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Conserved domains on  [gi|809281443|ref|NP_001295034|]
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synphilin-1 isoform B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SNCAIP_SNCA_bd super family cl25051
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 452-495 2.46e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


The actual alignment was detected with superfamily member pfam16700:

Pssm-ID: 435527  Cd Length: 45  Bit Score: 67.84  E-value: 2.46e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281443  452 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 495
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-449 2.15e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 289 AAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPS 362
Cdd:COG0666   79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 363 LIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 442
Cdd:COG0666  156 PLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231


                 ....*..
gi 809281443 443 TLCSRYL 449
Cdd:COG0666  232 LEIVKLL 238
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 452-495 2.46e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 67.84  E-value: 2.46e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281443  452 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 495
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-449 2.15e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 289 AAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPS 362
Cdd:COG0666   79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 363 LIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 442
Cdd:COG0666  156 PLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231


                 ....*..
gi 809281443 443 TLCSRYL 449
Cdd:COG0666  232 LEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
335-427 4.59e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 4.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443  335 NGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCIQ 414
Cdd:pfam12796   7 NGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 809281443  415 TLVEYGANVTMQN 427
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 362-450 3.08e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 362 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 441
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                 ....*....
gi 809281443 442 HTLCSRYLV 450
Cdd:PHA02874 202 DYACIKLLI 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 396-425 1.44e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 809281443   396 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 425
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 452-495 2.46e-14

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 67.84  E-value: 2.46e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 809281443  452 VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGK 495
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-449 2.15e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.83  E-value: 2.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 289 AAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPS 362
Cdd:COG0666   79 DINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNT 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 363 LIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 442
Cdd:COG0666  156 PLHLAAANGNLEIVKLLL----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGN 231


                 ....*..
gi 809281443 443 TLCSRYL 449
Cdd:COG0666  232 LEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
314-450 3.06e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 65.36  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 314 EYLKKVKSILNIVKEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQG 387
Cdd:COG0666   71 LLLLAAGADINAKDDGGNTLLhaaarNGDLEIVKLLL---EAGADVnARDKDGETPLHLAAYNGNLEIVKLLL----EAG 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 809281443 388 ISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 450
Cdd:COG0666  144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
Ank_2 pfam12796
Ankyrin repeats (3 copies);
335-427 4.59e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.35  E-value: 4.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443  335 NGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDqDGNSAVHVASQHGYLGCIQ 414
Cdd:pfam12796   7 NGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 809281443  415 TLVEYGANVTMQN 427
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
364-450 2.53e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 49.34  E-value: 2.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443  364 IHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYgANVTMQNHaGEKPSQSAERQGHT 443
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL----ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHL 74


                  ....*..
gi 809281443  444 LCSRYLV 450
Cdd:pfam12796  75 EIVKLLL 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
362-417 7.98e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 7.98e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 809281443  362 SLIHYAGCYGQEKILLWLLQFmqeqGISLDEVDQDGNSAVHVASQHGYLGCIQTLV 417
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
335-449 6.19e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.72  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 335 NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCI 413
Cdd:COG0666  163 NGNLEIVKLLL---EAGADVnARDNDGETPLHLAAENGHLEIVKLLL----EAGADVNAKDNDGKTALDLAAENGNLEIV 235

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 809281443 414 QTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 449
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
397-450 1.12e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.12e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 809281443  397 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 450
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 362-450 3.08e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.18  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 362 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 441
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                 ....*....
gi 809281443 442 HTLCSRYLV 450
Cdd:PHA02874 202 DYACIKLLI 210
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
350-450 3.31e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.40  E-value: 3.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 809281443 350 AIAELSCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHA 429
Cdd:COG0666   44 LLALALADALGALLLLAAALAGDLLVALLLL----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD 119

                         90       100
                 ....*....|....*....|.
gi 809281443 430 GEKPSQSAERQGHTLCSRYLV 450
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKLLL 140
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 385-441 7.49e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 7.49e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 809281443 385 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 441
Cdd:PTZ00322 103 TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 396-425 1.44e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 809281443   396 DGNSAVHVASQHGYLGCIQTLVEYGANVTM 425
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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