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Conserved domains on  [gi|295148122|ref|NP_001171176|]
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homeobox and leucine zipper protein Homez isoform 1 [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 12880132)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes; similar to Homo sapiens iroquois-class homeodomain protein IRX-6, a transcription factor that binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homez super family cl13082
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 430-477 7.86e-21

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


The actual alignment was detected with superfamily member pfam11569:

Pssm-ID: 463297  Cd Length: 57  Bit Score: 85.82  E-value: 7.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 295148122  430 DIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEV 477
Cdd:pfam11569  10 DIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 328-385 1.06e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 48.78  E-value: 1.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295148122 328 RKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQ 385
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 43-90 4.17e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 38.38  E-value: 4.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 295148122  43 NEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISW 90
Cdd:cd00086   12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
274-417 2.21e-03

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 38.96  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148122 274 KPLQPLgcisQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPD-MQHQRKTK-RKTKEQLAILKSFFLQCQ-- 349
Cdd:COG5576    1 SPVQPM----QPLSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDgSSPPKSKRrRTTDEQLMVLEREFEINPyp 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295148122 350 -WARREdyhKLEQITGLPrPEIIQ-WFGDTRYALK-HGQLKWFRDNAVLGTPSFQdpaIPTPSTRSLKEWA 417
Cdd:COG5576   77 sSITRI---KLSLLLNMP-PKSVQiWFQNKRAKEKkKRSGKVEQRPGEEEADLAK---IGSLSTGQISIIE 140
 
Name Accession Description Interval E-value
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 430-477 7.86e-21

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 85.82  E-value: 7.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 295148122  430 DIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEV 477
Cdd:pfam11569  10 DIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 328-385 1.06e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 48.78  E-value: 1.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295148122 328 RKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQ 385
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 327-382 4.56e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.78  E-value: 4.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 295148122   327 QRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALK 382
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 43-90 4.17e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 38.38  E-value: 4.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 295148122  43 NEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISW 90
Cdd:cd00086   12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
274-417 2.21e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 38.96  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148122 274 KPLQPLgcisQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPD-MQHQRKTK-RKTKEQLAILKSFFLQCQ-- 349
Cdd:COG5576    1 SPVQPM----QPLSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDgSSPPKSKRrRTTDEQLMVLEREFEINPyp 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295148122 350 -WARREdyhKLEQITGLPrPEIIQ-WFGDTRYALK-HGQLKWFRDNAVLGTPSFQdpaIPTPSTRSLKEWA 417
Cdd:COG5576   77 sSITRI---KLSLLLNMP-PKSVQiWFQNKRAKEKkKRSGKVEQRPGEEEADLAK---IGSLSTGQISIIE 140
 
Name Accession Description Interval E-value
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 430-477 7.86e-21

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 85.82  E-value: 7.86e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 295148122  430 DIRPLEKYWAAHQQLQEADILKLSQASRLSTQQVLDWFDSRLPKPAEV 477
Cdd:pfam11569  10 DIRPLEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASRLSKPAEV 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 328-385 1.06e-07

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 48.78  E-value: 1.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 295148122 328 RKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALKHGQ 385
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 327-382 4.56e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 43.78  E-value: 4.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 295148122   327 QRKTKRKTKEQLAILKSFFLQCQWARREDYHKLEQITGLPRPEIIQWFGDTRYALK 382
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 43-90 4.17e-04

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 38.38  E-value: 4.17e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 295148122  43 NEHLLQAFSYFPYPSLADIALLCLRHGLQMEKVKTWFMAQRLRCGISW 90
Cdd:cd00086   12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
274-417 2.21e-03

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 38.96  E-value: 2.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295148122 274 KPLQPLgcisQSLSPSKKALSPQVEPLWPQRLWNNSEPNSAGPTEYLSPD-MQHQRKTK-RKTKEQLAILKSFFLQCQ-- 349
Cdd:COG5576    1 SPVQPM----QPLSALESQRMPQIRTIKTTKNKREVEAADSEMKLERKQDgSSPPKSKRrRTTDEQLMVLEREFEINPyp 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 295148122 350 -WARREdyhKLEQITGLPrPEIIQ-WFGDTRYALK-HGQLKWFRDNAVLGTPSFQdpaIPTPSTRSLKEWA 417
Cdd:COG5576   77 sSITRI---KLSLLLNMP-PKSVQiWFQNKRAKEKkKRSGKVEQRPGEEEADLAK---IGSLSTGQISIIE 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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