|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
757-985 |
6.24e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
:
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.08 E-value: 6.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 757 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 836
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 837 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 916
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371876057 917 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 985
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1223-1335 |
3.75e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
:
Pssm-ID: 397128 Cd Length: 113 Bit Score: 130.09 E-value: 3.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1223 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1302
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 371876057 1303 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1335
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| PRK07003 super family |
cl35530 |
DNA polymerase III subunit gamma/tau; |
168-332 |
6.59e-06 |
|
DNA polymerase III subunit gamma/tau;
The actual alignment was detected with superfamily member PRK07003:
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 6.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 168 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 246
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 247 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 320
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 371876057 321 SPTSCTAASGPS 332
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
6-338 |
7.17e-05 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 6 QARSPGGFRPIQFFQRPQIQPPRAAI--------PNSSPSIRP-----GVQTPTAVYQANQHIMMVNHLPMPYPVTQGHQ 72
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLtsladpppPPPTPEPAPhalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA 2749
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 73 YCIPQYRHSGPPYVGPPQQYPVQPpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIR 152
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPA---------------APAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 153 DPNQggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYG-TVESAHLAASTPVTAASDQKQEEKPKP 231
Cdd:PHA03247 2813 APAA-----ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgDVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 232 DPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEPTPEPP-RTSSPTSLPPLARSSLPSPMSAALSSQPLFTAED------ 304
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPpQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgal 2967
|
330 340 350
....*....|....*....|....*....|....*...
gi 371876057 305 ---KCELPSSK-EEDAPPVPSPtsctAASGPSLTDNSD 338
Cdd:PHA03247 2968 vpgRVAVPRFRvPQPAPSREAP----ASSTPPLTGHSL 3001
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
757-985 |
6.24e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.08 E-value: 6.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 757 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 836
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 837 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 916
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371876057 917 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 985
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
758-982 |
3.30e-51 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 179.48 E-value: 3.30e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 758 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 837
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 838 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 917
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371876057 918 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 982
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1223-1335 |
3.75e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 130.09 E-value: 3.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1223 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1302
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 371876057 1303 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1335
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1223-1335 |
1.41e-32 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 122.74 E-value: 1.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1223 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1302
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 371876057 1303 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1335
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
168-332 |
6.59e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 6.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 168 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 246
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 247 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 320
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 371876057 321 SPTSCTAASGPS 332
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
6-338 |
7.17e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 6 QARSPGGFRPIQFFQRPQIQPPRAAI--------PNSSPSIRP-----GVQTPTAVYQANQHIMMVNHLPMPYPVTQGHQ 72
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLtsladpppPPPTPEPAPhalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA 2749
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 73 YCIPQYRHSGPPYVGPPQQYPVQPpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIR 152
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPA---------------APAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 153 DPNQggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYG-TVESAHLAASTPVTAASDQKQEEKPKP 231
Cdd:PHA03247 2813 APAA-----ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgDVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 232 DPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEPTPEPP-RTSSPTSLPPLARSSLPSPMSAALSSQPLFTAED------ 304
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPpQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgal 2967
|
330 340 350
....*....|....*....|....*....|....*...
gi 371876057 305 ---KCELPSSK-EEDAPPVPSPtsctAASGPSLTDNSD 338
Cdd:PHA03247 2968 vpgRVAVPRFRvPQPAPSREAP----ASSTPPLTGHSL 3001
|
|
| Pneumo_att_G |
pfam05539 |
Pneumovirinae attachment membrane glycoprotein G; |
117-303 |
2.41e-04 |
|
Pneumovirinae attachment membrane glycoprotein G;
Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 45.42 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 117 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 196
Cdd:pfam05539 186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 197 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqmPETAAGEPTPEPPRT 272
Cdd:pfam05539 248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308
|
170 180 190
....*....|....*....|....*....|.
gi 371876057 273 SSPTSLPPlarSSLPSPMSAALSSQPLFTAE 303
Cdd:pfam05539 309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
3-358 |
2.42e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 3 SQPQARSPGGFRPIQFFQR-PQIQPPRaaIPNSSPSIRPGVQTPTAVYQANQhimmvnhlPMPYPVTQGHQYCIPQYRHS 81
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQQtPTLHPQR--LPSPHPPLQPMTQPPPPSQVSPQ--------PLPQPSLHGQMPPMPHSLQT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 82 GPPYVGPPQQYPVqppgpgpfypGPGPGDFANAYGTPFYPSQPVYQSA--PIIVPTQQQPPPAKREKKTIRIRDPnqggk 159
Cdd:pfam03154 285 GPSHMQHPVPPQP----------FPLTPQSSQSQVPPGPSPAAPGQSQqrIHTPPSQSQLQSQQPPREQPLPPAP----- 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 160 diteeimsgggsrNPTPPIGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPS 239
Cdd:pfam03154 350 -------------LSMPHIKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLS 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 240 TVLRLVLSGEKKEQAGQMPETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPP 318
Cdd:pfam03154 401 SLSTHHPPSAHPPPLQLMPQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPP 478
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 371876057 319 VPSPTScTAASGPSLtdnsdicKKPCSVAPHDSQLISSTI 358
Cdd:pfam03154 479 SGPPTS-TSSAMPGI-------QPPSSASVSSSGPVPAAV 510
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
757-985 |
6.24e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.08 E-value: 6.24e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 757 FRKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLkvpmadkpgNTVNFR 836
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 837 KLLLNRCQKEFEKdkadddvfekkqkeleaasapeertrlHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCV 916
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 371876057 917 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLCN 985
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
758-982 |
3.30e-51 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 179.48 E-value: 3.30e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 758 RKVRSILNKLTPQMFNQLMKQVSALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVtLKVPmadkpgntvNFRK 837
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 838 LLLNRCQKEFEKDkadddvfekkqkeleaasapeertrlhdeLEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVV 917
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 371876057 918 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 982
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1223-1335 |
3.75e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 130.09 E-value: 3.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1223 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1302
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 371876057 1303 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1335
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1223-1335 |
1.41e-32 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 122.74 E-value: 1.41e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1223 VERKSKSIIDEFLHINDFKEATQCIEELSAQGPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKGFSE 1302
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 371876057 1303 TLELADDMAIDIPHIWLYLAELVTPMLKGGGIS 1335
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
168-332 |
6.59e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 51.00 E-value: 6.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 168 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 246
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAvPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 247 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTS-----LPPLARSSlPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVP- 320
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASapasdAPPDAAFE-PAPRAAAPSAATPAAVPDARAPAAASREDAPAAAa 526
|
170
....*....|..
gi 371876057 321 SPTSCTAASGPS 332
Cdd:PRK07003 527 PPAPEARPPTPA 538
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
6-338 |
7.17e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 7.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 6 QARSPGGFRPIQFFQRPQIQPPRAAI--------PNSSPSIRP-----GVQTPTAVYQANQHIMMVNHLPMPYPVTQGHQ 72
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLtsladpppPPPTPEPAPhalvsATPLPPGPAAARQASPALPAAPAPPAVPAGPA 2749
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 73 YCIPQYRHSGPPYVGPPQQYPVQPpgpgpfypgpgpgdfANAYGTPfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIR 152
Cdd:PHA03247 2750 TPGGPARPARPPTTAGPPAPAPPA---------------APAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVL 2812
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 153 DPNQggkdiTEEIMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYG-TVESAHLAASTPVTAASDQKQEEKPKP 231
Cdd:PHA03247 2813 APAA-----ALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgDVRRRPPSRSPAAKPAAPARPPVRRLA 2887
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 232 DPVFQSPSTVLRLVLSGEKKEQAGQMPETAAGEPTPEPP-RTSSPTSLPPLARSSLPSPMSAALSSQPLFTAED------ 304
Cdd:PHA03247 2888 RPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPpQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQpwlgal 2967
|
330 340 350
....*....|....*....|....*....|....*...
gi 371876057 305 ---KCELPSSK-EEDAPPVPSPtsctAASGPSLTDNSD 338
Cdd:PHA03247 2968 vpgRVAVPRFRvPQPAPSREAP----ASSTPPLTGHSL 3001
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
168-338 |
1.08e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.79 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 168 GGGSRNPTPPIGRPASTPTPPQQLPSQV-PEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRlvl 246
Cdd:PRK12323 368 SGGGAGPATAAAAPVAQPAPAAAAPAAAaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP--- 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 247 SGEKKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDAPPVPSPTSCT 326
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAE 524
|
170
....*....|..
gi 371876057 327 AASGPSLTDNSD 338
Cdd:PRK12323 525 SIPDPATADPDD 536
|
|
| Pneumo_att_G |
pfam05539 |
Pneumovirinae attachment membrane glycoprotein G; |
117-303 |
2.41e-04 |
|
Pneumovirinae attachment membrane glycoprotein G;
Pssm-ID: 114270 [Multi-domain] Cd Length: 408 Bit Score: 45.42 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 117 TPFYPSQpvyqsapiiVPTQQQPPPAKREKKTIRIRDPNQGgkditeeimSGGGSRNPTPPIGRPASTPTPPQQLPSQVP 196
Cdd:pfam05539 186 HPTYPSQ---------VTPQSQPATQGHQTATANQRLSSTE---------PVGTQGTTTSSNPEPQTEPPPSQRGPSGSP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 197 EHSPvvygtvesahlaaSTP----VTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKeqagqmPETAAGEPTPEPPRT 272
Cdd:pfam05539 248 QHPP-------------STTsqdqSTTGDGQEHTQRRKTPPATSNRRSPHSTATPPPTT------KRQETGRPTPRPTAT 308
|
170 180 190
....*....|....*....|....*....|.
gi 371876057 273 SSPTSLPPlarSSLPSPMSAALSSQPLFTAE 303
Cdd:pfam05539 309 TQSGSSPP---HSSPPGVQANPTTQNLVDCK 336
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
27-322 |
3.08e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 27 PRAAIPNSSPSIR----PGVQTPTAVYQanqhimmvnhlPMPYPVTQGHQYCIPQYRHSGP---PYVGPPQQYPVQPPGP 99
Cdd:PRK10263 347 ASVDVPPAQPTVAwqpvPGPQTGEPVIA-----------PAPEGYPQQSQYAQPAVQYNEPlqqPVQPQQPYYAPAAEQP 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 100 gpfypgpgpgdfanaygtpfyPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEimsggGSRNPTPPIG 179
Cdd:PRK10263 416 ---------------------AQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQ-----STYQTEQTYQ 469
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 180 RPAstPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEK------------PKPDPVfqspstvlrlvls 247
Cdd:PRK10263 470 QPA--AQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRarereqlaawyqPIPEPV------------- 534
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 371876057 248 gekKEQAGQMPETAAGEPTPEPPRTSSPTSLPPLA--RSSLPSPMSAALSSQPLFT-AEDKCELPSSKEEDAPPVPSP 322
Cdd:PRK10263 535 ---KEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASgvKKATLATGAAATVAAPVFSlANSGGPRPQVKEGIGPQLPRP 609
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1-269 |
5.80e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 44.67 E-value: 5.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 1 MNSQPQARSPGGFRPIQFFQRPQIQPPRAAIPNSSPSIRPGVQTPTAVYQAnqhimmvnhlPMPYPVTQGHQYCIPQyrh 80
Cdd:PHA03378 672 IPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATG----------RARPPAAAPGRARPPA--- 738
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 81 SGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFANAYGTPFYPSQ--PVYQSAPIIVPTQQQPPPAKREKKTIRIRD-PNQG 157
Cdd:PHA03378 739 AAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQapPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAaPGQQ 818
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 158 G--KDITEEIMSGGGSR-------------------NPTPPIGRPASTPT-----PPQQLPSQVPehspvvyGTVESAHL 211
Cdd:PHA03378 819 GptKQILRQLLTGGVKRgrpslkkpaalerqaaagpTPSPGSGTSDKIVQapvfyPPVLQPIQVM-------RQLGSVRA 891
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 371876057 212 AASTPVTAASDQKQEEKPKPDPVfqSPSTVLRlvlSGEKKEQAGQMPETAAGEPTPEP 269
Cdd:PHA03378 892 AAASTVTQAPTEYTGERRGVGPM--HPTDIPP---SKRAKTDAYVESQPPHGGQSHSF 944
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
180-335 |
9.11e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 9.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 180 RPASTPTPPQQLPSQvpEHSPVVygTVESAHLAASTPV---TAASDQKQEEKPKPDPVFQSPS------TVLRLVLSGEK 250
Cdd:PHA03307 23 RPPATPGDAADDLLS--GSQGQL--VSDSAELAAVTVVagaAACDRFEPPTGPPPGPGTEAPAnesrstPTWSLSTLAPA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 251 KEQAGQMPETAAGEPTPEPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKC-ELPSSKEEDAPPVPSPTSCTAAS 329
Cdd:PHA03307 99 SPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAaGASPAAVASDAASSRQAALPLSS 178
|
....*.
gi 371876057 330 GPSLTD 335
Cdd:PHA03307 179 PEETAR 184
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
167-332 |
1.15e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 167 SGGGSRNPTPPIGRPASTPTPPQQLPSQVPehSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVL 246
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPAPA--GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 247 SGEKKEQAGQMPETAAGEPTPEP----------PRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSKEEDA 316
Cdd:PRK07764 679 AAPPPAPAPAAPAAPAGAAPAQPapapaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQP 758
|
170
....*....|....*.
gi 371876057 317 PPVPSPTSCTAASGPS 332
Cdd:PRK07764 759 PPPPAPAPAAAPAAAP 774
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
121-248 |
1.20e-03 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 42.75 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 121 PSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDP---------NQGGKDITEEIMSGGGSRNPTPPIGRPASTPTPPQQL 191
Cdd:PRK11901 113 TAPPQDISAPPISPTPTQAAPPQTPNGQQRIELPgnisdalsqQQGQVNAASQNAQGNTSTLPTAPATVAPSKGAKVPAT 192
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 192 PSQVPEHSPVVYGT--VESAHLAASTPVTAASDQKQEEKPKPDPVFQS-PSTVLRLVLSG 248
Cdd:PRK11901 193 AETHPTPPQKPATKkpAVNHHKTATVAVPPATSGKPKSGAASARALSSaPASHYTLQLSS 252
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
3-358 |
2.42e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 3 SQPQARSPGGFRPIQFFQR-PQIQPPRaaIPNSSPSIRPGVQTPTAVYQANQhimmvnhlPMPYPVTQGHQYCIPQYRHS 81
Cdd:pfam03154 215 SQPPNQTQSTAAPHTLIQQtPTLHPQR--LPSPHPPLQPMTQPPPPSQVSPQ--------PLPQPSLHGQMPPMPHSLQT 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 82 GPPYVGPPQQYPVqppgpgpfypGPGPGDFANAYGTPFYPSQPVYQSA--PIIVPTQQQPPPAKREKKTIRIRDPnqggk 159
Cdd:pfam03154 285 GPSHMQHPVPPQP----------FPLTPQSSQSQVPPGPSPAAPGQSQqrIHTPPSQSQLQSQQPPREQPLPPAP----- 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 160 diteeimsgggsrNPTPPIGRPASTPTPPQQLPsQVPEHSPvvygtvesaHLAASTPVTAASDQkqeekpKPDPVFQSPS 239
Cdd:pfam03154 350 -------------LSMPHIKPPPTTPIPQLPNP-QSHKHPP---------HLSGPSPFQMNSNL------PPPPALKPLS 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 240 TVLRLVLSGEKKEQAGQMPETAAGEPTP-EPPRTSSPTSLPPLARSSLPSPMSAALSSQPLFTAEDKceLPSSKEEDAPP 318
Cdd:pfam03154 401 SLSTHHPPSAHPPPLQLMPQSQQLPPPPaQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPF--VPGGPPPITPP 478
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 371876057 319 VPSPTScTAASGPSLtdnsdicKKPCSVAPHDSQLISSTI 358
Cdd:pfam03154 479 SGPPTS-TSSAMPGI-------QPPSSASVSSSGPVPAAV 510
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
192-333 |
2.91e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.38 E-value: 2.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 192 PSQVPEHSPVVYGTVESAHLAASTPVTAASdqkQEEKPKPDPVFQSPStvlrlVLSGEKKEQAGQMP-ETAAGEPTPEPP 270
Cdd:PRK10263 301 QPEYDEYDPLLNGAPITEPVAVAAAATTAT---QSWAAPVEPVTQTPP-----VASVDVPPAQPTVAwQPVPGPQTGEPV 372
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 371876057 271 RTSSPTSLPPLARSSLPSPMSAALSSQPlFTAEDKCELPSSKEEDAPPVPSPTSCTAASGPSL 333
Cdd:PRK10263 373 IAPAPEGYPQQSQYAQPAVQYNEPLQQP-VQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY 434
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
24-348 |
3.18e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 24 IQPPRAAIPNSSPSIRPGVQTPTAVYQANQhimmvnhlpmpyPVTQGHQYCIPqyRHSGPPYVGPPQQYPVQPPGPGPFY 103
Cdd:PHA03247 2568 VPPPRPAPRPSEPAVTSRARRPDAPPQSAR------------PRAPVDDRGDP--RGPAPPSPLPPDTHAPDPPPPSPSP 2633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 104 PGPGPGDFANAYGTPfyPSQPVYQSAPiivPTQQQPPPAKREKKTIRIRDPNQGGKditeeimsgggSRNPTPPIGRPAS 183
Cdd:PHA03247 2634 AANEPDPHPPPTVPP--PERPRDDPAP---GRVSRPRRARRLGRAAQASSPPQRPR-----------RRAARPTVGSLTS 2697
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 184 TPTPPQQLPSQVPEHSPVVYGT----VESAHLAASTPVTAAsdqkqeekPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPE 259
Cdd:PHA03247 2698 LADPPPPPPTPEPAPHALVSATplppGPAAARQASPALPAA--------PAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 260 TAAGEPTPEPPRTSSPTSLPPL--ARSSLPSPMSAALSSQPLfTAEDKCELPSSKEedAPPVPSPTSCTAASGPSLTDNS 337
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLseSRESLPSPWDPADPPAAV-LAPAAALPPAASP--AGPLPPPTSAQPTAPPPPPGPP 2846
|
330
....*....|..
gi 371876057 338 DICKKPC-SVAP 348
Cdd:PHA03247 2847 PPSLPLGgSVAP 2858
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
42-328 |
5.37e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.59 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 42 VQTPTAVYQANQHIMMVNHLPMPYPVTQGHQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFaNAYGTPfYP 121
Cdd:PHA03378 574 IQPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITF-NVLVFP-TP 651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 122 SQPVYQSAPIIVPTQQQPPPAKREkktirirdPNQGGKDITEEIMSGGGSRNP---TPPIGRPASTPTPPQQLPSQVPEH 198
Cdd:PHA03378 652 HQPPQVEITPYKPTWTQIGHIPYQ--------PSPTGANTMLPIQWAPGTMQPpprAPTPMRPPAAPPGRAQRPAAATGR 723
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 199 SPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPSTVLRLVLSGEKKEQAGQMPETAA----GEPTPEPPRTSS 274
Cdd:PHA03378 724 ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprGAPTPQPPPQAG 803
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 371876057 275 PTSLPPLARSSLPSPMSAALSSQPLFTAEDKCELPSSK-----EEDAP--PVPSPTSCTAA 328
Cdd:PHA03378 804 PTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKkpaalERQAAagPTPSPGSGTSD 864
|
|
| DUF4045 |
pfam13254 |
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
134-317 |
5.63e-03 |
|
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.
Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 40.92 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 134 PTQQQPPPAKREKKTIRirdPNQGGKDiteeiMSGGGSRNPTPPIGRPASTPTPPQQLPSQVPEHSPVVYGTVESAHLAA 213
Cdd:pfam13254 170 PSQPAQPAWMKELNKIR---QSRASVD-----LGRPNSFKEVTPVGLMRSPAPGGHSKSPSVSGISADSSPTKEEPSEEA 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 371876057 214 STPVTaasdqKQEEKPKPDPVFQSPSTVLRLvlsgEKKEQAGQMPETAAGEPT--PEPPRTSSPTSLPPLARSSLPSPMS 291
Cdd:pfam13254 242 DTLST-----DKEQSPAPTSASEPPPKTKEL----PKDSEEPAAPSKSAEASTekKEPDTESSPETSSEKSAPSLLSPVS 312
|
170 180
....*....|....*....|....*.
gi 371876057 292 AALSSQPLFTAEDKCELPSSKEEDAP 317
Cdd:pfam13254 313 KASIDKPLSSPDRDPLSPKPKPQSPP 338
|
|
| |
