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Conserved domains on  [gi|665821234|ref|NP_001287871|]
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BRCA2-interacting transcriptional repressor EMSY isoform 1 [Homo sapiens]

Protein Classification

ENT and PHA03247 domain-containing protein( domain architecture ID 13690837)

ENT and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.18e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


:

Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.18e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665821234    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 965-1136 2.24e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.10  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234   965 KQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLPQMPQLSIRHQKLTPL---QQEQAQPKPDVQHTQHPM 1040
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  1041 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQ----PQTPQSQMSLPASSEKQTASQVEQPIItqgs 1116
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQggqnKKLAQVLASATPQMQKQVLGERLFPLV---- 517

                          170       180
                   ....*....|....*....|
gi 665821234  1117 svtkitfEGRQPPTVTKITG 1136
Cdd:TIGR01628  518 -------EAIEPALAAKITG 530
COG3889 super family cl28569
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.20e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


The actual alignment was detected with superfamily member COG3889:

Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.94  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQA------------TYTRPTVSPSIGrMAATPGAATYV 547
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAvsttiqtltdtdTTTTTSAKTTPS-LTTAATTTTTS 836

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 665821234  548 KTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   837 TTTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.18e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.18e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665821234    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 965-1136 2.24e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.10  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234   965 KQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLPQMPQLSIRHQKLTPL---QQEQAQPKPDVQHTQHPM 1040
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  1041 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQ----PQTPQSQMSLPASSEKQTASQVEQPIItqgs 1116
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQggqnKKLAQVLASATPQMQKQVLGERLFPLV---- 517

                          170       180
                   ....*....|....*....|
gi 665821234  1117 svtkitfEGRQPPTVTKITG 1136
Cdd:TIGR01628  518 -------EAIEPALAAKITG 530
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.20e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.94  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQA------------TYTRPTVSPSIGrMAATPGAATYV 547
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAvsttiqtltdtdTTTTTSAKTTPS-LTTAATTTTTS 836

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 665821234  548 KTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   837 TTTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Name Accession Description Interval E-value
ENT pfam03735
ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that ...
 17-81 6.18e-28

ENT domain; This presumed domain is named after Emsy N Terminus (ENT). Emsy is a protein that is amplified in breast cancer and interacts with BRCA2. The N terminus of this protein is found to be similar to other vertebrate and plant proteins of unknown function. This domain has a completely conserved histidine residue that may be functionally important.


Pssm-ID: 461032  Cd Length: 71  Bit Score: 107.65  E-value: 6.18e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665821234    17 KRILRKLELEAYAGVISALRAQGD-LTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAH 81
Cdd:pfam03735    1 KRQLRKLELEAYSSVLRAFRAQGDaLSWEKEKLLTELRKELNISDERHRAELRRVVNDERLKTIRE 66
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 965-1136 2.24e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.10  E-value: 2.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234   965 KQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQ-ADQLQHKLPQMPQLSIRHQKLTPL---QQEQAQPKPDVQHTQHPM 1040
Cdd:TIGR01628  364 KEQRRAHLQDQFMQLQPRMRQLPMGSPMGGAMGQpPYYGQGPQQQFNGQPLGWPRMSMMptpMGPGGPLRPNGLAPMNAV 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  1041 VAKDRQLPTLMAQPPQTVVQvlAVKTTQQLPKLQQAPNQPKIYVQ----PQTPQSQMSLPASSEKQTASQVEQPIItqgs 1116
Cdd:TIGR01628  444 RAPSRNAQNAAQKPPMQPVM--YPPNYQSLPLSQDLPQPQSTASQggqnKKLAQVLASATPQMQKQVLGERLFPLV---- 517

                          170       180
                   ....*....|....*....|
gi 665821234  1117 svtkitfEGRQPPTVTKITG 1136
Cdd:TIGR01628  518 -------EAIEPALAAKITG 530
COG3889 COG3889
Extracellular solute-binding protein, contains Ig-fold domain [General function prediction ...
 484-585 3.20e-03

Extracellular solute-binding protein, contains Ig-fold domain [General function prediction only];


Pssm-ID: 443097 [Multi-domain]  Cd Length: 878  Bit Score: 41.94  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665821234  484 LPKPVTATLPTSSNSPIMVVSSNGAIM----TTKLVTTPTGTQA------------TYTRPTVSPSIGrMAATPGAATYV 547
Cdd:COG3889   758 LPAEVTAKLSPGSYTLVVIAYSELVALpaiyTTSFIVTPAVTIAvsttiqtltdtdTTTTTSAKTTPS-LTTAATTTTTS 836

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 665821234  548 KTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTI 585
Cdd:COG3889   837 TTTSTTSVTTTAAALASAATAAIVVGVVAVAVAIATAI 874
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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