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Conserved domains on  [gi|442618835|ref|NP_001262529|]
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2mit, isoform B [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-458 2.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  106 LRTFNSTGGQWKGDFQVITAMDLSSNQLESL--SLDNFNQLRQLDLGNNSLEVIPLSLAD-TNMSlpfvTLDLSCNKFSQ 182
Cdd:COG4886    98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpeELANLTNLKELDLSNNQLTDLPEPLGNlTNLK----SLDLSNNQLTD 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  183 ISTSFfaQRLPQLKNLNLAHNELLNISrESFYNLLELQTLVLSHNNISDIDyETFLALPNLQYLDLSHNRLSGsairalq 262
Cdd:COG4886   174 LPEEL--GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  263 gIPDLVSLSiaynpdvgvamqefvaswSLKELDASGTGLCQVPAALA-QSVRTLKLSDNWLKAINcgdmdsyplLQYLDL 341
Cdd:COG4886   243 -LPELGNLT------------------NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK---------LKELEL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  342 SHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPL 421
Cdd:COG4886   295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 442618835  422 SLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDN 458
Cdd:COG4886   375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-458 2.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  106 LRTFNSTGGQWKGDFQVITAMDLSSNQLESL--SLDNFNQLRQLDLGNNSLEVIPLSLAD-TNMSlpfvTLDLSCNKFSQ 182
Cdd:COG4886    98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpeELANLTNLKELDLSNNQLTDLPEPLGNlTNLK----SLDLSNNQLTD 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  183 ISTSFfaQRLPQLKNLNLAHNELLNISrESFYNLLELQTLVLSHNNISDIDyETFLALPNLQYLDLSHNRLSGsairalq 262
Cdd:COG4886   174 LPEEL--GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  263 gIPDLVSLSiaynpdvgvamqefvaswSLKELDASGTGLCQVPAALA-QSVRTLKLSDNWLKAINcgdmdsyplLQYLDL 341
Cdd:COG4886   243 -LPELGNLT------------------NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK---------LKELEL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  342 SHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPL 421
Cdd:COG4886   295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 442618835  422 SLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDN 458
Cdd:COG4886   375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
193-253 1.05e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.25  E-value: 1.05e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618835   193 PQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRL 253
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-415 7.44e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 7.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  100 NLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLES---LSLDNFNQLRQLDLGNNSLE-VIPLSLADTNmSLPFVTLdl 175
Cdd:PLN00113  119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGeipNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLT-SLEFLTL-- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  176 SCNKFsqisTSFFAQRLPQLKNLNLAHNELLNISRESFYN---LLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNR 252
Cdd:PLN00113  196 ASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIPYEiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  253 LSGSAIRALQGIPDLVSLSIAYN------PDVGVAMQEF-----------------VAS---------WS---------- 290
Cdd:PLN00113  272 LSGPIPPSIFSLQKLISLDLSDNslsgeiPELVIQLQNLeilhlfsnnftgkipvaLTSlprlqvlqlWSnkfsgeipkn 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  291 ------LKELDASGT--------GLC-----------------QVPAALA--QSVRTLKLSDNWLKAINCGDMDSYPLLQ 337
Cdd:PLN00113  352 lgkhnnLTVLDLSTNnltgeipeGLCssgnlfklilfsnslegEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVY 431

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  338 YLDLSHSRIAQVEDDALGRLELLESLFLDRNllmRVPSSLPPS-----LEHLFLQHNQIMELPPQAFVGLVNLQTLDLSN 412
Cdd:PLN00113  432 FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508


                  ...
gi 442618835  413 NRL 415
Cdd:PLN00113  509 NKL 511
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 124-355 1.82e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.45  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  124 TAMDLSSNQLESLSLDNFNQLRQLDLGNNSLeviplsladtnmslpfvtLDLSCNKFSQISTSFFaqrlpqLKNLNLAHN 203
Cdd:cd00116    63 TGRIPRGLQSLLQGLTKGCGLQELDLSDNAL------------------GPDGCGVLESLLRSSS------LQELKLNNN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  204 EL----LNISRESFYNLLE-LQTLVLSHNNISDIDYE----TFLALPNLQYLDLSHNRLSGSAIRAL-QGIPD---LVSL 270
Cdd:cd00116   119 GLgdrgLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRALaEGLKAncnLEVL 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  271 SI---AYNPDVGVAMQEFVASW-SLKELDASGTGLCQVPAA--------LAQSVRTLKLSDNWLKAINCGD----MDSYP 334
Cdd:cd00116   199 DLnnnGLTDEGASALAETLASLkSLEVLNLGDNNLTDAGAAalasallsPNISLLTLSLSCNDITDDGAKDlaevLAEKE 278

                         250       260
                  ....*....|....*....|.
gi 442618835  335 LLQYLDLSHSRIAQVEDDALG 355
Cdd:cd00116   279 SLLELDLRGNKFGEEGAQLLA 299
LRR smart00370
Leucine-rich repeats, outliers;
379-399 7.91e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 7.91e-03
                            10        20
                    ....*....|....*....|.
gi 442618835    379 PSLEHLFLQHNQIMELPPQAF 399
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
106-458 2.27e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 113.49  E-value: 2.27e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  106 LRTFNSTGGQWKGDFQVITAMDLSSNQLESL--SLDNFNQLRQLDLGNNSLEVIPLSLAD-TNMSlpfvTLDLSCNKFSQ 182
Cdd:COG4886    98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpeELANLTNLKELDLSNNQLTDLPEPLGNlTNLK----SLDLSNNQLTD 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  183 ISTSFfaQRLPQLKNLNLAHNELLNISrESFYNLLELQTLVLSHNNISDIDyETFLALPNLQYLDLSHNRLSGsairalq 262
Cdd:COG4886   174 LPEEL--GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTD------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  263 gIPDLVSLSiaynpdvgvamqefvaswSLKELDASGTGLCQVPAALA-QSVRTLKLSDNWLKAINcgdmdsyplLQYLDL 341
Cdd:COG4886   243 -LPELGNLT------------------NLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK---------LKELEL 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  342 SHSRIAQVEDDALGRLELLESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLIFLPPL 421
Cdd:COG4886   295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 442618835  422 SLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDN 458
Cdd:COG4886   375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-460 7.40e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 7.40e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835   90 LELNAPANKLNLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLESLSLDNFNQLRQLDLGNNSLEVIPLSLADTNMSLP 169
Cdd:COG4886    10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  170 FVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISrESFYNLLELQTLVLSHNNISDIDyETFLALPNLQYLDLS 249
Cdd:COG4886    90 TDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  250 HNRLSgsairalqGIPD-LVSLSiaynpdvgvamqefvaswSLKELDASGTGLCQVPAALAQsvrtlklsdnwLKAincg 328
Cdd:COG4886   168 NNQLT--------DLPEeLGNLT------------------NLKELDLSNNQITDLPEPLGN-----------LTN---- 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  329 dmdsyplLQYLDLSHSRIAQVeDDALGRLELLESLFLDRNLLmrvpSSLP-----PSLEHLFLQHNQIMELPPQAfvGLV 403
Cdd:COG4886   207 -------LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQL----TDLPelgnlTNLEELDLSNNQLTDLPPLA--NLT 272

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 442618835  404 NLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPI 460
Cdd:COG4886   273 NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-470 1.66e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 1.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  120 FQVITAMDLSSNQLESLSLDNFNQLRQLDLGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLN 199
Cdd:COG4886    23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  200 LAHNELLnisresfYNLLELQTLVLSHNNISDIDYEtFLALPNLQYLDLSHNRLS--GSAIRALQgipdlvslsiaynpd 277
Cdd:COG4886   103 LSGNEEL-------SNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTdlPEPLGNLT--------------- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  278 vgvamqefvaswSLKELDASGTGLCQVPAALAQSVRtlklsdnwlkaincgdmdsyplLQYLDLSHSRIAQVEDdALGRL 357
Cdd:COG4886   160 ------------NLKSLDLSNNQLTDLPEELGNLTN----------------------LKELDLSNNQITDLPE-PLGNL 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  358 ELLESLFLDRNLLMRVPSSLP--PSLEHLFLQHNQIMELPpqAFVGLVNLQTLDLSNNRLiflpplslpklltLNLESSG 435
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL-------------TDLPPLA 269

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 442618835  436 vesvsqsivhTLPQLRDLLLEDNPIKCSDLLGIAE 470
Cdd:COG4886   270 ----------NLTNLKTLDLSNNQLTDLKLKELEL 294
LRR_8 pfam13855
Leucine rich repeat;
193-253 1.05e-16

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 75.25  E-value: 1.05e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618835   193 PQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRL 253
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-415 7.44e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 79.89  E-value: 7.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  100 NLTHRDLRTFNSTGGQWKGDFQVITAMDLSSNQLES---LSLDNFNQLRQLDLGNNSLE-VIPLSLADTNmSLPFVTLdl 175
Cdd:PLN00113  119 SLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGeipNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLT-SLEFLTL-- 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  176 SCNKFsqisTSFFAQRLPQLKNLNLAHNELLNISRESFYN---LLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNR 252
Cdd:PLN00113  196 ASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIPYEiggLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  253 LSGSAIRALQGIPDLVSLSIAYN------PDVGVAMQEF-----------------VAS---------WS---------- 290
Cdd:PLN00113  272 LSGPIPPSIFSLQKLISLDLSDNslsgeiPELVIQLQNLeilhlfsnnftgkipvaLTSlprlqvlqlWSnkfsgeipkn 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  291 ------LKELDASGT--------GLC-----------------QVPAALA--QSVRTLKLSDNWLKAINCGDMDSYPLLQ 337
Cdd:PLN00113  352 lgkhnnLTVLDLSTNnltgeipeGLCssgnlfklilfsnslegEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVY 431

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  338 YLDLSHSRIAQVEDDALGRLELLESLFLDRNllmRVPSSLPPS-----LEHLFLQHNQIMELPPQAFVGLVNLQTLDLSN 412
Cdd:PLN00113  432 FLDISNNNLQGRINSRKWDMPSLQMLSLARN---KFFGGLPDSfgskrLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508


                  ...
gi 442618835  413 NRL 415
Cdd:PLN00113  509 NKL 511
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
147-461 1.25e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  147 LDLGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSH 226
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  227 NNISDIDYETFLALPNLQYLDLSHNrlsgsairalqgipdlvslsiaynpdvgvamQEFVASWSLKELDASGTGLCQVPA 306
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGN-------------------------------EELSNLTNLESLDLSGNQLTDLPE 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  307 ALAQsvrtlklsdnwLKAincgdmdsyplLQYLDLSHSRIAQVeDDALGRLELLESLFLDRNLLMRVPSSLP--PSLEHL 384
Cdd:COG4886   131 ELAN-----------LTN-----------LKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKEL 187

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442618835  385 FLQHNQIMELPPqAFVGLVNLQTLDLSNNRLiflpplslpklltlnlessgvESVSQSIVHtLPQLRDLLLEDNPIK 461
Cdd:COG4886   188 DLSNNQITDLPE-PLGNLTNLEELDLSGNQL---------------------TDLPEPLAN-LTNLETLDLSNNQLT 241
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
123-395 3.74e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.04  E-value: 3.74e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  123 ITAMDLSSNQLESLSLDNFNQLRQLDLGNNSLEVIPLSLADTnmslpFVTLDLSCNKFSQIstsffAQRLPQlknlnlah 202
Cdd:PRK15370  201 ITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDT-----IQEMELSINRITEL-----PERLPS-------- 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  203 nellnisresfynllELQTLVLSHNNISdidyetflALPN-----LQYLDLSHNRLSgsairalqgipdlvslsiaynpd 277
Cdd:PRK15370  263 ---------------ALQSLDLFHNKIS--------CLPEnlpeeLRYLSVYDNSIR----------------------- 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  278 vgvAMQEFVASwSLKELDASGTGLCQVPAALAQSVRTLKLSDNwlkAINCGDMDSYPLLQYLDLSHSRIAqVEDDALGrl 357
Cdd:PRK15370  297 ---TLPAHLPS-GITHLNVQSNSLTALPETLPPGLKTLEAGEN---ALTSLPASLPPELQVLDVSKNQIT-VLPETLP-- 366

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 442618835  358 ELLESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIMELP 395
Cdd:PRK15370  367 PTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLP 404
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-380 5.01e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 5.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  123 ITAMDLSSNQLESL---SLDNFNQLRQLDLGNNSLE-VIPLSLADTNmSLPFVTLdlSCNKFS-QISTSFfaQRLPQLKN 197
Cdd:PLN00113  358 LTVLDLSTNNLTGEipeGLCSSGNLFKLILFSNSLEgEIPKSLGACR-SLRRVRL--QDNSFSgELPSEF--TKLPLVYF 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  198 LNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLAlPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPD 277
Cdd:PLN00113  433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  278 VGVAMQEFVASWSLKELDASGTGLC-QVPAALAQsvrtlklsdnwlkaincgdmdsYPLLQYLDLSHSRIAQVEDDALGR 356
Cdd:PLN00113  512 SGEIPDELSSCKKLVSLDLSHNQLSgQIPASFSE----------------------MPVLSQLDLSQNQLSGEIPKNLGN 569

                         250       260
                  ....*....|....*....|....
gi 442618835  357 LELLESLFLDRNLLMrvpSSLPPS 380
Cdd:PLN00113  570 VESLVQVNISHNHLH---GSLPST 590
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 110-275 3.98e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 3.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  110 NSTGGQWKGDF---QVITAMDLSSNQL----ESLSLDnFNQLRQLDLGNNSLEViplSLADTNMSLPFVTLDLSCNKFSQ 182
Cdd:PLN00113  414 NSFSGELPSEFtklPLVYFLDISNNNLqgriNSRKWD-MPSLQMLSLARNKFFG---GLPDSFGSKRLENLDLSRNQFSG 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  183 ISTSFFAQrLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQ 262
Cdd:PLN00113  490 AVPRKLGS-LSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLG 568

                         170
                  ....*....|...
gi 442618835  263 GIPDLVSLSIAYN 275
Cdd:PLN00113  569 NVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
218-276 8.59e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 8.59e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618835   218 ELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNP 276
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 151-415 2.65e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 2.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  151 NNSLEVIPLSLADTNMS---------LPFV-TLDLSCNKFS-QISTSFFAQRlPQLKNLNLAHNELL-NISRESFYNLle 218
Cdd:PLN00113   66 NNSSRVVSIDLSGKNISgkissaifrLPYIqTINLSNNQLSgPIPDDIFTTS-SSLRYLNLSNNNFTgSIPRGSIPNL-- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  219 lQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGvamqefvaswslkeldasg 298
Cdd:PLN00113  143 -ETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVG------------------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  299 tglcQVPAALAQsVRTLKlsdnWLkaincgdmdsypLLQYLDLSHSRIAQveddaLGRLELLESLFL-DRNLLMRVPSSL 377
Cdd:PLN00113  203 ----QIPRELGQ-MKSLK----WI------------YLGYNNLSGEIPYE-----IGGLTSLNHLDLvYNNLTGPIPSSL 256

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 442618835  378 P--PSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRL 415
Cdd:PLN00113  257 GnlKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSL 296
LRR_8 pfam13855
Leucine rich repeat;
334-415 2.29e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835   334 PLLQYLDLSHSRIAQVEDDALGRLelleslfldrnllmrvpsslpPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNN 413
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGL---------------------SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59


                   ..
gi 442618835   414 RL 415
Cdd:pfam13855   60 RL 61
LRR_8 pfam13855
Leucine rich repeat;
172-229 6.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 6.28e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 442618835   172 TLDLSCNKFSQISTSFFaQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNI 229
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAF-KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-277 1.19e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835   98 KLNLTHRDLRTFNSTGGQWKGdfqvITAMDLSSNQLESL--SLDNFNQLRQLDLGNNSLEVIPlSLAD-TNMSlpfvTLD 174
Cdd:COG4886   186 ELDLSNNQITDLPEPLGNLTN----LEELDLSGNQLTDLpePLANLTNLETLDLSNNQLTDLP-ELGNlTNLE----ELD 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  175 LSCNKFSQISTSFfaqRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLS 254
Cdd:COG4886   257 LSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                         170       180
                  ....*....|....*....|...
gi 442618835  255 GSAIRALQGIPDLVSLSIAYNPD 277
Cdd:COG4886   334 LVTLTTLALSLSLLALLTLLLLL 356
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 124-355 1.82e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.45  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  124 TAMDLSSNQLESLSLDNFNQLRQLDLGNNSLeviplsladtnmslpfvtLDLSCNKFSQISTSFFaqrlpqLKNLNLAHN 203
Cdd:cd00116    63 TGRIPRGLQSLLQGLTKGCGLQELDLSDNAL------------------GPDGCGVLESLLRSSS------LQELKLNNN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  204 EL----LNISRESFYNLLE-LQTLVLSHNNISDIDYE----TFLALPNLQYLDLSHNRLSGSAIRAL-QGIPD---LVSL 270
Cdd:cd00116   119 GLgdrgLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGDAGIRALaEGLKAncnLEVL 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  271 SI---AYNPDVGVAMQEFVASW-SLKELDASGTGLCQVPAA--------LAQSVRTLKLSDNWLKAINCGD----MDSYP 334
Cdd:cd00116   199 DLnnnGLTDEGASALAETLASLkSLEVLNLGDNNLTDAGAAalasallsPNISLLTLSLSCNDITDDGAKDlaevLAEKE 278

                         250       260
                  ....*....|....*....|.
gi 442618835  335 LLQYLDLSHSRIAQVEDDALG 355
Cdd:cd00116   279 SLLELDLRGNKFGEEGAQLLA 299
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 315-460 2.85e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.64  E-value: 2.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  315 LKLSDNWLKAINcgDMDSYPLLQYLDLSHSRIAQVEDdaLGRLELLESLFLDRNllmRVPS------------SLPPSLE 382
Cdd:cd21340    51 LYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQ---RLPPgekltfdprslaALSNSLR 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442618835  383 HLFLQHNQIMELppQAFVGLVNLQTLDLSNNRLiflpplslpklltlnlesSGVESVSQsIVHTLPQLRDLLLEDNPI 460
Cdd:cd21340   124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQI------------------SDLEELLD-LLSSWPSLRELDLTGNPV 180
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
194-460 5.04e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 5.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  194 QLKNLNLAHNELLNISRESFYNLlelQTLVLSHNNISDIDyETflaLPN-LQYLDLSHNRLsgsairalqgipdlvslsi 272
Cdd:PRK15370  200 QITTLILDNNELKSLPENLQGNI---KTLYANSNQLTSIP-AT---LPDtIQEMELSINRI------------------- 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  273 aynpdvgVAMQEFVASwSLKELDASGTGLCQVPAALAQSVRTLKLSDNWLKAincgdmdsypLLQYLDLSHSRIaQVEDD 352
Cdd:PRK15370  254 -------TELPERLPS-ALQSLDLFHNKISCLPENLPEELRYLSVYDNSIRT----------LPAHLPSGITHL-NVQSN 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  353 ALGRLEL-----LESLFLDRNLLMRVPSSLPPSLEHLFLQHNQIM----ELPPqafvglvNLQTLDLSNNRLIFLPPLSL 423
Cdd:PRK15370  315 SLTALPEtlppgLKTLEAGENALTSLPASLPPELQVLDVSKNQITvlpeTLPP-------TITTLDVSRNALTNLPENLP 387

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 442618835  424 PKLLTLNLESSGVESVSQSIVHTL---PQLRDLLLEDNPI 460
Cdd:PRK15370  388 AALQIMQASRNNLVRLPESLPHFRgegPQPTRIIVEYNPF 427
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 123-254 7.47e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 7.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  123 ITAMDLSSNQLESLS-LDNFNQLRQLDLGNNSLEVIP----------LSLADTNMSLPfVTLDLSCNKFSQISTSffaqr 191
Cdd:cd21340    48 LTHLYLQNNQIEKIEnLENLVNLKKLYLGGNRISVVEglenltnleeLHIENQRLPPG-EKLTFDPRSLAALSNS----- 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442618835  192 lpqLKNLNLAHNELLNIsrESFYNLLELQTLVLSHNNISDIDY--ETFLALPNLQYLDLSHNRLS 254
Cdd:cd21340   122 ---LRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 128-305 7.83e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 7.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  128 LSSNQLESLS-LDNFNQLRQLDLGNNSLEVIPlsladtnmslpfvtlDLSCnkfsqistsffaqrLPQLKNLNLAHNEll 206
Cdd:cd21340    31 LYDNKITKIEnLEFLTNLTHLYLQNNQIEKIE---------------NLEN--------------LVNLKKLYLGGNR-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  207 nISR-ESFYNLLELQTLVLSHNNISD-----IDYETFLAL-PNLQYLDLSHNRLsgSAIRALQGIPDLVSLSIAYNP-DV 278
Cdd:cd21340    80 -ISVvEGLENLTNLEELHIENQRLPPgekltFDPRSLAALsNSLRVLNISGNNI--DSLEPLAPLRNLEQLDASNNQiSD 156

                         170       180
                  ....*....|....*....|....*...
gi 442618835  279 GVAMQEFVASW-SLKELDASGTGLCQVP 305
Cdd:cd21340   157 LEELLDLLSSWpSLRELDLTGNPVCKKP 184
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 142-364 6.27e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 56.34  E-value: 6.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  142 NQLRQLDLGNNSLEVIPL-SLADTNMSLPFV-TLDLSCNKFSQISTSFFAQRL---PQLKNLNLAHNellNISRESFYNL 216
Cdd:COG5238   180 NSVETVYLGCNQIGDEGIeELAEALTQNTTVtTLWLKRNPIGDEGAEILAEALkgnKSLTTLDLSNN---QIGDEGVIAL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  217 LE-------LQTLVLSHNNISDidyETFLAL-------PNLQYLDLSHNRLSGSAIRA----LQGIPDLVSLSIAYNpDV 278
Cdd:COG5238   257 AEalknnttVETLYLSGNQIGA---EGAIALakalqgnTTLTSLDLSVNRIGDEGAIAlaegLQGNKTLHTLNLAYN-GI 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  279 GVAMQEFVASwSLKEL--------------DASGTGLCQVPaALAQSVRTLKLSDNWL---KAINCGDMDSYPLLQYLDL 341
Cdd:COG5238   333 GAQGAIALAK-ALQENttlhsldlsdnqigDEGAIALAKYL-EGNTTLRELNLGKNNIgkqGAEALIDALQTNRLHTLIL 410

                         250       260
                  ....*....|....*....|....
gi 442618835  342 SHSRIAQVEDDALGR-LELLESLF 364
Cdd:COG5238   411 DGNLIGAEAQQRLEQlLERIKSVY 434
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 193-374 1.33e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  193 PQLKNLNLAHNELLNIsrESFYNLLELQTLVLSHNNISDIdyETFLALPNLQYLDLSHNRLsgSAIRALQGIPDLVSLSI 272
Cdd:cd21340    24 KNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI--SVVEGLENLTNLEELHI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  273 AYnpdvgvamQEfvaswslkelDASGTGLCQVP---AALAQSVRTLKLSDNwlkaiNCGDMDS-YPL--LQYLDLSHSRI 346
Cdd:cd21340    98 EN--------QR----------LPPGEKLTFDPrslAALSNSLRVLNISGN-----NIDSLEPlAPLrnLEQLDASNNQI 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 442618835  347 AQVED--DALGRLELLESLFLDRNLLMRVP 374
Cdd:cd21340   155 SDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
379-460 3.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835   379 PSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNNRLiflpplslpklltlnlessgvESVS-QSIVHtLPQLRDLLLED 457
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL---------------------TTLSpGAFSG-LPSLRYLDLSG 58


                   ...
gi 442618835   458 NPI 460
Cdd:pfam13855   59 NRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 170-443 7.38e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 7.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  170 FVTLDLSCNKFSQISTSFFAQRL---PQLKNLNLAHNELLNISR------ESFYNLLELQTLVLSHNNISDID---YETF 237
Cdd:cd00116    25 LQVLRLEGNTLGEEAAKALASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGcgvLESL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  238 LALPNLQYLDLSHNRLSGSAIRALQ-GIPDLVSlsiaynpdvgvamqefvaswSLKELDASGTGL---CQVPAALA---- 309
Cdd:cd00116   105 LRSSSLQELKLNNNGLGDRGLRLLAkGLKDLPP--------------------ALEKLVLGRNRLegaSCEALAKAlran 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  310 QSVRTLKLSDNwlkAIN-------CGDMDSYPLLQYLDLSHSRIAQVEDDALGrlELLESLfldrnllmrvpsslpPSLE 382
Cdd:cd00116   165 RDLKELNLANN---GIGdagiralAEGLKANCNLEVLDLNNNGLTDEGASALA--ETLASL---------------KSLE 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442618835  383 HLFLQHNQIMELPPQAFV-----GLVNLQTLDLSNNrliflpplslpklltlNLESSGVESVSQSI 443
Cdd:cd00116   225 VLNLGDNNLTDAGAAALAsallsPNISLLTLSLSCN----------------DITDDGAKDLAEVL 274
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 240-470 8.35e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 8.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  240 LPNLQYLDLSHNRLSGSAIRA----LQGIPDLVSLSIAYN------PDVGVAMQEFVASWSLKELDASGTGLCQVPAALA 309
Cdd:cd00116    22 LLCLQVLRLEGNTLGEEAAKAlasaLRPQPSLKELCLSLNetgripRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  310 QSVRT------LKLSDNWL-----KAINCGDMDSYPLLQYLDLSHSRI--AQVED--DALGRLELLESLFLDRN-----L 369
Cdd:cd00116   102 ESLLRssslqeLKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLegASCEAlaKALRANRDLKELNLANNgigdaG 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  370 LMRVPSSLP--PSLEHLFLQHNQIMELPPQAFVGLV----NLQTLDLSNNrliflpplslpklltlNLESSGVESVSQSI 443
Cdd:cd00116   182 IRALAEGLKanCNLEVLDLNNNGLTDEGASALAETLaslkSLEVLNLGDN----------------NLTDAGAAALASAL 245

                         250       260
                  ....*....|....*....|....*..
gi 442618835  444 VHTLPQLRDLLLEDNPIKCSDLLGIAE 470
Cdd:cd00116   246 LSPNISLLTLSLSCNDITDDGAKDLAE 272
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 379-416 1.49e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.00  E-value: 1.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 442618835   379 PSLEHLFLQHNQIMELPPqaFVGLVNLQTLDLSNNRLI 416
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNKI 36
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 219-253 2.87e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 2.87e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 442618835   219 LQTLVLSHNNISDIDyeTFLALPNLQYLDLSHNRL 253
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
300-415 8.56e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 8.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  300 GLCQVPAALAQSVRTLKLSDNWLKaincgdmdSYPllqylDLSHSRIaqveddalgrlellESLFLDRNLLMRVPSSLPP 379
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNELK--------SLP-----ENLQGNI--------------KTLYANSNQLTSIPATLPD 241

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 442618835  380 SLEHLFLQHNQIMELP---PQAfvglvnLQTLDLSNNRL 415
Cdd:PRK15370  242 TIQEMELSINRITELPerlPSA------LQSLDLFHNKI 274
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 315-415 1.58e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835  315 LKLSDNWLKAIncGDMDSYPLLQYLDLshsriaqvEDDALGRLELLESLfldrnllmrvpsslpPSLEHLFLQHNQIMEL 394
Cdd:cd21340     7 LYLNDKNITKI--DNLSLCKNLKVLYL--------YDNKITKIENLEFL---------------TNLTHLYLQNNQIEKI 61

                          90       100
                  ....*....|....*....|.
gi 442618835  395 PPqaFVGLVNLQTLDLSNNRL 415
Cdd:cd21340    62 EN--LENLVNLKKLYLGGNRI 80
PLN03150 PLN03150
hypothetical protein; Provisional
 191-265 4.55e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 4.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442618835  191 RLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNRLSGSAIRALQGIP 265
Cdd:PLN03150  440 KLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGRL 514
LRR_9 pfam14580
Leucine-rich repeat;
173-276 1.54e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618835   173 LDLSCNKFSQISTsfFAQRLPQLKNLNLAHNELLNIsrESFYNLLELQTLVLSHNNISDIDYETFLALPNLQYLDLSHNR 252
Cdd:pfam14580   24 LDLRGYKIPIIEN--LGATLDQFDTIDFSDNEIRKL--DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNN 99

                           90       100
                   ....*....|....*....|....*
gi 442618835   253 L-SGSAIRALQGIPDLVSLSIAYNP 276
Cdd:pfam14580  100 LqELGDLDPLASLKKLTFLSLLRNP 124
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 193-233 2.63e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 2.63e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 442618835   193 PQLKNLNLAHNELLNIsrESFYNLLELQTLVLSHNN-ISDID 233
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNNkITDLS 40
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 241-276 6.19e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 6.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442618835   241 PNLQYLDLSHNRLSGsaIRALQGIPDLVSLSIAYNP 276
Cdd:pfam12799    1 PNLEVLDLSNNQITD--IPPLAKLPNLETLDLSGNN 34
LRR smart00370
Leucine-rich repeats, outliers;
379-399 7.91e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 7.91e-03
                            10        20
                    ....*....|....*....|.
gi 442618835    379 PSLEHLFLQHNQIMELPPQAF 399
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
379-399 7.91e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.02  E-value: 7.91e-03
                            10        20
                    ....*....|....*....|.
gi 442618835    379 PSLEHLFLQHNQIMELPPQAF 399
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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