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Conserved domains on  [gi|583966101|ref|NP_001276856|]
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early growth response protein 3 isoform 3 [Mus musculus]

Protein Classification

DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112506)

DUF3446 and COG5048 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 33-119 7.26e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101   33 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 94
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 583966101   95 NCGDLYSEPVSFHDPQGNPGLAYSP 119
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-321 1.53e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 583966101 249 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 321
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
206-279 2.54e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 583966101 206 KYPNRPSKTPLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 279
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 33-119 7.26e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101   33 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 94
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 583966101   95 NCGDLYSEPVSFHDPQGNPGLAYSP 119
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-321 1.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 583966101 249 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 321
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-290 2.88e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 2.88e-06
                          10        20
                  ....*....|....*....|....*.
gi 583966101  265 HLTTHIRTHTGEKPFACEFCGRKFAR 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-279 2.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 583966101 206 KYPNRPSKTPLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 279
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-245 2.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 583966101  221 HACPaeGCDRRFSRSDELTRHLRIH 245
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 250-297 9.33e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 583966101 250 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 297
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 33-119 7.26e-10

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 55.61  E-value: 7.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101   33 GKFAFDSP----SNWCQDNIISLMSaGILGV-PPASGALSTQTSTAS-----------MVQPPQGDVEAMYPALPPY--S 94
Cdd:pfam11928   1 GKFSIDPQypggGSLWPEGLISLVS-GLVGMaNPPSSSSSSSPSSSSspnssgplctmSCSVQSSEMEHIYSAPPPYpsS 79

                          90       100
                  ....*....|....*....|....*
gi 583966101   95 NCGDLYSEPVSFHDPQGNPGLAYSP 119
Cdd:pfam11928  80 GCGDLYQDPSAFLSTPSGPPLAYPP 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-321 1.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 1.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 583966101 249 KPFQCRICMRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSD--ERKRHAKIHLKQKEKKSEKGGAPSASSAP 321
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-290 2.88e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 2.88e-06
                          10        20
                  ....*....|....*....|....*.
gi 583966101  265 HLTTHIRTHTGEKPFACEFCGRKFAR 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 1.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 1.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 583966101  237 ELTRHLRIHTGHKPFQCRICMRSFSR 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 206-299 1.46e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101 206 KYPNRPSKTpLHERPHACPAEGCDRRFSRSDELTRHlRIHtGHK-----PFQCRICMRSFSRSDhltthirthtgeKPFA 280
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*....
gi 583966101 281 CEFCGRKFARSDERKRHAK 299
Cdd:COG5189  401 CEVCDKRYKNLNGLKYHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 251-273 3.95e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 3.95e-04
                          10        20
                  ....*....|....*....|...
gi 583966101  251 FQCRICMRSFSRSDHLTTHIRTH 273
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
223-302 2.24e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 39.62  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101 223 CPAEGCDRRFSRSDELTRHLRIHtgHKPFQCRICMR---------SFSRSDHLTTHIRTHTGEKPFA----CEFCGRKFA 289
Cdd:COG5236  154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGnkkdfwneiRLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                         90
                 ....*....|....*...
gi 583966101 290 RSDE-----RKRHAKIHL 302
Cdd:COG5236  232 DDDElrrhcRLRHEACHI 249
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 251-273 2.44e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.93  E-value: 2.44e-03
                          10        20
                  ....*....|....*....|...
gi 583966101  251 FQCRICMRSFSRSDHLTTHIRTH 273
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
228-324 2.47e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966101 228 CDRRFSRSDELTRHLR--IHTG--HKPFQCRI--CMRSFSRSDHLTTHIRTHTGEKPFAC--EFCGRKFARSDERKRHAK 299
Cdd:COG5048  295 CNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQS 374

                         90       100
                 ....*....|....*....|....*.
gi 583966101 300 IHLKQKEKKS-EKGGAPSASSAPTVS 324
Cdd:COG5048  375 LQQYKDLKNDkKSETLSNSCIRNFKR 400
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-279 2.54e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 583966101 206 KYPNRPSKTPLHERPHACPaeGCDRRFSRSDELTRHLRIHTGHKPFQCRICMR--SFSRSDHLTTHIRTHTGEKPF 279
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSD 92
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-245 2.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.57e-03
                          10        20
                  ....*....|....*....|....*
gi 583966101  221 HACPaeGCDRRFSRSDELTRHLRIH 245
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 250-297 9.33e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.01  E-value: 9.33e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 583966101 250 PFQCRICMRSFSRSDHLTTHIRTHTGEKpfACEFCGRKFARSDERKRH 297
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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