NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442622559|ref|NP_001260743|]
View 

coronin, isoform E [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-392 4.84e-89

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 282.55  E-value: 4.84e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNKVGRIAADHPLVGGHKGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  88 AWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEIL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 168 VHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSSERQYSL 246
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 247 RAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMPKRGCDV 326
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622559 327 TTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLKD 392
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSA 386
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-392 4.84e-89

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.55  E-value: 4.84e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNKVGRIAADHPLVGGHKGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  88 AWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEIL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 168 VHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSSERQYSL 246
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 247 RAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMPKRGCDV 326
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622559 327 TTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLKD 392
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSA 386
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 5.45e-39

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 136.47  E-value: 5.45e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622559    4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
79-208 5.59e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 5.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:COG2319  202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT-------GHSGSVRSVAFSPDG-RLLASGSADGTVRL 272

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 208
Cdd:COG2319  273 WDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-294 3.57e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPHnDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 158
Cdd:cd00200   49 GHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPD-GRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSkATRAIFLRHGLIFTTGFNR 238
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442622559 239 SSERQYSLRAPDALNEPIVMveldtSNGVMFPLYDADTNMIyLCGKGDSVIRYFEV 294
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGH-----ENGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-109 1.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.42e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442622559    79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 109
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-392 4.84e-89

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.55  E-value: 4.84e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559   9 SKFRHVYGQALKREQCYDNIRVSKSSWD-STFCAVNPKFLAIIVESAGGGAfiVLPHNKVGRIAADHPLVGGHKGPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  88 AWCPHNDNVIASGSEDCVVKVWQIPDGGLSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEIL 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 168 VHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFL-RHGLIFTTGFNRSSERQYSL 246
Cdd:PTZ00421 162 EVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAkRKDLIITLGCSKSQQRQIML 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 247 RAPDALNEPIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPPFVHYinTFQTTEPQRGIGLMPKRGCDV 326
Cdd:PTZ00421 242 WDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSLDT 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442622559 327 TTCEVAKFYRMNNNGLCQvISMTVPRK-SDL-FQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLKD 392
Cdd:PTZ00421 320 RKCEIARFYALTYHSLYT-IQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSA 386
PTZ00420 PTZ00420
coronin; Provisional
 25-392 4.23e-60

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 208.27  E-value: 4.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  25 YDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLP-HNKVGRiaadHPLVG--GHKGPVLDIAWCPHNDNVIASGS 101
Cdd:PTZ00420  19 FDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRlENQMRK----PPVIKlkGHTSSILDLQFNPCFSEILASGS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 102 EDCVVKVWQIPDGGLS-RTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDShPDIVYSA 180
Cdd:PTZ00420  95 EDLTIRVWEIPHNDESvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINM-PKKLSSL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 181 CFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLrHGL------IFTTGFNRSSERQYSLRAPDALNE 254
Cdd:PTZ00420 174 KWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWI-DGLggddnyILSTGFSKNNMREMKLWDLKNTTS 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 255 PIVMVELDTSNGVMFPLYDADTNMIYLCGKGDSVIRYFEVTPEPpfVHYINTFQTTEPQRGIGLMPKRGCDVTTCEVAKF 334
Cdd:PTZ00420 253 ALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRV 330

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442622559 335 YRMNNNGLCQVISMTVPRK-SDLFQEDLYPDTLAEDAAITAEEWIDGKDADPITFSLKD 392
Cdd:PTZ00420 331 YKNENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD 389
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 5.45e-39

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 136.47  E-value: 5.45e-39
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442622559    4 RVVRSSKFRHVYGQALKREQCYDNIRVSKSSWDSTFCAVNPKFLAIIVESAGGGAFIVLPHNKVGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 COG2319
WD40 repeat [General function prediction only];
79-208 5.59e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 5.59e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:COG2319  202 GHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLT-------GHSGSVRSVAFSPDG-RLLASGSADGTVRL 272

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 208
Cdd:COG2319  273 WDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
76-205 1.15e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  76 LVGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQ 155
Cdd:COG2319  283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFSPDG-KTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442622559 156 VVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRT 205
Cdd:COG2319  354 VRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
79-208 2.60e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 2.60e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:COG2319  118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTG-------HSGAVTSVAFSPDG-KLLASGSDDGTVRL 188

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 208
Cdd:COG2319  189 WDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-294 3.57e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPHnDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 158
Cdd:cd00200   49 GHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTG-------HTSYVSSVAFSPD-GRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSkATRAIFLRHGLIFTTGFNR 238
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE-VNSVAFSPDGEKLLSSSSD 198

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442622559 239 SSERQYSLRAPDALNEPIVMveldtSNGVMFPLYDADTNMIyLCGKGDSVIRYFEV 294
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGH-----ENGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-218 3.82e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.82e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPHNdNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:cd00200    7 GHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKG-------HTGPVRDVAASADG-TYLASGSSDKTIRL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGS 218
Cdd:cd00200   78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137
WD40 COG2319
WD40 repeat [General function prediction only];
78-208 6.88e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 6.88e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  78 GGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQVV 157
Cdd:COG2319  243 TGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-------HSGGVNSVAFSPDG-KLLASGSDDGTVR 313

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442622559 158 IWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 208
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-218 6.04e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 6.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPHNDnVIASGSEDCVVKVWQIPDGGLSRTLTepvvdlvFHQRRVGLVLWHPSaLNVLLTAGSDNQVVI 158
Cdd:cd00200  133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLT-------GHTGEVNSVAFSPD-GEKLLSSSSDGTIKL 203

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGsKLVTTC-KDKKIRIYDPRTAELESEAMCHEGS 218
Cdd:cd00200  204 WDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGsEDGTIRVWDLRTGECVQTLSGHTNS 263
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 343-385 2.03e-18

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 78.71  E-value: 2.03e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 442622559  343 CQVISMTVPRKS-DLFQEDLYPDTLAEDAAITAEEWIDGKDADP 385
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
79-208 2.48e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 2.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:COG2319   76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTG-------HTGAVRSVAFSPDG-KTLASGSADGTVRL 146

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442622559 159 WNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAEL 208
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-202 9.71e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 9.71e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSalNVLLTAGSDNQVV- 157
Cdd:cd00200  175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRG-------HENGVNSVAFSPD--GYLLASGSEDGTIr 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442622559 158 IWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 202
Cdd:cd00200  245 VWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
69-218 9.15e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 9.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559  69 RIAADHPLVGGHKGPVLDIAWCPhNDNVIASGSEDCVVKVWQIPDGGLSRTLTEpvvdlvfHQRRVGLVLWHPSAlNVLL 148
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGALLATLLG-------HTAAVLSVAFSPDG-RLLA 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 149 TAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGS 218
Cdd:COG2319   95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 87-184 3.14e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.43  E-value: 3.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559   87 IAWCPHNDnVIASGSEDCVV--------KVWQIPDGGLSRTLTEpvvdlvfhqrrvglVLWHPSAlNVLLTAGSDNQVVI 158
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGELllhrlnwqRVWTLSPDKEDLEVTS--------------LAWRPDG-KLLAVGYSDGTVRL 64

                          90       100
                  ....*....|....*....|....*.
gi 442622559  159 WNVGTGEILVHIDSHPDIVysACFNW 184
Cdd:pfam12894  65 LDAENGKIVHHFSAGSDLI--TCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-109 1.42e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.42e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 442622559    79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 109
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-202 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442622559   163 TGEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 202
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
79-109 2.91e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.91e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442622559   79 GHKGPVLDIAWCPhNDNVIASGSEDCVVKVW 109
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-238 5.68e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 5.68e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 169 HIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYDPRTAELESEAMCHEGSKATRAIFLRHGLIFTTGFNR 238
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK 73
WD40 pfam00400
WD domain, G-beta repeat;
164-202 2.70e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.70e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442622559  164 GEILVHIDSHPDIVYSACFNWDGSKLVTTCKDKKIRIYD 202
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
116-218 1.76e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622559 116 LSRTLTEPVVDLVFHQRRVGLVLWHPSALNVLLTAGSDNQVVIWNVGTGEILVHIDSHPDIVYSACFNWDGSKLVTTCKD 195
Cdd:COG2319   20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                         90       100
                 ....*....|....*....|...
gi 442622559 196 KKIRIYDPRTAELESEAMCHEGS 218
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGA 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH