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Conserved domains on  [gi|392884912|ref|NP_001249132|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
123-346 8.35e-22

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 8.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAI 282
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392884912 283 DLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  316 DLATGKLLRTLTGHTGAvRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
123-346 8.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 8.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAI 282
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392884912 283 DLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  316 DLATGKLLRTLTGHTGAvRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-414 8.63e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 8.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 133 RSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVPAQKTFVGH 212
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 213 TKAVTGFGIIGVGREFLSCSNDGTVRFwscknaaptetWSFEKGKCI-------DMAMSVD---DSRFAVI-CENNFLSA 281
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETGKCLttlrghtDWVNSVAfspDGTFVASsSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 282 IDLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCLKYYCNR--LIASFT 358
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEvNSVAFSPD--GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392884912 359 TGNVLAFPILSLPTSssiisaeYELTGADcEPVYDMAIYQKN--IYTCCRDGKIRTYK 414
Cdd:cd00200  240 DGTIRVWDLRTGECV-------QTLSGHT-NSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 207-241 1.30e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 392884912   207 KTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWS 241
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
206-241 2.56e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392884912  206 QKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWS 241
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 158-238 4.29e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 158 SRTAETLTELTGHTMDIYRCMYFPSGL-VVIGGGMDMAIRVWAVDKVPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGT 236
Cdd:PTZ00421 112 QNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191


                 ..
gi 392884912 237 VR 238
Cdd:PTZ00421 192 LN 193
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
123-346 8.35e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 8.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAI 282
Cdd:COG2319  236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392884912 283 DLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  316 DLATGKLLRTLTGHTGAvRSVAFSPD--GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-414 8.63e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 8.63e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 133 RSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVPAQKTFVGH 212
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 213 TKAVTGFGIIGVGREFLSCSNDGTVRFwscknaaptetWSFEKGKCI-------DMAMSVD---DSRFAVI-CENNFLSA 281
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSSRDKTIKV-----------WDVETGKCLttlrghtDWVNSVAfspDGTFVASsSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 282 IDLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCLKYYCNR--LIASFT 358
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEvNSVAFSPD--GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGylLASGSE 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 392884912 359 TGNVLAFPILSLPTSssiisaeYELTGADcEPVYDMAIYQKN--IYTCCRDGKIRTYK 414
Cdd:cd00200  240 DGTIRVWDLRTGECV-------QTLSGHT-NSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
112-346 6.60e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 6.60e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 112 RTTIFVGPTSEQNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGM 191
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 192 DMAIRVWAVDKVPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFA 271
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392884912 272 VICENNFLSAIDLHGDKIRRDIQLPS-VPTALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  221 SGSADGTVRLWDLATGKLLRTLTGHSgSVRSVAFSPD--GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-364 9.85e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 9.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 125 LRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVP 204
Cdd:cd00200   47 LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 205 AQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAIDL 284
Cdd:cd00200  127 CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 285 HGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCLkyycnrliASFTTGNVL 363
Cdd:cd00200  207 STGKCLGTLRGHENGvNSVAFSPD--GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSL--------AWSPDGKRL 276


                 .
gi 392884912 364 A 364
Cdd:cd00200  277 A 277
WD40 COG2319
WD40 repeat [General function prediction only];
123-329 2.47e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 2.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAI 282
Cdd:COG2319  278 GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 392884912 283 DLHGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSD 329
Cdd:COG2319  358 DLATGELLRTLTGHTGAvTSVAFSPD--GRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
125-346 5.83e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 5.83e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 125 LRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVP 204
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 205 AQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAIDL 284
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392884912 285 HGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  192 ATGKLLRTLTGHTGAvRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 125-320 1.45e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 125 LRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVP 204
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 205 AQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAIDL 284
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL 248

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 392884912 285 HGDKIRRDIQLPSVP-TALCFSGDegGKAVFVGFEDG 320
Cdd:cd00200  249 RTGECVQTLSGHTNSvTSLAWSPD--GKRLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-272 5.06e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 5.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAV 272
Cdd:cd00200  209 GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-241 1.73e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.52  E-value: 1.73e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 123 QNLRGLQSAPRSFDVSCTGSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDK 202
Cdd:cd00200  171 ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT 250

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 392884912 203 VPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWS 241
Cdd:cd00200  251 GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
141-346 5.30e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 5.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 141 GSTFVAADSSGKLIIANSRTAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVWAVDKVPAQKTFVGHTKAVTGFG 220
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 221 IIGVGREFLSCSNDGTVRFWSCKNAAPTETWSFEKGKCIDMAMSVDDSRFAVICENNFLSAIDLHGDKIRRDIQLPSVP- 299
Cdd:COG2319   86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAv 165

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 392884912 300 TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCL 346
Cdd:COG2319  166 TSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
181-336 7.99e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.08  E-value: 7.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 181 PSGLVVIGGGMDMAIRVWAVDKVPAQKTFVGHTKAVTGFGIIGVGRE-FLSCSNDGTVRFWSCKNAAPTETWSFEKGkCI 259
Cdd:COG3391   35 PLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRlYVANSGSGRVSVIDLATGKVVATIPVGGG-PR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 260 DMAMSVDDSRFAVICE-NNFLSAIDLHGDKIRRDIQLPSVPTALCFSGDegGKAVFVGFEDGH-----VAAYNVSDRRLI 333
Cdd:COG3391  114 GLAVDPDGGRLYVADSgNGRVSVIDTATGKVVATIPVGAGPHGIAVDPD--GKRLYVANSGSNtvsviVSVIDTATGKVV 191


                 ...
gi 392884912 334 GEI 336
Cdd:COG3391  192 ATI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 207-241 1.30e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 392884912   207 KTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWS 241
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
206-241 2.56e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392884912  206 QKTFVGHTKAVTGFGIIGVGREFLSCSNDGTVRFWS 241
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 160-198 1.04e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 392884912   160 TAETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVW 198
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 300-351 3.48e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 392884912  300 TALCFSGDegGKAVFVGFEDGHVAAYNVSDRRLIGEIVTKKGSVTCLKYYCN 351
Cdd:pfam12894  42 TSLAWRPD--GKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
PTZ00421 PTZ00421
coronin; Provisional
 158-238 4.29e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 158 SRTAETLTELTGHTMDIYRCMYFPSGL-VVIGGGMDMAIRVWAVDKVPAQKTFVGHTKAVTGFGIIGVGREFLSCSNDGT 236
Cdd:PTZ00421 112 QNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKK 191


                 ..
gi 392884912 237 VR 238
Cdd:PTZ00421 192 LN 193
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
225-315 5.77e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884912 225 GREFLSCSNDGTVRFWSCKNAAPTETWSFEKGkCIDMAMSVDDSRFAVICENN-----FLSAIDLHGDKIRRDIQLPSVP 299
Cdd:COG3391  122 GRLYVADSGNGRVSVIDTATGKVVATIPVGAG-PHGIAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGP 200

                         90
                 ....*....|....*.
gi 392884912 300 TALCFSGDegGKAVFV 315
Cdd:COG3391  201 VGVAVSPD--GRRLYV 214
WD40 pfam00400
WD domain, G-beta repeat;
162-198 9.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 9.77e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 392884912  162 ETLTELTGHTMDIYRCMYFPSGLVVIGGGMDMAIRVW 198
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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