 337
Cdd:cd23965  133 IKSgtwlstgwFTMLLALDVCDEIKV----YGMVPENycrehpnskVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 156-368 5.45e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 80.57  E-value: 5.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 235
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRY 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWL-----KYIVYKERVSasdgfwKSVATRVP---KEPP----------EIRILNPYFIQEAAFTLIGLPFNNGLMGRGN 297
Cdd:cd23974  164 IFLpdhdrDYLLVKAALT------HTPIDRGRdksKRPSkyfgkdvtaeKFKIYHPDFIRYLRNRFLWSPILNTKQRDIY 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 239937471 298 IPTLGSVAVTMALHGCDEVAVAGFgydmNTPNAPL---HYYETVRMAAIKESwTHNIQREKEFLRKLVKARVIT 368
Cdd:cd23974  238 RPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 156-340 1.10e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 75.67  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 229
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 230 FKWQDFKWLKYIVYKervsasdgfwksVATRVPKEPPEIRIlnpYFIQEAAFTLIGLPFNN----GLMGRGNIPTLGSVA 305
Cdd:cd23977   81 PERNMDRDGGGKTYR------------ALLTLAKMYPHLQV---YTLTEEKMAYCDGVFQNetgkNRMKSGSFLSTGWFT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 239937471 306 VTMALHGCDEVAVAG-----FGYDMNTPNAPLHYYETVRM 340
Cdd:cd23977  146 MILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 145-361 2.45e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 75.36  E-value: 2.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 145 YRLTPALDSL---HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI--------------- 206
Cdd:cd23987   50 YELLPRTSPLknkHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTmnpsvvqrafedlvn 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 207 -TYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNP---YFIQea 279
Cdd:cd23987  130 eTWKEKFLQRLQSLNGSILWIpafMAKGGEERVEWVNDLILKHHINVRTAY------------PSLRLLHAvrgYWLT-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 280 aftliglpfNNGLMGRgniPTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKE 356
Cdd:cd23987  196 ---------NKVHIKR---PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263


                 ....*
gi 239937471 357 FLRKL 361
Cdd:cd23987  264 ALKNL 268
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 155-361 2.56e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 75.13  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 155 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPE-QYERDSLF---VL--- 227
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLYnegILivw 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 228 --AGFKWQDFKWLKYIVYK--ERvsasdgfWKSVATRVPKEPpeIRILNPYF-------IQEAAFTLIGL-PFNNGLMGr 295
Cdd:cd23985  123 dpAPYHSDIPEWYKNPDYNffEN-------YKTYRRLNPNQP--FYILHPQMqwelwdiIQENSPEEIQPnPPSSGMLG- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 296 gniptlgsVAVTMALhgCDEVAVAGFgydmnTPNAP----LHYYETVRMAAIKESWTHNIQREKEFLRKL 361
Cdd:cd23985  193 --------IILMMTL--CDQVDVYEF-----LPSKRktdvCHYYQKFFDRACTMGAYHPLLYEKNLVKHL 247
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 148-361 4.69e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 74.37  E-value: 4.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 148 TPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE------GAMQRPEQYER 221
Cdd:cd23969   56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 222 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafTLIGLPF 288
Cdd:cd23969  136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKTAY------------PPLRLNH---------AIRGYWL 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 239937471 289 NNGLmgRGNIPTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 361
Cdd:cd23969  195 TTKF--RIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 145-367 9.82e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 73.58  E-value: 9.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 145 YRLTPA---LDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLrITYPEGAMQRpeQYER 221
Cdd:cd23970   54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-TTFNPSILEK--YYNN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 222 dsLFVLagfkwQDFKwlkyiVYKERVSASDG--FWKSVATRvPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGN-- 297
Cdd:cd23970  131 --LLTI-----QDRN-----NFFLSLKKLDGaiLWIPAFFF-HTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNry 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 298 ----------IPTlGSVAVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYETVRMA-AIKESWTHNIQREKEFLRKLVK 363
Cdd:cd23970  198 wktkhlspkrLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKGTKfTTKWQESHQLPAEFVLLYKMHG 276


                 ....
gi 239937471 364 ARVI 367
Cdd:cd23970  277 AGVL 280
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 124-363 1.31e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 73.33  E-value: 1.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 124 PPFGIKGQDNLIKAIlsvtkeyrltpALDSLHC---RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGS 200
Cdd:cd23986   25 APFSALGWEKYVPKI-----------PLSKLHLrgfRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGN 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 201 KTTLRITYPEGAMQRPEQYERDSLF---VL-----AGFKWQDFKWLK---------YIVYKErvsasdgfwksvatRVPK 263
Cdd:cd23986   94 KTTIRIINSQILTNPNHHFIDSSLYkdvILvawdpAPYSANLHKWYKkpdynlftpYVQYRK--------------RNPN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 264 EPpeIRILNPYF-------IQEaaftliglpfNNGLMGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMNTPNAPL-HYY 335
Cdd:cd23986  160 QP--FYILHPKFiwqlwdiIQE----------NTQEKIQPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYH 225

                        250       260
                 ....*....|....*....|....*...
gi 239937471 336 ETVRMAAIKESWTHNIQREKEFLRKLVK 363
Cdd:cd23986  226 ERYYDAACTLGAYHPLLYEKLLIQRMNK 253
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 154-336 9.45e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 67.20  E-value: 9.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 154 LHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITyPEGAMQR--PEQYE-----RDSLFV 226
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRilRNRNEllnvsQGTVFI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 227 LAG---FKWQDFKWLKY----------------IVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLiglp 287
Cdd:cd23976   92 FWGpsnYMRRDGKGLVYnnlqlmnqilpklkvyTITRHKMLQFDELFK-------RETGKDRKISNTWLSTGWFTM---- 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 239937471 288 fnnglmgrgniptlgsvavTMALHGCDEVAVAG-----FGYDMNTPNAPLHYYE 336
Cdd:cd23976  161 -------------------IIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 158-339 6.53e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 65.36  E-value: 6.53e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 158 RCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKgFERDVGSKTTL--------RITYPEGAMQRPEQYER-----DSL 224
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNLKKRRRPFVERmkvygNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 225 FVLAGFKW--------------QDFKWLKYIVY--KERVSASDGFWKSVATRvpkeppEIRIlnpyfiqeaaftliglpf 288
Cdd:cd23971  145 LLLPAFSYtsntepslralytlEDFGSPQKVLFfnPEYLRNLSRYWKSKGLK------ARRL------------------ 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 239937471 289 NNGLMgrgniptlgsvAVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYETVR 339
Cdd:cd23971  201 STGLM-----------LVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNVL 243
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 145-361 7.85e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.98  E-value: 7.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 145 YRLTPALDSLHCRR---CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE------GAMQR 215
Cdd:cd23988   50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 216 PEQYER---------DSLFVLAGFK----WQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafT 282
Cdd:cd23988  130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKLKVRTAY------------PSLRLIH---------A 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 283 LIGLPFNNGLmgrgNI--PTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEF 357
Cdd:cd23988  189 VRGYWLTNKV----NIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKT 264


                 ....
gi 239937471 358 LRKL 361
Cdd:cd23988  265 LNVL 268
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 156-339 7.08e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.49  E-value: 7.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLag 229
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVI-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 230 fkWQDFKWLK-----------------------YIVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLIgl 286
Cdd:cd23975   79 --WGPFRNMRkdgkgivynmlkkavesypqakiYVTTEKRMSYCDTVFK-------KETGKDRVQSGSYLSTGWFTLI-- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 239937471 287 pfnnglmgrgniptlgsvavtMALHGCDEVAVAGFGYDMNTPN-----APLHYYETVR 339
Cdd:cd23975  148 ---------------------LAMDACYGIHVYGMINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 157-338 1.58e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 61.31  E-value: 1.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKG-FERDVGSKTTL--------RITYPEGAMQRPEQYER-----D 222
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLvtanpsiiSIKYAKLNERRKPFLETvsvygD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 223 SLFVLAGFKW--------------QDFKW-LKYIVYKERVSASDG-FWKSVATRVPKeppeirilnpyfiqeaaftligl 286
Cdd:cd23991  145 AFLLLPAFSYrsntalsfkvyytlEDFKAkQKVIFFHPIYLKHLAqFWRSKGVQVYR----------------------- 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 239937471 287 pFNNGLMgrgniptlgsvAVTMALHGCDEVAVAGF-GYDMNTPNAPL--HYYETV 338
Cdd:cd23991  202 -LSTGLM-----------ITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ 244
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 156-206 2.09e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 2.09e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 239937471 156 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI 206
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 157-339 7.91e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 56.00  E-value: 7.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTLRITYPEGAMQRPEQYErdslfvlagfKWQDF 235
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLE----------KWRRP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 236 KWLKYIVYKERVSASDGFWKS----VATRVP------KEPPEIRILNP-YFIQEAAFTLiglpfNNGLmgRGNIPTLGSV 304
Cdd:cd23990  135 FYEVLQVYENASVVLPAFYNTrntdVSIRVKyvlddfESQQAVYYFHPqYLLNVSRFWL-----RQGV--RAKRISSGLM 207

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 239937471 305 AVTMALHGCDEVAVAGF-GYDMNTPNAPL--HYYETVR 339
Cdd:cd23990  208 LVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNVK 245
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 157-338 1.27e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 55.61  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 157 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTLRITYPEGAMQRPEQ--YERDSLfvLAGFKWQ 233
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNllWSRKSF--VESMKVY 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 239937471 234 DFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEaaftlIGLPFNNGLMGRGNIPTlGSVAVTMALHGC 313
Cdd:cd23989  142 GRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRN-----VGKFWKSKGVHAKRLST-GLFLVSAALGLC 215

                        170       180
                 ....*....|....*....|....*...
gi 239937471 314 DEVAVAGF-GYDMNTPNAPL--HYYETV 338
Cdd:cd23989  216 EEVTIYGFwPFSVDLDERTIshHYYDNV 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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