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Conserved domains on  [gi|442618954|ref|NP_001262546|]
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flyers-cup, isoform H [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-385 2.28e-44

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.80  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  55 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 134
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 135 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 214
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 215 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 294
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 295 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 374
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618954 375 GNPIKTIRRDI 385
Cdd:COG4886  327 LLLLKGLLVTL 337
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-385 2.28e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.80  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  55 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 134
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 135 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 214
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 215 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 294
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 295 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 374
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618954 375 GNPIKTIRRDI 385
Cdd:COG4886  327 LLLLKGLLVTL 337
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-376 5.13e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 5.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 172
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 173 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 244
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 245 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 298
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 299 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 375
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 442618954 376 N 376
Cdd:PLN00113 557 N 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-383 3.02e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 229 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 308
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 309 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 357
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 442618954 358 LPVTLSSLAHLISLQVEGNPIKTIRR 383
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
115-171 2.76e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618954  115 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-385 2.28e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.80  E-value: 2.28e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  55 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 134
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 135 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 214
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 215 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 294
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 295 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 374
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618954 375 GNPIKTIRRDI 385
Cdd:COG4886  327 LLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-371 1.03e-39

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 149.70  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  45 ERSTHEDDQVLTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNT 124
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQ 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 125 LTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDL 204
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 205 HMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELpPDLVNMRSLQKIDLMHNDLTSLPEDMGlLRKLDCLYLQHN 284
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 285 DI-------LELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISV 357
Cdd:COG4886  283 QLtdlklkeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                        330
                 ....*....|....
gi 442618954 358 LPVTLSSLAHLISL 371
Cdd:COG4886  363 LTLLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-381 1.07e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.50  E-value: 1.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEF 194
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 195 VELNPDISDLHMLEFLDGGHNNiqslpgGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 274
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 275 KLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNN 353
Cdd:COG4886  160 NLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260
                 ....*....|....*....|....*...
gi 442618954 354 TISVLPVtLSSLAHLISLQVEGNPIKTI 381
Cdd:COG4886  239 QLTDLPE-LGNLTNLEELDLSNNQLTDL 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-376 5.13e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 5.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 172
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 173 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 244
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 245 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 298
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 299 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 375
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 442618954 376 N 376
Cdd:PLN00113 557 N 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
187-388 7.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 7.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 187 LNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNdltsl 266
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 267 pEDMGLLRKLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPDELCLLRNL 345
Cdd:COG4886  107 -EELSNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 442618954 346 NRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQC 388
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
115-312 4.55e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 4.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPpEIGKLEKLVRLNVSHNKLSQLPrAMYSLPELRHLNISYNEF 194
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 195 VELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLL 273
Cdd:COG4886  285 TDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442618954 274 RKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIP 312
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-378 1.76e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.81  E-value: 1.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-------------------------ELPPEIGKLEKLVRLNVSH 168
Cdd:PLN00113 166 LKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLDLVY 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 169 NKLS-------------------------QLPRAMYSLPELRHLNISYN----EFVELnpdISDLHMLEFLDGGHNNIQ- 218
Cdd:PLN00113 246 NNLTgpipsslgnlknlqylflyqnklsgPIPPSIFSLQKLISLDLSDNslsgEIPEL---VIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 219 SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-------------------------SLPEDMGL 272
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGA 402

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 273 LRKLDCLYLQHNDIL-ELP-EFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKIT-ELPDeLCLLRNLNRLD 349
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPsEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD-SFGSKRLENLD 481

                        330       340       350
                 ....*....|....*....|....*....|
gi 442618954 350 VSNNTIS-VLPVTLSSLAHLISLQVEGNPI 378
Cdd:PLN00113 482 LSRNQFSgAVPRKLGSLSELMQLKLSENKL 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 150-371 1.42e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 150 ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLP-ELRHLNISYNEFV-----------------------ELNPDISDL 204
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgsiprgsipnletldlsnnmlsgEIPNDIGSF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 205 HMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPYNH-IKELPPDLVNMRSLQKI------------------------DL 258
Cdd:PLN00113 164 SSLKVLDlGGNVLVGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIylgynnlsgeipyeiggltslnhlDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 259 MHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGN-EALNELHA-SNNFIKI 310
Cdd:PLN00113 244 VYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgpippsifslqklisldlsdnslsgEIPELVIQlQNLEILHLfSNNFTGK 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442618954 311 IPKAMCSnLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISL 371
Cdd:PLN00113 324 IPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKL 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 229-383 3.02e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 229 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 308
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 309 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 357
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 442618954 358 LPVTLSSLAHLISLQVEGNPIKTIRR 383
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-306 6.50e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 6.50e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  72 SNKALARVPKRLYDINEADADSKAVNleQLTIKEEDAWWNQVPLNNLDLSSNTL-THISPKIENLQSLTVLTLHDNALV- 149
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTN--NLTGEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSg 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 150 ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFL 227
Cdd:PLN00113 419 ELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSL 498

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 228 VRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLP---EDMGLLRKLDclyLQHNDIL-ELPEFEGN-EALNE 300
Cdd:PLN00113 499 SELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMPVLSQLD---LSQNQLSgEIPKNLGNvESLVQ 575


                 ....*.
gi 442618954 301 LHASNN 306
Cdd:PLN00113 576 VNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
139-362 3.74e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 3.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 139 TVLTLHDNALVELPPEIGklEKLVRLNVSHNKLSQLPRAMYSlpELRHLNISYNEFVELNPDISDlhMLEFLDGGHNNIQ 218
Cdd:PRK15370 181 TELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD--TIQEMELSINRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 219 SLPGGIGflVRLTALLLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEfEGNEAL 298
Cdd:PRK15370 255 ELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPE-TLPPGL 327

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442618954 299 NELHASNNFIKIIPKAMCsnlPHLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL 362
Cdd:PRK15370 328 KTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLPENL 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-267 6.57e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 6.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 112 QVPLNN-LDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQ-LPRAMYSLPELRHLN 188
Cdd:PLN00113 426 KLPLVYfLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLK 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 189 ISYNEFVELNPD-ISDLHMLEFLDGGHNNIQ-SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDL-T 264
Cdd:PLN00113 506 LSENKLSGEIPDeLSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhG 585


                 ...
gi 442618954 265 SLP 267
Cdd:PLN00113 586 SLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-227 3.02e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 3.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLTHISP-KIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISY 191
Cdd:PLN00113 477 LENLDLSRNQFSGAVPrKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442618954 192 NEFV-ELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFL 227
Cdd:PLN00113 557 NQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFL 594
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-336 3.92e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 125 LTHIS------PKIENL---QSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQLPRaMYSLPELRHLNISYNEfv 195
Cdd:cd21340    4 ITHLYlndkniTKIDNLslcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNR-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 196 elnpdIS------DLHMLEFLdggHNNIQSLPGGIGFLVR---LTALLlpynhikelppdlvnmRSLQKIDLMHNDLTSL 266
Cdd:cd21340   80 -----ISvvegleNLTNLEEL---HIENQRLPPGEKLTFDprsLAALS----------------NSLRVLNISGNNIDSL 135

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 267 pEDMGLLRKLDCLYLQHNDILELPEFEGnealnelhasnnfikiipkaMCSNLPHLKILDLRDNKITELP 336
Cdd:cd21340  136 -EPLAPLRNLEQLDASNNQISDLEELLD--------------------LLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 115-267 6.10e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 6.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLTHIsPKIENLQSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQL-------------------- 174
Cdd:cd21340   26 LKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVVeglenltnleelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 175 --------PRAMYSL-PELRHLNISYNEFVELNPdISDLHMLEFLDGGHNNIQSlpggigflvrltalllpynhIKELPP 245
Cdd:cd21340  104 pgekltfdPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISD--------------------LEELLD 162

                        170       180
                 ....*....|....*....|..
gi 442618954 246 DLVNMRSLQKIDLMHNDLTSLP 267
Cdd:cd21340  163 LLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
115-171 2.76e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.76e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618954  115 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
138-378 3.03e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 138 LTVLTLHDNALVELP---PEIGKLEklvrlnVSHNKLSQLPRAMyslPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 214
Cdd:PRK15387 224 ITTLVIPDNNLTSLPalpPELRTLE------VSGNQLTSLPVLP---PGLLELSIFSNPLTHLPALPSGLCKLWIFGNQL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 215 NNIQSLPGGI-------GFLVRLTAL------LLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEdmgLLRKLDCLYL 281
Cdd:PRK15387 295 TSLPVLPPGLqelsvsdNQLASLPALpselckLWAYNNQLTSLPTLPS--GLQELSVSDNQLASLPT---LPSELYKLWA 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 282 QHNDILELPEFEgnEALNELHASNNFIKIIPKamcsnLP-HLKILDLRDNKITELPdelCLLRNLNRLDVSNNTISVLPV 360
Cdd:PRK15387 370 YNNRLTSLPALP--SGLKELIVSGNRLTSLPV-----LPsELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPE 439

                        250
                 ....*....|....*...
gi 442618954 361 TLSSLAHLISLQVEGNPI 378
Cdd:PRK15387 440 SLIHLSSETTVNLEGNPL 457
LRR_8 pfam13855
Leucine rich repeat;
274-332 6.68e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.68e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618954  274 RKLDCLYLQHNDILELPE--FEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKI 332
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
160-217 1.42e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.42e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  160 KLVRLNVSHNKLSQL-PRAMYSLPELRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNI 217
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
229-368 2.04e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 229 RLTALLLPYNHIKELPPDL-VNMRSLQkidLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEFegnealnelhasnnf 307
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIPAT--LPDTIQEMELSINRITELPER--------------- 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442618954 308 ikiIPKAmcsnlphLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL-SSLAHL 368
Cdd:PRK15370 260 ---LPSA-------LQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLpSGITHL 309
LRR_8 pfam13855
Leucine rich repeat;
229-286 1.07e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.07e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  229 RLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDLTSL-PEDMGLLRKLDCLYLQHNDI 286
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
182-240 7.96e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.96e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618954  182 PELRHLNISYNEFVELNPDI-SDLHMLEFLDGGHNNIQSL-PGGIGFLVRLTALLLPYNHI 240
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
115-288 1.06e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 115 LNNLDLSSNTLTHIsPKI-----------ENLQSLTV-------LTLHDNALVELPPEIGKLEKLVRLNvshNKLSQLPr 176
Cdd:PRK15387 264 LLELSIFSNPLTHL-PALpsglcklwifgNQLTSLPVlppglqeLSVSDNQLASLPALPSELCKLWAYN---NQLTSLP- 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 177 amySLPE-LRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLV----RLTALLLPYNHIKELPPDLVNMR 251
Cdd:PRK15387 339 ---TLPSgLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIvsgnRLTSLPVLPSELKELMVSGNRLT 415

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 442618954 252 SLQ-------KIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILE 288
Cdd:PRK15387 416 SLPmlpsgllSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PLN03150 PLN03150
hypothetical protein; Provisional
 115-182 1.77e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 1.77e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618954 115 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKLS-QLPRAMYSLP 182
Cdd:PLN03150 444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-274 2.79e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  68 TLNLSNKALARVPKRLydineadadSKAVNLEQLtikeeDAWWNQVP----------LNNLDLSSNTLTHIsPKIENLQS 137
Cdd:COG4886  209 ELDLSGNQLTDLPEPL---------ANLTNLETL-----DLSNNQLTdlpelgnltnLEELDLSNNQLTDL-PPLANLTN 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 138 LTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNI 217
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442618954 218 QSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 274
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PLN03150 PLN03150
hypothetical protein; Provisional
 209-284 4.12e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 4.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 209 FLDGGHNNIQSL----PGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQ 282
Cdd:PLN03150 419 FIDGLGLDNQGLrgfiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLN 498


                 ..
gi 442618954 283 HN 284
Cdd:PLN03150 499 GN 500
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 159-302 5.07e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.32  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  159 EKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPY 237
Cdd:PLN03210  611 ENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKlSDCSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442618954  238 NHIKELPPDLVNMRSLQKIDLMH-NDLTSLPEdmgLLRKLDCLYLQHNDILELPEFEGNEALNELH 302
Cdd:PLN03210  691 CENLEILPTGINLKSLYRLNLSGcSRLKSFPD---ISTNISWLDLDETAIEEFPSNLRLENLDELI 753
LRR_8 pfam13855
Leucine rich repeat;
298-378 5.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  298 LNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPdelcllrnlnrldvsnntisvlPVTLSSLAHLISLQVEGNP 377
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS----------------------PGAFSGLPSLRYLDLSGNR 60


                  .
gi 442618954  378 I 378
Cdd:pfam13855  61 L 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 112-334 1.10e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 112 QVPLNNLDLSSNTLTHISPKIENLQSLTV--LTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPE------ 183
Cdd:cd00116    2 QLSLKGELLKTERATELLPKLLCLQVLRLegNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQgltkgc 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954 184 -LRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVrLTALllpynhiKELPPDLvnmrslQKIDLMHN 261
Cdd:cd00116   82 gLQELDLSDNALGPDGCGvLESLLRSSSLQELKLNNNGLGDRGLRLL-AKGL-------KDLPPAL------EKLVLGRN 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442618954 262 DLTS-----LPEDMGLLRKLDCLYLQHNDILElpefEGNEALNELHASNnfikiipkamcsnlPHLKILDLRDNKITE 334
Cdd:cd00116  148 RLEGasceaLAKALRANRDLKELNLANNGIGD----AGIRALAEGLKAN--------------CNLEVLDLNNNGLTD 207
LRR_8 pfam13855
Leucine rich repeat;
207-263 1.48e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618954  207 LEFLDGGHNNIQSLPGGIGF-LVRLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDL 263
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 68-319 2.61e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.01  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954   68 TLNLSNKALARVPKRLYDINeadadskAVNLEQLTIKEEDAWWNQVPLNNLdlssntLTHISPkienlqSLTVLTLHDN- 146
Cdd:PLN03210  729 WLDLDETAIEEFPSNLRLEN-------LDELILCEMKSEKLWERVQPLTPL------MTMLSP------SLTRLFLSDIp 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  147 ALVELPPEIGKLEKLVRLNVSHNK-LSQLPRAMySLPELRHLNISYNEFVELNPDISdlhmlefldgghNNIQSlpggig 225
Cdd:PLN03210  790 SLVELPSSIQNLHKLEHLEIENCInLETLPTGI-NLESLESLDLSGCSRLRTFPDIS------------TNISD------ 850

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618954  226 flvrltaLLLPYNHIKELPPDLVNMRSLQKIDLMH-NDLTSLPEDMGLLRKLDclYLQHNDILELPEFEGNEALNEL-HA 303
Cdd:PLN03210  851 -------LNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLE--TVDFSDCGALTEASWNGSPSEVaMA 921

                         250
                  ....*....|....*.
gi 442618954  304 SNNFIKIIPKAMCSNL 319
Cdd:PLN03210  922 TDNIHSKLPSTVCINF 937
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 298-337 3.54e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.54e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 442618954  298 LNELHASNNFIKIIPkaMCSNLPHLKILDLRDN-KITELPD 337
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 273-335 5.69e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.69e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442618954 273 LRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITEL 335
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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