NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|340805875|ref|NP_001230048|]
View 

uncharacterized protein LOC630836 isoform 3 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 5.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 340805875    4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-429 2.29e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875  73 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 149
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 150 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 206
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 207 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 262
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 263 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 325
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 326 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 394
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 340805875 395 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 429
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 5.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 340805875    4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.89e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 8.89e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 340805875     4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 6.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 6.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 340805875   4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-429 2.29e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875  73 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 149
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 150 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 206
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 207 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 262
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 263 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 325
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 326 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 394
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 340805875 395 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 429
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 3.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 340805875  201 HLQRHKRTHTGEKPYVCNQCGKAFAY 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 5.24e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.82  E-value: 5.24e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 340805875    4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 8.89e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 74.17  E-value: 8.89e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 340805875     4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 6.03e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 6.03e-16
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 340805875   4 MTYADVHVNFTWEEWALLNPSQKSLYKEVMLETYENLT 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
73-429 2.29e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 2.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875  73 KPYECNHCGTAFARHGHLQRHKGTHTGEKLYECNRCGKVFA-WNCH-LRIHKRTHSGEKPYEC-DQCGTAFASHCRLQRH 149
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSfSRPLeLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 150 KRTHTGEKPYECNQCGKAFTQHSTLQ--VHKRTHTGEKPYE---------------------CSQCGKAYSRHSHLQRHK 206
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 207 RTHTGEKPYVCNQCGKAFAYQNSLQYHKRTH------------------------TGEKSYECKQCGKFFPCRKHLQIHK 262
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 263 RTH----------AGQKGYECNKCGKAFAFHSHFQRHKR---HIGE--KPYECNH--CDKAFASHNNLQKHIRRHTGEKP 325
Cdd:COG5048  272 SSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 326 YKCNLCDKAYAHH------SHLQTHERVHTEEKPYKC---NQCDKAFSQQSSLQVHKRIHTGEKPYECN--QCGKAFTCH 394
Cdd:COG5048  352 AKEKLLNSSSKFSpllnnePPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 340805875 395 RYLQRHKRTHTGEKPYECNQFGKIFAQHSTVHSIK 429
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
129-432 2.00e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 129 KPYECDQCGTAFASHCRLQRHKRTHTGEKPYECNQ--CGKAFTQHSTLQVHKRTHTGEKPYECS-QCGKAYSRHSHLQRH 205
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 206 KRTHTGEKPYVCNQCGKAFAYQNSLQYHKRTHTGEKSYECKQCGKFFP-----------------------CRKHLQIHK 262
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpssNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 263 RTHAGQKGYECNKCGKAFAFHSHFQRHKRHIGEKPYECNHCDKAF------ASHNNLQKHIRRHTGEKPYKCNLCDKAYA 336
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 337 HHSHLQTHERVHT-EEKPYKCNQCDKAFSQQSSLQVHKR--IHTGE--KPYEC--NQCGKAFTCHRYLQRHKRTHTGEKP 409
Cdd:COG5048  272 SSSPNESDSSSEKgFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340
                 ....*....|....*....|...
gi 340805875 410 YECnqfgkIFAQHSTVHSIKKGN 432
Cdd:COG5048  352 AKE-----KLLNSSSKFSPLLNN 369
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-400 1.16e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 169 TQHSTLQVHKRTHTGE----KPYECSQCGKAYSRHSHLQRHKRTHTGEKPYVCNQCGKAFAYQN--SLQYHKRTHTGEKS 242
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 243 YEC-KQCGKFFPCRKHLQIHKRTHAGQKGYECNKCGKAFAFHS---HFQRHKRHIGEKPYE-CNHCDKAFASHNNLQKHI 317
Cdd:COG5048   92 DLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDpqlPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 318 RRHtgekpykcNLCDKAYAHHSHLqTHERVHTEEKPYKCNQCDKAFSQQSSLQVHKRIHTGEKPYECNQCGKAFTCHRYL 397
Cdd:COG5048  172 PAN--------SLSKDPSSNLSLL-ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLS 242


                 ...
gi 340805875 398 QRH 400
Cdd:COG5048  243 QSP 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
201-226 3.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 3.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 340805875  201 HLQRHKRTHTGEKPYVCNQCGKAFAY 226
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
145-170 4.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 340805875  145 RLQRHKRTHTGEKPYECNQCGKAFTQ 170
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 155-238 5.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 5.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 155 GEKPYECN--QCGKAFTQHSTLQVHKRThtgekpyecSQCGKAYSRHSHLQRHKRTHTGEKPYVCNQCGKAFAYQNSLQY 232
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 340805875 233 HkRTHT 238
Cdd:COG5189  417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 293-373 1.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 293 IGEKPYECN--HCDKAFASHNNLQKHiRRHTGEKPYKCNLCDKayahhshlQTHERVHTEEKPYKCNQCDKAFSQQSSLQ 370
Cdd:COG5189  345 KDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ...
gi 340805875 371 VHK 373
Cdd:COG5189  416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
312-337 1.44e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*.
gi 340805875  312 NLQKHIRRHTGEKPYKCNLCDKAYAH 337
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 1.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 340805875  368 SLQVHKRIHTGEKPYECNQCGKAFTC 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 322-405 3.61e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 340805875 322 GEKPYKCNL--CDKAYAHHSHLQTHeRVHteekpykcNQCDKAFSQQSSLQVHKRIHTGEKPYECNQCGKAFTCHRYLQR 399
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 340805875 400 HkRTHT 405
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 4.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 340805875  340 HLQTHERVHTEEKPYKCNQCDKAFSQ 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-198 6.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.88e-03
                          10        20
                  ....*....|....*....|....*
gi 340805875  174 LQVHKRTHTGEKPYECSQCGKAYSR 198
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH