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Conserved domains on  [gi|281360736|ref|NP_001162727|]
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sclp, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-149 3.15e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  20 HLDLSSCELMQIPDAVYHLmrnTELITCNLSGNVLKSVsPKFSQKFSTITDLNLSHNKLSRLPEEFASLSALTKLNISNN 99
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 281360736 100 SFIVLPQVVFKLQSLASLDAQNNAILEIDTDEAITsdNLALVDLRNNPLS 149
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT 263
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-149 3.15e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  20 HLDLSSCELMQIPDAVYHLmrnTELITCNLSGNVLKSVsPKFSQKFSTITDLNLSHNKLSRLPEEFASLSALTKLNISNN 99
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 281360736 100 SFIVLPQVVFKLQSLASLDAQNNAILEIDTDEAITsdNLALVDLRNNPLS 149
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT 263
LRR_8 pfam13855
Leucine rich repeat;
48-101 1.46e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 281360736   48 NLSGNVLKSVSPKFSQKFSTITDLNLSHNKLSRL-PEEFASLSALTKLNISNNSF 101
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-160 1.96e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  71 LNLSHNKLSRLpEEFASLSALTKLNISNN---SFIVLPQVVFKLQSLASLDAQNNAILEIDT--DEAIT-SDNLALVDlr 144
Cdd:cd21340  125 LNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPKyrDKIILaSKSLEVLD-- 201

                         90
                 ....*....|....*.
gi 281360736 145 NNPLSRNCRRKLQSFK 160
Cdd:cd21340  202 GKEITDTERQFLKRLK 217
PLN03150 PLN03150
hypothetical protein; Provisional
 30-100 1.95e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 1.95e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281360736  30 QIPDAVYHLMRnteLITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKLNISNNS 100
Cdd:PLN03150 433 FIPNDISKLRH---LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNS 501
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
20-149 3.15e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.19  E-value: 3.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  20 HLDLSSCELMQIPDAVYHLmrnTELITCNLSGNVLKSVsPKFSQKFSTITDLNLSHNKLSRLPEEFASLSALTKLNISNN 99
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 281360736 100 SFIVLPQVVFKLQSLASLDAQNNAILEIDTDEAITsdNLALVDLRNNPLS 149
Cdd:COG4886  216 QLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT--NLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-149 6.10e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.95  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  37 HLMRNTELITCNLSGNVLKSVSPKFSQkFSTITDLNLSHNKLSRLPEEFASLSALTKLNISNNSFIVLPQVVFKLQSLAS 116
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKE 186

                         90       100       110
                 ....*....|....*....|....*....|....
gi 281360736 117 LDAQNNAILEIdtDEAITS-DNLALVDLRNNPLS 149
Cdd:COG4886  187 LDLSNNQITDL--PEPLGNlTNLEELDLSGNQLT 218
LRR_8 pfam13855
Leucine rich repeat;
48-101 1.46e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.46e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 281360736   48 NLSGNVLKSVSPKFSQKFSTITDLNLSHNKLSRL-PEEFASLSALTKLNISNNSF 101
Cdd:pfam13855   7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 71-160 1.96e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 1.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  71 LNLSHNKLSRLpEEFASLSALTKLNISNN---SFIVLPQVVFKLQSLASLDAQNNAILEIDT--DEAIT-SDNLALVDlr 144
Cdd:cd21340  125 LNISGNNIDSL-EPLAPLRNLEQLDASNNqisDLEELLDLLSSWPSLRELDLTGNPVCKKPKyrDKIILaSKSLEVLD-- 201

                         90
                 ....*....|....*.
gi 281360736 145 NNPLSRNCRRKLQSFK 160
Cdd:cd21340  202 GKEITDTERQFLKRLK 217
LRR_8 pfam13855
Leucine rich repeat;
66-124 1.74e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281360736   66 STITDLNLSHNKLSRLPEE-FASLSALTKLNISNNSFIVLPQVVF-KLQSLASLDAQNNAI 124
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFsGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 30-100 1.95e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 1.95e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281360736  30 QIPDAVYHLMRnteLITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKLNISNNS 100
Cdd:PLN03150 433 FIPNDISKLRH---LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNS 501
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 17-101 2.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  17 ESAHLDLSSCELM-QIPDavyHLMRNTELITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKL 94
Cdd:PLN00113 500 ELMQLKLSENKLSgEIPD---ELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQV 576


                 ....*..
gi 281360736  95 NISNNSF 101
Cdd:PLN00113 577 NISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 38-122 3.29e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  38 LMRNTELITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKLNISNNSFI-VLPQVVFKLQSLA 115
Cdd:PLN00113 495 LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLV 574


                 ....*..
gi 281360736 116 SLDAQNN 122
Cdd:PLN00113 575 QVNISHN 581
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-122 5.51e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  40 RNTELITCNLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKLNISNNSFI-VLPQVVFKLQSLASL 117
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQL 552


                 ....*
gi 281360736 118 DAQNN 122
Cdd:PLN00113 553 DLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 21-170 1.68e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  21 LDLSSCELM-QIPDAVYHLMRNTELItcnLSGNVLKSVSPKFSQKFSTITDLNLSHNKLS-RLPEEFASLSALTKLNISN 98
Cdd:PLN00113 361 LDLSTNNLTgEIPEGLCSSGNLFKLI---LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISN 437

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 281360736  99 NSFI-VLPQVVFKLQSLASLDAQNNAILEiDTDEAITSDNLALVDLRNNPLSRNCRRKLQSFKTPFHLEISKD 170
Cdd:PLN00113 438 NNLQgRINSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSEN 509
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-148 6.53e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 36.36  E-value: 6.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281360736  45 ITCNLSGNVL------KSVSPKFSQ---KFSTITDLNLSHNKLS-RLPEE-FASLSALTKLNISNNSFiVLPQVVFKLQS 113
Cdd:PLN00113  63 ITCNNSSRVVsidlsgKNISGKISSaifRLPYIQTINLSNNQLSgPIPDDiFTTSSSLRYLNLSNNNF-TGSIPRGSIPN 141

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 281360736 114 LASLDAQNNAIL-EIDTDEAITSdNLALVDLRNNPL 148
Cdd:PLN00113 142 LETLDLSNNMLSgEIPNDIGSFS-SLKVLDLGGNVL 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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