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Conserved domains on  [gi|665404309|ref|NP_001285607|]
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hoepel1, isoform J [Drosophila melanogaster]

Protein Classification

ArsB/NhaD family transporter( domain architecture ID 18136919)

ArsB/NhaD family transporter translocates substrates such as sodium, arsenate, sulfate, and organic anions across membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 349-837 2.15e-177

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


:

Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 517.19  E-value: 2.15e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 349 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 428
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 429 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 508
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 509 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 588
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 589 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 668
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 669 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 748
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 749 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 828
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 665404309 829 IIVTTGYLL 837
Cdd:cd01116  405 LILATVYLL 413
geminin-like_CC super family cl45898
coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin ...
 68-118 3.90e-04

coiled-coil domain found in the geminin family; The geminin family includes geminin, geminin coiled-coil domain-containing protein 1 (GemC1), and McIdas. Together, geminin, GemC1, and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. They were initially identified as cell cycle regulators associated with the chromosome cycle. Geminin is required to ensure once-per-cell-cycle genome replication, while McIdas and GemC1 bind to geminin and are implicated in DNA replication control. Geminin binds to Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC), in a timely manner to inhibit DNA replication. Geminin family members also function as early regulators of multiciliogenesis. GemC1 and McIdas specify the multiciliate cell fate by forming complexes with the E2F4/5 transcription factors, resulting in centriole amplification and cilia formation. Geminin family proteins contain a homologous central coiled-coil domain that mediates homo- and heterodimerization; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of the geminin family.


The actual alignment was detected with superfamily member cd22589:

Pssm-ID: 459243 [Multi-domain]  Cd Length: 65  Bit Score: 39.51  E-value: 3.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665404309  68 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 118
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 349-837 2.15e-177

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 517.19  E-value: 2.15e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 349 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 428
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 429 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 508
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 509 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 588
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 589 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 668
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 669 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 748
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 749 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 828
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 665404309 829 IIVTTGYLL 837
Cdd:cd01116  405 LILATVYLL 413
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
343-838 2.19e-108

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 339.03  E-value: 2.19e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 343 IYAAAVLCGLYVMIIWEI--VNRTFAAIIASTLSVgILAALnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDY 420
Cdd:COG1055    3 ILALAIFVLTYLLIILEPrgLNRAVAALLGAALLL-LLGVV----SLEDALEAIDWNTILFLLGMMIIVAILDESGFFEW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 421 LAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPN 500
Cdd:COG1055   78 LAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 501 VIIASNSyisknGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNisDLQFKDSPEVEElrheihvwkraaaslsayskde 580
Cdd:COG1055  158 IMIASAG-----GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRK--ELPAAPDLEDDP---------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 581 elvrqtlmkkvnrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVPelqRLSLGW 660
Cdd:COG1055  209 -----------------------------------------KEAIKDRRLLRISLLVLALLLVGFVLHSFL---GLPPAL 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 661 TALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVS 740
Cdd:COG1055  245 IALLGAAVLLLLARV-DVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG-----NLLLAALLILWLS 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 741 AVASAFVDNIPLTTMMvkitISLAQNSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKV 820
Cdd:COG1055  319 AILSAVVDNVPLVAAL----LPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394

                        490
                 ....*....|....*...
gi 665404309 821 GFPIMIGSIIVTTGYLLV 838
Cdd:COG1055  395 GLPLTLLTLLIALLYLLL 412
CitMHS pfam03600
Citrate transporter;
353-783 1.16e-83

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 271.11  E-value: 1.16e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  353 YVMIIWEIVNRTFAAIIastlsVGILAALNSRPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 432
Cdd:pfam03600   1 YVLIITEKLPRDVVALL-----GAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  433 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkn 512
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  513 gvnFAVFTLHMLPGVLLVMVQT-YIQLRFKFRNISDLQFKDSPEVEELRheihvwkraaaslsayskdeelvrqtlmkkv 591
Cdd:pfam03600 154 ---FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEEEAELEELR------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  592 nrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgwtALLGAIFLII 671
Cdd:pfam03600 200 ------------------------------KRAIKDKLLLAISALVLALVILGFLLLSV-----------LALAGALLLL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  672 LADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgedrRLMVAILIILWVSAVASAFVDNIP 751
Cdd:pfam03600 239 LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS-------GLLVALALILWLSALLSAFISNVP 311

                         410       420       430
                  ....*....|....*....|....*....|..
gi 665404309  752 LTTMMVKITISLAQNSTLNlPLQPLVWALALG 783
Cdd:pfam03600 312 TAALMAPIIVGMAPAAGLG-DPDPLAWALAVG 342
PLN00136 PLN00136
silicon transporter; Provisional
 361-832 1.45e-25

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 111.24  E-value: 1.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 361 VNRTFAAIIASTLSVgILAALNSRPSMATImgwiDVETLLLLFGMMILVAILSETGVFDYLA-VYAYKITNGHvwPLINC 439
Cdd:PLN00136  33 IGRTAGALLSAVLMI-VFHVISPDDAYASI----DLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 440 LCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkngvnFAVF 519
Cdd:PLN00136 106 VCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKIT-----FPKF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 520 TLHMLPGVLLVM-VQTYIQLRFKFRnisDLQFKDSPEVEELRHEihVWKRAAASLSAYSKDEELVRQTLMKKVNRLKRSL 598
Cdd:PLN00136 181 LLGILPAMLAGMaVNMVMLLCMYWK---DLDGGAELSVDGKQME--AVEEGRSPASAKSTKQQSPALLQAGLNGDGNGDM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 599 KKRMTaviepapnyqqtlANLQAKYPI------RNKPLLIKCSAALVFVISLfflhsVPELQRLSLGWTALLGAIFLIIL 672
Cdd:PLN00136 256 SSMMS-------------ENISTKHPWfmqcteHRRKLFLKSFAYVVTVGMV-----VAYMVGLNMSWTAITTAIALVVV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 673 aDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTeGIILGVGEDRRLMVAILIILWVSAVASafvdNIPL 752
Cdd:PLN00136 318 -DFRDAEPCLDTVSYSLLVFFSGMFITVSGFNKTGLPGAIWNFM-APYSKVNSVGGISVLSVIILLLSNLAS----NVPT 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 753 TTMM---VKITISLAQNSTLNLPLQPLVWAlalgACLGGNGTLIGASAN-VVC--AGVAEQHGYKFTFLQFFKVGFPimi 826
Cdd:PLN00136 392 VLLMgdeVAAAAALISPAAVTRSWLLLAWV----STVAGNLSLLGSAANlIVCeqARRAPRNAYDLTFWQHIVFGVP--- 464


                 ....*.
gi 665404309 827 GSIIVT 832
Cdd:PLN00136 465 STLIVT 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 347-835 2.60e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 76.23  E-value: 2.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  347 AVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDvETLLLLFGMMILVAILSETGVFDYLAvyaY 426
Cdd:TIGR00785  15 AIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNALSGFAD-PTIWLFFGAFILATALVKTGLGKRIA---Y 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  427 KITN--GHVWPLINCLCLF-TAVLSSFLDNVT--TVLLMTPVTIRLCEVMCLNPVPI-------LMCMVIYS-NIGGALT 493
Cdd:TIGR00785  91 KLVGkmGGTTLGLGYFLVFlETLLAPMWPSNTarAGGILLPIIKSLLPLLGSKPEKSprkigkyLMLGIAYSaSIGSSGF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  494 PVGDPPNVIIASN-SYISKNGVNFAVFTLHMLP-GVLLVMVQTYiqlrfkfrnisdLQFKDSPEVEELRHEIHVWKRaaa 571
Cdd:TIGR00785 171 LTGSAPNALAAGIlSKILGIQISWGDWFLAGLPlGIILLLLVPL------------LLYVLFPPELKLKDEVDLWAK--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  572 slsayskdEELVRQTLMkkvnrlkrSLKKRMTAVIepapnyqqtlanlqakypirnkpllikcsaaLVFVISLFF---LH 648
Cdd:TIGR00785 236 --------EELEEMGPM--------SFREKALLGI-------------------------------FLLALLLWIfggSL 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  649 SVPElqrlslGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGVGEdrr 728
Cdd:TIGR00785 269 GINA------SVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP--- 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  729 LMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVaeqh 808
Cdd:TIGR00785 340 TIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS--AQGIPLELLALALALSASLMGFLTPYATPPNAIAYGS---- 413

                         490       500
                  ....*....|....*....|....*..
gi 665404309  809 GYkFTFLQFFKVGFPIMIGSIIVTTGY 835
Cdd:TIGR00785 414 GY-VKIKDMWRVGAIIGIVGLIVLLLV 439
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 68-118 3.90e-04

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 39.51  E-value: 3.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665404309  68 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 118
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
 
Name Accession Description Interval E-value
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 349-837 2.15e-177

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 517.19  E-value: 2.15e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 349 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKI 428
Cdd:cd01116    1 FIITYALIIFEKVHRTVAALAGALWLVILGLATLS-PDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 429 TNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsy 508
Cdd:cd01116   80 SKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGS--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 509 isKNGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEveelrheihvwkraaaslsayskdeelvrqtlm 588
Cdd:cd01116  157 --AAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDVLA--------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 589 kkvnrlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLHSVPELqrlSLGWTALLGAIF 668
Cdd:cd01116  202 ---------------------------LAELEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGV---SLGWIALLGALL 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 669 LIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVD 748
Cdd:cd01116  252 LLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILG-----RIAVAVILILWISALLSAFID 326

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 749 NIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGS 828
Cdd:cd01116  327 NIPVTATMIPIVKDLA--SQLGIPLLPLWWALALGACLGGNGTLIGASANVVAAGIAEQHGYKISFWEFLKVGFPIMLVS 404


                 ....*....
gi 665404309 829 IIVTTGYLL 837
Cdd:cd01116  405 LILATVYLL 413
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
343-838 2.19e-108

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 339.03  E-value: 2.19e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 343 IYAAAVLCGLYVMIIWEI--VNRTFAAIIASTLSVgILAALnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDY 420
Cdd:COG1055    3 ILALAIFVLTYLLIILEPrgLNRAVAALLGAALLL-LLGVV----SLEDALEAIDWNTILFLLGMMIIVAILDESGFFEW 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 421 LAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPN 500
Cdd:COG1055   78 LAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGGAATPIGNPTN 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 501 VIIASNSyisknGVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNisDLQFKDSPEVEElrheihvwkraaaslsayskde 580
Cdd:COG1055  158 IMIASAG-----GLSFLDFLANLFPPSLVSLLVTLLVLYLLFRK--ELPAAPDLEDDP---------------------- 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 581 elvrqtlmkkvnrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVPelqRLSLGW 660
Cdd:COG1055  209 -----------------------------------------KEAIKDRRLLRISLLVLALLLVGFVLHSFL---GLPPAL 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 661 TALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVS 740
Cdd:COG1055  245 IALLGAAVLLLLARV-DVREVLKKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGG-----NLLLAALLILWLS 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 741 AVASAFVDNIPLTTMMvkitISLAQNSTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKV 820
Cdd:COG1055  319 AILSAVVDNVPLVAAL----LPLIPDLGATGNPEPLWLALALGATLGGNLTPIGSAANVIVLGIAEKKGIKISFGEFLKV 394

                        490
                 ....*....|....*...
gi 665404309 821 GFPIMIGSIIVTTGYLLV 838
Cdd:COG1055  395 GLPLTLLTLLIALLYLLL 412
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 353-836 8.10e-103

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 323.82  E-value: 8.10e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 353 YVMIIWEIVNRTFAAIIASTLSVGILAAlnsrpSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 432
Cdd:cd00625    1 YVLIRPEKLPRAVVALLGAVLLVLLGVV-----SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGS 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 433 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASnsyisKN 512
Cdd:cd00625   76 RRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPLLLALAFAANIGGAATPIGNPPNLIIAS-----LS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 513 GVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRNISDLQFKDSPEVeelrheihvwkraaaslsayskdeelvrqtlmkkvn 592
Cdd:cd00625  151 GLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTV------------------------------------ 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 593 rlkrslkkrmtaviepapnyqqtLANLQAKYPIRNKPLLIKCSAALVFVISLFFLhsvpelqrLSLGWTALLGAIFLIIL 672
Cdd:cd00625  195 -----------------------LAEPLPARPLLKKFLLLALLLLLLFVLLFFFL--------IPLGLIALLGALLLLLL 243

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 673 ADIE-DMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGvgedrRLMVAILIILWVSAVASAFVDNIP 751
Cdd:cd00625  244 LVRGlDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGL-----PPLAALLLIGLLSALLSNFISNVP 318

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 752 LTTMMVKITISLAqnstlnlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIV 831
Cdd:cd00625  319 TVALLLPIAASLA-------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVV 391


                 ....*
gi 665404309 832 TTGYL 836
Cdd:cd00625  392 SLLYL 396
CitMHS pfam03600
Citrate transporter;
353-783 1.16e-83

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 271.11  E-value: 1.16e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  353 YVMIIWEIVNRTFAAIIastlsVGILAALNSRPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGH 432
Cdd:pfam03600   1 YVLIITEKLPRDVVALL-----GAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  433 VWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkn 512
Cdd:pfam03600  76 PRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLS-- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  513 gvnFAVFTLHMLPGVLLVMVQT-YIQLRFKFRNISDLQFKDSPEVEELRheihvwkraaaslsayskdeelvrqtlmkkv 591
Cdd:pfam03600 154 ---FGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEEEAELEELR------------------------------- 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  592 nrlkrslkkrmtaviepapnyqqtlanlqaKYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgwtALLGAIFLII 671
Cdd:pfam03600 200 ------------------------------KRAIKDKLLLAISALVLALVILGFLLLSV-----------LALAGALLLL 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  672 LADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgedrRLMVAILIILWVSAVASAFVDNIP 751
Cdd:pfam03600 239 LTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS-------GLLVALALILWLSALLSAFISNVP 311

                         410       420       430
                  ....*....|....*....|....*....|..
gi 665404309  752 LTTMMVKITISLAQNSTLNlPLQPLVWALALG 783
Cdd:pfam03600 312 TAALMAPIIVGMAPAAGLG-DPDPLAWALAVG 342
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 362-836 1.94e-48

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 176.31  E-value: 1.94e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 362 NRTFAAIIASTLSVGILAalnsrPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDYLAVY-AYKITNGhvWPLINCL 440
Cdd:cd01117   12 DRWAIALLGAALMLLFGV-----ISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRiLVKAGSP--RRLLFLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 441 CLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSyisknGVNFAVFT 520
Cdd:cd01117   85 VLLSGILSALLTNDTACLVFTPIVLELARVAGLPPIPLLLALATAANIGSAATPIGNPQNLLIASES-----GISFPFFL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 521 LHMLPGVLLVMVQTYIQLRFKFrnisdlqfkdspeveelrheihvwkraaaslsayskdeelvrqtlmkkvnRLKRSLKK 600
Cdd:cd01117  160 AAMAPLALLGLLLLLILLLVLF--------------------------------------------------PGELKGLP 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 601 RMTAVIEPAPNyqqtlanlqakYPIRNKPLLIKCSAALVFVISLFFLHSVpelqrlslgWTALLGAIfLIILADIEDMEA 680
Cdd:cd01117  190 LDKATKEEGVG-----------ARKLAVKLLVLILLLLVAFLALLGVIPL---------WTAALVAA-VLLLLTRLKPRR 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 681 ILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIilgvgedrrlmVAILIILWVSAVASAFVDNIPLTTMMVKIT 760
Cdd:cd01117  249 VLKKVDWGLLLFFAGLFILVGGFAQGLPLEGLSRLLPLL-----------DSVLSLFLVSIGLSQLISNVPAVLLLLPFL 317

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665404309 761 ISLAQNSTLnlplqplvwALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYL 836
Cdd:cd01117  318 PSADEKDWL---------LLAAGSTIAGNLTLLGSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGILWL 384
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
403-838 3.00e-35

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 137.98  E-value: 3.00e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 403 FGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLN-----PVP 477
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 478 ILMCMVIYSNIGGALTPVGDPPNVIIASnsYISKN---GVNFAVFTLHMLPGVLLVMVQTYIQLRFKFRnisdlqfkdsP 554
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAG--LLEEAtgiPISFFEWMLVGLPVALVGLLLLWLVLYRLLP----------P 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 555 EVEELrheihvwkraaaslsaySKDEELVRQTLmKKVNRLKRslKKRMTAVIepapnyqqtlanlqakypirnkpllikc 634
Cdd:COG0471  149 EIKEV-----------------PGSKEVIREEL-AELGPLSR--REKIALAI---------------------------- 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 635 saaLVFVISLFFLhsvPELQRLSLGWTALLGAIFLIILaDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGN 714
Cdd:COG0471  181 ---FALTVLLWIT---GSLHGIPIAVVALLGAVLLLLT-GVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLAD 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 715 MTEGIILGVGedrrLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGAcLGGNGTLIG 794
Cdd:COG0471  254 ALLPLLGGLS----PLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQ--ALGVNPLPLALAVAFAA-SCAFLLPVG 326

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....
gi 665404309 795 ASANVVCAGVaeqhGYkFTFLQFFKVGFPIMIGSIIVTTGYLLV 838
Cdd:COG0471  327 TPPNAIVYGS----GY-YKFKDFLKVGLPLNLIGLVVLLLLGPL 365
PLN00136 PLN00136
silicon transporter; Provisional
 361-832 1.45e-25

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 111.24  E-value: 1.45e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 361 VNRTFAAIIASTLSVgILAALNSRPSMATImgwiDVETLLLLFGMMILVAILSETGVFDYLA-VYAYKITNGHvwPLINC 439
Cdd:PLN00136  33 IGRTAGALLSAVLMI-VFHVISPDDAYASI----DLPILGLLFATMVVGSYLKNAGMFKHLGrLLAWRSQGGR--DLLCR 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 440 LCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASNSYISkngvnFAVF 519
Cdd:PLN00136 106 VCVVTALASALFTNDTCCVVLTEFVLELAAERNLPAKPFLLALASSANIGSSATPIGNPQNLVIAFNSKIT-----FPKF 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 520 TLHMLPGVLLVM-VQTYIQLRFKFRnisDLQFKDSPEVEELRHEihVWKRAAASLSAYSKDEELVRQTLMKKVNRLKRSL 598
Cdd:PLN00136 181 LLGILPAMLAGMaVNMVMLLCMYWK---DLDGGAELSVDGKQME--AVEEGRSPASAKSTKQQSPALLQAGLNGDGNGDM 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 599 KKRMTaviepapnyqqtlANLQAKYPI------RNKPLLIKCSAALVFVISLfflhsVPELQRLSLGWTALLGAIFLIIL 672
Cdd:PLN00136 256 SSMMS-------------ENISTKHPWfmqcteHRRKLFLKSFAYVVTVGMV-----VAYMVGLNMSWTAITTAIALVVV 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 673 aDIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTeGIILGVGEDRRLMVAILIILWVSAVASafvdNIPL 752
Cdd:PLN00136 318 -DFRDAEPCLDTVSYSLLVFFSGMFITVSGFNKTGLPGAIWNFM-APYSKVNSVGGISVLSVIILLLSNLAS----NVPT 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 753 TTMM---VKITISLAQNSTLNLPLQPLVWAlalgACLGGNGTLIGASAN-VVC--AGVAEQHGYKFTFLQFFKVGFPimi 826
Cdd:PLN00136 392 VLLMgdeVAAAAALISPAAVTRSWLLLAWV----STVAGNLSLLGSAANlIVCeqARRAPRNAYDLTFWQHIVFGVP--- 464


                 ....*.
gi 665404309 827 GSIIVT 832
Cdd:PLN00136 465 STLIVT 470
CitMHS pfam03600
Citrate transporter;
653-831 1.49e-21

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 97.00  E-value: 1.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  653 LQRLSLGWTALLGAIFLIILAdIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMtegIILGVGEDRRLMVA 732
Cdd:pfam03600   6 TEKLPRDVVALLGAVLLVLLG-VLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALK---LLRLAGGKPRRLLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  733 ILIIlwVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKF 812
Cdd:pfam03600  82 ALML--ATALLSAFLSNDGTVLIMIPIVLALAR--RLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDF 157

                         170
                  ....*....|....*....
gi 665404309  813 TFLQFFKVGFPIMIGSIIV 831
Cdd:pfam03600 158 GFFMFPPVGVALLLVGLLP 176
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 385-838 8.10e-21

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 95.34  E-value: 8.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 385 PSMATIMGWIDVE---------TLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVT 455
Cdd:cd01115   26 PVLLVLLGVVPPKeafsgfsdpAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 456 TVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIIASN-SYISKNGVNFAVFTLHMLPGVLLVMvqt 534
Cdd:cd01115  106 TVAIMLPVALGLAAKLDISPSRLLMPLAFAASIGGMLTLIGTPPNLVASGYlESLGGQGFSFFEFTPIGLPLLIIGL--- 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 535 yIQLRFKFRnisdlqfkdspeveelrheihvwkraaaslsayskdeelvrqtlmkkvnrlkrslkkrmTAVIepapnyqq 614
Cdd:cd01115  183 -LYLWFIFR-----------------------------------------------------------LAVL-------- 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 615 tlanlqakypirnkPLLIKCSAALVFVISLFFLHSvpelqrlslgwTALLGAIFLIILADIeDMEAILARVEWSTLLFFA 694
Cdd:cd01115  195 --------------IITIVLLAALAAITGLLPVSV-----------AIAIGAIVLVFGGVL-LTKEDYKSIDWGIIFLFA 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 695 ALFILMEALTELGLIEWIGNMtegiILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQ 774
Cdd:cd01115  249 GGIPLGKALESSGAAALIAEA----LISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIAL--SLGLPPE 322

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665404309 775 PLVWALALGACLgGNGTLIGASANVVCAGVaeqhGYkFTFLQFFKVGFPIMIGSIIVTTGYLLV 838
Cdd:cd01115  323 ALLLAVAIGASC-AFMLPVGTPPNAIVLGP----GG-YKFSDFAKVGLPLSILSLVVSVTMIPL 380
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 655-838 1.34e-20

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 95.01  E-value: 1.34e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 655 RLSLGWTALLGAIFLIILADIeDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTegIILGVGEDRRLMVAIL 734
Cdd:cd00625    8 KLPRAVVALLGAVLLVLLGVV-SPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKL--ARASKGSRRLLLLLML 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 735 iilwVSAVASAFVDNIPLTTMMVKITISLAQNSTLNlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAeqhgyKFTF 814
Cdd:cd00625   85 ----LTAALSAFFSNDATAVLLTPIVLALLRKLGLS-PPVPLLLALAFAANIGGAATPIGNPPNLIIASLS-----GLGF 154

                        170       180
                 ....*....|....*....|....
gi 665404309 815 LQFFKVGFPIMIGSIIVTTGYLLV 838
Cdd:cd00625  155 LDFLAFMAPPALGLLLLLLGLLYL 178
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 344-837 1.08e-19

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 92.33  E-value: 1.08e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 344 YAAAVLCGLYVMIIWEIVNRTFAaiIASTLSVGILAALNSRPSMATIMGWIDV-ETLLLLFGMMILVAILSETGVFDYLA 422
Cdd:cd01118    1 LAIAIFVLTLVLVIWRPFGLPEA--VWAVLGAVIALILGLVSPHDALEVWGIVwDVTLTLIGVILLSLLLDEEGFFEWVA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 423 VYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNP---VPILMCMVIYSNIGGALTPVGDPP 499
Cdd:cd01118   79 ALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRALGAKKnrtLPFLYACAFIADAASLPLPISNLV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 500 NVIIASNSYISkngvnFAVFTLHMLPGVLLVMVQTYIQLRFKFRnisdlqfkdspeveelrheihvwKRAAASLSAYSKD 579
Cdd:cd01118  159 NIVTAGYFGIG-----FTEYAALMFLPSIVSILATYVVLYLFFR-----------------------RALPKRLETASVK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 580 EElvrqtlmkkvnrlKRSLKKRMTAVIepapnyqqtlanlqakypirnkplliKCSAALVFVISLFFLHSvpelqrLSLG 659
Cdd:cd01118  211 KP-------------SLAIKDPLLFGL--------------------------AWTLLVLLVVSAFGVDI------LLIP 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 660 WTALLGAIFLIILADIEDMEAILAR-----VEWSTLLFFAALFILMEALTELGLIEWIGNmtegiILGVGEDRRLMVAIL 734
Cdd:cd01118  246 PSFIAGVLALIFLLLARRGGAINPLkvlkeAPWGVLLFSLGLYVVVFGLKNAGLTAILAD-----LLNWLVSQGLLAAIL 320

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 735 IILWVSAVASAFVDNIPLTTMMvkiTISLAQNSTLnlplQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTF 814
Cdd:cd01118  321 GVGLLAAFLSNVMNNLPAVLIG---ALALAAGHAP----EALVYANLIGVDLGPKLTPIGSLATLLWLHVLRRKGIRVSW 393

                        490       500
                 ....*....|....*....|...
gi 665404309 815 LQFFKVGFPIMIGSIIVTTGYLL 837
Cdd:cd01118  394 GYYLKVGLIVTPPVLVVTLAALI 416
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 636-826 7.64e-17

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 83.40  E-value: 7.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 636 AALVFVISLFFLHSVPelqrlsLGWTALLgAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNM 715
Cdd:cd01115    2 AILVFAAVLFVTEALP------LDVTALL-VPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 716 tegIILGVGEDRRLMVAILIIlwVSAVASAFVDNIPLTTMMVKITISLAqnSTLNLPLQPLVWALALGACLGGNGTLIGA 795
Cdd:cd01115   75 ---LLKRAGKGERRLLLLLML--VTAFLSAFMSNTATVAIMLPVALGLA--AKLDISPSRLLMPLAFAASIGGMLTLIGT 147

                        170       180       190
                 ....*....|....*....|....*....|..
gi 665404309 796 SANVVCAGVAEQHGYK-FTFLQFFKVGFPIMI 826
Cdd:cd01115  148 PPNLVASGYLESLGGQgFSFFEFTPIGLPLLI 179
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 317-538 2.66e-16

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 81.91  E-value: 2.66e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 317 FTSSIEGELPLQLNVDESPIYKRDGVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDV 396
Cdd:cd00625  180 FRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDW 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 397 ETLLLLFGMMILVAILSETGVFDYLAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLcevmcLNPV 476
Cdd:cd00625  260 GTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL-----APPE 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665404309 477 PILMCMVIYSNIGGALTPVGDPPNVIIASNSYISKNGVNFAVFTLHMLPGVLLVMVQTYIQL 538
Cdd:cd00625  335 PAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGISFGEFLKVGLPLTLLSLVVSLLYL 396
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 347-835 2.60e-14

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 76.23  E-value: 2.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  347 AVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAALNSRPSMATIMGWIDvETLLLLFGMMILVAILSETGVFDYLAvyaY 426
Cdd:TIGR00785  15 AIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNALSGFAD-PTIWLFFGAFILATALVKTGLGKRIA---Y 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  427 KITN--GHVWPLINCLCLF-TAVLSSFLDNVT--TVLLMTPVTIRLCEVMCLNPVPI-------LMCMVIYS-NIGGALT 493
Cdd:TIGR00785  91 KLVGkmGGTTLGLGYFLVFlETLLAPMWPSNTarAGGILLPIIKSLLPLLGSKPEKSprkigkyLMLGIAYSaSIGSSGF 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  494 PVGDPPNVIIASN-SYISKNGVNFAVFTLHMLP-GVLLVMVQTYiqlrfkfrnisdLQFKDSPEVEELRHEIHVWKRaaa 571
Cdd:TIGR00785 171 LTGSAPNALAAGIlSKILGIQISWGDWFLAGLPlGIILLLLVPL------------LLYVLFPPELKLKDEVDLWAK--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  572 slsayskdEELVRQTLMkkvnrlkrSLKKRMTAVIepapnyqqtlanlqakypirnkpllikcsaaLVFVISLFF---LH 648
Cdd:TIGR00785 236 --------EELEEMGPM--------SFREKALLGI-------------------------------FLLALLLWIfggSL 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  649 SVPElqrlslGWTALLGAIFLIILADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIILGVGEdrr 728
Cdd:TIGR00785 269 GINA------SVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSP--- 339

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  729 LMVAILIILWVSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVaeqh 808
Cdd:TIGR00785 340 TIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS--AQGIPLELLALALALSASLMGFLTPYATPPNAIAYGS---- 413

                         490       500
                  ....*....|....*....|....*..
gi 665404309  809 GYkFTFLQFFKVGFPIMIGSIIVTTGY 835
Cdd:TIGR00785 414 GY-VKIKDMWRVGAIIGIVGLIVLLLV 439
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 662-840 4.36e-13

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 71.90  E-value: 4.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 662 ALLGAIFLIIL---ADIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTegIILGVGEDRRLMvaILIILw 738
Cdd:cd01116   19 ALAGALWLVILglaTLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWA--VKISKGRPWRLL--LLLGL- 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 739 VSAVASAFVDNIPLTTMMVKITISLAQnsTLNLPLQPLVWALALGACLGGNGTLIGASANVVCAGVAeqhgyKFTFLQFF 818
Cdd:cd01116   94 LTAFLSAFLDNVTTVLLMVPVTIRLCE--VLGLNPVPVLISEVIAANIGGAATLIGDPPNIMIGSAA-----GLTFNDFL 166

                        170       180
                 ....*....|....*....|..
gi 665404309 819 KVGFPIMIGSIIVTTGYLLVSH 840
Cdd:cd01116  167 LHMLPSVVLALVVTFILLYFLY 188
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
394-510 5.61e-13

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 71.34  E-value: 5.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 394 IDVETLLLLFGMMILVAILSETGVFDYLAVYAYKITNG-HVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMC 472
Cdd:COG0471  224 IPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGGlSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665404309 473 LNPVPILMCMVIySNIGGALTPVGDPPNVIIASNSYIS 510
Cdd:COG0471  304 VNPLPLALAVAF-AASCAFLLPVGTPPNAIVYGSGYYK 340
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 341-510 6.59e-12

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 68.00  E-value: 6.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 341 GVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSVGILAA-----LNSRPSMATIMGWIDVETLLLLFGMMILVAILSET 415
Cdd:cd01115  181 GLLYLWFIFRLAVLIITIVLLAALAAITGLLPVSVAIAIGaivlvFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESS 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 416 GVFDYLAVY-AYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYSNIgGALTP 494
Cdd:cd01115  261 GAAALIAEAlISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASC-AFMLP 339

                        170
                 ....*....|....*.
gi 665404309 495 VGDPPNVIIASNSYIS 510
Cdd:cd01115  340 VGTPPNAIVLGPGGYK 355
CitMHS pfam03600
Citrate transporter;
324-484 1.06e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 64.26  E-value: 1.06e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  324 ELPLQLNVDESPIYKRDGVIYAAAVLCGLYVMIIWEIVNrtFAAIIASTLSVGILAALNSRPSMATIMGWIDVETLLLLF 403
Cdd:pfam03600 184 LLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILG--FLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFA 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  404 GMMILVAILSETGVFDYLAVYAYKITNGHVwpLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVM-CLNPVPILMCM 482
Cdd:pfam03600 262 GLFILVGALEKTGLADALADALGGLSGLLV--ALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAgLGDPDPLAWAL 339


                  ..
gi 665404309  483 VI 484
Cdd:pfam03600 340 AV 341
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 637-831 3.80e-09

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 60.08  E-value: 3.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  637 ALVFVISLFFLHSVPELQrLSLGWTALLGAIFLIILAdIEDMEAILA-RVEWSTLLFFAALFILMEALTELGLIEWIGNM 715
Cdd:pfam00939 273 LGLFVLLLLLWIFGGSLN-IDATTVAIIGLALMLLLR-ILDWKDIVKnKGAWNTLIWLGGLIMLANGLERSGFIEWLGNT 350

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  716 TEGIIlgvgEDRRLMVAILIILWVS-AVASAFVDNIPLTTMMVKITISLAQNSTLNLPLQpLVWALALGACLGGNGTLIG 794
Cdd:pfam00939 351 LSTSL----SGFSPAMAFIIILSLFyLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPLL-AALLLGFAISLGGFLTPYG 425

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 665404309  795 ASANVVCAGVaeqhGYkFTFLQFFKVGFPIMIGSIIV 831
Cdd:pfam00939 426 TGPGPIYFGS----GY-LKVKDWWRIGAILTIIGLLI 457
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 636-838 1.75e-08

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 57.74  E-value: 1.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  636 AALVFVISLFFLHSVPelqrlsLGWTALLGAIFLIILADIEDMEAILARVEW----STLLFFAAlFILMEALTELGLIEW 711
Cdd:TIGR00785  15 AIFVAAIVGWILEPLP------LPVTALLAIPIIAVLLGVLSAFKFKNALSGfadpTIWLFFGA-FILATALVKTGLGKR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  712 IGNmtegIILGVGEDRRLMVAILIILWVSAVASAFVDNIPLTTMMVkitISLAQNSTLNLPLQP----------LVWALA 781
Cdd:TIGR00785  88 IAY----KLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGIL---LPIIKSLLPLLGSKPeksprkigkyLMLGIA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665404309  782 LGACLGGNGTLIGASANVVCAG-VAEQHGYKFTFLQFFKVGFPIMIGSIIVTTGYLLV 838
Cdd:TIGR00785 161 YSASIGSSGFLTGSAPNALAAGiLSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYV 218
PLN00136 PLN00136
silicon transporter; Provisional
 644-837 8.77e-08

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 55.77  E-value: 8.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 644 LFFLHSV-PELQRLSLGWTA--LLGAIFLIILADIEDMEAiLARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGII 720
Cdd:PLN00136  18 VFWMLAVfPSVPFLPIGRTAgaLLSAVLMIVFHVISPDDA-YASIDLPILGLLFATMVVGSYLKNAGMFKHLGRLLAWRS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 721 LGvgeDRRLMVAILIilwVSAVASAFVDNIPLTTMMVKITISLAQNStlNLPLQPLVWALALGACLGGNGTLIGASANVV 800
Cdd:PLN00136  97 QG---GRDLLCRVCV---VTALASALFTNDTCCVVLTEFVLELAAER--NLPAKPFLLALASSANIGSSATPIGNPQNLV 168

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 665404309 801 CAgvaeqHGYKFTFLQFFKVGFPIMIGSIIVTTGYLL 837
Cdd:PLN00136 169 IA-----FNSKITFPKFLLGILPAMLAGMAVNMVMLL 200
PLN00137 PLN00137
NHAD transporter family protein; Provisional
 331-840 1.26e-06

NHAD transporter family protein; Provisional


Pssm-ID: 215071  Cd Length: 424  Bit Score: 51.62  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 331 VDESPIYKRDGVIYAAAVlcglyvmIIWEIVnrtfaAIIASTLSVGILAAlnsRPSMATImgwidVETLLLLFGMMILVA 410
Cdd:PLN00137  21 FEESLAFNKSGVALLMAV-------SLWVIR-----AIGAPSLEIVTLEL---RHALAEV-----SEIVFFLLGAMTIVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 411 ILSETGVFDylaVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEvmclNPVPILMC---MVIYSN 487
Cdd:PLN00137  81 IVDAHQGFK---LVTDSITTRSPRTLLWVVGFITFFLSSILDNLTTTIVMVSLLRKLVP----PSEYRKLLgavVVVAAN 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 488 IGGALTPVGDPPNVIIASNSYISkngvnfavfTLHMLPGVLLvmvqtyiqlrfkfrnisdlqfkdsPEVEELrheihvwk 567
Cdd:PLN00137 154 AGGAWTPIGDVTTTMLWIHGQIS---------TLPTMQGLFL------------------------PSAVSL-------- 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 568 raAASLSAYSkdeelvrqtLMKKVNRLKRSLKKRMTAViEPAPNYQQTLAnlqakypirnkpllikcsaalVFVISLFFL 647
Cdd:PLN00137 193 --AVPLALMS---------LTSEENGSPQDSSPLLASE-QMAPRGQLVFG---------------------VGVGALLFV 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 648 HSVPELQRLSLGWTALLGAIFLIILADIE----------DMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTE 717
Cdd:PLN00137 240 PVFKALTGLPPYMGMLLGLGVLWILTDAIhygeserqalKVPQALSRIDTQGILFFLGILLSVGSLDAAGILRELANYLD 319

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 718 GIILGVGedrrlmvailIILWVSAVASAFVDNIPLT--TMMVKITISLAQNSTLnlplqplvWAL-ALGACLGGNGTLIG 794
Cdd:PLN00137 320 ANIPNVE----------LIASAIGVASAIIDNVPLVaaTMGMYDLTDYPMDSEL--------WQLiALCAGTGGSLLVIG 381

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 665404309 795 ASANVVCAGVAEqhgyKFTFLQFFKVGFPIMIGSIIVTTGYLLVSH 840
Cdd:PLN00137 382 SAAGVAFMGMEK----VDFFWYLRKVSGFAFAGYVAGIAAYLAVNG 423
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 338-538 4.52e-06

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 49.97  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 338 KRDGVIYAAAVLCGLYVMI--IWEIVNRTFAAIIASTLsvgilaALNSRPSMATIMGWIDVETLLLLFGMMILVAILSET 415
Cdd:cd01117  201 ARKLAVKLLVLILLLLVAFlaLLGVIPLWTAALVAAVL------LLLTRLKPRRVLKKVDWGLLLFFAGLFILVGGFAQG 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 416 GVFDYLAVYAykITNGHVWPLInclcLFTAVLSSFLDNVTTVLLMTPVTIRLcevmclnPVPILMCMVIYSNIGGALTPV 495
Cdd:cd01117  275 LPLEGLSRLL--PLLDSVLSLF----LVSIGLSQLISNVPAVLLLLPFLPSA-------DEKDWLLLAAGSTIAGNLTLL 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 665404309 496 GDPPNVIIASNSYISKNGVNFAVFTLHMLPGVLLVMVQTYIQL 538
Cdd:cd01117  342 GSAANLIVAEAAERRGVRLSFGEFLKYGVPLTLLTAAIGILWL 384
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 349-510 8.45e-06

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 49.29  E-value: 8.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  349 LCGLYVMIIWEIVNRTFAAIIASTLSVGILAALnsrpSMATIMGWIDV-------ETLLLLFGMMILVAILSETGVFDYL 421
Cdd:pfam00939 272 LLGLFVLLLLLWIFGGSLNIDATTVAIIGLALM----LLLRILDWKDIvknkgawNTLIWLGGLIMLANGLERSGFIEWL 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  422 AVYAYKITNGHVWPL--INCLCLFTAVLSSFLDNVTTVLLMTPVTIRLCEVMCLNPVPILMCMVIYS-NIGGALTPVGDP 498
Cdd:pfam00939 348 GNTLSTSLSGFSPAMafIIILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPLLAALLLGFAiSLGGFLTPYGTG 427

                         170
                  ....*....|..
gi 665404309  499 PNVIIASNSYIS 510
Cdd:pfam00939 428 PGPIYFGSGYLK 439
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 341-496 2.63e-04

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 44.18  E-value: 2.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 341 GVIYAAAVLCGLYVMIIWEIVNRTFAAIIASTLSvgILAALNSRPSMATIMGWIDVETLLLLFGMMILVAILSETGVFDY 420
Cdd:cd01118  225 AWTLLVLLVVSAFGVDILLIPPSFIAGVLALIFL--LLARRGGAINPLKVLKEAPWGVLLFSLGLYVVVFGLKNAGLTAI 302

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665404309 421 LAVYAYKITNGHVWPLINCLCLFTAVLSSFLDNVTTVLLMTPVTIRLcevmcLNPVPILMCMVIYSNIGGALTPVG 496
Cdd:cd01118  303 LADLLNWLVSQGLLAAILGVGLLAAFLSNVMNNLPAVLIGALALAAG-----HAPEALVYANLIGVDLGPKLTPIG 373
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
662-843 2.89e-04

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 44.01  E-value: 2.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 662 ALLGAIFLIILA---DIEDMEAILARVEWSTLLFFAALFILMEALTELGLIEWIGNMTEGIIlgvgeDRRLMVAILIILW 738
Cdd:PRK15445 251 AGVGALILLLVArrgHAINTKKVLKGAPWQIVIFSLGMYLVVYGLRNAGLTDYLAGVLNYLA-----DQGLFAATLGTGF 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 739 VSAVASAFVDNIPlTTMMVKITISLAQNSTLnlPLQPLVWALALGACLGGNGTLIGASANVVCAGVAEQHGYKFTFLQFF 818
Cdd:PRK15445 326 LAAFLSSVMNNMP-TVLIGALAIDGSNATGV--IKEAMIYANVIGSDLGPKITPIGSLATLLWLHVLAQKGVKISWGYYF 402

                        170       180
                 ....*....|....*....|....*
gi 665404309 819 KVGFPIMIGSIIVTTGYLLVSHSLF 843
Cdd:PRK15445 403 KVGIIITLPVLLVTLLALALRLSLF 427
geminin_CC cd22589
central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil ...
 68-118 3.90e-04

central coiled-coil domain of geminin; Geminin, together with geminin coiled-coil domain-containing protein 1 (GemC1) and McIdas (also called Idas or multicilin), controls both the cell cycle and differentiation decisions in cells. Geminin is an inhibitor of Cdt1, a key component and crucial regulator of pre-replicative complexes (pre-RC) that function in the duplication of chromosomal DNA. Pre-RC assembly culminates in the recruitment of the hexameric mini-chromosome maintenance complex (MCM) onto chromatin. Geminin tightly binds and sequesters Cdt1 in a complex that is unable to recruit MCM to origins, inhibiting DNA replication. It belongs to the geminin family of proteins that also includes GemC1 and McIdas. They share a homologous central coiled-coil domain that mediates homo- and heterodimerization with other family members; this ability is likely to be important for modulating their function in cycling and differentiating cells. This model represents the central coiled-coil domain of geminin.


Pssm-ID: 439143 [Multi-domain]  Cd Length: 65  Bit Score: 39.51  E-value: 3.90e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 665404309  68 QVWRTLPERIRQdpSLASFRQEHERLHGDVDQLHAEESELRVQNGHHEETA 118
Cdd:cd22589    2 QYWKELAEERRK--ALYEALQENEKLHKEIEQLDEEIARLKEENDELEELA 50
CitMHS_2 pfam16980
Putative citrate transport; CitMHS is a family of putative citrate transporters, belonging to ...
 399-532 1.71e-03

Putative citrate transport; CitMHS is a family of putative citrate transporters, belonging to the Na+/H+ antiporter NhaD-like permease superfamily.


Pssm-ID: 465328  Cd Length: 440  Bit Score: 41.81  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  399 LLLLFGMMILVAILSETGVFDYLA----VYA-YKITNG-HVW------PLINCLCLFT-AVLSSFLDnvTT---VLLMTP 462
Cdd:pfam16980  49 FAALFGVGAAGAELLHTLLLEYIPfiilLFAlFTVAGGiLIRgnlagtPLVNTLLLAIgTVLASWIG--TTgasMLLIRP 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309  463 VtIRLCEVMCLNPVPILMCMVIYSNIGGALTPVGDPPNVIiasnSYIskNGVNFAVFTLHMLPGVLLVMV 532
Cdd:pfam16980 127 L-IRANDWRKHKVHVVVFFIFLVSNIGGSLTPLGDPPLFL----GFL--KGVPFFWTTRHLLPETLFAVG 189
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
636-749 2.49e-03

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 41.31  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 636 AALVFVISLFFLHSVPelQRLSLGWTALLGAIFLII-----LADIEDMEAILarveWSTLLFFAALFILMEALTELGLIE 710
Cdd:PRK15445   3 AIAIFLLTLVLVIWQP--KGLGIGWSALLGAVLALLtgvvsLGDVPVVWGIV----WNATLTFIAIIIISLLLDEAGFFE 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665404309 711 WIG-NMtegIILGVGEDRRLMVAILIIlwvSAVASAFVDN 749
Cdd:PRK15445  77 WAAlHV---ARWAKGNGRKLFVYIVLL---GAAVAALFAN 110
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
 655-747 2.53e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 41.36  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665404309 655 RLSLGWTALLGAIFLI-------ILADIEDMEAILARVEWstLLFFAALFILMEAltelgliewIGNMTEGIILGVGEDR 727
Cdd:cd13133  315 KLALAYMLLLGILFLLfpelllsIFTPGADFALIAELAVP--LLRFVAAYILFDA---------LALVFAGALRGAGDTR 383

                         90       100
                 ....*....|....*....|
gi 665404309 728 RLMVAILIILWVSAVASAFV 747
Cdd:cd13133  384 FVMLAELIVAWLYLLPPAYL 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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