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Conserved domains on  [gi|320118881|ref|NP_001188502|]
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iron-sulfur cluster transfer protein NUBPL isoform 2 [Homo sapiens]

Protein Classification

Mrp/NBP35 family ATP-binding protein( domain architecture ID 10566257)

Mrp (multiple resistance and pH adaptation)/NBP35 (nucleotide-binding protein 35) family ATP-binding protein is an iron-sulfur (FeS) cluster protein that functions as a scaffold to assemble nascent FeS clusters for transfer to FeS-requiring enzymes

CATH:  3.40.50.300
Gene Ontology:  GO:0046872|GO:0005524|GO:0051536|GO:0140663|GO:0016226|GO:0016887
PubMed:  8921898

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-215 6.02e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


:

Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 348.29  E-value: 6.02e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881    1 MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVE-ESEPVVWRGLMVMSAIEKLLRQVDWG 79
Cdd:pfam10609  31 LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSIGFLLPdEDDAVIWRGPMKSGAIKQFLTDVDWG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   80 QLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFG 159
Cdd:pfam10609 111 ELDYLIIDLPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFG 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320118881  160 ADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 215
Cdd:pfam10609 191 KGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-215 6.02e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 348.29  E-value: 6.02e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881    1 MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVE-ESEPVVWRGLMVMSAIEKLLRQVDWG 79
Cdd:pfam10609  31 LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSIGFLLPdEDDAVIWRGPMKSGAIKQFLTDVDWG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   80 QLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFG 159
Cdd:pfam10609 111 ELDYLIIDLPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFG 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320118881  160 ADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 215
Cdd:pfam10609 191 KGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-186 1.29e-97

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 282.85  E-value: 1.29e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   1 MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQ 80
Cdd:cd02037   28 KGYKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVGGIKVMSIGFLLPEDDAVIWRGPMKSGAIKQFLKDVDWGE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  81 LDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGA 160
Cdd:cd02037  108 LDYLIIDLPPGTGDEHLSLVQLIPIDGAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGK 187

                        170       180
                 ....*....|....*....|....*.
gi 320118881 161 DGARKLAQTLGLEVLGDIPLHLNIRE 186
Cdd:cd02037  188 GGGEKLAEELGVPFLGKIPLDPELAK 213
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
5-218 9.34e-89

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 266.14  E-value: 9.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   5 IGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDY 83
Cdd:PRK11670 139 VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDY 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  84 LVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGA 163
Cdd:PRK11670 219 LVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGA 298

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 320118881 164 RKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRL 218
Cdd:PRK11670 299 EKLAEKYHTQLLGQMPLHISLREDLDRGTPTVVSRPESEFTAIYRQLADRVAAQL 353
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
6-221 8.94e-85

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 255.90  E-value: 8.94e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   6 GLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPL-LNYGIACMSMGFLVE-ESEPVVWRGLMVMSAIEKLLRQVDWGQLDY 83
Cdd:NF041136  38 GLLDVDIHGPSIPKLLGLEGKRLGSEDEGILPVeYSDNLKVMSIGFLLEnRDDAVIWRGPVKMGVIKQFLSDVEWGDLDY 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  84 LVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGA 163
Cdd:NF041136 118 LIIDSPPGTGDEPLSVAQLIPDAGAVIVTTPQELALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIFKSGGG 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 320118881 164 RKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSP 221
Cdd:NF041136 198 EKLAEEMGVPFLGRIPIDPEIVEAGDAGRPFVLDYAWSPAAKALEKIVDPILELLENK 255
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 6-159 4.12e-36

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 128.38  E-value: 4.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   6 GLLDVDVYGPSVPKMMNLKGNPELSQ--------SNLMRPLLNYGIACMSMGFLVEESEpvvwrGLMVMSAIEKLLRQVD 77
Cdd:COG0489  125 LLIDADLRGPSLHRMLGLENRPGLSDvlageaslEDVIQPTEVEGLDVLPAGPLPPNPS-----ELLASKRLKQLLEELR 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  78 wGQLDYLVVDMPPGTGDVQLSVSQNIpITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSvfqcpkCKHKTHI 157
Cdd:COG0489  200 -GRYDYVIIDTPPGLGVADATLLASL-VDGVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNMV------CPKGERY 271


                 ..
gi 320118881 158 FG 159
Cdd:COG0489  272 YG 273
 
Name Accession Description Interval E-value
ParA pfam10609
NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid ...
 1-215 6.02e-123

NUBPL iron-transfer P-loop NTPase; This family contains ATPases involved in plasmid partitioning. It also contains the cytosolic Fe-S cluster assembling factor NBP35 which is required for biogenesis and export of both ribosomal subunits.


Pssm-ID: 431392 [Multi-domain]  Cd Length: 246  Bit Score: 348.29  E-value: 6.02e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881    1 MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVE-ESEPVVWRGLMVMSAIEKLLRQVDWG 79
Cdd:pfam10609  31 LGYKVGLLDADIYGPSIPRMLGLEGERPEQSDGGIIPVEAHGIKVMSIGFLLPdEDDAVIWRGPMKSGAIKQFLTDVDWG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   80 QLDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFG 159
Cdd:pfam10609 111 ELDYLIIDLPPGTGDEQLTLAQLLPLTGAVIVTTPQDVALLDVRKAIDMFKKVNVPVLGVVENMSYFVCPHCGEETYIFG 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 320118881  160 ADGARKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVV 215
Cdd:pfam10609 191 KGGGEKLAEELGVPFLGEIPLDPDIREAGDEGKPFVLADPDSPAAKAFLKIADKVA 246
Mrp_NBP35 cd02037
Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically ...
 1-186 1.29e-97

Mrp/NBP35 ATP-binding protein family; Mrp/NBP35 ATP-binding family protein are typically iron-sulfur (FeS) cluster scaffolds that function to assemble nascent FeS clusters for transfer to FeS-requiring enzymes. Members include the eukaryotic nucleotide-binding protein 1 (NUBP1) which is a component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery and the archael [NiFe] hydrogenase maturation protein HypB which is required for nickel insertion into [NiFe] hydrogenase.


Pssm-ID: 349757 [Multi-domain]  Cd Length: 213  Bit Score: 282.85  E-value: 1.29e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   1 MSKAIGLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQ 80
Cdd:cd02037   28 KGYKVGLLDADIYGPSIPRLLGVEGKPLHQSEEGIVPVEVGGIKVMSIGFLLPEDDAVIWRGPMKSGAIKQFLKDVDWGE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  81 LDYLVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGA 160
Cdd:cd02037  108 LDYLIIDLPPGTGDEHLSLVQLIPIDGAVVVTTPQEVSLIDVRKAIDMCKKLNIPVLGIVENMSGFVCPHCGKKIYIFGK 187

                        170       180
                 ....*....|....*....|....*.
gi 320118881 161 DGARKLAQTLGLEVLGDIPLHLNIRE 186
Cdd:cd02037  188 GGGEKLAEELGVPFLGKIPLDPELAK 213
PRK11670 PRK11670
iron-sulfur cluster carrier protein ApbC;
5-218 9.34e-89

iron-sulfur cluster carrier protein ApbC;


Pssm-ID: 183270 [Multi-domain]  Cd Length: 369  Bit Score: 266.14  E-value: 9.34e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   5 IGLLDVDVYGPSVPKMMNLKGNPELSQSNL-MRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDWGQLDY 83
Cdd:PRK11670 139 VGILDADIYGPSIPTMLGAEDQRPTSPDGThMAPIMAHGLATNSIGYLVTDDNAMVWRGPMASKALMQMLQETLWPDLDY 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  84 LVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGA 163
Cdd:PRK11670 219 LVLDMPPGTGDIQLTLAQNIPVTGAVVVTTPQDIALIDAKKGIVMFEKVEVPVLGIVENMSMHICSNCGHHEPIFGTGGA 298

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 320118881 164 RKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRL 218
Cdd:PRK11670 299 EKLAEKYHTQLLGQMPLHISLREDLDRGTPTVVSRPESEFTAIYRQLADRVAAQL 353
MrpORP NF041136
iron-sulfur cluster carrier protein MrpORP;
6-221 8.94e-85

iron-sulfur cluster carrier protein MrpORP;


Pssm-ID: 469059 [Multi-domain]  Cd Length: 365  Bit Score: 255.90  E-value: 8.94e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   6 GLLDVDVYGPSVPKMMNLKGNPELSQSNLMRPL-LNYGIACMSMGFLVE-ESEPVVWRGLMVMSAIEKLLRQVDWGQLDY 83
Cdd:NF041136  38 GLLDVDIHGPSIPKLLGLEGKRLGSEDEGILPVeYSDNLKVMSIGFLLEnRDDAVIWRGPVKMGVIKQFLSDVEWGDLDY 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  84 LVVDMPPGTGDVQLSVSQNIPITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSVFQCPKCKHKTHIFGADGA 163
Cdd:NF041136 118 LIIDSPPGTGDEPLSVAQLIPDAGAVIVTTPQELALADVRKSINFCRKLNIPILGIVENMSGFVCPHCGKEIDIFKSGGG 197

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 320118881 164 RKLAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVRRLPSP 221
Cdd:NF041136 198 EKLAEEMGVPFLGRIPIDPEIVEAGDAGRPFVLDYAWSPAAKALEKIVDPILELLENK 255
Mrp COG0489
Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, ...
 6-159 4.12e-36

Fe-S cluster carrier ATPase, Mrp/ApbC/NBP35 family [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440255 [Multi-domain]  Cd Length: 289  Bit Score: 128.38  E-value: 4.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   6 GLLDVDVYGPSVPKMMNLKGNPELSQ--------SNLMRPLLNYGIACMSMGFLVEESEpvvwrGLMVMSAIEKLLRQVD 77
Cdd:COG0489  125 LLIDADLRGPSLHRMLGLENRPGLSDvlageaslEDVIQPTEVEGLDVLPAGPLPPNPS-----ELLASKRLKQLLEELR 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  78 wGQLDYLVVDMPPGTGDVQLSVSQNIpITGAVIVSTPQDIALMDAHKGAEMFRRVHVPVLGLVQNMSvfqcpkCKHKTHI 157
Cdd:COG0489  200 -GRYDYVIIDTPPGLGVADATLLASL-VDGVLLVVRPGKTALDDVRKALEMLEKAGVPVLGVVLNMV------CPKGERY 271


                 ..
gi 320118881 158 FG 159
Cdd:COG0489  272 YG 273
FlhG COG0455
MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell ...
 54-221 4.36e-13

MinD-like ATPase FlhG/YlxH, activator of the FlhF-type GTPase [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440223 [Multi-domain]  Cd Length: 230  Bit Score: 66.07  E-value: 4.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  54 ESEPVVWRGLMVMSAIEKLLRQVDwGQLDYLVVDMPPGTGDV---QLSVSQNIpitgaVIVSTPQDIALMDAHKGAEMFR 130
Cdd:COG0455   68 GSGPAELAELDPEERLIRVLEELE-RFYDVVLVDTGAGISDSvllFLAAADEV-----VVVTTPEPTSITDAYALLKLLR 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881 131 RVH-VPVLGLVQNMSvfqcpkckhKTHIFGADGARKLAQTLG------LEVLGDIPLHLNIREASDTGQPIVFSQPESDE 203
Cdd:COG0455  142 RRLgVRRAGVVVNRV---------RSEAEARDVFERLEQVAErflgvrLRVLGVIPEDPAVREAVRRGRPLVLAAPDSPA 212

                        170
                 ....*....|....*...
gi 320118881 204 AKAYLRIAVEVVRRLPSP 221
Cdd:COG0455  213 ARAIRELAARLAGWPVPE 230
ParA COG1192
ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein ...
 67-218 3.76e-07

ParA-like ATPase involved in chromosome/plasmid partitioning or cellulose biosynthesis protein BcsQ [Cell cycle control, cell division, chromosome partitioning, Cell motility];


Pssm-ID: 440805 [Multi-domain]  Cd Length: 253  Bit Score: 49.47  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  67 SAIEKLLRQVDwGQLDYLVVDMPPGtgdvqLSVSQNIPITGA---VIVSTPQDIALMDAHKGAEMFRRV------HVPVL 137
Cdd:COG1192  105 LRLKRALAPLA-DDYDYILIDCPPS-----LGLLTLNALAAAdsvLIPVQPEYLSLEGLAQLLETIEEVredlnpKLEIL 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881 138 GLVQNMsvFQCPKCKHKthifgaDGARKLAQTLGLEVLG-DIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAVEVVR 216
Cdd:COG1192  179 GILLTM--VDPRTRLSR------EVLEELREEFGDKVLDtVIPRSVALAEAPSAGKPVFEYDPKSKGAKAYRALAEELLE 250


                 ..
gi 320118881 217 RL 218
Cdd:COG1192  251 RL 252
CbiA pfam01656
CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid ...
 34-194 9.96e-07

CobQ/CobB/MinD/ParA nucleotide binding domain; This family consists of various cobyrinic acid a,c-diamide synthases. These include CbiA and CbiP from S.typhimurium, and CobQ from R. capsulatus. These amidases catalyze amidations to various side chains of hydrogenobyrinic acid or cobyrinic acid a,c-diamide in the biosynthesis of cobalamin (vitamin B12) from uroporphyrinogen III. Vitamin B12 is an important cofactor and an essential nutrient for many plants and animals and is primarily produced by bacteria. The family also contains dethiobiotin synthetases as well as the plasmid partitioning proteins of the MinD/ParA family.


Pssm-ID: 426369 [Multi-domain]  Cd Length: 228  Bit Score: 47.73  E-value: 9.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881   34 LMRPLLNYGIACMSMGFLVEESEPVVWRGLMVMSAIEKLLRQVDwGQLDYLVVDMPPGTGDvqLSVSQNIPITGAVIVST 113
Cdd:pfam01656  72 LLKEKSDEGGLDLIPGNIDLEKFEKELLGPRKEERLREALEALK-EDYDYVIIDGAPGLGE--LLRNALIAADYVIIPLE 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  114 PQDIALMDAHKGAEMFRRV-------HVPVLGLVQNMSVfqcpkcKHKTHIFGADGARKLAQtlGLEVLGDIPLHLNIRE 186
Cdd:pfam01656 149 PEVILVEDAKRLGGVIAALvggyallGLKIIGVVLNKVD------GDNHGKLLKEALEELLR--GLPVLGVIPRDEAVAE 220


                  ....*...
gi 320118881  187 ASDTGQPI 194
Cdd:pfam01656 221 APARGLPV 228
MinD cd02036
septum site-determining protein MinD; Septum site-determining protein MinD is part of the ...
 66-218 3.35e-06

septum site-determining protein MinD; Septum site-determining protein MinD is part of the operon MinCDE that determines the site of the formation of a septum at mid-cell, an important part of bacterial cell division. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal role, selecting the mid-cell over other sites through the activation and regulation of MinC and MinE. MinD is a membrane-associated ATPase, related to nitrogenase iron protein.


Pssm-ID: 349756 [Multi-domain]  Cd Length: 236  Bit Score: 46.43  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  66 MSAIEKLLRQVDwGQLDYLVVDMPPGTGdvQLSVSQNIPITGAVIVSTPQDIALMDAHKgaemfrrvhvpVLGLVQNMSV 145
Cdd:cd02036   97 PEKLEELVKELK-DSFDFILIDSPAGIE--SGFINAIAPADEAIIVTNPEISSVRDADR-----------VIGLLESKGI 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881 146 fqcpkcKHKTHI---FGADGARK--------LAQTLGLEVLGDIPLHLNIREASDTGQPIVFSQPESDEAKAYLRIAvev 214
Cdd:cd02036  163 ------VNIGLIvnrYRPEMVKSgdmlsvedIQEILGIPLLGVIPEDPEVIVATNRGEPLVLYKPNSLAAKAFENIA--- 233


                 ....
gi 320118881 215 vRRL 218
Cdd:cd02036  234 -RRL 236
FlhG-like cd02038
MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) ...
 80-202 2.14e-05

MinD-like ATPase FlhG; FlhG is a member of the SIMIBI superfamily. FlhG (also known as YlxH) is a major determinant for a variety of flagellation patterns. It effects location and number of bacterial flagella during C-ring assembly.


Pssm-ID: 349758 [Multi-domain]  Cd Length: 230  Bit Score: 44.10  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 320118881  80 QLDYLVVDMPPGTGDVQLSVSqnIPITGAVIVSTPQDIALMDAH---KgaEMFRRVHVPVLGLVQNMSvfqcpkckhKTH 156
Cdd:cd02038  110 NYDYLLIDTGAGISRNVLDFL--LAADEVIVVTTPEPTSITDAYaliK--VLSRRGGKKNFRLIVNMA---------RSP 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 320118881 157 IFGADGARKLAQTLG------LEVLGDIPLHLNIREASDTGQPIVFSQPESD 202
Cdd:cd02038  177 KEGRATFERLKKVAKrfldinLDFVGFIPYDQSVRRAVRSQKPFVLLFPNSK 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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