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Conserved domains on  [gi|387598087|ref|NP_001248380|]
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uridine-cytidine kinase 1 isoform d [Homo sapiens]

Protein Classification

uridine-cytidine kinase( domain architecture ID 10113977)

uridine kinase, or uridine cytidine kinase, catalyzes the ATP-dependent phosphorylation of uridine or cytidine to yield UMP or CMP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 42-235 1.04e-105

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


:

Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 305.25  E-value: 1.04e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQneveqrqRKVVILSQDRFYKVLTAEQKAKALKgqYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYD 121
Cdd:cd02023   13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 122 FVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVKPAF 200
Cdd:cd02023   84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVeRGRDLESVINQYLKFVKPMH 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 387598087 201 EEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDI 235
Cdd:cd02023  164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 42-235 1.04e-105

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 305.25  E-value: 1.04e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQneveqrqRKVVILSQDRFYKVLTAEQKAKALKgqYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYD 121
Cdd:cd02023   13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 122 FVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVKPAF 200
Cdd:cd02023   84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVeRGRDLESVINQYLKFVKPMH 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 387598087 201 EEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDI 235
Cdd:cd02023  164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 42-239 1.40e-79

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 239.29  E-value: 1.40e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQNeveqrqrKVVILSQDRFYK---VLTAEQKAKAlkgqyNFDHPDAFDNDLMHRTLKNIVEGKTVEVP 118
Cdd:PRK05480  20 TTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVKT-----NYDHPDAFDHDLLIEHLKALKAGKAIEIP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 119 TYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVK 197
Cdd:PRK05480  88 VYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNeRGRSLESVINQYLSTVR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 387598087 198 PAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGD 239
Cdd:PRK05480 168 PMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEKN 209
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 41-237 4.32e-68

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 210.32  E-value: 4.32e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087   41 QSTVCEKIMELLGQneveqrqRKVVILSQDRFYKVLtaEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTY 120
Cdd:TIGR00235  19 KTTVARKIYEQLGK-------LEIVIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  121 DFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDV-RRGRDLEQILTQYTTFVKPA 199
Cdd:TIGR00235  90 DYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDInERGRSLDSVIDQYRKTVRPM 169

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 387598087  200 FEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILN 237
Cdd:TIGR00235 170 YEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 42-234 1.49e-65

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 203.53  E-value: 1.49e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQNeveqrqrKVVILSQDRFYKVLtaEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYD 121
Cdd:COG0572   21 TTFARRLAEQLGAD-------KVVVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 122 FVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVKPAF 200
Cdd:COG0572   92 FATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEeRGRTAESVIEQYWATVRPGH 171

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 387598087 201 EEFCLPTKKYADVIIPRG-VDNMVAINLIVQHIQD 234
Cdd:COG0572  172 EQYIEPTKEYADIVIPNGgPLNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 39-224 7.13e-53

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 171.04  E-value: 7.13e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087   39 CLQSTVCEKIMELLGQNEVEQRQRK-VVILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEV 117
Cdd:pfam00485  10 SGKTTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  118 PTYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDV-RRGRDLEQILTQYtTFV 196
Cdd:pfam00485  90 PIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMaERGHSLEGVTDSI-LFR 168

                         170       180
                  ....*....|....*....|....*...
gi 387598087  197 KPAFEEFCLPTKKYADVIIPRGVDNMVA 224
Cdd:pfam00485 169 KPDYVNYIDPQFSYADLIIQRVPTNDTA 196
 
Name Accession Description Interval E-value
UMPK cd02023
Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or ...
 42-235 1.04e-105

Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, this enzyme combined with nucleoside diphosphate kinases further phosphorylates UMP and CMP to form UTP and CTP. This kinase also catalyzes the phosphorylation of several cytotoxic ribonucleoside analogs such as 5-flurrouridine and cyclopentenyl-cytidine.


Pssm-ID: 238981 [Multi-domain]  Cd Length: 198  Bit Score: 305.25  E-value: 1.04e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQneveqrqRKVVILSQDRFYKVLTAEQKAKALKgqYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYD 121
Cdd:cd02023   13 TTVAEEIIEQLGN-------PKVVIISQDSYYKDLSHEELEERKN--NNYDHPDAFDFDLLISHLQDLKNGKSVEIPVYD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 122 FVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVKPAF 200
Cdd:cd02023   84 FKTHSRLKETVTVYPADVIILEGILALYDKELRDLMDLKIFVDTDADVRLIRRIERDIVeRGRDLESVINQYLKFVKPMH 163

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 387598087 201 EEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDI 235
Cdd:cd02023  164 EQFIEPTKRYADVIIPRGGDNHVAIDLIVQHIKSK 198
PRK05480 PRK05480
uridine/cytidine kinase; Provisional
 42-239 1.40e-79

uridine/cytidine kinase; Provisional


Pssm-ID: 235492 [Multi-domain]  Cd Length: 209  Bit Score: 239.29  E-value: 1.40e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQNeveqrqrKVVILSQDRFYK---VLTAEQKAKAlkgqyNFDHPDAFDNDLMHRTLKNIVEGKTVEVP 118
Cdd:PRK05480  20 TTVASTIYEELGDE-------SIAVIPQDSYYKdqsHLSFEERVKT-----NYDHPDAFDHDLLIEHLKALKAGKAIEIP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 119 TYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVK 197
Cdd:PRK05480  88 VYDYTEHTRSKETIRVEPKDVIILEGILLLEDERLRDLMDIKIFVDTPLDIRLIRRLKRDVNeRGRSLESVINQYLSTVR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 387598087 198 PAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGD 239
Cdd:PRK05480 168 PMHLQFIEPSKRYADIIIPEGGKNRVAIDILKAKIRQLLEKN 209
udk TIGR00235
uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in ...
 41-237 4.32e-68

uridine kinase; Model contains a number of longer eukaryotic proteins and starts bringing in phosphoribulokinase hits at scores of 160 and below [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 272977  Cd Length: 207  Bit Score: 210.32  E-value: 4.32e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087   41 QSTVCEKIMELLGQneveqrqRKVVILSQDRFYKVLtaEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTY 120
Cdd:TIGR00235  19 KTTVARKIYEQLGK-------LEIVIISQDNYYKDQ--SHLEMAERKKTNFDHPDAFDNDLLYEHLKNLKNGSPIDVPVY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  121 DFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDV-RRGRDLEQILTQYTTFVKPA 199
Cdd:TIGR00235  90 DYVNHTRPKETVHIEPKDVVILEGIMPLFDERLRDLMDLKIFVDTPLDIRLIRRIERDInERGRSLDSVIDQYRKTVRPM 169

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 387598087  200 FEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILN 237
Cdd:TIGR00235 170 YEQFVEPTKQYADLIIPEGGRNEVAINVLDTKIKHLLE 207
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 42-234 1.49e-65

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 203.53  E-value: 1.49e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  42 STVCEKIMELLGQNeveqrqrKVVILSQDRFYKVLtaEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYD 121
Cdd:COG0572   21 TTFARRLAEQLGAD-------KVVVISLDDYYKDR--EHLPLDERGKPNFDHPEAFDLDLLNEHLEPLKAGESVELPVYD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 122 FVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDVR-RGRDLEQILTQYTTFVKPAF 200
Cdd:COG0572   92 FATGTRSGETVKVEPADVIIVEGIHALNDELLRDLLDLKIYVDADTDVRLIRRIVRDGEeRGRTAESVIEQYWATVRPGH 171

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 387598087 201 EEFCLPTKKYADVIIPRG-VDNMVAINLIVQHIQD 234
Cdd:COG0572  172 EQYIEPTKEYADIVIPNGgPLNPVALDLLVARLLS 206
PRK pfam00485
Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop ...
 39-224 7.13e-53

Phosphoribulokinase / Uridine kinase family; This family matches three types of P-loop containing kinases: phosphoribulokinases, uridine kinases and bacterial pantothenate kinases(CoaA). Arabidopsis and other organizms have a dual uridine kinase/uracil phosphoribosyltransferase protein where the N-terminal region consists of a UK domain and the C-terminal region of a UPRT domain.


Pssm-ID: 425711 [Multi-domain]  Cd Length: 196  Bit Score: 171.04  E-value: 7.13e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087   39 CLQSTVCEKIMELLGQNEVEQRQRK-VVILSQDRFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVEV 117
Cdd:pfam00485  10 SGKTTVARRIVSIFGREGVPAVGIEgDSFHSTDRFYMDLHPEDRKRAGNNGYSFDGPEANDFDLLYEQFKELKEGGSVDK 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  118 PTYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRRVLRDV-RRGRDLEQILTQYtTFV 196
Cdd:pfam00485  90 PIYNHVTHERDPTPELIEGADVLVIEGLHALYDERVAQLLDLKIYVDPDIDLELARKIQRDMaERGHSLEGVTDSI-LFR 168

                         170       180
                  ....*....|....*....|....*...
gi 387598087  197 KPAFEEFCLPTKKYADVIIPRGVDNMVA 224
Cdd:pfam00485 169 KPDYVNYIDPQFSYADLIIQRVPTNDTA 196
PTZ00301 PTZ00301
uridine kinase; Provisional
 90-238 2.71e-30

uridine kinase; Provisional


Pssm-ID: 140322 [Multi-domain]  Cd Length: 210  Bit Score: 113.17  E-value: 2.71e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  90 NFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDV 169
Cdd:PTZ00301  60 NYDHPKSLEHDLLTTHLRELKSGKTVQIPQYDYVHHTRSDTAVTMTPKSVLIVEGILLFTNAELRNEMDCLIFVDTPLDI 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 170 RLSRRVLRDVR-RGRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNG 238
Cdd:PTZ00301 140 CLIRRAKRDMReRGRTFESVIEQYEATVRPMYYAYVEPSKVYADIIVPSWKDNSVAVGVLRAKLNHDLEN 209
PLN02348 PLN02348
phosphoribulokinase
 93-215 4.76e-20

phosphoribulokinase


Pssm-ID: 215198  Cd Length: 395  Bit Score: 88.75  E-value: 4.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  93 HPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVThSRLPETTVVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLS 172
Cdd:PLN02348 120 DPRANNFDLMYEQVKALKEGKAVEKPIYNHVT-GLLDPPELIEPPKILVIEGLHPMYDERVRDLLDFSIYLDISDDVKFA 198

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 387598087 173 RRVLRDV-RRGRDLEQILTQYTTfVKPAFEEFCLPTKKYADVII 215
Cdd:PLN02348 199 WKIQRDMaERGHSLESIKASIEA-RKPDFDAYIDPQKQYADVVI 241
PRK cd02026
Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or ...
 93-215 9.99e-19

Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH produced by the primary reactions of photosynthesis.


Pssm-ID: 238984 [Multi-domain]  Cd Length: 273  Bit Score: 83.54  E-value: 9.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  93 HPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHS-RLPETtvVYPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRL 171
Cdd:cd02026   53 DPRANNFDLMYEQLKALKEGQAIEKPIYNHVTGLiDPPEL--IKPTKIVVIEGLHPLYDERVRELLDFSVYLDISDEVKF 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 387598087 172 SRRVLRDV-RRGRDLEQILTQYTTfVKPAFEEFCLPTKKYADVII 215
Cdd:cd02026  131 AWKIQRDMaERGHSLEDVLASIEA-RKPDFEAYIDPQKQYADVVI 174
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 54-203 5.53e-18

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 79.27  E-value: 5.53e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  54 QNEVEQRQRKVVILSQDRFYKVLTAEQKAkalkgQYNFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTV 133
Cdd:cd02028   20 SNQLRVNGIGPVVISLDDYYVPRKTPRDE-----DGNYDFESILDLDLLNKNLHDLLNGKEVELPIYDFRTGKRRGYRKL 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387598087 134 VYP-ADVVLFEGIlvfY--SQEIRDMFHLRLFVDT-DSDVRLSRRVLRDV-RRGRDLEQILTQYTTFvkPAFEEF 203
Cdd:cd02028   95 KLPpSGVVILEGI---YalNERLRSLLDIRVAVSGgVHLNRLLRRVVRDIqFRGYSAELTILMWPSV--PSGEEF 164
PRK07429 PRK07429
phosphoribulokinase; Provisional
 21-215 1.44e-14

phosphoribulokinase; Provisional


Pssm-ID: 180975  Cd Length: 327  Bit Score: 72.35  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  21 QRPFLI---GDERfqagipllCLQSTVCEKIMELLGQneveqrQRKVVILSQDrfYKVLTAEQKAK----ALkgqynfdH 93
Cdd:PRK07429   6 DRPVLLgvaGDSG--------CGKTTFLRGLADLLGE------ELVTVICTDD--YHSYDRKQRKElgitAL-------D 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  94 PDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTVVyPADVVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSR 173
Cdd:PRK07429  63 PRANNLDIMYEHLKALKTGQPILKPIYNHETGTFDPPEYIE-PNKIVVVEGLHPLYDERVRELYDFKVYLDPPEEVKIAW 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 387598087 174 RVLRDV-RRGRDLEQILTQYTTfVKPAFEEFCLPTKKYADVII 215
Cdd:PRK07429 142 KIKRDMaKRGHTYEQVLAEIEA-REPDFEAYIRPQRQWADVVI 183
PLN02318 PLN02318
phosphoribulokinase/uridine kinase
 90-215 2.22e-14

phosphoribulokinase/uridine kinase


Pssm-ID: 177952 [Multi-domain]  Cd Length: 656  Bit Score: 72.97  E-value: 2.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  90 NFDHPDAFDNDLMHRTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPAD-VVLFEGILVFySQEIRDMFHLRLFVDTDSD 168
Cdd:PLN02318 110 NFDDPRLTDYDTLLDNIHDLKAGKSVQVPIYDFKSSSRVGYRTLEVPSSrIVIIEGIYAL-SEKLRPLLDLRVSVTGGVH 188

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 387598087 169 VRLSRRVLRDVRR-GRDLEQILTQYTTFVKPAFEEFCLPTKKYADVII 215
Cdd:PLN02318 189 FDLVKRVLRDIQRaGQEPEEIIHQISETVYPMYKAFIEPDLQTAHIKI 236
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 65-174 1.95e-08

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 53.10  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  65 VILSQDRFYKvlTAEQKAKALKGQYNFDHPDAFDNDLMHRTLKNIVEGKTVE--------VPTYDFVTHSRLPETTVVYP 136
Cdd:cd02024   27 CVIHQDDFFK--PEDEIPVDENGFKQWDVLEALDMEAMMSTLDYWRETGHFPkflrshgnENDPEKEFIEDAQIEETKAD 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 387598087 137 AD------VVLFEGILVFYSQEIRDMFHLRLFVDTDSDVRLSRR 174
Cdd:cd02024  105 LLgaedlhILIVDGFLLYNYKPLVDLFDIRYFLRVPYETCKRRR 148
PRK08233 PRK08233
hypothetical protein; Provisional
 152-236 5.86e-07

hypothetical protein; Provisional


Pssm-ID: 181310 [Multi-domain]  Cd Length: 182  Bit Score: 48.59  E-value: 5.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 152 EIRDMFHLRLFVDTDSDVRLSRRVLRDVRR--GRDLEQILTQYTTFVKPAFEEFCLPTKKYADVIIprgvDNMVAINLIV 229
Cdd:PRK08233  93 EMRQFIDVTIFIDTPLDIAMARRILRDFKEdtGNEIHNDLKHYLNYARPLYLEALHTVKPNADIVL----DGALSVEEII 168


                 ....*..
gi 387598087 230 QHIQDIL 236
Cdd:PRK08233 169 NQIEEEL 175
PRK09270 PRK09270
nucleoside triphosphate hydrolase domain-containing protein; Reviewed
 94-194 2.67e-03

nucleoside triphosphate hydrolase domain-containing protein; Reviewed


Pssm-ID: 236442  Cd Length: 229  Bit Score: 38.38  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087  94 PDAFD----NDLMHRtLKNivEGKTVEVPTYDFVTHSRLPETTVVYP-ADVVLFEGILVFYSQ----EIRDMFHLRLFVD 164
Cdd:PRK09270  92 PETFDvaglAALLRR-LRA--GDDEVYWPVFDRSLEDPVADAIVVPPtARLVIVEGNYLLLDEepwrRLAGLFDFTIFLD 168

                         90       100       110
                 ....*....|....*....|....*....|
gi 387598087 165 TDSDVRLSRRVLRDVRRGRDLEQILTQYTT 194
Cdd:PRK09270 169 APAEVLRERLVARKLAGGLSPEAAEAFVLR 198
PRK06696 PRK06696
uridine kinase; Validated
 120-215 4.69e-03

uridine kinase; Validated


Pssm-ID: 180660  Cd Length: 223  Bit Score: 37.65  E-value: 4.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387598087 120 YDFVTHSRLPETTVVYPADVVLF-EGILVFySQEIRDMFHLRLFVDTDSDVRLSRRVLRDVRRGRDLEQILTQYTTFVKP 198
Cdd:PRK06696 110 HDLKTDIPVHNPPLLAAPNAVLIvDGTFLL-RPELRDLWDYKIFLDTDFEVSRRRGAKRDTEAFGSYEEAEKMYLARYHP 188

                         90       100
                 ....*....|....*....|
gi 387598087 199 AFE---EFCLPtKKYADVII 215
Cdd:PRK06696 189 AQKlyiAEANP-KERADVVI 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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