NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392894976|ref|NP_001254926|]
View 

THO complex subunit 5 [Caenorhabditis elegans]

Protein Classification

THO complex subunit 5( domain architecture ID 11184601)

THO complex subunit 5 is a component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
100-431 1.89e-107

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


:

Pssm-ID: 462889  Cd Length: 347  Bit Score: 326.96  E-value: 1.89e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  100 RLTHYGTALMRKEVAERMENVDAKLLQLQNVTSEVQHIQKEIDRCLDFSAGDEELELVPFEQFHTEASEILA--NETADN 177
Cdd:pfam09766   1 RLAKIRLKTGRDETHEAKQKVDSLHLQLQNLLYEKSHLKKEIKKCLDFKSKDEDIELVPEEEFYAEAPEDISkpELTKDD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  178 EHEQYLARLKFENEQRRELLSTLNELEGRRNVLQSDIRGKEVRLQGLKPKLEDLTKVAEPVFEMVGAkfkDLSIEGEQRK 257
Cdd:pfam09766  81 EHQLMLARLEWELEQRKELAKQLKELEQSKKKLLQEIESKKKRLSSLPPALKSLLKATKPLQEALGL---PLDKERKQHE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  258 LSLQLPAPLAVAHIHAAAYKEIHDDKlFEFRILGTNDTEKQSK---------------DETEAMKRKRKEDETTQEKINK 322
Cdd:pfam09766 158 LASLLPKPLYVLYIQLTAYQEACDKN-LTVEIVGDVEEAKAFKeatnqqeedssdsdaEGEELNRRKKRRRKTREGKQEE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  323 MASELLEVHPMSLEFEIECSENIKISMQIQYLTELKVTTAKWHINTDSklKKSPFFSIDSLMSDLFENDTGDKCPNDVGE 402
Cdd:pfam09766 237 KSSKLLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS--SAGDLLSDESLLSNLFPGDTGLESPNPANK 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 392894976  403 MKIEHLKMN-FNSSAKQIGKPFKFIQEISG 431
Cdd:pfam09766 315 YQLQNLGLDeFNDNFSELGKPYKWAQRLCG 344
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
100-431 1.89e-107

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 326.96  E-value: 1.89e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  100 RLTHYGTALMRKEVAERMENVDAKLLQLQNVTSEVQHIQKEIDRCLDFSAGDEELELVPFEQFHTEASEILA--NETADN 177
Cdd:pfam09766   1 RLAKIRLKTGRDETHEAKQKVDSLHLQLQNLLYEKSHLKKEIKKCLDFKSKDEDIELVPEEEFYAEAPEDISkpELTKDD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  178 EHEQYLARLKFENEQRRELLSTLNELEGRRNVLQSDIRGKEVRLQGLKPKLEDLTKVAEPVFEMVGAkfkDLSIEGEQRK 257
Cdd:pfam09766  81 EHQLMLARLEWELEQRKELAKQLKELEQSKKKLLQEIESKKKRLSSLPPALKSLLKATKPLQEALGL---PLDKERKQHE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  258 LSLQLPAPLAVAHIHAAAYKEIHDDKlFEFRILGTNDTEKQSK---------------DETEAMKRKRKEDETTQEKINK 322
Cdd:pfam09766 158 LASLLPKPLYVLYIQLTAYQEACDKN-LTVEIVGDVEEAKAFKeatnqqeedssdsdaEGEELNRRKKRRRKTREGKQEE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  323 MASELLEVHPMSLEFEIECSENIKISMQIQYLTELKVTTAKWHINTDSklKKSPFFSIDSLMSDLFENDTGDKCPNDVGE 402
Cdd:pfam09766 237 KSSKLLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS--SAGDLLSDESLLSNLFPGDTGLESPNPANK 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 392894976  403 MKIEHLKMN-FNSSAKQIGKPFKFIQEISG 431
Cdd:pfam09766 315 YQLQNLGLDeFNDNFSELGKPYKWAQRLCG 344
 
Name Accession Description Interval E-value
FmiP_Thoc5 pfam09766
Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues ...
100-431 1.89e-107

Fms-interacting protein/Thoc5; This entry carries part of the crucial 144 N-terminal residues of the FmiP (Fms interacting protein). A member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) complex which is a subcomplex of the transcription/export (TREX) complex. It is essential for the binding of the protein to the cytoplasmic domain of activated Fms-molecules in M-CSF induced haematopoietic differentiation of macrophages. Fmip is also known as THOC5 (THO complex subunit 5) a 683 amino acids long protein which contains a nuclear localization sequence (NLS), a leucine zipper and a PEST like sequence (aa. 303-319) that carries three ataxia-telangiectasia mutated (ATM) kinase specific phosphorylation sites. The C-terminus contains a THOC1 binding site. The level of FMIP/Thoc5 expression might form a threshold that determines whether cells differentiate into macrophages or into granulocytes.


Pssm-ID: 462889  Cd Length: 347  Bit Score: 326.96  E-value: 1.89e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  100 RLTHYGTALMRKEVAERMENVDAKLLQLQNVTSEVQHIQKEIDRCLDFSAGDEELELVPFEQFHTEASEILA--NETADN 177
Cdd:pfam09766   1 RLAKIRLKTGRDETHEAKQKVDSLHLQLQNLLYEKSHLKKEIKKCLDFKSKDEDIELVPEEEFYAEAPEDISkpELTKDD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  178 EHEQYLARLKFENEQRRELLSTLNELEGRRNVLQSDIRGKEVRLQGLKPKLEDLTKVAEPVFEMVGAkfkDLSIEGEQRK 257
Cdd:pfam09766  81 EHQLMLARLEWELEQRKELAKQLKELEQSKKKLLQEIESKKKRLSSLPPALKSLLKATKPLQEALGL---PLDKERKQHE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  258 LSLQLPAPLAVAHIHAAAYKEIHDDKlFEFRILGTNDTEKQSK---------------DETEAMKRKRKEDETTQEKINK 322
Cdd:pfam09766 158 LASLLPKPLYVLYIQLTAYQEACDKN-LTVEIVGDVEEAKAFKeatnqqeedssdsdaEGEELNRRKKRRRKTREGKQEE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392894976  323 MASELLEVHPMSLEFEIECSENIKISMQIQYLTELKVTTAKWHINTDSklKKSPFFSIDSLMSDLFENDTGDKCPNDVGE 402
Cdd:pfam09766 237 KSSKLLKPHPLSVELTIKCKDDTKLKLQFRYLPKLNIVTVKAQLTLDS--SAGDLLSDESLLSNLFPGDTGLESPNPANK 314
                         330       340       350
                  ....*....|....*....|....*....|
gi 392894976  403 MKIEHLKMN-FNSSAKQIGKPFKFIQEISG 431
Cdd:pfam09766 315 YQLQNLGLDeFNDNFSELGKPYKWAQRLCG 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH