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Conserved domains on  [gi|554790356|ref|NP_001273023|]
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transmembrane protein 9B isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_9 super family cl05152
TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to ...
 1-123 5.00e-44

TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localized to the late endosomes and lysosomes. Members of this family contain pfam03128 repeats in their N-terminal region.


The actual alignment was detected with superfamily member pfam05434:

Pssm-ID: 428471  Cd Length: 145  Bit Score: 140.58  E-value: 5.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790356    1 MPVRGPDVEaYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFAN 80
Cdd:pfam05434  25 MPVKGKEVE-FCPRCECKYESRNTTTIKVVVIIVIWVISLLVIYMLFLMCLDPLLNKRNLAASYQEHNNEEDETSPPLSS 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 554790356   81 AHDVLARSRsRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVL 123
Cdd:pfam05434 104 TSQSMGTRA-RSNVLNRVGHQQDKWKRQVREQRRNIYDRHTML 145
 
Name Accession Description Interval E-value
Tmemb_9 pfam05434
TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to ...
 1-123 5.00e-44

TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localized to the late endosomes and lysosomes. Members of this family contain pfam03128 repeats in their N-terminal region.


Pssm-ID: 428471  Cd Length: 145  Bit Score: 140.58  E-value: 5.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790356    1 MPVRGPDVEaYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFAN 80
Cdd:pfam05434  25 MPVKGKEVE-FCPRCECKYESRNTTTIKVVVIIVIWVISLLVIYMLFLMCLDPLLNKRNLAASYQEHNNEEDETSPPLSS 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 554790356   81 AHDVLARSRsRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVL 123
Cdd:pfam05434 104 TSQSMGTRA-RSNVLNRVGHQQDKWKRQVREQRRNIYDRHTML 145
 
Name Accession Description Interval E-value
Tmemb_9 pfam05434
TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to ...
 1-123 5.00e-44

TMEM9; This family contains several eukaryotic transmembrane proteins which are homologous to human transmembrane protein 9. The TMEM9 gene encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites and three conserved cys-rich domains in the N-terminus, but no known functional domains. The protein is highly conserved between species from Caenorhabditis elegans to man and belongs to a novel family of transmembrane proteins. The exact function of TMEM9 is unknown although it has been found to be widely expressed and localized to the late endosomes and lysosomes. Members of this family contain pfam03128 repeats in their N-terminal region.


Pssm-ID: 428471  Cd Length: 145  Bit Score: 140.58  E-value: 5.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790356    1 MPVRGPDVEaYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFAN 80
Cdd:pfam05434  25 MPVKGKEVE-FCPRCECKYESRNTTTIKVVVIIVIWVISLLVIYMLFLMCLDPLLNKRNLAASYQEHNNEEDETSPPLSS 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 554790356   81 AHDVLARSRsRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVL 123
Cdd:pfam05434 104 TSQSMGTRA-RSNVLNRVGHQQDKWKRQVREQRRNIYDRHTML 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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