|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
28-442 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 565.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLRMVPCM-VVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:cd17399 81 IGAVIRVISSLpFVDPSFRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 187 KKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASStSEKFLDGLKlQLMWNKAYVILAVCLGGMIGISASF 266
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHE-SEPFFVGLK-QLFKNKQYLILMLCFGGGIGLFNAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 267 SALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQLQGQTLALAAT 346
Cdd:cd17399 239 STLLEQILCPSGYSNNFAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQSVLLAVL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 347 CSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVRRSEPSL-----STCQQGEDPLDWT 421
Cdd:cd17399 319 CGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIMQALATPLSVYDLpiqcaSSASGNITPLDWT 398
|
410 420
....*....|....*....|.
gi 661567306 422 VSLLLMAGLCTFFSCILAVFF 442
Cdd:cd17399 399 VPLLVMAGLAAVLAIIFVVFF 419
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
28-442 |
6.03e-156 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 451.86 E-value: 6.03e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLRMVPCmvvGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17334 81 LGSVLKCIPL---GQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 KGED-IPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEK------FLDGLKLQLMWNKAYVILAVCLGGMI 260
Cdd:cd17334 158 PPKGtKKEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNsehvilELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 261 GISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVSQ---LQ 337
Cdd:cd17334 238 GVFAGFSSVLAQILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTRMFKLIGLIILALGTVVCTFFMLLVDrygLP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 338 GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVrrsepslstcqqgedP 417
Cdd:cd17334 318 YVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLG---------------P 382
|
410 420
....*....|....*....|....*
gi 661567306 418 LDWTVSLLLMAGLCTFFSCILAVFF 442
Cdd:cd17334 383 TPTESKYLLWFILCTVGSCLGALFF 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
28-399 |
1.83e-61 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 208.25 E-value: 1.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLRmvpCMVVGTqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17398 81 LGAWLK---LFSSSP-DLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 KGEDIP-----LMLGVYTIPA-GVVCLLSTICLWESVPPTPPSAGAASSTSEK-----FLDGLKlQLMWNKAYVILAVCL 256
Cdd:cd17398 157 NSENKDeigkgLSILFYGVAGiCTALFILVIIFFKEKPPIPPSRAQAAAQELRsedqsYLGSLK-RLFKNKGFLLLLITY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 257 GGMIGISASFSALLEQ-ILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQ 335
Cdd:cd17398 236 GINTGVYYAISTLLNQmVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETT-IIVYILSFIGMVAFTFTL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 661567306 336 LQGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTAL 399
Cdd:cd17398 315 DLGSIWVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGAL 378
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
28-400 |
2.20e-41 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 154.22 E-value: 2.20e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLRmvpCMVVGtQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17455 81 LGAWVK---CASVR-PDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 K--------GEDIPLMLGVYTIPAGVVCLLsTICLWESVPPTPPSAGAA---SSTSEKFLDGLKL-QLMWNKAYVILAVC 255
Cdd:cd17455 157 NtvddidlmGHNISIMFYGTAAVSTLLFIL-TIIVFKEKPPLPPSQAQAvlqGIPSEDYSYKQSIiNLFKNVPFVLLLIS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 256 LGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFAL 332
Cdd:cd17455 236 YGIMTGTFYSVSTLLNQMIIT--HYEGeevNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTF 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 661567306 333 VSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALT 400
Cdd:cd17455 314 TLDL-GYLIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLT 380
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
28-397 |
1.38e-40 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 151.30 E-value: 1.38e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAE-------DLVLSMeqiNWLSLVYLVVSTPFgvaaIWILDSVGLRAATI 100
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPafgwsdsDIALLA---NWGPIGFVPTFFFM----AWLMDVKGLRIAVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 101 LGAWLNFAGSVLRMVPcmvvgTQNPFAFLM--GGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVA 178
Cdd:cd17397 74 SSAFLVAAGTGLRCIP-----VPNHLATWLihIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAAS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 179 NVLSpvlvkkgediPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAgAASSTSEKFLDGLkLQLMWNKAYVILAVCLGG 258
Cdd:cd17397 149 FLIG----------PLVLMYLEFGWSALIFLAMLIYFPSKPPTPPSV-SASTQRLSYKSGI-LSLLKNKRFWLIALAYGI 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 259 MIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEatKIGLCLFSLACVPFALVSQLQ- 337
Cdd:cd17397 217 PTGVYAGWSGVLDVNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRMK--LILLLLFSGATGSFLWFTLICl 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 661567306 338 ----GQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMT 397
Cdd:cd17397 295 kllpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLLILI 358
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
28-395 |
1.46e-36 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 140.69 E-value: 1.46e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLRmvpcmvVGTQNP--FAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVL 185
Cdd:cd17456 81 LGAWIK------TGSARPdlFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 186 VKKGEDIPLMLG----VYTIPAGVVCLLS--TICLWESVPPTPPS---AGAASSTSEKF-LDGLKLQLMWNKAYVILAVC 255
Cdd:cd17456 155 VPNIDDLDELAYhisiMFYGTAAVATLLFilVIIVFQEKPKIPPSqaqAAIQSIPSQDYsYLQSILRLLKNVNFILLVVS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 256 LGGMIGISASFSALLEQILCAsgHSSG---FSGLCGALFITFGILGALALGPYVDRTKHFTEATkIGLCLFSLA-CVPFA 331
Cdd:cd17456 235 YGLNTGCFYALSTLLNRMVIF--HYPGeevNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTT-LAVYIMSLVgMVVYT 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 661567306 332 LVSQLqGQTLALAATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLA 395
Cdd:cd17456 312 FTLNL-GHLWVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTIS 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-399 |
5.91e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 91.87 E-value: 5.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAwln 106
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 107 fagsVLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG2223 78 ----LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 187 KKGeDIPLMLGVYtipaGVVCLLSTICLWESVPPTPPSAGAASSTSEK-FLDGLKLQLMWnKAYVILAVCLGGMIGISAS 265
Cdd:COG2223 154 AAF-GWRNAFLIL----GILLLVVAVLAWLFLRDPPAGAAAAAKASLRdQLEALRDPRFW-LLSLLYFGTFGSFIGFSSW 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 266 FSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAA 345
Cdd:COG2223 228 LPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLSDRIG----GRRVLLIVFALMALGLLLLALALGSLWLFLV 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 661567306 346 TCSLLGLF-GFSVGPVAMELAVecSFPVGE-GAATGMIFVLGQAEGILIMLAMTAL 399
Cdd:COG2223 301 LFLLLGLAlGGGNGAVFALVPD--IFPTKNaGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
27-385 |
4.50e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 86.47 E-value: 4.50e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLN 106
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 107 FAGSVLRmvpcmvvGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHqRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG2807 94 AAGLLLR-------SLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 187 kKGEDIPLMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSekfldglklqLMWNKAYVILAVCLGGMIGISASF 266
Cdd:COG2807 166 -AALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS----------LWRSPLAWLLTLFFGLQSLLYYAV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 267 SALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRTKHfteatKIGLCLFSLACVPFALVSQLQGQTLALAAT 346
Cdd:COG2807 235 VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGD-----RRPLLLLLGLLGLAGLLGLLLAPGSLPWLW 309
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 661567306 347 CSLLGLFGFSVGPVAMELAVECSFPVGE-GAATGMIFVLG 385
Cdd:COG2807 310 AVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVG 349
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
28-448 |
5.60e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 85.69 E-value: 5.60e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:COG2271 87 LATLL----FGFATS---FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 KGeDIPLMLGVYTIPAGVVCLLSTICLWesvpptppsagaasstsekfldglklqlmwnkayVILAVCLGGMIGISASFS 267
Cdd:COG2271 160 AF-GWRAAFLILGLPGLLLALLRFWLLA----------------------------------LAYFLVYFALYGFLTWLP 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 268 ALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRtkhFTEATKIGLCLFSLACVPFALVSQLQGQTLALAATC 347
Cdd:COG2271 205 TYLVEVR---GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR---LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 348 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTvrrsepslstcqqgeDPLDWTVSLLLM 427
Cdd:COG2271 279 FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---------------DATGYQAAFLLL 343
|
410 420
....*....|....*....|.
gi 661567306 428 AGLCtFFSCILAVFFHTPYRR 448
Cdd:COG2271 344 AALA-LLAALLALLLLRETRK 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-402 |
8.86e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 85.17 E-value: 8.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 36 ISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMV 115
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 116 PcmvvgtqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDI-PL 194
Cdd:cd06174 81 A-------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 195 MLGVYTIPAGVVCLLSTIClwesvPPTPPSAGAASSTSEKFLDGLKLQLMW--NKAYVILAVCLGGMIGISASFSALLEQ 272
Cdd:cd06174 154 VFLIAAALALLAAILLLLV-----VPDPPESARAKNEEASSKSVLKLLKRVlkNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 273 ILCASGHSSG-FSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACVPFALVsqLQGQTLALAATCSLLG 351
Cdd:cd06174 229 FLLDLGGLSVaVAGLLLSLFGLAGALGSLLLGLLSDR--LIGRKPLLLIGLLLMALGLALLL--LAPSLLLLLLLLLLLG 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 661567306 352 LFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAMTALTVR 402
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
28-387 |
1.79e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 78.09 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:COG2814 87 LGSLL----CALAPS---LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 KGeDIPLMLGVytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMwnkAYVILAVCLGGMIGISASFS 267
Cdd:COG2814 160 LF-GWRWVFLV----NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLL---LLLLAFLLGFGFFALFTYLP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 268 ALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqtLALAATC 347
Cdd:COG2814 232 LYLQEVL---GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALAGSL----WLLLLAL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 661567306 348 SLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQA 387
Cdd:COG2814 304 FLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
41-391 |
3.35e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 77.07 E-value: 3.35e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 41 CSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAGSVLRMVPcmvv 120
Cdd:pfam07690 7 LAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA---- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 121 gtqNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVkkgeDIPLMLGVYT 200
Cdd:pfam07690 83 ---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA----SLFGWRAAFL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 201 IpAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISAsFSALLEQILCASGHS 280
Cdd:pfam07690 156 I-LAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 281 SGFSGLCGALFITFGILGALALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLQGQTLALAAtCSLLGLFGFSVGPV 360
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR-RLLLALLLLILAALGLLLLSLTLSSLWLLLA-LLLLGFGFGLVFPA 311
|
330 340 350
....*....|....*....|....*....|.
gi 661567306 361 AMELAVECSFPVGEGAATGMIFVLGQAEGIL 391
Cdd:pfam07690 312 LNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
51-393 |
1.10e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 51 APVADVIAEDLVLSMEQINWL----SLVYLVVSTPFGvaaiWILDSVGLRAATILGawlnFAGSVLRMVPCMVVGTqnpF 126
Cdd:cd17325 16 IPILPLYAESLGASVAQIGLIvaayALAQLLFSPPAG----RLSDRFGRKRLLLLG----LLLLAVSTLLFAFATS---Y 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 127 AFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGeDIPLMLGVYTIPAGVV 206
Cdd:cd17325 85 WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 207 CLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWnKAYVILAVCLGGMIGISASFSALLEQILCASghssgfSGL 286
Cdd:cd17325 164 LVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLL-ALFLAIFVLAFAFGALEPFLPLYAAELGGLS------PAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 287 CGALFITFGILGALA---LGPYVDRTKHFTEATkIGLCLFSLACVPFALVSQLqgqtLALAATCSLLGLFGFSVGPVAME 363
Cdd:cd17325 237 IGLLFGAQGLASALSqppAGKLSDRIGRKPLIL-IGLLLSAVALLLLPLATSF----WLLLLLLALLGLGLGLVFPATLA 311
|
330 340 350
....*....|....*....|....*....|...
gi 661567306 364 LAVECSFPVGEGAATG---MIFVLGQAEGILIM 393
Cdd:cd17325 312 LLADIVPPEGRGTAMGlfnTAFSLGMVLGPLLG 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
158-362 |
5.57e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 5.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 158 HQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIP----LMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGaassts 232
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAfGGDAAlgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVS------ 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 233 ekFLDGLKlQLMWNKAYVIL-AVCLGGMIGISASFSALLEQILCASGHSSGFSGLCGALFITFGILGALALGPYVDRT-K 310
Cdd:COG2211 217 --LKESLK-ALLKNRPFLLLlLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFgK 293
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 661567306 311 HFTeaTKIGLCLFSLACVPFALVSqlQGQTLALAATCSLLGLF--GFSVGPVAM 362
Cdd:COG2211 294 KKA--FIIGLLLAALGLLLLFFLG--PGNLWLLLVLAALAGIGlgAILVLPWAM 343
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-385 |
7.35e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.31 E-value: 7.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGsvlrmvpCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMsNPLGVLVANVLSPVLVK 187
Cdd:COG0738 85 LG-------LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLIL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 188 KGEDIPLMLGVYTIpaGVVCLLSTICLWES-VPPTPPSAGAASSTSEKFLDGLKLQLMWnkAYVILAVCLGGM-IGISAS 265
Cdd:COG0738 157 LGLSLSWHLPYLIL--AVLLLLLALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLL--LGGLAIFLYVGAeGAIGDW 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 266 FSALLEQILcasGHSSGFSGLCGALFITFGILGALALGPYVDRTKhfteATKIGLCLFSLACVPFALVSQLQGQTLALAA 345
Cdd:COG0738 233 LPLYLKDVL---GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG----PVRLLRLSALLAAVGLLLALLAPGPWLALIG 305
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 661567306 346 tCSLLGlFGFSVG-PVAMELAVEcSFPVGEGAATGMIFVLG 385
Cdd:COG0738 306 -LALVG-LGLSLMfPTIFSLALD-GLGKRTAAAVSAVLIMG 343
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
49-393 |
3.28e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 3.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 49 SFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGlRAATILGAWLNFAGSvlrmvpCMVVGTQNPFAF 128
Cdd:cd17474 17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFG-RKKVLLPGLLLFGIG------GLLCGLSDSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 129 LMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIPAGVVCL 208
Cdd:cd17474 90 LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 209 LstICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMwnkaYVILAVCLGGMIGISASFSALLEQILCASGHSSGFSgLCG 288
Cdd:cd17474 170 L--FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTF----LVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL-FAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 289 ALFITfgILGALALGPYVDRTKHFTEATKIGLCLFSLAcvpFALVSQLQGQTLALAATcSLLGLFGFSVGPVAMELAVEC 368
Cdd:cd17474 243 WSVLL--ALGSLFVGRLLKKRFGARRILVIGLLLYALS---LLLLGFVPSLALLLIAI-VLFGLGLGLNLPLLTTLVTEL 316
|
330 340
....*....|....*....|....*...
gi 661567306 369 SFPVGEGAAT---GMIFVLGQAEGILIM 393
Cdd:cd17474 317 APEEERGTASslyNFVRFLGQAVGPLLF 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
31-380 |
4.07e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 31 VFLLAISLLnCSNATLWLsFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATIlgawlnfAGS 110
Cdd:cd17324 1 LLALALAAF-AIGTTEYV-IQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLL-------VLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 111 VLRMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLvkkGE 190
Cdd:cd17324 72 LLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL---GQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 191 diplMLG--VYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWnKAYVILAVCLGGMIGISASFSA 268
Cdd:cd17324 149 ----LLGwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLR-LAYLITFLLFGGFFALYTYLAP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 269 LLEQIlcaSGHSSGFSGLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALvsqlqGQTLALAATCS 348
Cdd:cd17324 224 FLTDV---PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG-----PSPLLLLVGLV 295
|
330 340 350
....*....|....*....|....*....|..
gi 661567306 349 LLGLFGFSVGPVAMELAVECSfPVGEGAATGM 380
Cdd:cd17324 296 LWGLGFFAAHSALQTRVLRLA-PEARGLASSL 326
|
|
| PHA03381 |
PHA03381 |
tegument protein VP22; Provisional |
452-557 |
7.21e-05 |
|
tegument protein VP22; Provisional
Pssm-ID: 177618 [Multi-domain] Cd Length: 290 Bit Score: 45.00 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 452 ESGEPPSTRNAVGGAD-SGPGVDRGGAGRAGVLGPSTATPECTARGAslEDPRGPGSPH---PACHRATPRAQGPAATdA 527
Cdd:PHA03381 83 RPADPRPSRRPHAQPEaSGPGPARGARGPAGSRGRGRRAESPSPRDP--PNPKGASAPRgrkSACADSAALLDAPAPA-A 159
|
90 100 110
....*....|....*....|....*....|
gi 661567306 528 PSRPGRLAGRVQASRFidpAGSHSSFSSPW 557
Cdd:PHA03381 160 PKRQKTPAGLARKLHF---STAPTSPTAPW 186
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
47-396 |
1.00e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 44.93 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 47 WLSFAPVADVIAEDLVLSMEQInwlslvYLVVSTPFGVAAIWILdSVGLRAATILGAWLNFAGSVLRMVPCMVVG--TQN 124
Cdd:cd17341 15 WFLFAPLGPVIRDDLGLSTSQI------GLLVAIPVLAGALLRL-PYGFLCDRFGGRRVFIASLLLLLIPLLALAlaVSS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 125 PFAFLMGGqSLCALAqsLVIFSPA-KLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVYTIP- 202
Cdd:cd17341 88 YWGLLVLG-FLLGFA--GANFASGqPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWRNAFf 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 203 -AGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAyVILAVCLGGMIGISASFSALLEQILCASGHSS 281
Cdd:cd17341 165 vPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVLKNYRTWILS-LLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 282 GFSGLCGALfitFGILGALALGPYVDR--TKHFTEATKIGLCLFSLACVPFalvSQLQGQTLALAATCSLLGLFGFSVGP 359
Cdd:cd17341 244 GILAALFPL---AGALARPAGGWLSDRfgGRRRLWWLFIVMTIGAALLSLS---LPTSGTNLVLFLALFVALGLGAGAGN 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 661567306 360 VAMELAVECSFPVGEGAATGMIFVLGQAEGILIMLAM 396
Cdd:cd17341 318 GSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLF 354
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-393 |
1.49e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 48 LSFAPVADVIAEDLVLSMEQINWL-SLVYLVVSTpFGVAAIWILDSVGLRAATILGAWL--------NFAGSVLRMVPCM 118
Cdd:cd17475 13 QGIPALAPFLQEDLHLSLAQVGLLlSALNLGVAV-SMLPAGWLLDRFGERRVLAVGLLLmgaaallmALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 119 VVGTQNPFAFLMGGQslcalaqslvifspaKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKK-GEDIPLMLg 197
Cdd:cd17475 92 FLVGAGYGSVQPGGG---------------RAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHyGWRAAFVV- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 198 vytipAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFldGLKLQLMWNKAYVILAVCLGGMIGISASFSALLEQILCAS 277
Cdd:cd17475 156 -----AGLVSILAAVLFWLFYREPPAASAATESASTLL--RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDH 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 278 GH-SSGFSGLCGALFITFGILGALALGPYVDRtkHFTEATKIGLCLFSLACV-PFALVSQLQGQT--LALAATCSLLGLF 353
Cdd:cd17475 229 LGlSVVAAGALLAVAQLGGALGRIGLGRVSDR--VFGGRRRPVLVITAAIAAaALLVLSLLSPGTplWLLVLLLILLGLF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 661567306 354 GFSVGPVAMELAVECSFPVGEGAATGMIFVLGQAeGILIM 393
Cdd:cd17475 307 AIGWNGLYLTLVAESAGPEQAGTALGLANTINFI-GIAIG 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
30-386 |
3.22e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 30 WVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNFAG 109
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 110 SVLrmvpcmVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVanvLSPVLVKKG 189
Cdd:cd17355 82 LVL------LALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLV---FLPLGAALI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 190 EDIP--LMLGVYTIPAGVVCLLSTICLWESVPPTPPSAGAASSTSEkfLDGLKLQLMWNKAYVIL----AVCLGGMIGIS 263
Cdd:cd17355 153 EAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPAS--PGSTLKEALRSASFWLLalafFLCGFAVVGLI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 264 ASFSALLeqilCASGHSSGFSGLCGALFITFGILGALALGPYVDRtkhfTEATKIGLCLFSLACVPFALVSQLQGQTLAL 343
Cdd:cd17355 231 VHLVPYL----ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR----YSPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 661567306 344 AATCSLLGLFGFSVGPVAMELAVECSFPVGEGAATGMIFVLGQ 386
Cdd:cd17355 303 LLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQ 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
27-270 |
3.51e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 42.88 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 27 ARRWVFLLAISLLNCSNATLWLSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLN 106
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 107 FAGSVLrmvpCMVVGTqnpFAFLMGGQSLCALAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLV 186
Cdd:COG0477 90 GLASLL----CGLAPS---PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 187 KK-GEDIPLMLGVytiPAGVVCLLSTICLWESVPPTPPSAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISAS 265
Cdd:COG0477 163 AAlGWRWIFLINA---PLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAAL 239
|
....*
gi 661567306 266 FSALL 270
Cdd:COG0477 240 LLLLA 244
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
34-395 |
1.08e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.84 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 34 LAISLLNCSNATLWLSFAPVADVIAEDLvLSMEQINWLSLVYLVvstpfGVAAIWILdsVGlRAATILG-AWLNFAGSVL 112
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADL-GPSSNSTWISTAWSL-----AQAVLGPI--VG-RLSDLFGrRWFFIGGNLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 113 RMVPCMVVGTQNPFAFLMGGQSLCALAQSLVIFSPAKLAALwFPEHQRATANMLATMSNPLGVLVANVLSPVLVKkgEDI 192
Cdd:cd06179 72 GVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASEL-VPNKYRGLVQGVVNLVASPGSALGPLIAGALVE--ANA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 193 PLMLGVYTIPAGVvCLLSTICLWESVPPTPPSAGAASSTSEK-----------FLDGLKLQLM----------WNKAYVI 251
Cdd:cd06179 149 AGWRWIFYINAIF-NALALILLFFFYHPPPRPQLHGSSTRQKlkrldwvglflLIAGLVLFLLglswggnpypWSSAHVI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 252 ----------------------------------------LAVC-LGGMIGISASfSALLEQILCASGHSSGFSGLCGAL 290
Cdd:cd06179 228 aplviggvlliafglyewkgtkdgllpprllfrgrnfaliLIVAfVEGMIFYSLN-IFWPQQISLLFTTDPLKAGLYQLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 291 FITFGILGALALGPYVDRTKHFTEATKIGLCLFSLACVPFALVsqlQGQTLALAATCSLLGLFGFSVGPVAMELAVECSF 370
Cdd:cd06179 307 FGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALI---TPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSV 383
|
410 420
....*....|....*....|....*....
gi 661567306 371 PVGE-GAATGMIF---VLGQAEGILIMLA 395
Cdd:cd06179 384 PPEDiGTASGLLGsarALGGAVGTAIFTS 412
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
72-360 |
1.14e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 72 SLVYLVVSTPFGVAA------IWILDSVGLRAATILGAWLNFAGSVLRMVPCMVvgtqnpFAFLMGGQSlcalaqslVIF 145
Cdd:cd06173 44 FLPFLLFSPFAGVLAdrfdrrRLLILADLLRALLAAVLALLALLGSLSLWLLLV------LAFLLGIAS--------AFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 146 SPAKLAAL--WFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVytipaGVVCLLSTICLWESVPPTPP 223
Cdd:cd06173 110 GPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAIN-----ALSFLLSALLLLFIRRPPPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 224 SAGAASSTSEKFLDGLKLQLMWNKAYVILAVCLGGMIGISASFSALLeqILCASGHSSGFSGLCGALFITFGI---LGAL 300
Cdd:cd06173 185 APGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLL--PLLAKEVLGGGAAGYGLLLAAFGVgalLGAL 262
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 301 ALGPYVDRTKHFTeATKIGLCLFSLACVPFALVSQLqgqTLALAAtcslLGLFGFSVGPV 360
Cdd:cd06173 263 LLGRLSKRRRRGR-LLLIGALLLGLALLVLGLSPSL---WLLLAA----LFLLGLAGGLF 314
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
146-442 |
1.50e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.07 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 146 SPAKLAALwFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGEDIPLMLGVyTIPAGVVCLLstICLWesVPPTPPSA 225
Cdd:cd17328 108 APTIIADL-FPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV-TGVLGVLLAI--LLLL--FVREPPRG 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 226 GAA-----SSTSEKFLDGLKlQLMWNKAYVIL---AVCLGGMIGISASFSALLEQ-ILCASGHSSGFSGLC-GALFITFG 295
Cdd:cd17328 182 AAEggvmaKSTATSFLADLK-ALAKNPSFILStlgFTAVSFVTGALAFWAPTFFLrAFGVGDLSSADVGLIfGAITCIAG 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 296 ILGALALGPYVDRTKHFTEATKIGLCLFS-LACVPFALVSQLQGQT-LALAATCSLLGLFGFSV--GPVAMELaVECSFP 371
Cdd:cd17328 261 VLGVLLGGILADRLRRKTPRADPLVCAVGlLAAAPFLFLALVLALSnLLLAWVLLFLGEFLLSLnwAPVFAIL-LYVVIP 339
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 661567306 372 VGEGAATGMIFV----LGQAEGILIMLAMTALTVRRSEPSLSTCQQgedpldWTVSLLlmagLCTFFSCILAVFF 442
Cdd:cd17328 340 TRRSTASAIQILlshlLGDAGSPYLIGLISDLLRQNKDSPLAEAAS------LQYALL----LCSFVLVLGGFFF 404
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-441 |
3.41e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.86 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 48 LSFApvADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRA--ATILGAW--LNFAGSVLRMVPCMVVgtq 123
Cdd:cd17319 22 ISVA--APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlAVSMLLWslFTALTGFATSLTSLYV--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 124 npFAFLMGgqslcaLAQSLVIFSPAKLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVkkgedipLMLG---VYT 200
Cdd:cd17319 97 --LRFLLG------VAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-------LLFGwrwAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 201 IPAGVVCLLSTICLWesvpptppsagaasstsekfldglKLQLMWnkayvILAVCLGGMIGISASFSALLEQILCASGHS 280
Cdd:cd17319 162 IEGLLGLLLAVLWWF------------------------YLRQVW-----GLALGYFGINYALYGLLTWLPTYLKQARGF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 281 SGFS-GLCGALFITFGILGALALGPYVDRTKHFTEATKIGLCLFsLACVPFALVSQLQGQTLALAATCSLLGLFGFSVGP 359
Cdd:cd17319 213 SLKQvGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLL-LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 360 VAmelAVECSFPVGE--GAATGMIFVLGQAEGILIMLAMTALtvrrsepslstcqqgedpLDWTVS---LLLMAGLCTFF 434
Cdd:cd17319 292 FW---SLPADLLPGEaaATAGGLINSGGNLGGFVAPLLIGYL------------------VDATGSytaAFLFLAAVALL 350
|
....*..
gi 661567306 435 SCILAVF 441
Cdd:cd17319 351 AALLVLL 357
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
28-188 |
5.95e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.13 E-value: 5.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 28 RRWVFLLAISLLNCSNATLWlSFAPVADVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAWLNF 107
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQY-AWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 108 AGSVLrmvpcMVVGTQNPFAFLMGGqSLCALAQSLVIFSPAKLAALWFPEHqRATANMLATMSNPLGVLVANVLSPVLVK 187
Cdd:cd17353 80 LGFIL-----SAFAISLPLLFLGYG-VLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLIN 152
|
.
gi 661567306 188 K 188
Cdd:cd17353 153 T 153
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
47-271 |
9.99e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.44 E-value: 9.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 47 WLSFAPVA-DVIAEDLVLSMEQINWLSLVYLVVSTPFGVAAIWILDSVGLRAATILGAwlnfagsVLRMVPCMVVGT-QN 124
Cdd:TIGR00886 17 WFAFSPLAvFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSL-------LLLAIPCLWAGLaVQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 125 PFAFLMGGQSLCALA-QSLVIFSPakLAALWFPEHQRATANMLATMSNPLGVLVANVLSPVLVKKGED-----------I 192
Cdd:TIGR00886 90 SYSVLLLIRLFIGIAgGSFASCMP--WISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFgggqpahlawgW 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 661567306 193 PLMLGVYTIPAGVVCLLSTICLWEsvPPTPPSAGAASSTSekFLDGLKLQLMW--NKAYVilaVCLGGMIGISASFSALL 270
Cdd:TIGR00886 168 AFVIVPAGILLLPALLIFFVGADT--PPGKPATGKLSFKE--ALKVFGNRHTWilALLYS---VTFGSFLGVSSIFAMLF 240
|
.
gi 661567306 271 E 271
Cdd:TIGR00886 241 K 241
|
|
| |
