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Conserved domains on  [gi|410442540|ref|NP_001258579|]
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5-azacytidine-induced protein 2 isoform d [Homo sapiens]

Protein Classification

TBD domain-containing protein( domain architecture ID 10582370)

TBD domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBD pfam12845
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 101-153 4.12e-16

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


:

Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 70.93  E-value: 4.12e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 410442540  101 SISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---KACAPVGCSED 153
Cdd:pfam12845   1 GDSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLKIEQETAgeiQFSMPIQCTDD 56
FapA super family cl47856
Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta ...
 48-121 9.25e-03

Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta solenoid domain of FapA and its homologs. Members of this family include FapA (flagellar assembly protein A) found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction. This entry shows similarity to pfam03775 suggesting a similar functional role.


The actual alignment was detected with superfamily member pfam03961:

Pssm-ID: 461111 [Multi-domain]  Cd Length: 272  Bit Score: 36.89  E-value: 9.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410442540   48 VEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNL 121
Cdd:pfam03961 149 VDFPELKEKLEELEKELEELEEELEKLKKRLKKLPKKARGQLPPEKREQLEKLLETKNKLSEELEELEEELKEL 222
 
Name Accession Description Interval E-value
TBD pfam12845
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 101-153 4.12e-16

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 70.93  E-value: 4.12e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 410442540  101 SISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---KACAPVGCSED 153
Cdd:pfam12845   1 GDSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLKIEQETAgeiQFSMPIQCTDD 56
FapA pfam03961
Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta ...
 48-121 9.25e-03

Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta solenoid domain of FapA and its homologs. Members of this family include FapA (flagellar assembly protein A) found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction. This entry shows similarity to pfam03775 suggesting a similar functional role.


Pssm-ID: 461111 [Multi-domain]  Cd Length: 272  Bit Score: 36.89  E-value: 9.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410442540   48 VEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNL 121
Cdd:pfam03961 149 VDFPELKEKLEELEKELEELEEELEKLKKRLKKLPKKARGQLPPEKREQLEKLLETKNKLSEELEELEEELKEL 222
 
Name Accession Description Interval E-value
TBD pfam12845
TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, ...
 101-153 4.12e-16

TBD domain; The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.


Pssm-ID: 463729 [Multi-domain]  Cd Length: 56  Bit Score: 70.93  E-value: 4.12e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 410442540  101 SISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIK---KACAPVGCSED 153
Cdd:pfam12845   1 GDSSVNLEKAYWELKEEMHRLCMLTRVQAEHLRKLKIEQETAgeiQFSMPIQCTDD 56
FapA pfam03961
Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta ...
 48-121 9.25e-03

Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta solenoid domain of FapA and its homologs. Members of this family include FapA (flagellar assembly protein A) found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction. This entry shows similarity to pfam03775 suggesting a similar functional role.


Pssm-ID: 461111 [Multi-domain]  Cd Length: 272  Bit Score: 36.89  E-value: 9.25e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 410442540   48 VEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNL 121
Cdd:pfam03961 149 VDFPELKEKLEELEKELEELEEELEKLKKRLKKLPKKARGQLPPEKREQLEKLLETKNKLSEELEELEEELKEL 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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