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Conserved domains on  [gi|594591612|ref|NP_001277603|]
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sodium channel protein type 9 subunit alpha isoform a [Mus musculus]

Protein Classification

Na_trans_assoc and Ion_trans domain-containing protein( domain architecture ID 11999294)

protein containing domains Na_trans_cytopl, Na_trans_assoc, Ion_trans, and Na_channel_gate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
534-693 9.92e-89

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 463401  Cd Length: 163  Bit Score: 285.86  E-value: 9.92e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   534 SPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSP---PV 610
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSrshPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   611 LPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMS 690
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 594591612   691 RAS 693
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
981-1185 1.59e-70

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 461936  Cd Length: 195  Bit Score: 234.92  E-value: 1.59e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   981 DTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKG-SKDTKRTADPNNKRENYISNRTLAEISKDhnflkekdkis 1059
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1060 gfssslDKSFMDEnDYQSFIHNPSLTVTVPIAPGESDLENMNTEELSSD-----SDSDYSKERRNRSSSSECSTVDNPLP 1134
Cdd:pfam06512   70 ------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQssdeeKSKQQEQLEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 594591612  1135 GEEEAEAEPINAD--EPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYR 1185
Cdd:pfam06512  143 EEELEKIPEEAEElkEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1189-1464 4.74e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 212.51  E-value: 4.74e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1189 HSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIiLEYADKIFTYIFILEMLLKWVAYGY-KTYFTNAWCWLDFLIVDVS 1267
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTV-LEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1268 LVTLVANTlgYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYE 1347
Cdd:pfam00520   80 LISLVLSS--VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1348 CVNTTDGsrfsvsqvanrsecfalmnvsgnvrwknlKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSvnvnaqpiyEY 1427
Cdd:pfam00520  158 WENPDNG-----------------------------RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KG 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 594591612  1428 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1464
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1512-1768 2.53e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.95  E-value: 2.53e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1512 NQAFDITIMVLICLNMVTMMVEKEGQTD-YMSFVLYWINVVFIILFTGECVLKLISLR--HYYFTVGWNIFDFVVVILSI 1588
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1589 VGMFLAEMiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV- 1667
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1668 -KKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPpdcdpkkvhpgssvegdcgnPSVGIFYFVSYIIISF 1746
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 594591612  1747 LVVVNMYIAVILENFSVATEES 1768
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-955 1.48e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.48e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   742 DPFVDLAITICIVLNTLFMAMEHHPMTDE-FKNVLAVGNLVFTGIFAAEMVLKLIAMDP-YEYFQVGWNIFDSLIVTLSL 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   820 VELFLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 896
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   897 KINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVYMMVMVIGN 955
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410 3.20e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.01  E-value: 3.20e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   125 HSLFSMLIMCTILTNCIFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCvgeFTFLRDPWNWLDFVVIV 197
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   198 FAYLT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKH 273
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   274 kcfrkdleqnetlesimstaeseeelkryfyylegskdallcgfstdsgqcpegyecvtaGRNPDYGYTSFDTFGWAFLA 353
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 594591612   354 LFRLMTQDYWENLYQQTLRAAGKTYM-IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1456-1508 5.79e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 5.79e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 594591612 1456 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFD 1508
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
534-693 9.92e-89

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 285.86  E-value: 9.92e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   534 SPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSP---PV 610
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSrshPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   611 LPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMS 690
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 594591612   691 RAS 693
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
981-1185 1.59e-70

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 234.92  E-value: 1.59e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   981 DTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKG-SKDTKRTADPNNKRENYISNRTLAEISKDhnflkekdkis 1059
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1060 gfssslDKSFMDEnDYQSFIHNPSLTVTVPIAPGESDLENMNTEELSSD-----SDSDYSKERRNRSSSSECSTVDNPLP 1134
Cdd:pfam06512   70 ------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQssdeeKSKQQEQLEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 594591612  1135 GEEEAEAEPINAD--EPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYR 1185
Cdd:pfam06512  143 EEELEKIPEEAEElkEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1189-1464 4.74e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 212.51  E-value: 4.74e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1189 HSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIiLEYADKIFTYIFILEMLLKWVAYGY-KTYFTNAWCWLDFLIVDVS 1267
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTV-LEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1268 LVTLVANTlgYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYE 1347
Cdd:pfam00520   80 LISLVLSS--VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1348 CVNTTDGsrfsvsqvanrsecfalmnvsgnvrwknlKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSvnvnaqpiyEY 1427
Cdd:pfam00520  158 WENPDNG-----------------------------RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KG 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 594591612  1428 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1464
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1512-1768 2.53e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.95  E-value: 2.53e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1512 NQAFDITIMVLICLNMVTMMVEKEGQTD-YMSFVLYWINVVFIILFTGECVLKLISLR--HYYFTVGWNIFDFVVVILSI 1588
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1589 VGMFLAEMiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV- 1667
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1668 -KKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPpdcdpkkvhpgssvegdcgnPSVGIFYFVSYIIISF 1746
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 594591612  1747 LVVVNMYIAVILENFSVATEES 1768
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-955 1.48e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.48e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   742 DPFVDLAITICIVLNTLFMAMEHHPMTDE-FKNVLAVGNLVFTGIFAAEMVLKLIAMDP-YEYFQVGWNIFDSLIVTLSL 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   820 VELFLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 896
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   897 KINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVYMMVMVIGN 955
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410 3.20e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.01  E-value: 3.20e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   125 HSLFSMLIMCTILTNCIFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCvgeFTFLRDPWNWLDFVVIV 197
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   198 FAYLT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKH 273
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   274 kcfrkdleqnetlesimstaeseeelkryfyylegskdallcgfstdsgqcpegyecvtaGRNPDYGYTSFDTFGWAFLA 353
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 594591612   354 LFRLMTQDYWENLYQQTLRAAGKTYM-IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1456-1508 5.79e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 5.79e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 594591612 1456 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFD 1508
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
534-693 9.92e-89

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 463401  Cd Length: 163  Bit Score: 285.86  E-value: 9.92e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   534 SPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHRPRERRSSNISQASRSP---PV 610
Cdd:pfam11933    1 SLLSIPGSPFSPRRSSRGSIFSFRGRGRDVGSENDFADDENSTFEDSESRRGSLFVPRRHLERRSSYQSQASRSSrshPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   611 LPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMS 690
Cdd:pfam11933   81 LPQNGKRHSTVDCNGVVSLVGGGPEPTSPGGQLLPEVILDKPATGDSTTTEEELRKRRLSSYQLSMDYLEEPFQRQRAVS 160

                   ...
gi 594591612   691 RAS 693
Cdd:pfam11933  161 AAS 163
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
981-1185 1.59e-70

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 461936  Cd Length: 195  Bit Score: 234.92  E-value: 1.59e-70
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   981 DTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKG-SKDTKRTADPNNKRENYISNRTLAEISKDhnflkekdkis 1059
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKSTLRDFCCRLCKEPQLPkKKPLTELKDARSKLTNQIANHTSLKKAPG----------- 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1060 gfssslDKSFMDEnDYQSFIHNPSLTVTVPIAPGESDLENMNTEELSSD-----SDSDYSKERRNRSSSSECSTVDNPLP 1134
Cdd:pfam06512   70 ------GKYELDE-DHMDFITNPNLTVCVPIAEGESDLENEEDDDESSQssdeeKSKQQEQLEDDDSSSSEGSTVDLQDP 142
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 594591612  1135 GEEEAEAEPINAD--EPEACFTDGCVRRFPCCQVNIDSGKGKVWWTIRKTCYR 1185
Cdd:pfam06512  143 EEELEKIPEEAEElkEPEDCFTEGCVRRFPCCAVDTTKGPWKIWWNLRKTCYR 195
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1189-1464 4.74e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 212.51  E-value: 4.74e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1189 HSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIiLEYADKIFTYIFILEMLLKWVAYGY-KTYFTNAWCWLDFLIVDVS 1267
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTV-LEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1268 LVTLVANTlgYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYE 1347
Cdd:pfam00520   80 LISLVLSS--VGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1348 CVNTTDGsrfsvsqvanrsecfalmnvsgnvrwknlKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSvnvnaqpiyEY 1427
Cdd:pfam00520  158 WENPDNG-----------------------------RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KG 199
                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 594591612  1428 NLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1464
Cdd:pfam00520  200 EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1512-1768 2.53e-56

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 195.95  E-value: 2.53e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1512 NQAFDITIMVLICLNMVTMMVEKEGQTD-YMSFVLYWINVVFIILFTGECVLKLISLR--HYYFTVGWNIFDFVVVILSI 1588
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1589 VGMFLAEMiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV- 1667
Cdd:pfam00520   81 ISLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1668 -KKEAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPpdcdpkkvhpgssvegdcgnPSVGIFYFVSYIIISF 1746
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG--------------------EFWAYIYFVSFIILGG 215
                          250       260
                   ....*....|....*....|..
gi 594591612  1747 LVVVNMYIAVILENFSVATEES 1768
Cdd:pfam00520  216 FLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-955 1.48e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.48e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   742 DPFVDLAITICIVLNTLFMAMEHHPMTDE-FKNVLAVGNLVFTGIFAAEMVLKLIAMDP-YEYFQVGWNIFDSLIVTLSL 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   820 VELFLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 896
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   897 KINENCKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQTMCLIVYMMVMVIGN 955
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
125-410 3.20e-52

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 184.01  E-value: 3.20e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   125 HSLFSMLIMCTILTNCIFMTMSNPP-------DWTKNVEYTFTGIYTFESLIKILARGFCvgeFTFLRDPWNWLDFVVIV 197
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFqpeepltTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   198 FAYLT----EFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKH 273
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612   274 kcfrkdleqnetlesimstaeseeelkryfyylegskdallcgfstdsgqcpegyecvtaGRNPDYGYTSFDTFGWAFLA 353
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 594591612   354 LFRLMTQDYWENLYQQTLRAAGKTYM-IFFVVVIFLGSFYLINLILAVVAMAYEEQNQ 410
Cdd:pfam00520  178 LFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTE 235
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1456-1508 5.79e-32

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 119.21  E-value: 5.79e-32
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 594591612 1456 DNFNQQKKKLGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGCIFD 1508
Cdd:cd13433     1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1537-1762 4.31e-07

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 53.05  E-value: 4.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1537 QTDYMSFVL--YWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLaeMIEKYFVSPTLFRVI---- 1610
Cdd:pfam08016    3 VTNRSLFILlcEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVL--NIYRDFLADRLIKSVeasp 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1611 -------RLARIGRILRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAyv 1667
Cdd:pfam08016   81 vtfidfdRVAQLDNLYRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG-- 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594591612  1668 kkeagiNDMFNFETFGNSMICLFQITTSA-GWDGLlapilnsappdcdpkkvhpgssvegDCGNPSVGIFYFVSYIIISF 1746
Cdd:pfam08016  159 ------TQAPNFSNFVKSILTLFRTILGDfGYNEI-------------------------FSGNRVLGPLLFLTFVFLVI 207
                          250
                   ....*....|....*.
gi 594591612  1747 LVVVNMYIAVILENFS 1762
Cdd:pfam08016  208 FILLNLFLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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