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Conserved domains on  [gi|442626390|ref|NP_001260148|]
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thrombospondin, isoform H [Drosophila melanogaster]

Protein Classification

calcium-binding EGF-like domain-containing protein; wall-associated receptor kinase family protein( domain architecture ID 10042925)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| wall-associated receptor kinase (WAK) family protein containing the calcium-binding EGF and serine/threonine kinase domains but lacking the WAK galacturonan-binding domain, catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and may function as a signaling receptor of extracellular matrix component

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 432-628 1.15e-112

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


:

Pssm-ID: 461725  Cd Length: 198  Bit Score: 336.15  E-value: 1.15e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  432 QADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPR 511
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  512 PFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRL 591
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 442626390  592 IFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCN 628
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCL 197
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 247-281 5.37e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442626390  247 DTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQ 281
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_CA pfam07645
Calcium-binding EGF domain;
68-99 2.15e-07

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 2.15e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442626390   68 DVDECRTGFFRCPEHSTCINEIGSYRCQCHEG 99
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 305-342 3.60e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 43.89  E-value: 3.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442626390  305 KDRDMDFVGDACHRDIDGDddGVPNSLDNCPMVSNSDQ 342
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDND--GVPDLLDNCPNNANIDQ 36
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 380-413 9.51e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


:

Pssm-ID: 367074  Cd Length: 36  Bit Score: 42.74  E-value: 9.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442626390  380 DFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIH 413
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 12-48 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.31e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 442626390  12 DMNECLLYDPCDELATCTNLSPGFQCSpCPVGFDGTH 48
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 432-628 1.15e-112

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 336.15  E-value: 1.15e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  432 QADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPR 511
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  512 PFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRL 591
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 442626390  592 IFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCN 628
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCL 197
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 247-281 5.37e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442626390  247 DTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQ 281
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_CA pfam07645
Calcium-binding EGF domain;
68-99 2.15e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 2.15e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442626390   68 DVDECRTGFFRCPEHSTCINEIGSYRCQCHEG 99
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 305-342 3.60e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 43.89  E-value: 3.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442626390  305 KDRDMDFVGDACHRDIDGDddGVPNSLDNCPMVSNSDQ 342
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDND--GVPDLLDNCPNNANIDQ 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
68-105 3.95e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 3.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442626390    68 DVDECRTGFfRCPEHSTCINEIGSYRCQCHEGYVTNGT 105
Cdd:smart00179   1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 68-100 6.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 6.37e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442626390  68 DVDECRTGFfRCPEHSTCINEIGSYRCQCHEGY 100
Cdd:cd00054    1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGY 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 380-413 9.51e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 42.74  E-value: 9.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442626390  380 DFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIH 413
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 12-48 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.31e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 442626390  12 DMNECLLYDPCDELATCTNLSPGFQCSpCPVGFDGTH 48
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
12-48 2.57e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442626390    12 DMNECLLYDPCDELATCTNLSPGFQCSpCPVGF-DGTH 48
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE-CPPGYtDGRN 37
 
Name Accession Description Interval E-value
TSP_C pfam05735
Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and ...
 432-628 1.15e-112

Thrombospondin C-terminal region; This region is found at the C-terminus of thrombospondin and related proteins.


Pssm-ID: 461725  Cd Length: 198  Bit Score: 336.15  E-value: 1.15e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  432 QADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPR 511
Cdd:pfam05735   1 QIDPIWVIRNQGREIQQTDNSDPGLAIGFDRFGSVDFSGTFFVNTDDDDDYIGFVFGYQSNSKFYVVMWKQVNQSYWPFK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442626390  512 PFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRL 591
Cdd:pfam05735  81 PFRATGLKGIQLKVVKSTTGPGENLRNALWHTGDTTNQVRLLWHDPTWRGWKDRTAYRWHLQHRPSIGLIRVRVYEGITL 160

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 442626390  592 IFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCN 628
Cdd:pfam05735 161 LADSGNVYDTTIRGGRLGVFCFSQENVIWSDLKYKCL 197
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 247-281 5.37e-08

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 49.29  E-value: 5.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442626390  247 DTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQ 281
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANIDQ 36
EGF_CA pfam07645
Calcium-binding EGF domain;
68-99 2.15e-07

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 47.23  E-value: 2.15e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 442626390   68 DVDECRTGFFRCPEHSTCINEIGSYRCQCHEG 99
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 305-342 3.60e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 43.89  E-value: 3.60e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 442626390  305 KDRDMDFVGDACHRDIDGDddGVPNSLDNCPMVSNSDQ 342
Cdd:pfam02412   1 TDSDSDGVGDACDNDFDND--GVPDLLDNCPNNANIDQ 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
68-105 3.95e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 3.95e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442626390    68 DVDECRTGFfRCPEHSTCINEIGSYRCQCHEGYVTNGT 105
Cdd:smart00179   1 DIDECASGN-PCQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 68-100 6.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 6.37e-06
                         10        20        30
                 ....*....|....*....|....*....|...
gi 442626390  68 DVDECRTGFfRCPEHSTCINEIGSYRCQCHEGY 100
Cdd:cd00054    1 DIDECASGN-PCQNGGTCVNTVGSYRCSCPPGY 32
TSP_3 pfam02412
Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which ...
 380-413 9.51e-06

Thrombospondin type 3 repeat; The thrombospondin repeat is a short aspartate rich repeat which binds to calcium ions. The repeat was initially identified in thrombospondin proteins that contained 7 of these repeats. The repeat lacks defined secondary structure.


Pssm-ID: 367074  Cd Length: 36  Bit Score: 42.74  E-value: 9.51e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 442626390  380 DFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIH 413
Cdd:pfam02412   2 DSDSDGVGDACDNDFDNDGVPDLLDNCPNNANID 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 12-48 1.31e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 1.31e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 442626390  12 DMNECLLYDPCDELATCTNLSPGFQCSpCPVGFDGTH 48
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCS-CPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
12-48 2.57e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442626390    12 DMNECLLYDPCDELATCTNLSPGFQCSpCPVGF-DGTH 48
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCE-CPPGYtDGRN 37
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 72-106 9.41e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 9.41e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 442626390   72 CRTGFFRCPEHSTCINEIGSYRCQCHEGYVTNGTY 106
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVT 35
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 79-108 3.68e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 3.68e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 442626390  79 CPEHSTCINEIGSYRCQCHEGYVtnGTYSC 108
Cdd:cd00053    8 CSNGGTCVNTPGSYRCVCPPGYT--GDRSC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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