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Conserved domains on  [gi|242332536|ref|NP_001156383|]
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zinc finger protein 782 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.15e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.15e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 242332536    4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-471 1.21e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 178 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 254
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 255 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 312
Cdd:COG5048  103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 313 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 392
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 393 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 457
Cdd:COG5048  261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                        330
                 ....*....|....
gi 242332536 458 NHVRIHTGQKPFKC 471
Cdd:COG5048  341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-171 4.82e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|....*
gi 242332536  147 HLKRHERYHTGEQPFTCNECDKVFS 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.15e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.15e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 242332536    4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 4.03e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.03e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 242332536   4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-45 1.19e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.78  E-value: 1.19e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 242332536     4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIGF 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-471 1.21e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 178 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 254
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 255 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 312
Cdd:COG5048  103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 313 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 392
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 393 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 457
Cdd:COG5048  261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                        330
                 ....*....|....
gi 242332536 458 NHVRIHTGQKPFKC 471
Cdd:COG5048  341 RHILLHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 242332536  371 SLQRHIRIHTGEKPYKCNQCDKAFSQ 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-171 4.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|....*
gi 242332536  147 HLKRHERYHTGEQPFTCNECDKVFS 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.15e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.15e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 242332536    4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 4.03e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 4.03e-17
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 242332536   4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-45 1.19e-16

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 73.78  E-value: 1.19e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 242332536     4 VTYEDLHVNFTQEEWALLDPSQKKLYKHVMLETYRNLNAIGF 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-471 1.21e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 1.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 178 THISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKC--DQCDKAFSEKCNLQTHIRIHSGEKPYKC-DQCDKTF 254
Cdd:COG5048   23 TLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 255 SEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQC----------------------DKAFSQ 312
Cdd:COG5048  103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSS 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 313 YGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKTHRRTHTGEKPYKCNQCdkAFSEKCSLQRHIRIHTGEKPYKCNQCDK 392
Cdd:COG5048  183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASES 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 393 AFSQYSTLQTHRRTHTG---------EKPYKCNQCDKAFSQYSNLQTHRRT--HTGE--KPYKC--NQCDKAFSMKCNLQ 457
Cdd:COG5048  261 PRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                        330
                 ....*....|....
gi 242332536 458 NHVRIHTGQKPFKC 471
Cdd:COG5048  341 RHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-473 1.55e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 1.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 123 HKRTQTGQKPYEC--KQCGKGFAKPSHLKRHERYHTGEQPFTCN---------------------------ECDKVFSFK 173
Cdd:COG5048   52 HIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsssssnsndnnlLSSHSLPPS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 174 HHLQTHISIRTGEKPFKCNLCDKSFSKHNHLQSHRRTHTGEKPYKCDQCDKAFSekcnLQTHIRIHSGEKPYKCDQCDKT 253
Cdd:COG5048  132 SRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLS----LLISSNVSTSIPSSSENSPLSS 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 254 FSEKCHLQKHIRIHTGEKPYKCNQCDKAF-------SQYNTLKTHRRTHTGEKPYKCNQcDKAFSQYGHLQTHRRTHTG- 325
Cdd:COG5048  208 SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSLP-TASSQSSSPNESDSSSEKGf 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 326 EKPYKCNQCDKAFSQYNTLKTHRRT--HTGE--KPYKC--NQCDKAFSEKCSLQRHIRIHTGEKPYKC--NQCDKAFSQY 397
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPL 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 398 ST-----LQTHRRTHTGEKPYKC--NQCDKAFSQYSNLQTHRRTHTGEKP--YKCNQCDKAFSMKCNLQNHVRIHTGQKP 468
Cdd:COG5048  367 LNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446


                 ....*
gi 242332536 469 FKCNQ 473
Cdd:COG5048  447 LLCSI 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-452 2.53e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 192 NLCDKSFSKHNHLQSHRRTHTGEKPYKCDQCDKAFSEKCNLQTHIRIHSGEKPYKCDQCdkTFSEKCHLQKHIRIHTGEK 271
Cdd:COG5048  174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 272 PYKCNQCDKAFSQYNTLKTHRRTHTG---------EKPYKCNQCDKAFSQYGHLQTHRRT--HTGE--KPYKC--NQCDK 336
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNEsdsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 337 AFSQYNTLKTHRRTHTGEKPYKC--NQCDKAFS-----EKCSLQRHIRIHTGEKPYKC--NQCDKAFSQYSTLQTHRRTH 407
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 242332536 408 TGEKP--YKCNQCDKAFSQYSNLQTHRRTHTGEKPYKCNQCDKAFSM 452
Cdd:COG5048  412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 269-352 2.37e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 2.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 269 GEKPYKCN--QCDKAFSQYNTLKTHRrthtgekpyKCNQCDKAFSQYGHLQTHRRTHTGEKPYKCNQCDKAFSQYNTLKT 346
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 242332536 347 HRRTHT 352
Cdd:COG5189  417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 213-296 1.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 213 GEKPYKCD--QCDKAFSEKCNLQTHiRIHSgekpykcdQCDKTFSEKCHLQKHIRIHTGEKPYKCNQCDKAFSQYNTLKT 290
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 242332536 291 HRRTHT 296
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
371-396 1.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 242332536  371 SLQRHIRIHTGEKPYKCNQCDKAFSQ 396
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
259-284 2.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 242332536  259 HLQKHIRIHTGEKPYKCNQCDKAFSQ 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
203-227 4.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.61e-04
                          10        20
                  ....*....|....*....|....*
gi 242332536  203 HLQSHRRTHTGEKPYKCDQCDKAFS 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-340 5.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.14e-04
                          10        20
                  ....*....|....*....|....*.
gi 242332536  315 HLQTHRRTHTGEKPYKCNQCDKAFSQ 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-451 7.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.46e-04
                          10        20
                  ....*....|....*....|....*
gi 242332536  427 NLQTHRRTHTGEKPYKCNQCDKAFS 451
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-255 8.31e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.31e-04
                          10        20
                  ....*....|....*....|....*
gi 242332536  231 NLQTHIRIHSGEKPYKCDQCDKTFS 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-312 9.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.26e-04
                          10        20
                  ....*....|....*....|....*
gi 242332536  288 LKTHRRTHTGEKPYKCNQCDKAFSQ 312
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
400-424 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*
gi 242332536  400 LQTHRRTHTGEKPYKCNQCDKAFSQ 424
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
344-367 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....
gi 242332536  344 LKTHRRTHTGEKPYKCNQCDKAFS 367
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
147-171 4.82e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.82e-03
                          10        20
                  ....*....|....*....|....*
gi 242332536  147 HLKRHERYHTGEQPFTCNECDKVFS 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
357-381 7.98e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 33.68  E-value: 7.98e-03
                          10        20
                  ....*....|....*....|....*
gi 242332536  357 YKCNQCDKAFSEKCSLQRHIRIHTG 381
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 353-436 8.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 8.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242332536 353 GEKPYKCN--QCDKAFSEKCSLQRHiRIHtgekpykcNQCDKAFSQYSTLQTHRRTHTGEKPYKCNQCDKAFSQYSNLQT 430
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 242332536 431 HRRTHT 436
Cdd:COG5189  417 HRKHSH 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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