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Conserved domains on  [gi|442626006|ref|NP_001260060|]
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hoepel1, isoform I [Drosophila melanogaster]

Protein Classification

ArsB/NhaD family transporter( domain architecture ID 18136919)

ArsB/NhaD family transporter translocates substrates such as sodium, arsenate, sulfate, and organic anions across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 315-803 1.10e-176

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


:

Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 514.11  E-value: 1.10e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 315 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 394
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 395 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 474
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 475 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 554
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 555 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 634
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 635 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 714
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 715 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 794
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 442626006 795 IIVTTGYLL 803
Cdd:cd01116  405 LILATVYLL 413
geminin-like_CC super family cl45898
coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin ...
 34-84 4.01e-04

coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin coiled-coil domain-containing protein 1 (GemC1), and McIdas. Together, geminin, GemC1, and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. They were initially identified as cell cycle regulators associated with the chromosome cycle. Geminin is required to ensure once-per-cell-cycle genome replication, while McIdas and GemC1 bind to geminin and are implicated in DNA replication control. Geminin binds to Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC), in a timely manner to inhibit DNA replication. Geminin family members also function as early regulators of multiciliogenesis. GemC1 and McIdas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. Geminin family proteins contain a homologous central coiled-coil domain that mediates homo- and heterodimerization; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of the geminin family.


The actual alignment was detected with superfamily member cd22589:

Pssm-ID: 459243 [Multi-domain]  Cd Length: 65  Bit Score: 39.12  E-value: 4.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442626006  34 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 84
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 315-803 1.10e-176

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 514.11  E-value: 1.10e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 315 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 394
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 395 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 474
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 475 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 554
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 555 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 634
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 635 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 714
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 715 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 794
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 442626006 795 IIVTTGYLL 803
Cdd:cd01116  405 LILATVYLL 413
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
309-804 1.38e-107

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 335.94  E-value: 1.38e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 309 IYAAAVLCGLYVMIIWEI--VNRTFAAIIASTLSVgILAALnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDY 386
Cdd:COG1055    3 ILALAIFVLTYLLIILEPrgLNRAVAALLGAALLL-LLGVV----SLEDALEAIDWNTILFLLGMMIIVAILDESGFFEW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 387 LAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPN 466
Cdd:COG1055   78 LAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 467 VIIASNSyisknGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNisDLQFKDSPEVEElrheihvwkraaaslsayskde 546
Cdd:COG1055  158 IMIASAG-----GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRK--ELPAAPDLEDDP---------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 547 elvrqtlmkkvnrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVPelqRLSLGW 626
Cdd:COG1055  209 -----------------------------------------KEAIKDRRLLRISLLVLALLLVGFVLHSFL---GLPPAL 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 627 TALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVS 706
Cdd:COG1055  245 IALLGAAVLLLLARV-DVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG-----NLLLAALLILWLS 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 707 AVASAFVDNIPLTTMMvkitISLAQNSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKV 786
Cdd:COG1055  319 AILSAVVDNVPLVAAL----LPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394

                        490
                 ....*....|....*...
gi 442626006 787 GFPIMIGSIIVTTGYLLV 804
Cdd:COG1055  395 GLPLTLLTLLIALLYLLL 412
CitMHS pfam03600
Citrate transporter;
319-749 9.46e-83

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 268.03  E-value: 9.46e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  319 YVMIIWEIVNRTFAAIIastlsVGILAALNSRPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 398
Cdd:pfam03600   1 YVLIITEKLPRDVVALL-----GAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  399 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkn 478
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  479 gvnFAVFTLHMLPGVLLVMVQT-YIQLRFKFRNISDLQFKDSPEVEELRheihvwkraaaslsayskdeelvrqtlmkkv 557
Cdd:pfam03600 154 ---FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEEEAELEELR------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  558 nrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgwtALLGAIFLII 637
Cdd:pfam03600 200 ------------------------------KRAIKDKLLLAISALVLALVILGFLLLSV-----------LALAGALLLL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  638 LADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgedrRLMVAILIILWVSAVASAFVDNIP 717
Cdd:pfam03600 239 LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS-------GLLVALALILWLSALLSAFISNVP 311

                         410       420       430
                  ....*....|....*....|....*....|..
gi 442626006  718 LTTMMVKITISLAQNSTLNlPLQPLVWALALG 749
Cdd:pfam03600 312 TAALMAPIIVGMAPAAGLG-DPDPLAWALAVG 342
PLN00136 PLN00136
silicon transporter; Provisional
 327-798 2.59e-25

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 110.47  E-value: 2.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 327 VNRTFAAIIASTLSVgILAALNSRPSMATImgwiDVETLLLLFGMMILVAILSETGVFDYLA-VYAYKITNGHvwPLINC 405
Cdd:PLN00136  33 IGRTAGALLSAVLMI-VFHVISPDDAYASI----DLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 406 LCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkngvnFAVF 485
Cdd:PLN00136 106 VCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKIT-----FPKF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 486 TLHMLPGVLLVM-VQTYIQLRFKFRnisDLQFKDSPEVEELRHEihVWKRAAASLSAYSKDEELVRQTLMKKVNRLKRSL 564
Cdd:PLN00136 181 LLGILPAMLAGMaVNMVMLLCMYWK---DLDGGAELSVDGKQME--AVEEGRSPASAKSTKQQSPALLQAGLNGDGNGDM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 565 KKRMTaviepapnyqqtlANLQAKYPI------RNKPLLIKCSAALVFVISLfflhsVPELQRLSLGWTALLGAIFLIIL 638
Cdd:PLN00136 256 SSMMS-------------ENISTKHPWfmqcteHRRKLFLKSFAYVVTVGMV-----VAYMVGLNMSWTAITTAIALVVV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 639 aDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTeGIILGVGEDRRLMVAILIILWVSAVASafvdNIPL 718
Cdd:PLN00136 318 -DFRDAEPCLDTVSYSLLVFFSGMFITVSGFNKTGLPGAIWNFM-APYSKVNSVGGISVLSVIILLLSNLAS----NVPT 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 719 TTMM---VKITISLAQNSTLNLPLQPLVWAlalgACLGGNGTLIGASAN-VVC--AGVAEQHGYKFTFLQFFKVGFPimi 792
Cdd:PLN00136 392 VLLMgdeVAAAAALISPAAVTRSWLLLAWV----STVAGNLSLLGSAANlIVCeqARRAPRNAYDLTFWQHIVFGVP--- 464


                 ....*.
gi 442626006 793 GSIIVT 798
Cdd:PLN00136 465 STLIVT 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 313-801 3.21e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 75.84  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  313 AVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDvETLLLLFGMMILVAILSETGVFDYLAvyaY 392
Cdd:TIGR00785  15 AIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNALSGFAD-PTIWLFFGAFILATALVKTGLGKRIA---Y 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  393 KITN--GHVWPLINCLCLF-TAVLSSFLDNVT--TVLLMTPVTIRLCEVMCLNPVPI-------LMCMVIYS-NIGGALT 459
Cdd:TIGR00785  91 KLVGkmGGTTLGLGYFLVFlETLLAPMWPSNTarAGGILLPIIKSLLPLLGSKPEKSprkigkyLMLGIAYSaSIGSSGF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  460 PVGDPPNVIIASN-SYISKNGVNFAVFTLHMLP-GVLLVMVQTYiqlrfkfrnisdLQFKDSPEVEELRHEIHVWKRaaa 537
Cdd:TIGR00785 171 LTGSAPNALAAGIlSKILGIQISWGDWFLAGLPlGIILLLLVPL------------LLYVLFPPELKLKDEVDLWAK--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  538 slsayskdEELVRQTLMkkvnrlkrSLKKRMTAVIepapnyqqtlanlqakypirnkpllikcsaaLVFVISLFF---LH 614
Cdd:TIGR00785 236 --------EELEEMGPM--------SFREKALLGI-------------------------------FLLALLLWIfggSL 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  615 SVPElqrlslGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGVGEdrr 694
Cdd:TIGR00785 269 GINA------SVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP--- 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  695 LMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVaeqh 774
Cdd:TIGR00785 340 TIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS--AQGIPLELLALALALSASLMGFLTPYATPPNAIAYGS---- 413

                         490       500
                  ....*....|....*....|....*..
gi 442626006  775 GYkFTFLQFFKVGFPIMIGSIIVTTGY 801
Cdd:TIGR00785 414 GY-VKIKDMWRVGAIIGIVGLIVLLLV 439
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 34-84 4.01e-04

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 39.12  E-value: 4.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442626006  34 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 84
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 315-803 1.10e-176

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 514.11  E-value: 1.10e-176
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 315 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 394
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 395 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 474
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 475 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 554
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 555 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 634
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 635 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 714
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 715 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 794
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 442626006 795 IIVTTGYLL 803
Cdd:cd01116  405 LILATVYLL 413
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
309-804 1.38e-107

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 335.94  E-value: 1.38e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 309 IYAAAVLCGLYVMIIWEI--VNRTFAAIIASTLSVgILAALnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDY 386
Cdd:COG1055    3 ILALAIFVLTYLLIILEPrgLNRAVAALLGAALLL-LLGVV----SLEDALEAIDWNTILFLLGMMIIVAILDESGFFEW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 387 LAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPN 466
Cdd:COG1055   78 LAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 467 VIIASNSyisknGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNisDLQFKDSPEVEElrheihvwkraaaslsayskde 546
Cdd:COG1055  158 IMIASAG-----GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRK--ELPAAPDLEDDP---------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 547 elvrqtlmkkvnrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVPelqRLSLGW 626
Cdd:COG1055  209 -----------------------------------------KEAIKDRRLLRISLLVLALLLVGFVLHSFL---GLPPAL 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 627 TALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVS 706
Cdd:COG1055  245 IALLGAAVLLLLARV-DVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG-----NLLLAALLILWLS 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 707 AVASAFVDNIPLTTMMvkitISLAQNSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKV 786
Cdd:COG1055  319 AILSAVVDNVPLVAAL----LPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394

                        490
                 ....*....|....*...
gi 442626006 787 GFPIMIGSIIVTTGYLLV 804
Cdd:COG1055  395 GLPLTLLTLLIALLYLLL 412
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 319-802 7.79e-102

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 320.35  E-value: 7.79e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 319 YVMIIWEIVNRTFAAIIASTLSVGILAAlnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 398
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-----SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 399 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsyisKN 478
Cdd:cd00625   76 RRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIAS-----LS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 479 GVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEVeelrheihvwkraaaslsayskdeelvrqtlmkkvn 558
Cdd:cd00625  151 GLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTV------------------------------------ 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 559 rlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLhsvpelqrLSLGWTALLGAIFLIIL 638
Cdd:cd00625  195 -----------------------LAEPLPARPLLKKFLLLALLLLLLFVLLFFFL--------IPLGLIALLGALLLLLL 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 639 ADIE-DMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVDNIP 717
Cdd:cd00625  244 LVRGlDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGL-----PPLAALLLIGLLSALLSNFISNVP 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 718 LTTMMVKITISLAqnstlnlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIV 797
Cdd:cd00625  319 TVALLLPIAASLA-------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVV 391


                 ....*
gi 442626006 798 TTGYL 802
Cdd:cd00625  392 SLLYL 396
CitMHS pfam03600
Citrate transporter;
319-749 9.46e-83

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 268.03  E-value: 9.46e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  319 YVMIIWEIVNRTFAAIIastlsVGILAALNSRPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 398
Cdd:pfam03600   1 YVLIITEKLPRDVVALL-----GAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  399 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkn 478
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  479 gvnFAVFTLHMLPGVLLVMVQT-YIQLRFKFRNISDLQFKDSPEVEELRheihvwkraaaslsayskdeelvrqtlmkkv 557
Cdd:pfam03600 154 ---FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEEEAELEELR------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  558 nrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgwtALLGAIFLII 637
Cdd:pfam03600 200 ------------------------------KRAIKDKLLLAISALVLALVILGFLLLSV-----------LALAGALLLL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  638 LADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgedrRLMVAILIILWVSAVASAFVDNIP 717
Cdd:pfam03600 239 LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS-------GLLVALALILWLSALLSAFISNVP 311

                         410       420       430
                  ....*....|....*....|....*....|..
gi 442626006  718 LTTMMVKITISLAQNSTLNlPLQPLVWALALG 749
Cdd:pfam03600 312 TAALMAPIIVGMAPAAGLG-DPDPLAWALAVG 342
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 328-802 6.19e-48

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 174.77  E-value: 6.19e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 328 NRTFAAIIASTLSVGILAalnsrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVY-AYKITNGhvWPLINCL 406
Cdd:cd01117   12 DRWAIALLGAALMLLFGV-----ISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRiLVKAGSP--RRLLFLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 407 CLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSyisknGVNFAVFT 486
Cdd:cd01117   85 VLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASES-----GISFPFFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 487 LHMLPGVLLVMVQTYIQLRFKFrnisdlqfkdspeveelrheihvwkraaaslsayskdeelvrqtlmkkvnRLKRSLKK 566
Cdd:cd01117  160 AAMAPLALLGLLLLLILLLVLF--------------------------------------------------PGELKGLP 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 567 RMTAVIEPAPNyqqtlanlqakYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgWTALLGAIfLIILADIEDMEA 646
Cdd:cd01117  190 LDKATKEEGVG-----------ARKLAVKLLVLILLLLVAFLALLGVIPL---------WTAALVAA-VLLLLTRLKPRR 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 647 ILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIilgvgedrrlmVAILIILWVSAVASAFVDNIPLTTMMVKIT 726
Cdd:cd01117  249 VLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLL-----------DSVLSLFLVSIGLSQLISNVPAVLLLLPFL 317

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442626006 727 ISLAQNSTLnlplqplvwALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYL 802
Cdd:cd01117  318 PSADEKDWL---------LLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGILWL 384
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
369-804 9.04e-35

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 136.44  E-value: 9.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 369 FGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLN-----PVP 443
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 444 ILMCMVIYSNIGGALTPVGDPPNVIIASnsYISKN---GVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRnisdlqfkdsP 520
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAG--LLEEAtgiPISFFEWMLVGLPVALVGLLLLWLVLYRLLP----------P 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 521 EVEELrheihvwkraaaslsaySKDEELVRQTLmKKVNRLKRslKKRMTAVIepapnyqqtlanlqakypirnkpllikc 600
Cdd:COG0471  149 EIKEV-----------------PGSKEVIREEL-AELGPLSR--REKIALAI---------------------------- 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 601 saaLVFVISLFFLhsvPELQRLSLGWTALLGAIFLIILaDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGN 680
Cdd:COG0471  181 ---FALTVLLWIT---GSLHGIPIAVVALLGAVLLLLT-GVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLAD 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 681 MTEGIILGVGedrrLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGAcLGGNGTLIG 760
Cdd:COG0471  254 ALLPLLGGLS----PLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQ--ALGVNPLPLALAVAFAA-SCAFLLPVG 326

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 442626006 761 ASANVVCAGVaeqhGYkFTFLQFFKVGFPIMIGSIIVTTGYLLV 804
Cdd:COG0471  327 TPPNAIVYGS----GY-YKFKDFLKVGLPLNLIGLVVLLLLGPL 365
PLN00136 PLN00136
silicon transporter; Provisional
 327-798 2.59e-25

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 110.47  E-value: 2.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 327 VNRTFAAIIASTLSVgILAALNSRPSMATImgwiDVETLLLLFGMMILVAILSETGVFDYLA-VYAYKITNGHvwPLINC 405
Cdd:PLN00136  33 IGRTAGALLSAVLMI-VFHVISPDDAYASI----DLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 406 LCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkngvnFAVF 485
Cdd:PLN00136 106 VCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKIT-----FPKF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 486 TLHMLPGVLLVM-VQTYIQLRFKFRnisDLQFKDSPEVEELRHEihVWKRAAASLSAYSKDEELVRQTLMKKVNRLKRSL 564
Cdd:PLN00136 181 LLGILPAMLAGMaVNMVMLLCMYWK---DLDGGAELSVDGKQME--AVEEGRSPASAKSTKQQSPALLQAGLNGDGNGDM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 565 KKRMTaviepapnyqqtlANLQAKYPI------RNKPLLIKCSAALVFVISLfflhsVPELQRLSLGWTALLGAIFLIIL 638
Cdd:PLN00136 256 SSMMS-------------ENISTKHPWfmqcteHRRKLFLKSFAYVVTVGMV-----VAYMVGLNMSWTAITTAIALVVV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 639 aDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTeGIILGVGEDRRLMVAILIILWVSAVASafvdNIPL 718
Cdd:PLN00136 318 -DFRDAEPCLDTVSYSLLVFFSGMFITVSGFNKTGLPGAIWNFM-APYSKVNSVGGISVLSVIILLLSNLAS----NVPT 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 719 TTMM---VKITISLAQNSTLNLPLQPLVWAlalgACLGGNGTLIGASAN-VVC--AGVAEQHGYKFTFLQFFKVGFPimi 792
Cdd:PLN00136 392 VLLMgdeVAAAAALISPAAVTRSWLLLAWV----STVAGNLSLLGSAANlIVCeqARRAPRNAYDLTFWQHIVFGVP--- 464


                 ....*.
gi 442626006 793 GSIIVT 798
Cdd:PLN00136 465 STLIVT 470
CitMHS pfam03600
Citrate transporter;
619-797 3.12e-21

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 95.84  E-value: 3.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  619 LQRLSLGWTALLGAIFLIILAdIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMtegIILGVGEDRRLMVA 698
Cdd:pfam03600   6 TEKLPRDVVALLGAVLLVLLG-VLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALK---LLRLAGGKPRRLLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  699 ILIIlwVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKF 778
Cdd:pfam03600  82 ALML--ATALLSAFLSNDGTVLIMIPIVLALAR--RLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDF 157

                         170
                  ....*....|....*....
gi 442626006  779 TFLQFFKVGFPIMIGSIIV 797
Cdd:pfam03600 158 GFFMFPPVGVALLLVGLLP 176
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 351-804 1.77e-20

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 94.19  E-value: 1.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 351 PSMATIMGWIDVE---------TLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVT 421
Cdd:cd01115   26 PVLLVLLGVVPPKeafsgfsdpAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 422 TVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASN-SYISKNGVNFAVFTLHMLPGVLLVMvqt 500
Cdd:cd01115  106 TVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYlESLGGQGFSFFEFTPIGLPLLIIGL--- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 501 yIQLRFKFRnisdlqfkdspeveelrheihvwkraaaslsayskdeelvrqtlmkkvnrlkrslkkrmTAVIepapnyqq 580
Cdd:cd01115  183 -LYLWFIFR-----------------------------------------------------------LAVL-------- 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 581 tlanlqakypirnkPLLIKCSAALVFVISLFFLHSvpelqrlslgwTALLGAIFLIILADIeDMEAILARVEWSTLLFFA 660
Cdd:cd01115  195 --------------IITIVLLAALAAITGLLPVSV-----------AIAIGAIVLVFGGVL-LTKEDYKSIDWGIIFLFA 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 661 ALFILMEALTELGLIEWIGNMtegiILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQ 740
Cdd:cd01115  249 GGIPLGKALESSGAAALIAEA----LISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIAL--SLGLPPE 322

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442626006 741 PLVWALALGACLgGNGTLIGASANVVCAGVAeqhgyKFTFLQFFKVGFPIMIGSIIVTTGYLLV 804
Cdd:cd01115  323 ALLLAVAIGASC-AFMLPVGTPPNAIVLGPG-----GYKFSDFAKVGLPLSILSLVVSVTMIPL 380
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 621-804 2.62e-20

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 93.85  E-value: 2.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 621 RLSLGWTALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTegIILGVGEDRRLMVAIL 700
Cdd:cd00625    8 KLPRAVVALLGAVLLVLLGVV-SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKL--ARASKGSRRLLLLLML 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 701 iilwVSAVASAFVDNIPLTTMMVKITISLAQNSTLNlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAeqhgyKFTF 780
Cdd:cd00625   85 ----LTAALSAFFSNDATAVLLTPIVLALLRKLGLS-PPVPLLLALAFAANIGGAATPIGNPPNLIIASLS-----GLGF 154

                        170       180
                 ....*....|....*....|....
gi 442626006 781 LQFFKVGFPIMIGSIIVTTGYLLV 804
Cdd:cd00625  155 LDFLAFMAPPALGLLLLLLGLLYL 178
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 366-803 2.41e-19

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 91.17  E-value: 2.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 366 LLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNP---V 442
Cdd:cd01118   56 LTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKnrtL 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 443 PILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkngvnFAVFTLHMLPGVLLVMVQTYIQLRFKFRnisdlqfkdspev 522
Cdd:cd01118  136 PFLYACAFIADAASLPLPISNLVNIVTAGYFGIG-----FTEYAALMFLPSIVSILATYVVLYLFFR------------- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 523 eelrheihvwKRAAASLSAYSKDEElvrqtlmkkvnrlKRSLKKRMTAVIepapnyqqtlanlqakypirnkplliKCSA 602
Cdd:cd01118  198 ----------RALPKRLETASVKKP-------------SLAIKDPLLFGL--------------------------AWTL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 603 ALVFVISLFFLHSvpelqrLSLGWTALLGAIFLIILADIEDMEAILAR-----VEWSTLLFFAALFILMEALTELGLIEW 677
Cdd:cd01118  229 LVLLVVSAFGVDI------LLIPPSFIAGVLALIFLLLARRGGAINPLkvlkeAPWGVLLFSLGLYVVVFGLKNAGLTAI 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 678 IGNmtegiILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMvkiTISLAQNSTLnlplQPLVWALALGACLGGNGT 757
Cdd:cd01118  303 LAD-----LLNWLVSQGLLAAILGVGLLAAFLSNVMNNLPAVLIG---ALALAAGHAP----EALVYANLIGVDLGPKLT 370

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 442626006 758 LIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYLL 803
Cdd:cd01118  371 PIGSLATLLWLHVLRRKGIRVSWGYYLKVGLIVTPPVLVVTLAALI 416
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 602-792 1.24e-16

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 82.63  E-value: 1.24e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 602 AALVFVISLFFLHSVPelqrlsLGWTALLgAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNM 681
Cdd:cd01115    2 AILVFAAVLFVTEALP------LDVTALL-VPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 682 tegIILGVGEDRRLMVAILIIlwVSAVASAFVDNIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGA 761
Cdd:cd01115   75 ---LLKRAGKGERRLLLLLML--VTAFLSAFMSNTATVAIMLPVALGLA--AKLDISPSRLLMPLAFAASIGGMLTLIGT 147

                        170       180       190
                 ....*....|....*....|....*....|..
gi 442626006 762 SANVVCAGVAEQHGYK-FTFLQFFKVGFPIMI 792
Cdd:cd01115  148 PPNLVASGYLESLGGQgFSFFEFTPIGLPLLI 179
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 283-504 4.55e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 81.14  E-value: 4.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 283 FTSSIEGELPLQLNVDESPIYKRDGVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDV 362
Cdd:cd00625  180 FRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDW 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 363 ETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLcevmcLNPV 442
Cdd:cd00625  260 GTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL-----APPE 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442626006 443 PILMCMVIYSNIGGALTPVGDPPNVIIASNSYISKNGVNFAVFTLHMLPGVLLVMVQTYIQL 504
Cdd:cd00625  335 PAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 313-801 3.21e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 75.84  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  313 AVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDvETLLLLFGMMILVAILSETGVFDYLAvyaY 392
Cdd:TIGR00785  15 AIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNALSGFAD-PTIWLFFGAFILATALVKTGLGKRIA---Y 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  393 KITN--GHVWPLINCLCLF-TAVLSSFLDNVT--TVLLMTPVTIRLCEVMCLNPVPI-------LMCMVIYS-NIGGALT 459
Cdd:TIGR00785  91 KLVGkmGGTTLGLGYFLVFlETLLAPMWPSNTarAGGILLPIIKSLLPLLGSKPEKSprkigkyLMLGIAYSaSIGSSGF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  460 PVGDPPNVIIASN-SYISKNGVNFAVFTLHMLP-GVLLVMVQTYiqlrfkfrnisdLQFKDSPEVEELRHEIHVWKRaaa 537
Cdd:TIGR00785 171 LTGSAPNALAAGIlSKILGIQISWGDWFLAGLPlGIILLLLVPL------------LLYVLFPPELKLKDEVDLWAK--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  538 slsayskdEELVRQTLMkkvnrlkrSLKKRMTAVIepapnyqqtlanlqakypirnkpllikcsaaLVFVISLFF---LH 614
Cdd:TIGR00785 236 --------EELEEMGPM--------SFREKALLGI-------------------------------FLLALLLWIfggSL 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  615 SVPElqrlslGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGVGEdrr 694
Cdd:TIGR00785 269 GINA------SVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP--- 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  695 LMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVaeqh 774
Cdd:TIGR00785 340 TIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS--AQGIPLELLALALALSASLMGFLTPYATPPNAIAYGS---- 413

                         490       500
                  ....*....|....*....|....*..
gi 442626006  775 GYkFTFLQFFKVGFPIMIGSIIVTTGY 801
Cdd:TIGR00785 414 GY-VKIKDMWRVGAIIGIVGLIVLLLV 439
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 628-806 6.12e-13

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 71.51  E-value: 6.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 628 ALLGAIFLIIL---ADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGnmTEGIILGVGEDRRLMvaILIILw 704
Cdd:cd01116   19 ALAGALWLVILglaTLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLA--IWAVKISKGRPWRLL--LLLGL- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 705 VSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAeqhgyKFTFLQFF 784
Cdd:cd01116   94 LTAFLSAFLDNVTTVLLMVPVTIRLCE--VLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSAA-----GLTFNDFL 166

                        170       180
                 ....*....|....*....|..
gi 442626006 785 KVGFPIMIGSIIVTTGYLLVSH 806
Cdd:cd01116  167 LHMLPSVVLALVVTFILLYFLY 188
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
360-476 7.66e-13

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 70.95  E-value: 7.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 360 IDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNG-HVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMC 438
Cdd:COG0471  224 IPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442626006 439 LNPVPILMCMVIySNIGGALTPVGDPPNVIIASNSYIS 476
Cdd:COG0471  304 VNPLPLALAVAF-AASCAFLLPVGTPPNAIVYGSGYYK 340
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 307-476 9.13e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 67.61  E-value: 9.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 307 GVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAA-----LNSRPSMATIMGWIDVETLLLLFGMMILVAILSET 381
Cdd:cd01115  181 GLLYLWFIFRLAVLIITIVLLAALAAITGLLPVSVAIAIGaivlvFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESS 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 382 GVFDYLAVY-AYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIgGALTP 460
Cdd:cd01115  261 GAAALIAEAlISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASC-AFMLP 339

                        170
                 ....*....|....*.
gi 442626006 461 VGDPPNVIIASNSYIS 476
Cdd:cd01115  340 VGTPPNAIVLGPGGYK 355
CitMHS pfam03600
Citrate transporter;
290-450 1.75e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 63.49  E-value: 1.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  290 ELPLQLNVDESPIYKRDGVIYAAAVLCGLYVMIIWEIVNrtFAAIIASTLSVGILAALNSRPSMATIMGWIDVETLLLLF 369
Cdd:pfam03600 184 LLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILG--FLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  370 GMMILVAILSETGVFDYLAVYAYKITNGHVwpLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVM-CLNPVPILMCM 448
Cdd:pfam03600 262 GLFILVGALEKTGLADALADALGGLSGLLV--ALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAgLGDPDPLAWAL 339


                  ..
gi 442626006  449 VI 450
Cdd:pfam03600 340 AV 341
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 603-797 4.70e-09

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 59.69  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  603 ALVFVISLFFLHSVPELQrLSLGWTALLGAIFLIILAdIEDMEAILA-RVEWSTLLFFAALFILMEALTELGLIEWIGNM 681
Cdd:pfam00939 273 LGLFVLLLLLWIFGGSLN-IDATTVAIIGLALMLLLR-ILDWKDIVKnKGAWNTLIWLGGLIMLANGLERSGFIEWLGNT 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  682 TEGIIlgvgEDRRLMVAILIILWVS-AVASAFVDNIPLTTMMVKITISLAQNSTLNLPLQpLVWALALGACLGGNGTLIG 760
Cdd:pfam00939 351 LSTSL----SGFSPAMAFIIILSLFyLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPLL-AALLLGFAISLGGFLTPYG 425

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 442626006  761 ASANVVCAGVaeqhGYkFTFLQFFKVGFPIMIGSIIV 797
Cdd:pfam00939 426 TGPGPIYFGS----GY-LKVKDWWRIGAILTIIGLLI 457
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 602-804 2.17e-08

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 57.35  E-value: 2.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  602 AALVFVISLFFLHSVPelqrlsLGWTALLGAIFLIILADIEDMEAILARVEW----STLLFFAAlFILMEALTELGLIEW 677
Cdd:TIGR00785  15 AIFVAAIVGWILEPLP------LPVTALLAIPIIAVLLGVLSAFKFKNALSGfadpTIWLFFGA-FILATALVKTGLGKR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  678 IGNmtegIILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVkitISLAQNSTLNLPLQP----------LVWALA 747
Cdd:TIGR00785  88 IAY----KLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGIL---LPIIKSLLPLLGSKPeksprkigkyLMLGIA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 442626006  748 LGACLGGNGTLIGASANVVCAG-VAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYLLV 804
Cdd:TIGR00785 161 YSASIGSSGFLTGSAPNALAAGiLSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYV 218
PLN00136 PLN00136
silicon transporter; Provisional
 610-803 1.15e-07

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 55.00  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 610 LFFLHSV-PELQRLSLGWTA--LLGAIFLIILADIEDMEAiLARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGII 686
Cdd:PLN00136  18 VFWMLAVfPSVPFLPIGRTAgaLLSAVLMIVFHVISPDDA-YASIDLPILGLLFATMVVGSYLKNAGMFKHLGRLLAWRS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 687 LGvgeDRRLMVAILIilwVSAVASAFVDNIPLTTMMVKITISLAQNStlNLPLQPLVWALALGACLGGNGTLIGASANVV 766
Cdd:PLN00136  97 QG---GRDLLCRVCV---VTALASALFTNDTCCVVLTEFVLELAAER--NLPAKPFLLALASSANIGSSATPIGNPQNLV 168

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 442626006 767 CAgvaeqHGYKFTFLQFFKVGFPIMIGSIIVTTGYLL 803
Cdd:PLN00136 169 IA-----FNSKITFPKFLLGILPAMLAGMAVNMVMLL 200
PLN00137 PLN00137
NHAD transporter family protein; Provisional
 297-806 1.86e-06

NHAD transporter family protein; Provisional


Pssm-ID: 215071  Cd Length: 424  Bit Score: 51.23  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 297 VDESPIYKRDGVIYAAAVlcglyvmIIWEIVnrtfaAIIASTLSVGILAAlnsRPSMATImgwidVETLLLLFGMMILVA 376
Cdd:PLN00137  21 FEESLAFNKSGVALLMAV-------SLWVIR-----AIGAPSLEIVTLEL---RHALAEV-----SEIVFFLLGAMTIVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 377 ILSETGVFDylaVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEvmclNPVPILMC---MVIYSN 453
Cdd:PLN00137  81 IVDAHQGFK---LVTDSITTRSPRTLLWVVGFITFFLSSILDNLTTTIVMVSLLRKLVP----PSEYRKLLgavVVVAAN 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 454 IGGALTPVGDPPNVIIASNSYISkngvnfavfTLHMLPGVLLvmvqtyiqlrfkfrnisdlqfkdsPEVEELrheihvwk 533
Cdd:PLN00137 154 AGGAWTPIGDVTTTMLWIHGQIS---------TLPTMQGLFL------------------------PSAVSL-------- 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 534 raAASLSAYSkdeelvrqtLMKKVNRLKRSLKKRMTAViEPAPNYQQTLAnlqakypirnkpllikcsaalVFVISLFFL 613
Cdd:PLN00137 193 --AVPLALMS---------LTSEENGSPQDSSPLLASE-QMAPRGQLVFG---------------------VGVGALLFV 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 614 HSVPELQRLSLGWTALLGAIFLIILADIE----------DMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTE 683
Cdd:PLN00137 240 PVFKALTGLPPYMGMLLGLGVLWILTDAIhygeserqalKVPQALSRIDTQGILFFLGILLSVGSLDAAGILRELANYLD 319

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 684 GIILGVGedrrlmvailIILWVSAVASAFVDNIPLT--TMMVKITISLAQNSTLnlplqplvWAL-ALGACLGGNGTLIG 760
Cdd:PLN00137 320 ANIPNVE----------LIASAIGVASAIIDNVPLVaaTMGMYDLTDYPMDSEL--------WQLiALCAGTGGSLLVIG 381

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 442626006 761 ASANVVCAGVAEqhgyKFTFLQFFKVGFPIMIGSIIVTTGYLLVSH 806
Cdd:PLN00137 382 SAAGVAFMGMEK----VDFFWYLRKVSGFAFAGYVAGIAAYLAVNG 423
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 602-802 1.87e-06

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 51.11  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 602 AALVFVISLFFLHSVPelQRLSLGWTALLGAIFLIIL-----ADIEDMEAILarveWSTLLFFAALFILMEALTELGLIE 676
Cdd:cd01118    2 AIAIFVLTLVLVIWRP--FGLPEAVWAVLGAVIALILglvspHDALEVWGIV----WDVTLTLIGVILLSLLLDEEGFFE 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 677 WIGNMTegIILGVGEDRRLMVAILIilwVSAVASAFVDNIplTTMMVKITISLAQNSTLNL---PLQPLVWALALGACLG 753
Cdd:cd01118   76 WVAALA--ARWARGSGRKLFTLIVL---LGAAVTAFFAND--GTALILTPIVIALLRALGAkknRTLPFLYACAFIADAA 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 442626006 754 GNGTLIGASANVVCAGvaeqhGYKFTFLQFFKVGFPIMIGSIIVTTGYL 802
Cdd:cd01118  149 SLPLPISNLVNIVTAG-----YFGIGFTEYAALMFLPSIVSILATYVVL 192
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 304-504 6.13e-06

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 49.20  E-value: 6.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 304 KRDGVIYAAAVLCGLYVMI--IWEIVNRTFAAIIASTLsvgilaALNSRPSMATIMGWIDVETLLLLFGMMILVAILSET 381
Cdd:cd01117  201 ARKLAVKLLVLILLLLVAFlaLLGVIPLWTAALVAAVL------LLLTRLKPRRVLKKVDWGLLLFFAGLFILVGGFAQG 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 382 GVFDYLAVYAykITNGHVWPLInclcLFTAVLSSFLDNVTTVLLMTPVTIRLcevmclnPVPILMCMVIYSNIGGALTPV 461
Cdd:cd01117  275 LPLEGLSRLL--PLLDSVLSLF----LVSIGLSQLISNVPAVLLLLPFLPSA-------DEKDWLLLAAGSTIAGNLTLL 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 442626006 462 GDPPNVIIASNSYISKNGVNFAVFTLHMLPGVLLVMVQTYIQL 504
Cdd:cd01117  342 GSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGILWL 384
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 315-476 9.05e-06

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 48.91  E-value: 9.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  315 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALnsrpSMATIMGWIDV-------ETLLLLFGMMILVAILSETGVFDYL 387
Cdd:pfam00939 272 LLGLFVLLLLLWIFGGSLNIDATTVAIIGLALM----LLLRILDWKDIvknkgawNTLIWLGGLIMLANGLERSGFIEWL 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  388 AVYAYKITNGHVWPL--INCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYS-NIGGALTPVGDP 464
Cdd:pfam00939 348 GNTLSTSLSGFSPAMafIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPLLAALLLGFAiSLGGFLTPYGTG 427

                         170
                  ....*....|..
gi 442626006  465 PNVIIASNSYIS 476
Cdd:pfam00939 428 PGPIYFGSGYLK 439
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
628-809 3.35e-04

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 44.01  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 628 ALLGAIFLIILA---DIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgeDRRLMVAILIILW 704
Cdd:PRK15445 251 AGVGALILLLVArrgHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLA-----DQGLFAATLGTGF 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 705 VSAVASAFVDNIPlTTMMVKITISLAQNSTLnlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFF 784
Cdd:PRK15445 326 LAAFLSSVMNNMP-TVLIGALAIDGSNATGV--IKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYYF 402

                        170       180
                 ....*....|....*....|....*
gi 442626006 785 KVGFPIMIGSIIVTTGYLLVSHSLF 809
Cdd:PRK15445 403 KVGIIITLPVLLVTLLALALRLSLF 427
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 365-462 3.48e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 43.79  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 365 LLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLcevmcLNPVPI 444
Cdd:cd01118  281 LLFSLGLYVVVFGLKNAGLTAILADLLNWLVSQGLLAAILGVGLLAAFLSNVMNNLPAVLIGALALAAG-----HAPEAL 355

                         90
                 ....*....|....*...
gi 442626006 445 LMCMVIYSNIGGALTPVG 462
Cdd:cd01118  356 VYANLIGVDLGPKLTPIG 373
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 34-84 4.01e-04

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 39.12  E-value: 4.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442626006  34 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 84
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
CitMHS_2 pfam16980
Putative citrate transport; CitMHS is a family of putative citrate transporters, belonging to ...
 365-498 1.89e-03

Putative citrate transport; CitMHS is a family of putative citrate transporters, belonging to the Na+/H+ antiporter NhaD-like permease superfamily.


Pssm-ID: 465328  Cd Length: 440  Bit Score: 41.43  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  365 LLLLFGMMILVAILSETGVFDYLA----VYA-YKITNG-HVW------PLINCLCLFT-AVLSSFLDnvTT---VLLMTP 428
Cdd:pfam16980  49 FAALFGVGAAGAELLHTLLLEYIPfiilLFAlFTVAGGiLIRgnlagtPLVNTLLLAIgTVLASWIG--TTgasMLLIRP 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006  429 VtIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIiasnSYIskNGVNFAVFTLHMLPGVLLVMV 498
Cdd:pfam16980 127 L-IRANDWRKHKVHVVVFFIFLVSNIGGSLTPLGDPPLFL----GFL--KGVPFFWTTRHLLPETLFAVG 189
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
602-715 2.89e-03

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 40.93  E-value: 2.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 602 AALVFVISLFFLHSVPelQRLSLGWTALLGAIFLII-----LADIEDMEAILarveWSTLLFFAALFILMEALTELGLIE 676
Cdd:PRK15445   3 AIAIFLLTLVLVIWQP--KGLGIGWSALLGAVLALLtgvvsLGDVPVVWGIV----WNATLTFIAIIIISLLLDEAGFFE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 442626006 677 WIG-NMtegIILGVGEDRRLMVAILIIlwvSAVASAFVDN 715
Cdd:PRK15445  77 WAAlHV---ARWAKGNGRKLFVYIVLL---GAAVAALFAN 110
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 621-713 3.43e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 40.59  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626006 621 RLSLGWTALLGAIFLI-------ILADIEDMEAILARVEWstLLFFAALFILMEAltelgliewIGNMTEGIILGVGEDR 693
Cdd:cd13133  315 KLALAYMLLLGILFLLfpelllsIFTPGADFALIAELAVP--LLRFVAAYILFDA---------LALVFAGALRGAGDTR 383

                         90       100
                 ....*....|....*....|
gi 442626006 694 RLMVAILIILWVSAVASAFV 713
Cdd:cd13133  384 FVMLAELIVAWLYLLPPAYL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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