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Conserved domains on  [gi|576796052|ref|NP_001276688|]
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interferon-induced protein with tetratricopeptide repeats 3 isoform b [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 708416)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 3-270 1.44e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 88.13  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   3 NLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQtckkfsnpYSIE 82
Cdd:COG3914    5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAA--------ALLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  83 YSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLG 162
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 163 LKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIgccykakVRQMQN 242
Cdd:COG3914  154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL-------LFALRQ 226

                        250       260
                 ....*....|....*....|....*....
gi 576796052 243 TGESE-ASGNKEMIEALKQYAMDYSNKAL 270
Cdd:COG3914  227 ACDWEvYDRFEELLAALARGPSELSPFAL 255
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 3-270 1.44e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 88.13  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   3 NLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQtckkfsnpYSIE 82
Cdd:COG3914    5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAA--------ALLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  83 YSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLG 162
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 163 LKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIgccykakVRQMQN 242
Cdd:COG3914  154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL-------LFALRQ 226

                        250       260
                 ....*....|....*....|....*....
gi 576796052 243 TGESE-ASGNKEMIEALKQYAMDYSNKAL 270
Cdd:COG3914  227 ACDWEvYDRFEELLAALARGPSELSPFAL 255
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 3-274 3.58e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.57  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    3 NLLAYIKHLDGNNEAALECLRQAEELiqQEHADQAEIRsLVTwgnyawVYYHLGRLSDAQIYVDKVKqtcKKFSNPYSIE 82
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIAL--RPNNIAVLLA-LAT------ILIEAGEFEEAEKHADALL---KKAPNSPLAH 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   83 YSEldceeGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPE-KQFSTDVLKQAielsPDNQYVKVLL 161
Cdd:TIGR02917 265 YLK-----ALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQaYQYLNQILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  162 GLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCY--KAKVRQ 239
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKlsQGDPSE 415

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 576796052  240 MQNTGESEASGNKEMIEA--------LKQYAMDYSNKALEKGL 274
Cdd:TIGR02917 416 AIADLETAAQLDPELGRAdlllilsyLRSGQFDKALAAAKKLE 458
TPR_12 pfam13424
Tetratricopeptide repeat;
1-64 8.56e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.83  E-value: 8.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576796052    1 MYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRsLVTWGNYAWVYYHLGRLSDAQIY 64
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT-ATTLLNLGRLYLELGRYEEALEL 67
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 98-222 5.05e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 42.76  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   98 GRNERAKVCFEKALEEKPNNPE--FSSGL--------AIAMYHLDNHPEKQFSTDVLkqaiELSPDNQYVKVL-LGLKLQ 166
Cdd:PRK11447  509 GQRSQADALMRRLAQQKPNDPEqvYAYGLylsgsdrdRAALAHLNTLPRAQWNSNIQ----ELAQRLQSDQVLeTANRLR 584

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052  167 KMNKEAEGEQFveeaLEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:PRK11447  585 DSGKEAEAEAL----LRQQPPSTRIDLTLADWAQQRGDYAAARAAYQRVLTREPGN 636
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 3-270 1.44e-18

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 88.13  E-value: 1.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   3 NLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQtckkfsnpYSIE 82
Cdd:COG3914    5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAA--------ALLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  83 YSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLG 162
Cdd:COG3914   77 LAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEE---ALAALRRALALNPDFAEAYLNLG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 163 LKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIgccykakVRQMQN 242
Cdd:COG3914  154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL-------LFALRQ 226

                        250       260
                 ....*....|....*....|....*....
gi 576796052 243 TGESE-ASGNKEMIEALKQYAMDYSNKAL 270
Cdd:COG3914  227 ACDWEvYDRFEELLAALARGPSELSPFAL 255
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
91-238 2.91e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.82  E-value: 2.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  91 GWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNK 170
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEE---ALADYEQALELDPDDAEALNNLGLALQALGR 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576796052 171 EAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVR 238
Cdd:COG0457   92 YEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGR 159
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 89-222 2.67e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 69.84  E-value: 2.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  89 EEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKM 168
Cdd:COG4783    9 ALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDE---AIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 576796052 169 NKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:COG4783   86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 102-222 7.80e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 68.11  E-value: 7.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 102 RAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEA 181
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDE---ALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 576796052 182 LEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:COG4235   78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 98-235 2.24e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.14  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  98 GRNERAKVCFEKALEEKPNNPEFSSGLAiAMYHLDNHPEKqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQF 177
Cdd:COG2956   90 GLLDRAEELLEKLLELDPDDAEALRLLA-EIYEQEGDWEK--AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEA 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 576796052 178 VEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKA 235
Cdd:COG2956  167 LEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEK 224
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 94-236 1.47e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.45  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  94 QLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAE 173
Cdd:COG2956   18 YLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDR---AIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 576796052 174 GEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAK 236
Cdd:COG2956   95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ 157
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 3-274 3.58e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.57  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    3 NLLAYIKHLDGNNEAALECLRQAEELiqQEHADQAEIRsLVTwgnyawVYYHLGRLSDAQIYVDKVKqtcKKFSNPYSIE 82
Cdd:TIGR02917 197 LLKGDLLLSLGNIELALAAYRKAIAL--RPNNIAVLLA-LAT------ILIEAGEFEEAEKHADALL---KKAPNSPLAH 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   83 YSEldceeGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPE-KQFSTDVLKQAielsPDNQYVKVLL 161
Cdd:TIGR02917 265 YLK-----ALVDFQKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQaYQYLNQILKYA----PNSHQARRLL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  162 GLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCY--KAKVRQ 239
Cdd:TIGR02917 336 ASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKlsQGDPSE 415

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 576796052  240 MQNTGESEASGNKEMIEA--------LKQYAMDYSNKALEKGL 274
Cdd:TIGR02917 416 AIADLETAAQLDPELGRAdlllilsyLRSGQFDKALAAAKKLE 458
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-217 5.06e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 5.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEElIQQEHADqaeirslvTWGNYAWVYYHLGRLsdaqiyvdkvkqtckkfsnpysi 81
Cdd:COG0457   11 YNNLGLAYRRLGRYEEAIEDYEKALE-LDPDDAE--------ALYNLGLAYLRLGRY----------------------- 58

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  82 eyseldceegwtqlkcgrnERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLL 161
Cdd:COG0457   59 -------------------EEALADYEQALELDPDDAEALNNLGLALQALGRYEE---ALEDYDKALELDPDDAEALYNL 116

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052 162 GLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:COG0457  117 GLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEA 172
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
111-288 5.93e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.41  E-value: 5.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 111 LEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTD 190
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEE---AIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 191 VLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYkakvrqmQNTGESEasgnkemiEALKQYamdysNKAL 270
Cdd:COG0457   78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAL-------LELGRYD--------EAIEAY-----ERAL 137

                        170
                 ....*....|....*...
gi 576796052 271 EKGLNPLNAYSDLAEFLE 288
Cdd:COG0457  138 ELDPDDADALYNLGIALE 155
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 144-235 1.06e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.13  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 144 LKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNG 223
Cdd:COG4783   27 LEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHP 106

                         90
                 ....*....|..
gi 576796052 224 YLYHQIGCCYKA 235
Cdd:COG4783  107 EAYLRLARAYRA 118
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 91-186 1.48e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 58.86  E-value: 1.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  91 GWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNK 170
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE---AEELLERALALDPDNPEALYLLGLAAFQQGD 100

                         90
                 ....*....|....*.
gi 576796052 171 EAEGEQFVEEALEKSP 186
Cdd:COG4235  101 YAEAIAAWQKLLALLP 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-217 6.75e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 6.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEELiqqeHADQAEirslvTWGNYAWVYYHLGRLsdaqiyvdkvkqtckkfsnpysi 81
Cdd:COG3914   81 LELAALLLQALGRYEEALALYRRALAL----NPDNAE-----ALFNLGNLLLALGRL----------------------- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  82 eyseldceegwtqlkcgrnERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLL 161
Cdd:COG3914  129 -------------------EEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE---AIAALRRALELDPDNAEALNNL 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052 162 GLKLQKMNKEAEGEQFVEEALEKSPcQTDVLRSAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:COG3914  187 GNALQDLGRLEEAIAAYRRALELDP-DNADAHSNLLFALRQACDWEVYDRFEELLA 241
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 2-217 2.59e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.82  E-value: 2.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEELIQQEhadqaeirslvtwgnyAWVYYHLGRLSDAQiyvdkvkqtckkfsnpysi 81
Cdd:COG2956  113 LRLLAEIYEQEGDWEKAIEVLERLLKLGPEN----------------AHAYCELAELYLEQ------------------- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  82 eyseldceegwtqlkcGRNERAKVCFEKALEEKPNNPEFSSGLAiAMYHLDNHPEKqfSTDVLKQAIELSPDNQYVKVLL 161
Cdd:COG2956  158 ----------------GDYDEAIEALEKALKLDPDCARALLLLA-ELYLEQGDYEE--AIAALERALEQDPDYLPALPRL 218

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052 162 GLKLQKMNKEAEGEQFVEEALEKSPcQTDVLRSAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:COG2956  219 AELYEKLGDPEEALELLRKALELDP-SDDLLLALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 51-388 8.09e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 8.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   51 VYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSeldceegwTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAmyH 130
Cdd:TIGR02917 304 SEYQLGNLEQAYQYLNQILKYAPNSHQARRLLAS--------IQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEA--Y 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  131 LDN-HPEKqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAI 209
Cdd:TIGR02917 374 LALgDFEK--AAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLRSGQFDKAL 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  210 ELFQRVLESTPNNGYLYHQIGCCYkakvrqmqntgeseaSGNKEMIEALKQYamdysNKALEKGLNPLNAYSDLAEFLET 289
Cdd:TIGR02917 452 AAAKKLEKKQPDNASLHNLLGAIY---------------LGKGDLAKAREAF-----EKALSIEPDFFPAAANLARIDIQ 511

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  290 EcyqtpfnKEVPDAekqqsHQRYCNLQKYNGKSEDTAVQhgLEGLSISKKSTD------KEEIKDQPQNV------SENL 357
Cdd:TIGR02917 512 E-------GNPDDA-----IQRFEKVLTIDPKNLRAILA--LAGLYLRTGNEEeavawlEKAAELNPQEIepalalAQYY 577

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 576796052  358 LPQN------------------APNYWYLQGLIHKQNGDLLQAAKCYEK 388
Cdd:TIGR02917 578 LGKGqlkkalailneaadaapdSPEAWLMLGRAQLAAGDLNKAVSSFKK 626
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
144-221 2.53e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 2.53e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 576796052 144 LKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFvEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPN 221
Cdd:COG3063   15 YEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 5-154 6.21e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 6.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   5 LAYIKHLDGNNEAALECLRQAEELiqqeHADQAEIrslvtWGNYAWVYYHLGRLSDAQIYVDKVKQTckkfsNPysiEYS 84
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALEL----DPDNPEA-----FALLGEILLQLGDLDEAIVLLHEALEL-----DP---DEP 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  85 ELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQfstDVLKQAIELSPDN 154
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAI---AALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
94-186 3.88e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 47.86  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  94 QLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPE-KQFstdvlKQAIELSPDNQYVKVLLGLKLQKMNKEA 172
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEaIAL-----EKALKLDPNNAEALLNLAELLLELGDYD 76

                         90
                 ....*....|....
gi 576796052 173 EGEQFVEEALEKSP 186
Cdd:COG3063   77 EALAYLERALELDP 90
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
95-217 7.21e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 7.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  95 LKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEG 174
Cdd:COG4785   84 DSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDA---ALEDFDRALELDPDYAYAYLNRGIALYYLGRYELA 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 576796052 175 EQFVEEALEKSP-----------CQTDVLRSAAKF---------YRRKGDLDKAIELFQRVLE 217
Cdd:COG4785  161 IADLEKALELDPndperalwlylAERKLDPEKALAllledwataYLLQGDTEEARELFKLALA 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-214 7.77e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 7.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEELiqqehadqaEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTckkfsNPYSI 81
Cdd:COG0457   45 LYNLGLAYLRLGRYEEALADYEQALEL---------DPDDAEALNNLGLALQALGRYEEALEDYDKALEL-----DPDDA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  82 E-YSELdceeGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVL 160
Cdd:COG0457  111 EaLYNL----GLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEA 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 576796052 161 LGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQR 214
Cdd:COG0457  187 ALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALAL 240
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 161-235 8.27e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 48.26  E-value: 8.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 576796052 161 LGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKA 235
Cdd:COG4783   10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 58-222 1.07e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   58 LSDAQIYVDKVKQTCKKFSNPYSI---EYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLA-IAMYHLDN 133
Cdd:TIGR02917  96 LARAYLLQGKFQQVLDELPGKTLLddeGAAELLALRGLAYLGLGQLELAQKSYEQALAIDPRSLYAKLGLAqLALAENRF 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  134 HPEKQFSTDVL------------------------------KQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALE 183
Cdd:TIGR02917 176 DEARALIDEVLtadpgnvdalllkgdlllslgnielalaayRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLK 255

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 576796052  184 KSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:TIGR02917 256 KAPNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEY 294
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 142-220 1.46e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.03  E-value: 1.46e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576796052 142 DVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTP 220
Cdd:COG5010   75 ALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 2-222 3.38e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 3.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    2 YNLLAYIKHLDGNNEAALECLRQAEElIQQEHADQAeirslvtwGNYAWVYYHLGRLSDAQIYVDKVKQTCKKfSNPYSI 81
Cdd:TIGR02917 468 HNLLGAIYLGKGDLAKAREAFEKALS-IEPDFFPAA--------ANLARIDIQEGNPDDAIQRFEKVLTIDPK-NLRAIL 537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   82 EYSELdceegwtQLKCGRNERAKVCFEKALEEkpNNPEFSSGLAIAMYHLDNHPEKQfSTDVLKQAIELSPDNQYVKVLL 161
Cdd:TIGR02917 538 ALAGL-------YLRTGNEEEAVAWLEKAAEL--NPQEIEPALALAQYYLGKGQLKK-ALAILNEAADAAPDSPEAWLML 607

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576796052  162 GLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:TIGR02917 608 GRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDN 668
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 155-230 1.56e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 1.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052 155 QYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIG 230
Cdd:COG2956    8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELA 83
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 2-152 1.58e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.95  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSi 81
Cdd:COG5010   14 LLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYY- 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576796052  82 eyseldcEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQfstDVLKQAIELSP 152
Cdd:COG5010   93 -------NLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAK---AALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 95-217 2.68e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 46.52  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   95 LKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDvlkQAIELSPDNQYVKVLLGLKLQKMNKEAEG 174
Cdd:TIGR00990 376 LELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQ---KSIDLDPDFIFSHIQLGVTQYKEGSIASS 452

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 576796052  175 EQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:TIGR00990 453 MATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIE 495
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 165-236 2.96e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.96e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 576796052 165 LQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAK 236
Cdd:COG5010   64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 82-231 3.30e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 46.13  E-value: 3.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   82 EYSELDCEEGWTQLKCGRN----------ERAKVCFEKALEEKpnnpEFSSGLAIAMYH------LDNHPEKQFSTdvLK 145
Cdd:TIGR00990 282 DSNELDEETGNGQLQLGLKspeskadesyEEAARAFEKALDLG----KLGEKEAIALNLrgtfkcLKGKHLEALAD--LS 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  146 QAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYL 225
Cdd:TIGR00990 356 KSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFIFS 435


                  ....*.
gi 576796052  226 YHQIGC 231
Cdd:TIGR00990 436 HIQLGV 441
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
98-217 8.32e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 44.10  E-value: 8.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  98 GRNERAKVCFEKALE-EKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKV--LLGLKLQKMNKEAEG 174
Cdd:COG4700  103 GRYDEAIELYEEALTgIFADDPHILLGLAQALFELGRYAE---ALETLEKLIAKNPDFKSSDAhlLYARALEALGDLEAA 179

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 576796052 175 EQFVEEALEKSPCQTDVLRsAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:COG4700  180 EAELEALARRYSGPEARYR-YAKFLARQGRTAEAKELLEEILD 221
TPR_12 pfam13424
Tetratricopeptide repeat;
1-64 8.56e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 40.83  E-value: 8.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 576796052    1 MYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRsLVTWGNYAWVYYHLGRLSDAQIY 64
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLT-ATTLLNLGRLYLELGRYEEALEL 67
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
165-236 9.63e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.92  E-value: 9.63e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 576796052 165 LQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIElFQRVLESTPNNGYLYHQIGCCYKAK 236
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLEL 72
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 95-223 1.74e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.92  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   95 LKCGRNERAKVCFEKALEEKPNNPEFSSGLAiAMYHLDNHPEKqfSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEG 174
Cdd:TIGR02917 510 IQEGNPDDAIQRFEKVLTIDPKNLRAILALA-GLYLRTGNEEE--AVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKA 586

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 576796052  175 EQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNG 223
Cdd:TIGR02917 587 LAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSA 635
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
2-184 4.55e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.53  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEElIQQEHADqaeirslvTWGNYAWVYYHLGRLSDAQIYVDKVKQtckkfsnpYSI 81
Cdd:COG0457   79 LNNLGLALQALGRYEEALEDYDKALE-LDPDDAE--------ALYNLGLALLELGRYDEAIEAYERALE--------LDP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  82 EYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLL 161
Cdd:COG0457  142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAE 221

                        170       180
                 ....*....|....*....|...
gi 576796052 162 GLKLQKMNKEAEGEQFVEEALEK 184
Cdd:COG0457  222 LLLLALALLLALRLAALALYQYR 244
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 98-222 5.05e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 42.76  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   98 GRNERAKVCFEKALEEKPNNPE--FSSGL--------AIAMYHLDNHPEKQFSTDVLkqaiELSPDNQYVKVL-LGLKLQ 166
Cdd:PRK11447  509 GQRSQADALMRRLAQQKPNDPEqvYAYGLylsgsdrdRAALAHLNTLPRAQWNSNIQ----ELAQRLQSDQVLeTANRLR 584

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 576796052  167 KMNKEAEGEQFveeaLEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNN 222
Cdd:PRK11447  585 DSGKEAEAEAL----LRQQPPSTRIDLTLADWAQQRGDYAAARAAYQRVLTREPGN 636
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 4-235 1.75e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    4 LLAYIKHLDGNNEAALECLRQAEELiqQEHADQAEIRslvtwgnyawvyyhLGRLSDAQIYVDKVKQTCKKFSNPYsIEY 83
Cdd:TIGR02917 640 LLADAYAVMKNYAKAITSLKRALEL--KPDNTEAQIG--------------LAQLLLAAKRTESAKKIAKSLQKQH-PKA 702

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   84 SELDCEEGWTQLKCGRNERAKVCFEKALEEKPN-------------NPEFSSGLAIAMYHLDNHPE-------------K 137
Cdd:TIGR02917 703 ALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSsqnaiklhrallaSGNTAEAVKTLEAWLKTHPNdavlrtalaelylA 782

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  138 QFSTD----VLKQAIELSPDNQYVKVLLGLKLQKmNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQ 213
Cdd:TIGR02917 783 QKDYDkaikHYQTVVKKAPDNAVVLNNLAWLYLE-LKDPRALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLR 861

                         250       260
                  ....*....|....*....|..
gi 576796052  214 RVLESTPNNGYLYHQIGCCYKA 235
Cdd:TIGR02917 862 KAVNIAPEAAAIRYHLALALLA 883
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
2-112 2.50e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   2 YNLLAYIKHLDGNNEAALECLRQAEELiQQEHADqaeirslvTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSI 81
Cdd:COG4785  110 YNNRGLAYLLLGDYDAALEDFDRALEL-DPDYAY--------AYLNRGIALYYLGRYELAIADLEKALELDPNDPERALW 180

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 576796052  82 EY------------SELDCEEGWTQLKCGRNERAKVCFEKALE 112
Cdd:COG4785  181 LYlaerkldpekalALLLEDWATAYLLQGDTEEARELFKLALA 223
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 116-230 3.92e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 39.12  E-value: 3.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 116 NNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLGLKLqkmNKEAEGEQFVEEALEKSPCQTDVLRSA 195
Cdd:COG3071  191 RDPELAAAYARALIALGDHDE---AERLLREALKRQWDPRLVRLYGRLQG---GDPAKQLKRAEKWLKKHPNDPDLLLAL 264

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 576796052 196 AKFYRRKGDLDKAIELFQRVLESTPNN------GYLYHQIG 230
Cdd:COG3071  265 GRLCLRNQLWGKAREYLEAALALRPSAeayaelARLLEQLG 305
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 179-265 4.12e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 4.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052 179 EEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYkakvRQMQNTGESEASGNK------ 252
Cdd:COG4235    7 RQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEAL----LAAGDTEEAEELLERalaldp 82

                         90
                 ....*....|...
gi 576796052 253 EMIEALKQYAMDY 265
Cdd:COG4235   83 DNPEALYLLGLAA 95
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 2-239 7.77e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 38.43  E-value: 7.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    2 YNLLAYIKHLDGNNEAALECLRQAEEL---------------IQQEHADQAE---IRSLVTWGNYAWVYYH-------LG 56
Cdd:TIGR00990 334 LNLRGTFKCLKGKHLEALADLSKSIELdprvtqsyikrasmnLELGDPDKAEedfDKALKLNSEDPDIYYHraqlhfiKG 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   57 RLSDAQIYVDKVKQTCKKFSNPYsieyseldCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPE 136
Cdd:TIGR00990 414 EFAQAGKDYQKSIDLDPDFIFSH--------IQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDE 485

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052  137 --KQFSTDVlkqAIELSPDNQYVKV--LLGLKL---QKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAI 209
Cdd:TIGR00990 486 aiEKFDTAI---ELEKETKPMYMNVlpLINKALalfQWKQDFIEAENLCEKALIIDPECDIAVATMAQLLLQQGDVDEAL 562

                         250       260       270
                  ....*....|....*....|....*....|
gi 576796052  210 ELFQRVLESTPNNGYLYHQIGCCYKAKVRQ 239
Cdd:TIGR00990 563 KLFERAAELARTEGELVQAISYAEATRTQI 592
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 3-223 8.31e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052    3 NLLAYIKHLDGNNEAALECLRQAEELiqqehaDQAEIRSLVTWGNYawvYYHLGRLSDAQIYVDKVKQTCKKfsnpySIE 82
Cdd:TIGR02917 537 LALAGLYLRTGNEEEAVAWLEKAAEL------NPQEIEPALALAQY---YLGKGQLKKALAILNEAADAAPD-----SPE 602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 576796052   83 YSELdceEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEkqfSTDVLKQAIELSPDNQYVKVLLG 162
Cdd:TIGR02917 603 AWLM---LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAK---AITSLKRALELKPDNTEAQIGLA 676

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 576796052  163 LKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNG 223
Cdd:TIGR02917 677 QLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQ 737
TPR_12 pfam13424
Tetratricopeptide repeat;
157-217 8.79e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 35.06  E-value: 8.79e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 576796052  157 VKVLLGLKLQKMNKEAEGEQFVEEALE--------KSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLE 217
Cdd:pfam13424   5 ALNNLAAVLRRLGRYDEALELLEKALEiarrllgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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