NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|570359544|ref|NP_001275643|]
View 

protein kinase C-binding protein NELL1 isoform 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 29-156 6.21e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984  Cd Length: 184  Bit Score: 96.66  E-value: 6.21e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDiereIHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544   108 ELEHR-----------------------------------------------------------IYERVIDPPD--TNLP 126
Cdd:smart00210  76 AQNVRqfglevdgrantlllryqgvdgkqhtvsfrnlpladgqwhklalsvsgssatlyvdcneIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 570359544   127 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 156
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 423-458 6.39e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.83  E-value: 6.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 570359544  423 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 458
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 216-274 2.35e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 2.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 570359544  216 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 274
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-529 5.56e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 570359544   492 DIDECSEGIIeCHNHSRCVNLPGWYHCECRSGFHDDGT 529
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTDGRN 37
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-692 2.04e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 42.41  E-value: 2.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 570359544  644 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 692
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
539-570 5.34e-05

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 5.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  539 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 570
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
377-408 2.89e-04

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  377 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 408
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 29-156 6.21e-23

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 96.66  E-value: 6.21e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDiereIHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544   108 ELEHR-----------------------------------------------------------IYERVIDPPD--TNLP 126
Cdd:smart00210  76 AQNVRqfglevdgrantlllryqgvdgkqhtvsfrnlpladgqwhklalsvsgssatlyvdcneIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 570359544   127 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 156
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 423-458 6.39e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.83  E-value: 6.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 570359544  423 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 458
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 216-274 2.35e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 2.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 570359544  216 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 274
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-529 5.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 570359544   492 DIDECSEGIIeCHNHSRCVNLPGWYHCECRSGFHDDGT 529
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTDGRN 37
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-692 2.04e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 570359544  644 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 692
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 492-525 4.27e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.27e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 570359544 492 DIDECSEGIIeCHNHSRCVNLPGWYHCECRSGFH 525
Cdd:cd00054    1 DIDECASGNP-CQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
539-570 5.34e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 5.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  539 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 570
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC smart00214
von Willebrand factor (vWF) type C domain;
646-692 2.83e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 2.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 570359544   646 YRSGDNWT-HSCQQCRCLEGE-VDCWPLTCP-NLSCE--YTAILEGECCPRC 692
Cdd:smart00214   8 YNDGETWKpDPCQICTCLDGTtVLCDPVECPpPPDCPnpERVKPPGECCPRC 59
EGF_CA pfam07645
Calcium-binding EGF domain;
377-408 2.89e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  377 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 408
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
377-409 2.91e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.91e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 570359544   377 DIDECAAKmHYCHANTVCVNLPGLYRCDCVPGY 409
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
539-577 7.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 7.21e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 570359544   539 DIDECALRtHTCWNDSACINLAGGFDCLCPSGPSCSGDC 577
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 377-410 1.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 570359544 377 DIDECAAkMHYCHANTVCVNLPGLYRCDCVPGYI 410
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
VWC smart00214
von Willebrand factor (vWF) type C domain;
216-274 4.97e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.95  E-value: 4.97e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544   216 CQVSGLLYRDQDSWVDgDHCRNCTCKSGA-VECRRMSCPPLNCSPDSLPVHIAGQCCKVC 274
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 539-570 5.09e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.09e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 570359544 539 DIDECALRtHTCWNDSACINLAGGFDCLCPSG 570
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 421-453 5.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.45e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 570359544 421 DECGSGqHNCDENAICTNTVQGHSCTCKPGYVG 453
Cdd:cd00054    3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
 
Name Accession Description Interval E-value
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 29-156 6.21e-23

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 96.66  E-value: 6.21e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544    29 QMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDiereIHAAPHVSEKLIQlFRNKSEFTILATVQQKPSTSGVILSI-R 107
Cdd:smart00210   1 GQDLLQVFDLPSLSFAIRQVVGPEPGSPAYRLGD----PALVPQPTRDLFP-SGLPEDFSLLTTFRQTPKSRGVLFAIyD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544   108 ELEHR-----------------------------------------------------------IYERVIDPPD--TNLP 126
Cdd:smart00210  76 AQNVRqfglevdgrantlllryqgvdgkqhtvsfrnlpladgqwhklalsvsgssatlyvdcneIDSRPLDRPGqpPIDT 155

                          170       180       190
                   ....*....|....*....|....*....|
gi 570359544   127 PGINLWLGQRNQkHGLFKGIIQDGKIIFMP 156
Cdd:smart00210 156 DGIEVRGAQAAD-RKPFQGDLQQLKIVCDP 184
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 423-458 6.39e-09

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.83  E-value: 6.39e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 570359544  423 CGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTIC 458
Cdd:pfam12947   1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 216-274 2.35e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 2.35e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 570359544  216 CQVSGLLYRDQDSWVDgDHCRNCTCKSGAVECRRMSCPPLNCsPDSLPVHIAGQCCKVC 274
Cdd:pfam00093   1 CVQNGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPLDC-PNPRLEIPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
492-529 5.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 5.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 570359544   492 DIDECSEGIIeCHNHSRCVNLPGWYHCECRSGFHDDGT 529
Cdd:smart00179   1 DIDECASGNP-CQNGGTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
421-450 1.65e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 1.65e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 570359544  421 DECGSGQHNCDENAICTNTVQGHSCTCKPG 450
Cdd:pfam07645   3 DECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 644-692 2.04e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 570359544  644 KLYRSGDNWT-HSCQQCRCLEGEVDCWPLTCPNLSCE--YTAILEGECCPRC 692
Cdd:pfam00093   6 VVYENGETWKpDLCTICTCDDGKVLCDKIICPPLDCPnpRLEIPPGECCPVC 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 492-525 4.27e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 4.27e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 570359544 492 DIDECSEGIIeCHNHSRCVNLPGWYHCECRSGFH 525
Cdd:cd00054    1 DIDECASGNP-CQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
539-570 5.34e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 40.68  E-value: 5.34e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  539 DIDECALRTHTCWNDSACINLAGGFDCLCPSG 570
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
VWC smart00214
von Willebrand factor (vWF) type C domain;
646-692 2.83e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 2.83e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 570359544   646 YRSGDNWT-HSCQQCRCLEGE-VDCWPLTCP-NLSCE--YTAILEGECCPRC 692
Cdd:smart00214   8 YNDGETWKpDPCQICTCLDGTtVLCDPVECPpPPDCPnpERVKPPGECCPRC 59
EGF_CA pfam07645
Calcium-binding EGF domain;
377-408 2.89e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 2.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 570359544  377 DIDECAAKMHYCHANTVCVNLPGLYRCDCVPG 408
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
377-409 2.91e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.91e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 570359544   377 DIDECAAKmHYCHANTVCVNLPGLYRCDCVPGY 409
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
539-577 7.21e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 7.21e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 570359544   539 DIDECALRtHTCWNDSACINLAGGFDCLCPSGPSCSGDC 577
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 377-410 1.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.13e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 570359544 377 DIDECAAkMHYCHANTVCVNLPGLYRCDCVPGYI 410
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
VWC smart00214
von Willebrand factor (vWF) type C domain;
216-274 4.97e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.95  E-value: 4.97e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 570359544   216 CQVSGLLYRDQDSWVDgDHCRNCTCKSGA-VECRRMSCPPLNCSPDSLPVHIAGQCCKVC 274
Cdd:smart00214   1 CVHNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPPPPDCPNPERVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 539-570 5.09e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.09e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 570359544 539 DIDECALRtHTCWNDSACINLAGGFDCLCPSG 570
Cdd:cd00054    1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 421-453 5.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 5.45e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 570359544 421 DECGSGqHNCDENAICTNTVQGHSCTCKPGYVG 453
Cdd:cd00054    3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH