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Concise Results
Standard Results
Full Results
urocanate hydratase isoform 2 [Homo sapiens]
Protein Classification
HutU family protein ( domain architecture ID 10006832 )
HutU family protein
List of domain hits
Name
Accession
Description
Interval
E-value
HutU
COG2987 Urocanate hydratase [Amino acid transport and metabolism];
68-729
0e+00
Urocanate hydratase [Amino acid transport and metabolism];
Pssm-ID: 442226 [Multi-domain]
Cd Length: 567
Bit Score: 856.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 68 LQL YG H IY M YRF C P DI E M RA Y P IEQY P CQTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGG N G QVFS NWAQ FW L TMF YL SK 147
Cdd:COG2987 1 MTT YG R IY G YRF R P ER E I RA P P GTEL P AKGWQQE A ALR M L MNNLDP E VA EH P E ELV V YGG T G RAAR NWAQ YD L IVK YL KE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 148 MTEEQ TL VMY SG H P L G L F PSSRS APR LV I T N GMVI PN YSSRTEY E K L F ALG V TMYGQMTAGS YC YIGPQGIV H GT VL T VL 227
Cdd:COG2987 81 LEDDE TL LVQ SG K P V G V F RTHPD APR VL I A N SNLV PN WANWEDF E E L E ALG L TMYGQMTAGS WI YIGPQGIV Q GT YE T FA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 228 NAAR RYL G i E DLAGK V F V T S GLGGM S GAQ AK AA VIV G CI G V IAEVD KAAL EKR HR QG W L M EV T D S LD rciqrlrvlqlgl 307
Cdd:COG2987 161 NAAR KHF G - G DLAGK L F L T A GLGGM G GAQ PL AA TMA G GV G L IAEVD PSRI EKR LE QG Y L D EV A D D LD ------------- 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 308 q Q AL GW A glpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcps R EA RK KKE V LS L G YH GN VVALWER LV H 387
Cdd:COG2987 227 - E AL AR A ---------------------------------------------- K EA KA KKE P LS I G LL GN AADVLPE LV R 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 388 E ldttg ECLV DL GS DQTS C H N P F NG g Y Y P VQ LSF T EA QS L M A SN P AV FK D LV Q ES LR R Q V S A INRLAEEKFF F W DYGN AF 467
Cdd:COG2987 260 R ----- GIVP DL VT DQTS A H D P L NG - Y L P AG LSF E EA NE L R A ED P EE FK E LV K ES MA R H V E A MLEFQARGAY F F DYGN NI 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 468 LL EA QR AG AD vekkgagr TE F RY P SY V QHIMGDI F SQ G F GPFRWV CT SGDP Q D LAV TDE L A TSVLE eaiadgvkvsvkl Q 547
Cdd:COG2987 334 RQ EA YD AG VK -------- DA F DF P GF V PAYIRPL F CY G K GPFRWV AL SGDP E D IYK TDE A A LELFP ------------- Q 392
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 548 YM D NI RWIR E A ARHR L VV G SQ ARI LYSDQKG R VA IA V A I N QAIACRRI KAP V V LS RDH H DV SGTD SP F RET S N IY DGS AF 627
Cdd:COG2987 393 DR D LH RWIR M A RENV L FQ G LP ARI CWLGYGE R AK IA L A F N EMVRKGEL KAP I V IG RDH L DV GSVA SP N RET E N MK DGS DA 472
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 628 C AD MAVQ N FV G DAC RGATWV A LH N GGGVG W G EV I NG GF GL V L DG TP EA EG R ARLM L SW D VSN GVAR RCWS G NQK A Y E iic 707
Cdd:COG2987 473 V AD WPLL N AL G NTA RGATWV S LH H GGGVG I G YS I HA GF VI V A DG SE EA DE R LKRV L TN D PGM GVAR HADA G YEE A I E --- 549
650 660
....*....|....*....|..
gi 260306182 708 q T MQ E NS tlv VTLP HK V E DE RV 729
Cdd:COG2987 550 - T AK E RG --- VTLP ML V D DE LL 567
Name
Accession
Description
Interval
E-value
HutU
COG2987 Urocanate hydratase [Amino acid transport and metabolism];
68-729
0e+00
Urocanate hydratase [Amino acid transport and metabolism];
Pssm-ID: 442226 [Multi-domain]
Cd Length: 567
Bit Score: 856.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 68 LQL YG H IY M YRF C P DI E M RA Y P IEQY P CQTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGG N G QVFS NWAQ FW L TMF YL SK 147
Cdd:COG2987 1 MTT YG R IY G YRF R P ER E I RA P P GTEL P AKGWQQE A ALR M L MNNLDP E VA EH P E ELV V YGG T G RAAR NWAQ YD L IVK YL KE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 148 MTEEQ TL VMY SG H P L G L F PSSRS APR LV I T N GMVI PN YSSRTEY E K L F ALG V TMYGQMTAGS YC YIGPQGIV H GT VL T VL 227
Cdd:COG2987 81 LEDDE TL LVQ SG K P V G V F RTHPD APR VL I A N SNLV PN WANWEDF E E L E ALG L TMYGQMTAGS WI YIGPQGIV Q GT YE T FA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 228 NAAR RYL G i E DLAGK V F V T S GLGGM S GAQ AK AA VIV G CI G V IAEVD KAAL EKR HR QG W L M EV T D S LD rciqrlrvlqlgl 307
Cdd:COG2987 161 NAAR KHF G - G DLAGK L F L T A GLGGM G GAQ PL AA TMA G GV G L IAEVD PSRI EKR LE QG Y L D EV A D D LD ------------- 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 308 q Q AL GW A glpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcps R EA RK KKE V LS L G YH GN VVALWER LV H 387
Cdd:COG2987 227 - E AL AR A ---------------------------------------------- K EA KA KKE P LS I G LL GN AADVLPE LV R 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 388 E ldttg ECLV DL GS DQTS C H N P F NG g Y Y P VQ LSF T EA QS L M A SN P AV FK D LV Q ES LR R Q V S A INRLAEEKFF F W DYGN AF 467
Cdd:COG2987 260 R ----- GIVP DL VT DQTS A H D P L NG - Y L P AG LSF E EA NE L R A ED P EE FK E LV K ES MA R H V E A MLEFQARGAY F F DYGN NI 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 468 LL EA QR AG AD vekkgagr TE F RY P SY V QHIMGDI F SQ G F GPFRWV CT SGDP Q D LAV TDE L A TSVLE eaiadgvkvsvkl Q 547
Cdd:COG2987 334 RQ EA YD AG VK -------- DA F DF P GF V PAYIRPL F CY G K GPFRWV AL SGDP E D IYK TDE A A LELFP ------------- Q 392
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 548 YM D NI RWIR E A ARHR L VV G SQ ARI LYSDQKG R VA IA V A I N QAIACRRI KAP V V LS RDH H DV SGTD SP F RET S N IY DGS AF 627
Cdd:COG2987 393 DR D LH RWIR M A RENV L FQ G LP ARI CWLGYGE R AK IA L A F N EMVRKGEL KAP I V IG RDH L DV GSVA SP N RET E N MK DGS DA 472
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 628 C AD MAVQ N FV G DAC RGATWV A LH N GGGVG W G EV I NG GF GL V L DG TP EA EG R ARLM L SW D VSN GVAR RCWS G NQK A Y E iic 707
Cdd:COG2987 473 V AD WPLL N AL G NTA RGATWV S LH H GGGVG I G YS I HA GF VI V A DG SE EA DE R LKRV L TN D PGM GVAR HADA G YEE A I E --- 549
650 660
....*....|....*....|..
gi 260306182 708 q T MQ E NS tlv VTLP HK V E DE RV 729
Cdd:COG2987 550 - T AK E RG --- VTLP ML V D DE LL 567
PRK05414
PRK05414 urocanate hydratase; Provisional
74-722
0e+00
urocanate hydratase; Provisional
Pssm-ID: 235448 [Multi-domain]
Cd Length: 556
Bit Score: 764.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 74 IY M YRF C P DI E M RA YPIEQYPCQTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGG N G QVFS NW AQFWLTMFY L SKMTEEQ T 153
Cdd:PRK05414 1 IY G YRF R P ER E I RA PRGTELTAKGWLQE A ALR M L MNNLDP E VA ER P E ELV V YGG I G RAAR NW ECYDAIVKT L KELEDDE T 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 154 L VMY SG H P L G L F PSSRS APR LV I T N GMVI P NYSSRTEYEK L F A L G V TMYGQMTAGS YC YIG P QGIV H GT VL T VLN AAR RY 233
Cdd:PRK05414 81 L LVQ SG K P V G V F KTHPD APR VL I A N SNLV P HWANWEHFNE L E A K G L TMYGQMTAGS WI YIG S QGIV Q GT YE T FAE AAR QH 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 234 L G i E DLAG KVFV T S GLGGM S GAQ AK AA VIV G CIGVIA EVD KAALE KR H R Q G W L M E VT D S LD rciqrlrvlqlglq Q AL GW 313
Cdd:PRK05414 161 F G - G DLAG RLVL T A GLGGM G GAQ PL AA TMA G AVCLAV EVD ESRID KR L R T G Y L D E KA D D LD -------------- E AL AL 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 314 A glpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcps R EA RKKK E V LS L G YH GN VVALWER LV HE ldttg 393
Cdd:PRK05414 226 A ---------------------------------------------- E EA KAAG E P LS I G LL GN AADVLPE LV RR ----- 254
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 394 ECLV DL GS DQTS C H N P F NG g Y Y PV QLSFT EA QS L M A SN P AV F KDLVQE S LR R Q V S A INRLAEEKFFFW DYGN AFLLE A QR 473
Cdd:PRK05414 255 GIRP DL VT DQTS A H D P L NG - Y L PV GWTLE EA AE L R A ED P EE F VKAAKA S MA R H V E A MLAFQARGAYVF DYGN NIRQM A FD 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 474 AG AD vekkgagr TE F RY P SY V QHIMGDI F SQ G F GPFRWV CT SGDP Q D LAV TD ELATSVLE eaiadgvkvsvkl QYMDNI R 553
Cdd:PRK05414 334 AG VE -------- NA F DF P GF V PAYIRPL F CE G K GPFRWV AL SGDP E D IYK TD AAVKELFP ------------- DDEHLH R 392
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 554 WI RE A ARHR L VV G SQ ARI LYSDQKG R VAIAV A I N QAIACRRI KAP V V LS RDH H D VSGTD SP F RET SNIY DGS AFC AD MAV 633
Cdd:PRK05414 393 WI DM A RERI L FQ G LP ARI CWLGYGE R ARLGL A F N EMVRNGEL KAP I V IG RDH L D SGSVA SP N RET EAMK DGS DAV AD WPL 472
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 634 Q N FVGDACR GATWV A LH N GGGVG W G EV I NG GF GL V L DGT P EA EG R ARLM L SW D VSN GV A R RCWS G nqka YEI ICQ T MQ E N 713
Cdd:PRK05414 473 L N ALLNTAS GATWV S LH H GGGVG M G YS I HA GF VI V A DGT E EA AE R LERV L TN D PAT GV M R HADA G ---- YEI AIE T AK E K 548
....*....
gi 260306182 714 S tlv V TLP H 722
Cdd:PRK05414 549 G --- I TLP M 554
hutU
TIGR01228 urocanate hydratase; This model represents the second of four enzymes involved in the ...
102-706
3.15e-123
urocanate hydratase; This model represents the second of four enzymes involved in the degradation of histidine to glutamate. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130295
Cd Length: 545
Bit Score: 379.18
E-value: 3.15e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 102 A IMH M I MNNLDP A VA QF P QE LV T YGG N G QVFS NW AQ F WLTMFY L SKMTEEQ TL VMY SG H P L G L F PSSRS APR LV I T N GMV 181
Cdd:TIGR01228 20 A ALR M L MNNLDP E VA ED P EN LV V YGG I G KAAR NW EA F DKIVET L KRLENDE TL LVQ SG K P V G V F KTHEN APR VL I A N SNL 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 182 I P NYSSRTEYEK L F A L G VT MYGQMTAGS YC YIG P QGI VH GT VL T VLNA AR RYL G i ED L A GK VFV T S GLGGM S GAQ AK A AV 261
Cdd:TIGR01228 100 V P HWADWEHFHE L E A K G LM MYGQMTAGS WI YIG T QGI LQ GT YE T FAEL AR QHF G - GS L K GK WVL T A GLGGM G GAQ PL A VT 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 262 IV G CIGVIA EVD KAALE KR HRQGWLM E V TDSLD rciqrlrvlqlglq Q AL GW A GLPA A L G lcvlscfvnlaplgegrcla 341
Cdd:TIGR01228 179 MN G GVSIAV EVD ESRID KR LETKYCD E Q TDSLD -------------- E AL AR A EEAK A E G -------------------- 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 342 psgfsrpllgapvlllcpsrearkkk EVL S L G YH GN VVALWER L V h ELDTT gecl V D LGS DQTS C H N P F NG g Y Y P VQLSF 421
Cdd:TIGR01228 225 -------------------------- KPI S I G LL GN AAEVLPE L L - KRGVV ---- P D VVT DQTS A H D P L NG - Y I P EGYTV 272
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 422 TE A QS L MASN P AVFKDLVQE S LRRQ V S A INRLAEEKFFFW DYGN AFLLE A QRA G A dvekkgag RTE F RY P SY V QHIMGDI 501
Cdd:TIGR01228 273 ED A DK L RQEE P EAYVKAAKQ S MAKH V R A MLAFQKQGSVTF DYGN NIRQV A KEE G V -------- EDA F DF P GF V PAYIRPL 344
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 502 F SQ G F GPFRWV CT SGDP Q D LAV TD ELATSVLE E aiadgvkv SVK L Q ymdni RWI RE A ARHRLVV G SQ ARI LYSDQKG R VA 581
Cdd:TIGR01228 345 F CR G K GPFRWV AL SGDP A D IYR TD AAVKELFP E -------- DAH L H ----- RWI DM A QERVSFQ G LP ARI CWLGYGE R AK 411
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 582 IAV AIN QAIACRRI KAPVV LS RDH H D VSGTD SP F RET SNIY DGS AFCA D MAVQ N FVGDACR GATWV AL H N GGGVG W G EVI 661
Cdd:TIGR01228 412 LGL AIN EMVRSGEL KAPVV IG RDH L D AGSVA SP N RET EAMK DGS DAVS D WPLL N ALLNTAA GATWV SF H H GGGVG M G FSL 491
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 260306182 662 NG G FGL V L DGT P EA EG R ARLM L SW D VSN GV A R RCWS G NQK A YEII 706
Cdd:TIGR01228 492 HA G MVI V A DGT D EA AE R IARV L TN D PGM GV I R HADA G YEI A IDVA 536
Urocanase_C
pfam17392 Urocanase C-terminal domain;
500-708
8.58e-120
Urocanase C-terminal domain;
Pssm-ID: 465414 [Multi-domain]
Cd Length: 196
Bit Score: 357.19
E-value: 8.58e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 500 DI F SQ GFGPFRWV CT SGDP Q D LAV TDE L A TSVLE eaiadgvkvsvkl Q YM D N IRWI RE A ARHR L VV G SQ ARI L Y SDQKG R 579
Cdd:pfam17392 1 PL F CE GFGPFRWV AL SGDP E D IYR TDE A A LELFP ------------- Q DE D L IRWI KL A RENV L FQ G LP ARI C Y LGYGE R 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 580 VA IA V A I N QAIACRR I K AP V V LS RDH H DV SGTD SPFRET S N IY DGS AFC AD MAVQ N FV G D A C RGATWV A LHNGGGVG W G E 659
Cdd:pfam17392 68 AK IA L A F N ELVREGE I S AP I V IG RDH L DV GSVA SPFRET E N MK DGS DAI AD WPLL N AL G N A A RGATWV S LHNGGGVG I G Y 147
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 260306182 660 V I NG GFG L V L DGT P EA EG R A R LM L S WD VS NGVAR RCWS G NQK A YEIICQ 708
Cdd:pfam17392 148 S I HA GFG M V A DGT E EA DE R L R RV L T WD PG NGVAR HADA G YEE A IDVARR 196
Name
Accession
Description
Interval
E-value
HutU
COG2987 Urocanate hydratase [Amino acid transport and metabolism];
68-729
0e+00
Urocanate hydratase [Amino acid transport and metabolism];
Pssm-ID: 442226 [Multi-domain]
Cd Length: 567
Bit Score: 856.32
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 68 LQL YG H IY M YRF C P DI E M RA Y P IEQY P CQTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGG N G QVFS NWAQ FW L TMF YL SK 147
Cdd:COG2987 1 MTT YG R IY G YRF R P ER E I RA P P GTEL P AKGWQQE A ALR M L MNNLDP E VA EH P E ELV V YGG T G RAAR NWAQ YD L IVK YL KE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 148 MTEEQ TL VMY SG H P L G L F PSSRS APR LV I T N GMVI PN YSSRTEY E K L F ALG V TMYGQMTAGS YC YIGPQGIV H GT VL T VL 227
Cdd:COG2987 81 LEDDE TL LVQ SG K P V G V F RTHPD APR VL I A N SNLV PN WANWEDF E E L E ALG L TMYGQMTAGS WI YIGPQGIV Q GT YE T FA 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 228 NAAR RYL G i E DLAGK V F V T S GLGGM S GAQ AK AA VIV G CI G V IAEVD KAAL EKR HR QG W L M EV T D S LD rciqrlrvlqlgl 307
Cdd:COG2987 161 NAAR KHF G - G DLAGK L F L T A GLGGM G GAQ PL AA TMA G GV G L IAEVD PSRI EKR LE QG Y L D EV A D D LD ------------- 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 308 q Q AL GW A glpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcps R EA RK KKE V LS L G YH GN VVALWER LV H 387
Cdd:COG2987 227 - E AL AR A ---------------------------------------------- K EA KA KKE P LS I G LL GN AADVLPE LV R 259
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 388 E ldttg ECLV DL GS DQTS C H N P F NG g Y Y P VQ LSF T EA QS L M A SN P AV FK D LV Q ES LR R Q V S A INRLAEEKFF F W DYGN AF 467
Cdd:COG2987 260 R ----- GIVP DL VT DQTS A H D P L NG - Y L P AG LSF E EA NE L R A ED P EE FK E LV K ES MA R H V E A MLEFQARGAY F F DYGN NI 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 468 LL EA QR AG AD vekkgagr TE F RY P SY V QHIMGDI F SQ G F GPFRWV CT SGDP Q D LAV TDE L A TSVLE eaiadgvkvsvkl Q 547
Cdd:COG2987 334 RQ EA YD AG VK -------- DA F DF P GF V PAYIRPL F CY G K GPFRWV AL SGDP E D IYK TDE A A LELFP ------------- Q 392
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 548 YM D NI RWIR E A ARHR L VV G SQ ARI LYSDQKG R VA IA V A I N QAIACRRI KAP V V LS RDH H DV SGTD SP F RET S N IY DGS AF 627
Cdd:COG2987 393 DR D LH RWIR M A RENV L FQ G LP ARI CWLGYGE R AK IA L A F N EMVRKGEL KAP I V IG RDH L DV GSVA SP N RET E N MK DGS DA 472
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 628 C AD MAVQ N FV G DAC RGATWV A LH N GGGVG W G EV I NG GF GL V L DG TP EA EG R ARLM L SW D VSN GVAR RCWS G NQK A Y E iic 707
Cdd:COG2987 473 V AD WPLL N AL G NTA RGATWV S LH H GGGVG I G YS I HA GF VI V A DG SE EA DE R LKRV L TN D PGM GVAR HADA G YEE A I E --- 549
650 660
....*....|....*....|..
gi 260306182 708 q T MQ E NS tlv VTLP HK V E DE RV 729
Cdd:COG2987 550 - T AK E RG --- VTLP ML V D DE LL 567
PRK05414
PRK05414 urocanate hydratase; Provisional
74-722
0e+00
urocanate hydratase; Provisional
Pssm-ID: 235448 [Multi-domain]
Cd Length: 556
Bit Score: 764.68
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 74 IY M YRF C P DI E M RA YPIEQYPCQTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGG N G QVFS NW AQFWLTMFY L SKMTEEQ T 153
Cdd:PRK05414 1 IY G YRF R P ER E I RA PRGTELTAKGWLQE A ALR M L MNNLDP E VA ER P E ELV V YGG I G RAAR NW ECYDAIVKT L KELEDDE T 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 154 L VMY SG H P L G L F PSSRS APR LV I T N GMVI P NYSSRTEYEK L F A L G V TMYGQMTAGS YC YIG P QGIV H GT VL T VLN AAR RY 233
Cdd:PRK05414 81 L LVQ SG K P V G V F KTHPD APR VL I A N SNLV P HWANWEHFNE L E A K G L TMYGQMTAGS WI YIG S QGIV Q GT YE T FAE AAR QH 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 234 L G i E DLAG KVFV T S GLGGM S GAQ AK AA VIV G CIGVIA EVD KAALE KR H R Q G W L M E VT D S LD rciqrlrvlqlglq Q AL GW 313
Cdd:PRK05414 161 F G - G DLAG RLVL T A GLGGM G GAQ PL AA TMA G AVCLAV EVD ESRID KR L R T G Y L D E KA D D LD -------------- E AL AL 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 314 A glpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcps R EA RKKK E V LS L G YH GN VVALWER LV HE ldttg 393
Cdd:PRK05414 226 A ---------------------------------------------- E EA KAAG E P LS I G LL GN AADVLPE LV RR ----- 254
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 394 ECLV DL GS DQTS C H N P F NG g Y Y PV QLSFT EA QS L M A SN P AV F KDLVQE S LR R Q V S A INRLAEEKFFFW DYGN AFLLE A QR 473
Cdd:PRK05414 255 GIRP DL VT DQTS A H D P L NG - Y L PV GWTLE EA AE L R A ED P EE F VKAAKA S MA R H V E A MLAFQARGAYVF DYGN NIRQM A FD 333
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 474 AG AD vekkgagr TE F RY P SY V QHIMGDI F SQ G F GPFRWV CT SGDP Q D LAV TD ELATSVLE eaiadgvkvsvkl QYMDNI R 553
Cdd:PRK05414 334 AG VE -------- NA F DF P GF V PAYIRPL F CE G K GPFRWV AL SGDP E D IYK TD AAVKELFP ------------- DDEHLH R 392
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 554 WI RE A ARHR L VV G SQ ARI LYSDQKG R VAIAV A I N QAIACRRI KAP V V LS RDH H D VSGTD SP F RET SNIY DGS AFC AD MAV 633
Cdd:PRK05414 393 WI DM A RERI L FQ G LP ARI CWLGYGE R ARLGL A F N EMVRNGEL KAP I V IG RDH L D SGSVA SP N RET EAMK DGS DAV AD WPL 472
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 634 Q N FVGDACR GATWV A LH N GGGVG W G EV I NG GF GL V L DGT P EA EG R ARLM L SW D VSN GV A R RCWS G nqka YEI ICQ T MQ E N 713
Cdd:PRK05414 473 L N ALLNTAS GATWV S LH H GGGVG M G YS I HA GF VI V A DGT E EA AE R LERV L TN D PAT GV M R HADA G ---- YEI AIE T AK E K 548
....*....
gi 260306182 714 S tlv V TLP H 722
Cdd:PRK05414 549 G --- I TLP M 554
hutU
TIGR01228 urocanate hydratase; This model represents the second of four enzymes involved in the ...
102-706
3.15e-123
urocanate hydratase; This model represents the second of four enzymes involved in the degradation of histidine to glutamate. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130295
Cd Length: 545
Bit Score: 379.18
E-value: 3.15e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 102 A IMH M I MNNLDP A VA QF P QE LV T YGG N G QVFS NW AQ F WLTMFY L SKMTEEQ TL VMY SG H P L G L F PSSRS APR LV I T N GMV 181
Cdd:TIGR01228 20 A ALR M L MNNLDP E VA ED P EN LV V YGG I G KAAR NW EA F DKIVET L KRLENDE TL LVQ SG K P V G V F KTHEN APR VL I A N SNL 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 182 I P NYSSRTEYEK L F A L G VT MYGQMTAGS YC YIG P QGI VH GT VL T VLNA AR RYL G i ED L A GK VFV T S GLGGM S GAQ AK A AV 261
Cdd:TIGR01228 100 V P HWADWEHFHE L E A K G LM MYGQMTAGS WI YIG T QGI LQ GT YE T FAEL AR QHF G - GS L K GK WVL T A GLGGM G GAQ PL A VT 178
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 262 IV G CIGVIA EVD KAALE KR HRQGWLM E V TDSLD rciqrlrvlqlglq Q AL GW A GLPA A L G lcvlscfvnlaplgegrcla 341
Cdd:TIGR01228 179 MN G GVSIAV EVD ESRID KR LETKYCD E Q TDSLD -------------- E AL AR A EEAK A E G -------------------- 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 342 psgfsrpllgapvlllcpsrearkkk EVL S L G YH GN VVALWER L V h ELDTT gecl V D LGS DQTS C H N P F NG g Y Y P VQLSF 421
Cdd:TIGR01228 225 -------------------------- KPI S I G LL GN AAEVLPE L L - KRGVV ---- P D VVT DQTS A H D P L NG - Y I P EGYTV 272
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 422 TE A QS L MASN P AVFKDLVQE S LRRQ V S A INRLAEEKFFFW DYGN AFLLE A QRA G A dvekkgag RTE F RY P SY V QHIMGDI 501
Cdd:TIGR01228 273 ED A DK L RQEE P EAYVKAAKQ S MAKH V R A MLAFQKQGSVTF DYGN NIRQV A KEE G V -------- EDA F DF P GF V PAYIRPL 344
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 502 F SQ G F GPFRWV CT SGDP Q D LAV TD ELATSVLE E aiadgvkv SVK L Q ymdni RWI RE A ARHRLVV G SQ ARI LYSDQKG R VA 581
Cdd:TIGR01228 345 F CR G K GPFRWV AL SGDP A D IYR TD AAVKELFP E -------- DAH L H ----- RWI DM A QERVSFQ G LP ARI CWLGYGE R AK 411
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 582 IAV AIN QAIACRRI KAPVV LS RDH H D VSGTD SP F RET SNIY DGS AFCA D MAVQ N FVGDACR GATWV AL H N GGGVG W G EVI 661
Cdd:TIGR01228 412 LGL AIN EMVRSGEL KAPVV IG RDH L D AGSVA SP N RET EAMK DGS DAVS D WPLL N ALLNTAA GATWV SF H H GGGVG M G FSL 491
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 260306182 662 NG G FGL V L DGT P EA EG R ARLM L SW D VSN GV A R RCWS G NQK A YEII 706
Cdd:TIGR01228 492 HA G MVI V A DGT D EA AE R IARV L TN D PGM GV I R HADA G YEI A IDVA 536
Urocanase_C
pfam17392 Urocanase C-terminal domain;
500-708
8.58e-120
Urocanase C-terminal domain;
Pssm-ID: 465414 [Multi-domain]
Cd Length: 196
Bit Score: 357.19
E-value: 8.58e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 500 DI F SQ GFGPFRWV CT SGDP Q D LAV TDE L A TSVLE eaiadgvkvsvkl Q YM D N IRWI RE A ARHR L VV G SQ ARI L Y SDQKG R 579
Cdd:pfam17392 1 PL F CE GFGPFRWV AL SGDP E D IYR TDE A A LELFP ------------- Q DE D L IRWI KL A RENV L FQ G LP ARI C Y LGYGE R 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 580 VA IA V A I N QAIACRR I K AP V V LS RDH H DV SGTD SPFRET S N IY DGS AFC AD MAVQ N FV G D A C RGATWV A LHNGGGVG W G E 659
Cdd:pfam17392 68 AK IA L A F N ELVREGE I S AP I V IG RDH L DV GSVA SPFRET E N MK DGS DAI AD WPLL N AL G N A A RGATWV S LHNGGGVG I G Y 147
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 260306182 660 V I NG GFG L V L DGT P EA EG R A R LM L S WD VS NGVAR RCWS G NQK A YEIICQ 708
Cdd:pfam17392 148 S I HA GFG M V A DGT E EA DE R L R RV L T WD PG NGVAR HADA G YEE A IDVARR 196
Urocanase
pfam01175 Urocanase Rossmann-like domain;
214-497
1.74e-102
Urocanase Rossmann-like domain;
Pssm-ID: 460098 [Multi-domain]
Cd Length: 209
Bit Score: 312.81
E-value: 1.74e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 214 G P QGIV H GT VL T VLN AAR RYL G i E DLAGK V FVT S GLGGM S GAQ AK AA VIV G CI G VIA EVD KAAL EKR HR QG W L M EV T D S L 293
Cdd:pfam01175 1 G T QGIV Q GT YE T FAA AAR KHF G - G DLAGK L FVT A GLGGM G GAQ PL AA TMA G GV G LVV EVD PSRI EKR LE QG Y L D EV A D D L 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 294 D RCIQ R LR vlqlglqqalgwaglpaalglcvlscfvnlaplgegrclapsgfsrpllgapvlllcpsr EA RKK KE V LS L G 373
Cdd:pfam01175 80 D EALA R AK ------------------------------------------------------------ EA KAE KE P LS I G 99
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 374 YH GN VVALW E R LV HE ldttg ECLV DL GS DQTS C H N P F NG g Y Y P VQ L S F T EA QS L MASN P AVF K D LVQES LR R Q V S A INR L 453
Cdd:pfam01175 100 LL GN AADVL E E LV RR ----- GIIP DL VT DQTS A H D P L NG - Y I P AG L T F E EA NE L RKED P EKY K E LVQES MA R H V E A MLA L 173
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 260306182 454 AEEKFF F W DYGN A F L LEA QR AG A D vekk GA grte F RY P SY V QHI 497
Cdd:pfam01175 174 QARGAY F F DYGN N F R LEA KD AG V D ---- GA ---- F DF P GF V PAY 209
Urocanase_N
pfam17391 Urocanase N-terminal domain;
85-211
4.14e-78
Urocanase N-terminal domain;
Pssm-ID: 465413 [Multi-domain]
Cd Length: 127
Bit Score: 246.30
E-value: 4.14e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260306182 85 M RA YPIEQY PC QTKVAA A IMH M I MNNLDP A VA QF P Q ELV T YGGNG QVFS NWAQF W L TMF YL SKMT E E QTL VMY SG H P L GL 164
Cdd:pfam17391 1 I RA PRGTEL PC KGWQQE A ALR M L MNNLDP E VA EY P E ELV V YGGNG KAAR NWAQF D L IVK YL KELE E D QTL LVQ SG K P V GL 80
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 260306182 165 F PSSRS APR LV I T N GMVI PN YSSRTEY E K L F ALG V TMYGQMTAGS YC 211
Cdd:pfam17391 81 F RTHPD APR VL I A N SNLV PN WATWEDF E R L E ALG L TMYGQMTAGS WI 127
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
