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Conserved domains on  [gi|375331892|ref|NP_001243578|]
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zinc finger protein 43 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-57 5.04e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 5.04e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 375331892     2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 57
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-748 3.69e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 280 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 357
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 358 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 436
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 437 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 516
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 517 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 592
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 593 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 670
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 671 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 747
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331892 748 R 748
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
727-788 8.80e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331892 727 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 788
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-57 5.04e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 5.04e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 375331892     2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 57
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 1.96e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.36  E-value: 1.96e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 375331892    2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-37 3.47e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 3.47e-16
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 375331892   2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 37
Cdd:cd07765    5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-748 3.69e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 280 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 357
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 358 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 436
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 437 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 516
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 517 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 592
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 593 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 670
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 671 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 747
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331892 748 R 748
Cdd:COG5048  466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-571 5.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.50e-04
                          10        20
                  ....*....|....*....|....*
gi 375331892  547 LTKHKRIHTGEKPYKCEECGKAFTQ 571
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
727-788 8.80e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331892 727 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 788
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
742-767 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  742 HLNTHKRIHTKEQPYKCKECGKAFNQ 767
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-57 5.04e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 5.04e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 375331892     2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 57
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 1.96e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 76.36  E-value: 1.96e-17
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 375331892    2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-37 3.47e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 72.58  E-value: 3.47e-16
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 375331892   2 DVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 37
Cdd:cd07765    5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-748 3.69e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.05  E-value: 3.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 280 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 357
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 358 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 436
Cdd:COG5048  114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 437 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 516
Cdd:COG5048  189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 517 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 592
Cdd:COG5048  268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 593 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 670
Cdd:COG5048  327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 671 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 747
Cdd:COG5048  387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                 .
gi 375331892 748 R 748
Cdd:COG5048  466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-776 4.82e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.04  E-value: 4.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 374 SRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKC--EECGKAFNWPSTLTKHNRIHTGEKPYKCE 451
Cdd:COG5048   16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 452 VCGKAFNQFSNLTTHKRIHTAE-KPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEEC--------------------- 509
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpans 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 510 --GKAFKWSSKLTEHKITHTGEKPYKCEECGKaFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKF 587
Cdd:COG5048  176 lsKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 588 YKCEECGKAFTQSSNLTTHKKIHTG-------GKPYKCEECGKAFNQFSTLTKHK--IIHTEE--KPYKCEE--CGKAFK 654
Cdd:COG5048  255 SSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 655 WSSTLTKHKIIHTGEKPYKC--EECGKAF------KLSSTLSTHKIIHTGEKPYKCE-KCGKAFNRSSNLIEHKKIHTGE 725
Cdd:COG5048  335 RNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSF 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 375331892 726 QP--YKCEECGKAFNYSSHLNTHKRIHTKEQPYKCkECGKAFNQYSNLTTHNK 776
Cdd:COG5048  415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-567 3.80e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 197 KCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWS----------------SRLTTHKKNYTRYKLYKCE----- 255
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrthhnnpSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 256 --------ECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPStltkHK 327
Cdd:COG5048  115 snsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI----SS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 328 RIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKL 407
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 408 TEHKLTHTGE-------KPYKCEECGKAFNWPSTLTKHNR--IHTGE--KPYKC--EVCGKAFNQFSNLTTHKRIHTAEK 474
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 475 PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCE---------ECGKAFKWSSKLTEHKITHTGEKP--YKCEECGKAFNH 543
Cdd:COG5048  351 PAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                        410       420
                 ....*....|....*....|....
gi 375331892 544 FSILTKHKRIHTGEKPYKCEECGK 567
Cdd:COG5048  431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
446-778 3.65e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 3.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 446 KPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKC--EECGKAFSRSSNLTKHKKIHIEKKPYKCE-ECGKAFKWSSKLTEH 522
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 523 KITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFykceeCGKAFTQSSN 602
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 603 LTTHKKIHTGGKPYKCEECGKA------------FNQFSTLTKHKIIHTEEKPYKCE---------------ECGKAFKW 655
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 656 SSTLTKHKIIHTGE-------KPYKCEECGKAFKLSSTLSTHK--IIHTGE--KPYKC--EKCGKAFNRSSNLIEHKKIH 722
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 375331892 723 TGEQPYKCEEC------GKAFNYSSHLNTHKRIHTKEQPYKC---KECGKAFNQYSNLTTHNKIH 778
Cdd:COG5048  347 TSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITH 411
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 390-467 6.67e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 390 KPYKCE--ECGKAFKWSSKLTEHKLtHTGEKPYKCEEcgkafnwPSTLtKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHK 467
Cdd:COG5189  348 KPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPE-KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 584-663 1.27e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 584 GEKFYKCE--ECGKAFTQSSNLTTHKKiHTggkpykceECGKAFNQFSTLTKHKIIHTEEKPYKCEECGKAFKWSSTLTK 661
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 375331892 662 HK 663
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-571 5.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.50e-04
                          10        20
                  ....*....|....*....|....*
gi 375331892  547 LTKHKRIHTGEKPYKCEECGKAFTQ 571
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 612-691 7.73e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 612 GGKPYKCE--ECGKAFNQFSTLTKHKIiHTEEKPYKCEecgkafkwSSTLTKHKIIHTGEKPYKCEECGKAFKLSSTLST 689
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 375331892 690 HK 691
Cdd:COG5189  417 HR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
727-788 8.80e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 375331892 727 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 788
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-347 1.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.27e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  323 LTKHKRIHTGEKPYTCEECGKAFNQ 347
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 640-720 1.37e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 640 EEKPYKCE--ECGKAFKWSSTLTKHKiihtgekpyKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIE 717
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 375331892 718 HKK 720
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  462 NLTTHKRIHTAEKPYKCEECGKAFSR 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
742-767 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  742 HLNTHKRIHTKEQPYKCKECGKAFNQ 767
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-543 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  519 LTEHKITHTGEKPYKCEECGKAFNH 543
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-627 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  602 NLTTHKKIHTGGKPYKCEECGKAFNQ 627
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  378 NLTKHKKIHTEKKPYKCEECGKAFK 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-459 2.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  435 LTKHNRIHTGEKPYKCEVCGKAFNQ 459
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
714-739 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  714 NLIEHKKIHTGEQPYKCEECGKAFNY 739
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 2.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  294 NLTEHKKIHPGEKPYKCEECGKAFN 318
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
574-599 2.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 375331892  574 NLTTHKKIHTGEKFYKCEECGKAFTQ 599
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-415 2.95e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 332 GEKPYTCE--ECGKAFNQFSNLTTHKrihtaekfyKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTE 409
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 375331892 410 HKlTHT 415
Cdd:COG5189  417 HR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
659-682 3.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.03e-03
                          10        20
                  ....*....|....*....|....
gi 375331892  659 LTKHKIIHTGEKPYKCEECGKAFK 682
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
687-711 4.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|....*
gi 375331892  687 LSTHKIIHTGEKPYKCEKCGKAFNR 711
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-430 5.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|....
gi 375331892  407 LTEHKLTHTGEKPYKCEECGKAFN 430
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 444-527 8.55e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 375331892 444 GEKPYKCEV--CGKAFNQFSNLTTHKRI-HTAEK--PYKCEECGKAFSrssnltkhkkihIEKKPYKCEECGKAFKWSSK 518
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKlhENPSPEKMNIFS------------AKDKPYRCEVCDKRYKNLNG 413


                 ....*....
gi 375331892 519 LTEHkITHT 527
Cdd:COG5189  414 LKYH-RKHS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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