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Conserved domains on  [gi|312283729|ref|NP_001186049|]
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ribonuclease P protein subunit p21 isoform 1 [Homo sapiens]

Protein Classification

ribonuclease P Rpr2/Rpp21/SNM1 subunit( domain architecture ID 10513160)

ribonuclease P (RNAse P) Rpr2/Rpp21/SNM1 subunit is a component of RNAse P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends; ribonuclease P protein component 4 is part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends

EC:  3.1.26.5
Gene Ontology:  GO:0046872|GO:0006278|GO:0004526|GO:0030677
PubMed:  21930585|14550630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-104 6.30e-22

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


:

Pssm-ID: 427665  Cd Length: 88  Bit Score: 83.89  E-value: 6.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283729   13 RLNFLYQAAHcvLAQDPENQALARFYCYTERTIAKRLVLRRPlsssaprdPSVKRTLCRGCSSLLVPGLTCT------QR 86
Cdd:pfam04032   1 RLNFLYQAAH--LLARPGNPELSRRYVSLLRAISKKAVLRLP--------PSIKRTICKKCGTLLIPGVTCTvrienkSK 70

                          90
                  ....*....|....*...
gi 312283729   87 QRRCRGQRWTVQTCLTCQ 104
Cdd:pfam04032  71 GGKKPWADVLVYTCLTCG 88
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-104 6.30e-22

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 83.89  E-value: 6.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283729   13 RLNFLYQAAHcvLAQDPENQALARFYCYTERTIAKRLVLRRPlsssaprdPSVKRTLCRGCSSLLVPGLTCT------QR 86
Cdd:pfam04032   1 RLNFLYQAAH--LLARPGNPELSRRYVSLLRAISKKAVLRLP--------PSIKRTICKKCGTLLIPGVTCTvrienkSK 70

                          90
                  ....*....|....*...
gi 312283729   87 QRRCRGQRWTVQTCLTCQ 104
Cdd:pfam04032  71 GGKKPWADVLVYTCLTCG 88
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 6-109 8.37e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 37.13  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283729   6 KDREAFQRLNFLYQAAHCVLAQDPEnqaLARFYCYTERTIAKRLVLRRPlsssaprdPSVKRTLCRGCSSLLVPGLTCTQ 85
Cdd:PRK03954  14 KKRIARERIDTLFTLAERVFPYSPE---LANRYVELALAVQQKAKVKLP--------RKWKRRYCKRCHSFLVPGVNARV 82

                         90       100
                 ....*....|....*....|....
gi 312283729  86 RQRRCRGQRwTVQTCLTCQRSQRF 109
Cdd:PRK03954  83 RLRQKRMPH-VVITCLECGHIMRY 105
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 13-104 6.30e-22

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 83.89  E-value: 6.30e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283729   13 RLNFLYQAAHcvLAQDPENQALARFYCYTERTIAKRLVLRRPlsssaprdPSVKRTLCRGCSSLLVPGLTCT------QR 86
Cdd:pfam04032   1 RLNFLYQAAH--LLARPGNPELSRRYVSLLRAISKKAVLRLP--------PSIKRTICKKCGTLLIPGVTCTvrienkSK 70

                          90
                  ....*....|....*...
gi 312283729   87 QRRCRGQRWTVQTCLTCQ 104
Cdd:pfam04032  71 GGKKPWADVLVYTCLTCG 88
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 6-109 8.37e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 37.13  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 312283729   6 KDREAFQRLNFLYQAAHCVLAQDPEnqaLARFYCYTERTIAKRLVLRRPlsssaprdPSVKRTLCRGCSSLLVPGLTCTQ 85
Cdd:PRK03954  14 KKRIARERIDTLFTLAERVFPYSPE---LANRYVELALAVQQKAKVKLP--------RKWKRRYCKRCHSFLVPGVNARV 82

                         90       100
                 ....*....|....*....|....
gi 312283729  86 RQRRCRGQRwTVQTCLTCQRSQRF 109
Cdd:PRK03954  83 RLRQKRMPH-VVITCLECGHIMRY 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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