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Conserved domains on  [gi|665408481|ref|NP_001286030|]
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uncharacterized protein Dmel_CG5758, isoform F [Drosophila melanogaster]

Protein Classification

fasciclin domain-containing protein( domain architecture ID 10651137)

fasciclin domain-containing protein may be involved in cell adhesion; similar to fasciclin-like arabinogalactan proteins, a subclass of arabinogalactan proteins (AGPs)

CATH:  2.30.180.10
Gene Ontology:  GO:0007155
SCOP:  4002728

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
447-545 1.13e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.25  E-value: 1.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   447 TFFVPEDRAFEK--QGFDKLSDEVMasqrgVKMLLNHFVKGRLYNRDLRDNEVFETIGGGHIKITRNPGSNYTSVNNAQI 524
Cdd:smart00554   1 TVFAPTDEAFQKlpPDLNSLLADKL-----KNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARI 75
                           90       100
                   ....*....|....*....|.
gi 665408481   525 TESEVFVYNlGTMYYLDDILY 545
Cdd:smart00554  76 VEADIAATN-GVVHVIDRVLL 95
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
281-380 3.98e-11

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


:

Pssm-ID: 214719  Cd Length: 97  Bit Score: 59.68  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   281 TVLIPSDNAFQRWHPidwGFYPFSvPEFTESVLRNHFLPmqRPLRLADVRNmdEVVVTTMGGEDVVFHGQP---TPTVNN 357
Cdd:smart00554   1 TVFAPTDEAFQKLPP---DLNSLL-ADKLKNLLLYHVVP--GRLSSADLLN--GGTLPTLAGSKLRITRSGgsgTVTVNG 72
                           90       100
                   ....*....|....*....|....
gi 665408481   358 VSIM-SDYNLSNGnQVFIISEVLF 380
Cdd:smart00554  73 ARIVeADIAATNG-VVHVIDRVLL 95
 
Name Accession Description Interval E-value
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
447-545 1.13e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.25  E-value: 1.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   447 TFFVPEDRAFEK--QGFDKLSDEVMasqrgVKMLLNHFVKGRLYNRDLRDNEVFETIGGGHIKITRNPGSNYTSVNNAQI 524
Cdd:smart00554   1 TVFAPTDEAFQKlpPDLNSLLADKL-----KNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARI 75
                           90       100
                   ....*....|....*....|.
gi 665408481   525 TESEVFVYNlGTMYYLDDILY 545
Cdd:smart00554  76 VEADIAATN-GVVHVIDRVLL 95
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
423-545 1.73e-14

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 70.36  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481  423 PRFTQITRYLNSAEIAPHISGA--NYTFFVPEDRAFEKQGFDKLsDEVMASQRGVKMLL-NHFVKGRLYNRDLRDNEVFE 499
Cdd:pfam02469   1 PGFSTFVALLKAAGLVDTLNGSqgPFTVFAPTNEAFAKLPAGTL-NFLLKDKEQLKNLLkYHVVPGRLTSSDLKNGGTLA 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 665408481  500 TIGGGHIKITRNpgSNYTSVNNAQITESEVfVYNLGTMYYLDDILY 545
Cdd:pfam02469  80 TLQGSKLRVNVT--GGSVTVNGARVVQADI-EATNGVIHVIDKVLL 122
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
418-544 4.23e-12

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.54  E-value: 4.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481 418 ALERDPRFTQITRYLNSAEIAPHISGA-NYTFFVPEDRAFEKQGFDKLSDEVMASQRG--VKMLLNHFVKGRLYNRDLRD 494
Cdd:COG2335   36 TAANNPDFSTLVAALKAAGLVDTLSGEgPFTVFAPTDAAFAALPAGTLDALLKPENKAtlTKILTYHVVPGKVTAADLKD 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 665408481 495 NEVFETIGGGHIKITRNpGSNYTsVNNAQITESEVFVYNlGTMYYLDDIL 544
Cdd:COG2335  116 GKTLTTLQGQTLTVTVS-GGGVT-VNGANVITADIEASN-GVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
281-380 3.98e-11

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 59.68  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   281 TVLIPSDNAFQRWHPidwGFYPFSvPEFTESVLRNHFLPmqRPLRLADVRNmdEVVVTTMGGEDVVFHGQP---TPTVNN 357
Cdd:smart00554   1 TVFAPTDEAFQKLPP---DLNSLL-ADKLKNLLLYHVVP--GRLSSADLLN--GGTLPTLAGSKLRITRSGgsgTVTVNG 72
                           90       100
                   ....*....|....*....|....
gi 665408481   358 VSIM-SDYNLSNGnQVFIISEVLF 380
Cdd:smart00554  73 ARIVeADIAATNG-VVHVIDRVLL 95
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
258-379 1.19e-09

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 56.49  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481  258 GTKVFQHFLSKSNLTRIMDDNA--YTVLIPSDNAFQRWHPIDWGFYPfSVPEFTESVLRNHFLPMQrpLRLADVRNMDEv 335
Cdd:pfam02469   2 GFSTFVALLKAAGLVDTLNGSQgpFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVPGR--LTSSDLKNGGT- 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 665408481  336 vVTTMGGEDV-VFHGQPTPTVNNVSIM-SDYNLSNGNqVFIISEVL 379
Cdd:pfam02469  78 -LATLQGSKLrVNVTGGSVTVNGARVVqADIEATNGV-IHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
266-379 1.08e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 42.97  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481 266 LSKSNLTRIMDDN-AYTVLIPSDNAFQRWhPIDWG---FYPFSVPEFTeSVLRNHFLPMQrpLRLADVRNMDEvvVTTMG 341
Cdd:COG2335   50 LKAAGLVDTLSGEgPFTVFAPTDAAFAAL-PAGTLdalLKPENKATLT-KILTYHVVPGK--VTAADLKDGKT--LTTLQ 123
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665408481 342 GEDVVFHGQ-PTPTVNNVSI-MSDYNLSNGNqVFIISEVL 379
Cdd:COG2335  124 GQTLTVTVSgGGVTVNGANViTADIEASNGV-IHVIDKVL 162
 
Name Accession Description Interval E-value
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
447-545 1.13e-18

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 81.25  E-value: 1.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   447 TFFVPEDRAFEK--QGFDKLSDEVMasqrgVKMLLNHFVKGRLYNRDLRDNEVFETIGGGHIKITRNPGSNYTSVNNAQI 524
Cdd:smart00554   1 TVFAPTDEAFQKlpPDLNSLLADKL-----KNLLLYHVVPGRLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARI 75
                           90       100
                   ....*....|....*....|.
gi 665408481   525 TESEVFVYNlGTMYYLDDILY 545
Cdd:smart00554  76 VEADIAATN-GVVHVIDRVLL 95
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
423-545 1.73e-14

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 70.36  E-value: 1.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481  423 PRFTQITRYLNSAEIAPHISGA--NYTFFVPEDRAFEKQGFDKLsDEVMASQRGVKMLL-NHFVKGRLYNRDLRDNEVFE 499
Cdd:pfam02469   1 PGFSTFVALLKAAGLVDTLNGSqgPFTVFAPTNEAFAKLPAGTL-NFLLKDKEQLKNLLkYHVVPGRLTSSDLKNGGTLA 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 665408481  500 TIGGGHIKITRNpgSNYTSVNNAQITESEVfVYNLGTMYYLDDILY 545
Cdd:pfam02469  80 TLQGSKLRVNVT--GGSVTVNGARVVQADI-EATNGVIHVIDKVLL 122
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
418-544 4.23e-12

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 64.54  E-value: 4.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481 418 ALERDPRFTQITRYLNSAEIAPHISGA-NYTFFVPEDRAFEKQGFDKLSDEVMASQRG--VKMLLNHFVKGRLYNRDLRD 494
Cdd:COG2335   36 TAANNPDFSTLVAALKAAGLVDTLSGEgPFTVFAPTDAAFAALPAGTLDALLKPENKAtlTKILTYHVVPGKVTAADLKD 115
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 665408481 495 NEVFETIGGGHIKITRNpGSNYTsVNNAQITESEVFVYNlGTMYYLDDIL 544
Cdd:COG2335  116 GKTLTTLQGQTLTVTVS-GGGVT-VNGANVITADIEASN-GVIHVIDKVL 162
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
281-380 3.98e-11

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 59.68  E-value: 3.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481   281 TVLIPSDNAFQRWHPidwGFYPFSvPEFTESVLRNHFLPmqRPLRLADVRNmdEVVVTTMGGEDVVFHGQP---TPTVNN 357
Cdd:smart00554   1 TVFAPTDEAFQKLPP---DLNSLL-ADKLKNLLLYHVVP--GRLSSADLLN--GGTLPTLAGSKLRITRSGgsgTVTVNG 72
                           90       100
                   ....*....|....*....|....
gi 665408481   358 VSIM-SDYNLSNGnQVFIISEVLF 380
Cdd:smart00554  73 ARIVeADIAATNG-VVHVIDRVLL 95
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
258-379 1.19e-09

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 56.49  E-value: 1.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481  258 GTKVFQHFLSKSNLTRIMDDNA--YTVLIPSDNAFQRWHPIDWGFYPfSVPEFTESVLRNHFLPMQrpLRLADVRNMDEv 335
Cdd:pfam02469   2 GFSTFVALLKAAGLVDTLNGSQgpFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVPGR--LTSSDLKNGGT- 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 665408481  336 vVTTMGGEDV-VFHGQPTPTVNNVSIM-SDYNLSNGNqVFIISEVL 379
Cdd:pfam02469  78 -LATLQGSKLrVNVTGGSVTVNGARVVqADIEATNGV-IHVIDKVL 121
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
266-379 1.08e-04

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 42.97  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665408481 266 LSKSNLTRIMDDN-AYTVLIPSDNAFQRWhPIDWG---FYPFSVPEFTeSVLRNHFLPMQrpLRLADVRNMDEvvVTTMG 341
Cdd:COG2335   50 LKAAGLVDTLSGEgPFTVFAPTDAAFAAL-PAGTLdalLKPENKATLT-KILTYHVVPGK--VTAADLKDGKT--LTTLQ 123
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665408481 342 GEDVVFHGQ-PTPTVNNVSI-MSDYNLSNGNqVFIISEVL 379
Cdd:COG2335  124 GQTLTVTVSgGGVTVNGANViTADIEASNGV-IHVIDKVL 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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