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Conserved domains on  [gi|756761824|ref|NP_001291933|]
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myelin proteolipid protein isoform 3 [Homo sapiens]

Protein Classification

myelin proteolipid family protein( domain architecture ID 10472648)

myelin proteolipid family protein similar to human myelin proteolipid protein (PLP) that plays an important role in the formation or maintenance of the multilamellar structure of myelin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
2-218 6.38e-77

Myelin proteolipid protein (PLP or lipophilin);


:

Pssm-ID: 460144  Cd Length: 231  Bit Score: 231.03  E-value: 6.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824    2 DYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahsle 81
Cdd:pfam01275  54 DYELLATWIDAFQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-------------------- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824   82 rvchclgkwlghpdkFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFP 161
Cdd:pfam01275 114 ---------------FMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATP 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 756761824  162 GKVCGSN-LLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGR 218
Cdd:pfam01275 174 GKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
2-218 6.38e-77

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 231.03  E-value: 6.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824    2 DYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahsle 81
Cdd:pfam01275  54 DYELLATWIDAFQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-------------------- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824   82 rvchclgkwlghpdkFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFP 161
Cdd:pfam01275 114 ---------------FMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATP 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 756761824  162 GKVCGSN-LLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGR 218
Cdd:pfam01275 174 GKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
124-183 4.03e-36

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 121.44  E-value: 4.03e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824   124 NTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFH 183
Cdd:smart00002   1 NTWTTCQSITFPEKTTTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Name Accession Description Interval E-value
Myelin_PLP pfam01275
Myelin proteolipid protein (PLP or lipophilin);
2-218 6.38e-77

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 460144  Cd Length: 231  Bit Score: 231.03  E-value: 6.38e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824    2 DYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATvtggqkgrgsrgqhqahsle 81
Cdd:pfam01275  54 DYELLATWIDAFQYVIYGIAAFFFLLGLLLLAEGFLTTGATKQVYGAFRSTVGGRCSCAV-------------------- 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824   82 rvchclgkwlghpdkFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKtsasiGSLCADARMYGVLPWNAFP 161
Cdd:pfam01275 114 ---------------FMGITYVLALVWLLVFAFLAIPVFIFTNFWSTCQNINVLST-----NQLCIDFRQFGFLPWNATP 173

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 756761824  162 GKVCGSN-LLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGR 218
Cdd:pfam01275 174 GKVCGMTeLKAFCKDYEEKMTFHLFILAFAGAGATLLALVHYLMCLTANYAHLRDHGR 231
PLP smart00002
Myelin proteolipid protein (PLP or lipophilin);
124-183 4.03e-36

Myelin proteolipid protein (PLP or lipophilin);


Pssm-ID: 128322  Cd Length: 60  Bit Score: 121.44  E-value: 4.03e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 756761824   124 NTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFH 183
Cdd:smart00002   1 NTWTTCQSITFPEKTTTSIGTLCVDARQYGILPWNAFPGKVCGSNLLSICKTSEFQMTFH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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