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Conserved domains on  [gi|550822052|ref|NP_001272450|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-345 1.53e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.53e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 299
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 550822052 300 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-345 1.53e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.53e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 299
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 550822052 300 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 99-350 1.27e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 264.47  E-value: 1.27e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052   99 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 178
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  179 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 248
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  249 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIK 328
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 550822052  329 ESWTHNIQREKEFLRKLVKARV 350
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-345 1.53e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.53e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 299
Cdd:cd23981   82 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 550822052 300 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23981  162 VAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 140-345 4.56e-128

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 365.46  E-value: 4.56e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglMGRGNIPTLGSVAVTMALHGCDE 299
Cdd:cd23967   82 LWLQAVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCDE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 550822052 300 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23967  160 VDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 139-345 4.70e-90

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 268.92  E-value: 4.70e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 139 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 218
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 219 FKWLKYIVYKERVSASDG--FWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL--PFNNGLMGRGNIPTLGSVAVTMAL 294
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRlfFWKEVADSIPLKPSQFRILNPLIIKETALDILQYpePQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822052 295 HGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 99-350 1.27e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 264.47  E-value: 1.27e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052   99 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGF 178
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  179 ERDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 248
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  249 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMNTPNAPLHYYETVRMAAIK 328
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 550822052  329 ESWTHNIQREKEFLRKLVKARV 350
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 140-345 1.22e-76

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 234.64  E-value: 1.22e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASdGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 299
Cdd:cd23984   82 RWLLDLLMGKKVSAK-GFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 550822052 300 VAVAGFGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23984  161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 140-345 1.77e-73

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 226.47  E-value: 1.77e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQD 218
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 219 FKWLKYIVYKERVSAsDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPfnnGLMGRGNIPTLGSVAVTMALHGCD 298
Cdd:cd23982   82 FYWLYEILSNEKRVR-KGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVP---GQRKKKQKPTTGLLAITLALHLCD 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 550822052 299 EVAVAGFGY-DMNTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKL 345
Cdd:cd23982  158 EVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 143-345 7.61e-52

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 170.62  E-value: 7.61e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 143 CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 213
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 214 FKWQDFKWLKYIVYkervsasdgfwksvatRVPKEPPEIRILNPYFIQEAAFTLIGLpfNNGLMGRGNIPTLGSVAVTMA 293
Cdd:cd19952   81 AAAADFKRLKRRKK----------------RHDNAVLLLTDPAPDLLSYVRKRLEKL--GLKSFFGGNAPSSGLLAVLLA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 550822052 294 LHGCDEVAVAGFGYDM-NTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 345
Cdd:cd19952  143 LQLCDSVDLYGFGVDSgHAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 90-352 3.31e-42

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 148.56  E-value: 3.31e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  90 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTKeYRLTPALDSLH-----CRRCIIVGNGGVLANKSLGSR 160
Cdd:cd23964   24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLN-LTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKE 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 161 IDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGF 237
Cdd:cd23964  103 IDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 238 WKSV-ATRVPKEPPE-IRILNPYFIQEAaftliglpFNNGL-MGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmntPNA 314
Cdd:cd23964  183 GKRPpPLFGPKLNATnVRLLHPDFIRYL--------FNRWLnSSTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRF 251

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 550822052 315 PLHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVIT 352
Cdd:cd23964  252 SLHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 139-352 8.50e-40

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 142.03  E-value: 8.50e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 139 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 217
Cdd:cd23966   76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 218 DFKWLKyivykervSA-SDGFWKSVATRVPK----EPPEIRILNPYFIQEAAFTLIGlpfnnglmGRGNIPTLGSVAVTM 292
Cdd:cd23966  151 DLQWLI--------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIF 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550822052 293 ALHGCDEVAVAGFGYDMNtpNAPLHYYETVRmAAIKESWT--HNIQREKEFLRKLVKARVIT 352
Cdd:cd23966  215 ALHICDEVSVFGFGADSK--GNWHHYWEKNR-SAGAFRKTgvHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 94-320 8.22e-29

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 112.67  E-value: 8.22e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  94 DDSFRKWARIREFVPPfgiKGQDNLIKAILSVTK-EYRLTPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNS 172
Cdd:cd23980   37 EDTYKWWLRLQREKKP---KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 173 APVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWLKYIVYKERVSASdgfWKSVATRVPKEPPEI 252
Cdd:cd23980  114 APTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVISATTTGTISHT---YVPVPRKIKVKKEKI 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550822052 253 RILNPYFIQEAaftliglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmnTPNAPLHYYE 320
Cdd:cd23980  187 LIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGAD--SKGNWHHYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 136-351 9.91e-27

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 107.26  E-value: 9.91e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 136 DSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 215
Cdd:cd23979   76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 216 WQDFKWLKYIVYKERVSASDGFWKSVaTRVPKEppEIRILNPYFiqeaaFTLIglpFNNGLMGRGNIPTLGSVAVTMALH 295
Cdd:cd23979  152 TLDLLWITSALSTGQIRFTYAPVKQF-LRVDKD--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALH 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 550822052 296 GCDEVAVAGFGYDmNTPNAPlHYYETVRMAA-IKESWTHNIQREKEFLRKLVKARVI 351
Cdd:cd23979  221 VCDEVNVYGFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLAKAGKI 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 141-345 1.83e-22

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 95.03  E-value: 1.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 141 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFV--- 210
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVwdp 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 211 -------LAGFKWQDFKWL-KYIVYKErvsasdgfwksvatRVPKEPPEirILNPYF-------IQEAAFTliglpfnng 275
Cdd:cd23968  125 ssynvnlEKWYKKPDFDFFpNYIKYRR--------------RHPEEPFY--LIDPRFlwrlwdiLQEYTPE--------- 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 550822052 276 lMGRGNIPTLGSVAVTMALHGCDEVAVagfgYDMNTPNAP---LHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23968  180 -KIKPNPPSSGFIGIVLMLHLCDWVDV----YEYVPSVRQtdrCHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 91-351 2.24e-21

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 92.89  E-value: 2.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052  91 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLHCRRCIIVGNGGVLANKSLGSRI 161
Cdd:cd23973   25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 162 DDYDIVIRLNSAPVKGFERDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKYIVYKE 229
Cdd:cd23973  105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEALLKNK 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 230 RVsaSDGFWKSvatRVPKE-------PPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAV 302
Cdd:cd23973  183 TI--PSGAYYG---RRPRSyfsgdftEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSA 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 550822052 303 AGF---GYDmntpNAPLHYYETvrmaaikeSWT-------HNIQREKEFLRKLVKARVI 351
Cdd:cd23973  258 YGFiteDYR----KYPDHYYDK--------KKTklvfyinHDFRLEKKLWKRLHDEKII 304
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 141-345 2.52e-21

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 91.94  E-value: 2.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 141 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTL------RITYPEGAMQRPEQYERdslFVlagf 214
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsILKRRYNSLKKNRDRDK---FL---- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 215 kwQDFKWLK--YIVY-KERVSASDGFWKSVATRVPKEPPEIRIL--NP-YFIQEAAFtliglpfnNGLMGRGNIPTLGSV 288
Cdd:cd23963  137 --NRLKEYNgsILWYpKFSFKSSTNLLLKAARALKKNGLNLTVVysNPeHFLAVQKF--------WKRRGLEKRPSTGLY 206

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 289 AVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYEtvRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23963  207 LVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEEFKLLREL 264
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 100-351 2.36e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 87.19  E-value: 2.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 100 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDSLH-CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAP 174
Cdd:cd23972   37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTPGkCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 175 VKGFERDVGSKTTLR-----------ITYPEGAMQRPEQyERDSLFVLAGFKWQDFKWLKYIVYKERV-SASDGFWKSVA 242
Cdd:cd23972  117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAILGVPVpEGLDKGDRPHK 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 243 TRVPKEPPE-IRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmNTPNAPLHYYET 321
Cdd:cd23972  196 YFGPEASAKkFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKFSDHYYER 274

                        250       260       270
                 ....*....|....*....|....*....|
gi 550822052 322 VRMAAIKESwTHNIQREKEFLRKLVKARVI 351
Cdd:cd23972  275 KKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 140-321 2.40e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 85.37  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI----TYPEGAMQRPEQYERDS---LFVLa 212
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 213 gfkwqdfkWLKYIVYKERVSASDGFWKSVATRVPKeppeiriLNPYFiqeaaftliglpFNNGLMGRGN--------IPT 284
Cdd:cd23965   80 --------WGPETKMNKDGAGKYNLLRSLSKKYPD-------VEFYS------------LTPEKMDYADelfeketgKSR 132

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822052 285 LGS--------VAVTMALHGCDEVAVagfgYDMNTPN---------APLHYYET 321
Cdd:cd23965  133 IKSgtwlstgwFTMLLALDVCDEIKV----YGMVPENycrehpnskVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 140-352 5.69e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 80.57  E-value: 5.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 219
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRY 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWL-----KYIVYKERVSasdgfwKSVATRVP---KEPP----------EIRILNPYFIQEAAFTLIGLPFNNGLMGRGN 281
Cdd:cd23974  164 IFLpdhdrDYLLVKAALT------HTPIDRGRdksKRPSkyfgkdvtaeKFKIYHPDFIRYLRNRFLWSPILNTKQRDIY 237

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 550822052 282 IPTLGSVAVTMALHGCDEVAVAGFgydmNTPNAPL---HYYETVRMAAIKESwTHNIQREKEFLRKLVKARVIT 352
Cdd:cd23974  238 RPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 140-324 9.69e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 75.67  E-value: 9.69e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 213
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 214 FKWQDFKWLKYIVYKervsasdgfwksVATRVPKEPPEIRIlnpYFIQEAAFTLIGLPFNN----GLMGRGNIPTLGSVA 289
Cdd:cd23977   81 PERNMDRDGGGKTYR------------ALLTLAKMYPHLQV---YTLTEEKMAYCDGVFQNetgkNRMKSGSFLSTGWFT 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 550822052 290 VTMALHGCDEVAVAG-----FGYDMNTPNAPLHYYETVRM 324
Cdd:cd23977  146 MILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 129-345 2.14e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 75.36  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 129 YRLTPALDSL---HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI--------------- 190
Cdd:cd23987   50 YELLPRTSPLknkHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTmnpsvvqrafedlvn 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 191 -TYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNP---YFIQea 263
Cdd:cd23987  130 eTWKEKFLQRLQSLNGSILWIpafMAKGGEERVEWVNDLILKHHINVRTAY------------PSLRLLHAvrgYWLT-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 264 aftliglpfNNGLMGRgniPTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKE 340
Cdd:cd23987  196 ---------NKVHIKR---PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263


                 ....*
gi 550822052 341 FLRKL 345
Cdd:cd23987  264 ALKNL 268
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 139-345 2.24e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 75.13  E-value: 2.24e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 139 HCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPEgAMQRPE-QYERDSLF---VL--- 211
Cdd:cd23985   44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLYnegILivw 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 212 --AGFKWQDFKWLKYIVYK--ERvsasdgfWKSVATRVPKEPpeIRILNPYF-------IQEAAFTLIGL-PFNNGLMGr 279
Cdd:cd23985  123 dpAPYHSDIPEWYKNPDYNffEN-------YKTYRRLNPNQP--FYILHPQMqwelwdiIQENSPEEIQPnPPSSGMLG- 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 280 gniptlgsVAVTMALhgCDEVAVAGFgydmnTPNAP----LHYYETVRMAAIKESWTHNIQREKEFLRKL 345
Cdd:cd23985  193 --------IILMMTL--CDQVDVYEF-----LPSKRktdvCHYYQKFFDRACTMGAYHPLLYEKNLVKHL 247
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 132-345 4.16e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 74.37  E-value: 4.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 132 TPALDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE------GAMQRPEQYER 205
Cdd:cd23969   56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 206 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafTLIGLPF 272
Cdd:cd23969  136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKTAY------------PPLRLNH---------AIRGYWL 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 550822052 273 NNGLmgRGNIPTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 345
Cdd:cd23969  195 TTKF--RIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 129-351 1.08e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 73.58  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 129 YRLTPA---LDSLHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLrITYPEGAMQRpeQYER 205
Cdd:cd23970   54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-TTFNPSILEK--YYNN 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 206 dsLFVLagfkwQDFKwlkyiVYKERVSASDG--FWKSVATRvPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGN-- 281
Cdd:cd23970  131 --LLTI-----QDRN-----NFFLSLKKLDGaiLWIPAFFF-HTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNry 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 282 ----------IPTlGSVAVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYETVRMA-AIKESWTHNIQREKEFLRKLVK 347
Cdd:cd23970  198 wktkhlspkrLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKGTKfTTKWQESHQLPAEFVLLYKMHG 276


                 ....
gi 550822052 348 ARVI 351
Cdd:cd23970  277 AGVL 280
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 108-347 1.54e-14

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 72.95  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 108 PPFGIKGQDNLIKAIlsvtkeyrltpALDSLHC---RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGS 184
Cdd:cd23986   25 APFSALGWEKYVPKI-----------PLSKLHLrgfRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGN 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 185 KTTLRITYPEGAMQRPEQYERDSLF---VL-----AGFKWQDFKWLK---------YIVYKErvsasdgfwksvatRVPK 247
Cdd:cd23986   94 KTTIRIINSQILTNPNHHFIDSSLYkdvILvawdpAPYSANLHKWYKkpdynlftpYVQYRK--------------RNPN 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 248 EPpeIRILNPYF-------IQEaaftliglpfNNGLMGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMNTPNAPL-HYY 319
Cdd:cd23986  160 QP--FYILHPKFiwqlwdiIQE----------NTQEKIQPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYH 225

                        250       260
                 ....*....|....*....|....*...
gi 550822052 320 ETVRMAAIKESWTHNIQREKEFLRKLVK 347
Cdd:cd23986  226 ERYYDAACTLGAYHPLLYEKLLIQRMNK 253
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 138-320 1.07e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 67.20  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 138 LHCRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITyPEGAMQR--PEQYE-----RDSLFV 210
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRilRNRNEllnvsQGTVFI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 211 LAG---FKWQDFKWLKY----------------IVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLiglp 271
Cdd:cd23976   92 FWGpsnYMRRDGKGLVYnnlqlmnqilpklkvyTITRHKMLQFDELFK-------RETGKDRKISNTWLSTGWFTM---- 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822052 272 fnnglmgrgniptlgsvavTMALHGCDEVAVAG-----FGYDMNTPNAPLHYYE 320
Cdd:cd23976  161 -------------------IIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 129-345 7.10e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.98  E-value: 7.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 129 YRLTPALDSLHCRR---CIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRITYPE------GAMQR 199
Cdd:cd23988   50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 200 PEQYER---------DSLFVLAGFK----WQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafT 266
Cdd:cd23988  130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKLKVRTAY------------PSLRLIH---------A 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 267 LIGLPFNNGLmgrgNI--PTLGSVAVTMALHGCDEVAVAG---FGYDMNTPNAPLHYYETVRMAAIKESWTHNIQREKEF 341
Cdd:cd23988  189 VRGYWLTNKV----NIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKT 264


                 ....
gi 550822052 342 LRKL 345
Cdd:cd23988  265 LNVL 268
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 142-323 7.48e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 64.97  E-value: 7.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 142 RCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKgFERDVGSKTTL--------RITYPEGAMQRPEQYER-----DSL 208
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNLKKRRRPFVERmkvygNAL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 209 FVLAGFKW--------------QDFKWLKYIVY--KERVSASDGFWKSVATRvpkeppEIRIlnpyfiqeaaftliglpf 272
Cdd:cd23971  145 LLLPAFSYtsntepslralytlEDFGSPQKVLFfnPEYLRNLSRYWKSKGLK------ARRL------------------ 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 550822052 273 NNGLMgrgniptlgsvAVTMALHGCDEVAVAGF---GYDMNTPNAPLHYYETVR 323
Cdd:cd23971  201 STGLM-----------LVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNVL 243
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 140-323 6.51e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 61.49  E-value: 6.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLag 213
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVI-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 214 fkWQDFKWLK-----------------------YIVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLIgl 270
Cdd:cd23975   79 --WGPFRNMRkdgkgivynmlkkavesypqakiYVTTEKRMSYCDTVFK-------KETGKDRVQSGSYLSTGWFTLI-- 147

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 550822052 271 pfnnglmgrgniptlgsvavtMALHGCDEVAVAGFGYDMNTPN-----APLHYYETVR 323
Cdd:cd23975  148 ---------------------LAMDACYGIHVYGMINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 141-188 1.68e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 60.92  E-value: 1.68e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 550822052 141 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKG-FERDVGSKTTL 188
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL 113
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 140-190 1.93e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 60.25  E-value: 1.93e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550822052 140 CRRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPVKGFERDVGSKTTLRI 190
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 141-323 8.60e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 56.00  E-value: 8.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 141 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTLRITYPEGAMQRPEQYErdslfvlagfKWQDF 219
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLE----------KWRRP 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 220 KWLKYIVYKERVSASDGFWKS----VATRVP------KEPPEIRILNP-YFIQEAAFTLiglpfNNGLmgRGNIPTLGSV 288
Cdd:cd23990  135 FYEVLQVYENASVVLPAFYNTrntdVSIRVKyvlddfESQQAVYYFHPqYLLNVSRFWL-----RQGV--RAKRISSGLM 207

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 550822052 289 AVTMALHGCDEVAVAGF-GYDMNTPNAPL--HYYETVR 323
Cdd:cd23990  208 LVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNVK 245
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 141-322 1.32e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 55.22  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 141 RRCIIVGNGGVLANKSLGSRIDDYDIVIRLNSAPV-KGFERDVGSKTTLRITYPEGAMQRPEQ--YERDSLfvLAGFKWQ 217
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNllWSRKSF--VESMKVY 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550822052 218 DFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEaaftlIGLPFNNGLMGRGNIPTlGSVAVTMALHGC 297
Cdd:cd23989  142 GRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRN-----VGKFWKSKGVHAKRLST-GLFLVSAALGLC 215

                        170       180
                 ....*....|....*....|....*...
gi 550822052 298 DEVAVAGF-GYDMNTPNAPL--HYYETV 322
Cdd:cd23989  216 EEVTIYGFwPFSVDLDERTIshHYYDNV 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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