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Conserved domains on  [gi|959994610|ref|NP_001304658|]
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aquaporin-4 isoform M1x [Mus musculus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 2.18e-87

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 262.64  E-value: 2.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610   31 TQAFWKAVSAEFLATLIFVLLGVGSTINWGGS-ENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  110 ISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 2.18e-87

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 262.64  E-value: 2.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610   31 TQAFWKAVSAEFLATLIFVLLGVGSTINWGGS-ENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  110 ISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 8.31e-77

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 235.61  E-value: 8.31e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINWGGSENpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 116 VFYIIAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959994610 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WANHWIYWVGPIMGAVLAGALYEYV 251
Cdd:cd00333  160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 1.97e-71

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 221.40  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610   40 AEFLATLIFVLLGVGSTI---NWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  117 FYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 959994610  195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 2.21e-65

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 206.52  E-value: 2.21e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  34 FWKAVSAEFLATLIFVLLGVGSTINWGGSenPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 114 KSVFYIIAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580   80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 959994610 186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWANHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:COG0580  159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 9.02e-48

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 161.64  E-value: 9.02e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINWGG--SENPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 113 AKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959994610 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 31-248 2.18e-87

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 262.64  E-value: 2.18e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610   31 TQAFWKAVSAEFLATLIFVLLGVGSTINWGGS-ENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRK 109
Cdd:pfam00230   4 SVSFLRAVIAEFLATLLFVFFGVGSALGVKKLvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  110 ISIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSI 189
Cdd:pfam00230  84 FSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSLGTV 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:pfam00230 164 ApLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-251 8.31e-77

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 235.61  E-value: 8.31e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINWGGSENpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:cd00333    1 RKYLAEFLGTFLLVFFGCGSVLAVKLAGG-ASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 116 VFYIIAQCLGAIIGAGILYLVTPPSVVGGLGV---------TTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVT 186
Cdd:cd00333   80 IPYIIAQLLGAILGAALLYGLYYGLYLEFLGAnnivagifgTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPP 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959994610 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGN---WANHWIYWVGPIMGAVLAGALYEYV 251
Cdd:cd00333  160 GGLApLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLarhWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 40-248 1.97e-71

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 221.40  E-value: 1.97e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610   40 AEFLATLIFVLLGVGSTI---NWGGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnVAGAYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  117 FYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVHGN-LTAGHGLLVELIITFQLVFTIFASCD-SKRTDVTGSIALAIG 194
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAgVSSGQAFFVEFIGTAILVLVIFATTDdRNRVPRGGFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 959994610  195 FSVAIGHLFAINYTGASMNPARSFGPAVI--MGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFagLAGWGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 34-252 2.21e-65

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 206.52  E-value: 2.21e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  34 FWKAVSAEFLATLIFVLLGVGSTINWGGSenPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:COG0580    2 LMKRLLAEFLGTFILVLLGCGVVAVLAGT--KGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 114 KSVFYIIAQCLGAIIGAGILYLV--------TPPSVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIFASCDSKRTDv 185
Cdd:COG0580   80 DVLPYIIAQLLGAFLGAALVYLIygghfdatEDGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAP- 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 959994610 186 TGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIM------GNWANHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:COG0580  159 GGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALF 231
PLN00166 PLN00166
aquaporin TIP2; Provisional
 36-252 9.02e-48

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 161.64  E-value: 9.02e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINWGG--SENPL-PVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00166  19 KAYLSEFIATLLFVFAGVGSAIAFAKltSDAALdPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 113 AKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIA-L 191
Cdd:PLN00166  99 ITGFFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA---GLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIApI 175

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959994610 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:PLN00166 176 AIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGGALAGLIYGDVF 236
PLN00027 PLN00027
aquaporin TIP; Provisional
 36-252 2.18e-45

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 155.71  E-value: 2.18e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINW-----GGSENPLPVDMVLISLCFGLSIATMVQCfgHISGGHINPAVTVAMVCTRKI 110
Cdd:PLN00027  21 KAALAEFISTLIFVFAGEGSGMAFnkltdNGSTTPAGLVAAALAHAFALFVAVSVGA--NISGGHVNPAVTFGAFIGGNI 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 111 SIAKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTvhgNLTAGHGLLVELIITFQLVFTIFASC-DSKRTDVtGSI 189
Cdd:PLN00027  99 TLLRGILYWIAQLLGSVVACLLLKFSTGGLETSAFSLSS---GVGVWNAFVFEIVMTFGLVYTVYATAvDPKKGDL-GII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 959994610 190 A-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:PLN00027 175 ApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAGLVYELIF 238
PRK05420 PRK05420
aquaporin Z; Provisional
 36-252 1.94e-41

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 144.73  E-value: 1.94e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTINWGGSENpLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKS 115
Cdd:PRK05420   3 KKLAAEFFGTFWLVFGGCGSAVLAAAFPE-LGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKEL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 116 VFYIIAQCLGAIIGAGILYLVTPP----SVVGGLGVTTVHGNLTAGH-----GLLVELIITFQLVFTIFASCDsKRTDVt 186
Cdd:PRK05420  82 VPYIIAQVVGGIAAAAVLYLIASGkagfDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATD-KRAPA- 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 959994610 187 GSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWA--NHWIYWVGPIMGAVLAGALYEYVF 252
Cdd:PRK05420 160 GFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWAleQLWLFWVAPIVGAIIGGLIYRLLL 227
PLN00167 PLN00167
aquaporin TIP5; Provisional
 21-254 1.49e-38

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 138.11  E-value: 1.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  21 SIMVAFKGVWTQAFWKAVSAEFLATLIFVLLGVGSTINW-----GGSENPLPVDMVLISLCFGLSIATMVQcfGHISGGH 95
Cdd:PLN00167   8 SLSARFQQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSrklmpDAASDPSSLLIVAIANAFALSSAVYIA--ANISGGH 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  96 INPAVTVAMVCTRKISIAKSVFYIIAQCLGAIIGAGILYLVTppsVVGGLGVTTVHGNLTAGHGLLVELIITFQLVFTIF 175
Cdd:PLN00167  86 VNPAVTFGMAVGGHISVPTAMFYWISQMLASVMACLFLKVTT---VGQHVPTYKIAEEMTGFGASVLEGVLTFGLVYTVY 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959994610 176 ASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCP 254
Cdd:PLN00167 163 AAGDPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLLYDNVVFP 241
PLN00026 PLN00026
aquaporin NIP; Provisional
 36-257 5.06e-33

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 124.59  E-value: 5.06e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLATLIFVLLGVGSTI---NWGGSENPLPvdmvlISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISI 112
Cdd:PLN00026  72 RKLGAEFVGTFILIFAATAGPIvnqKYDGAETLIG-----NAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 113 AKSVFYIIAQCLGAIIGAGILYLVTPPSVVGGLGVTTVhgnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-L 191
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSV----STGQAFALEFIITFNLLFVVTAVATDTRA--VGELAgI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 959994610 192 AIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVE 257
Cdd:PLN00026 221 AVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAGTYTAVKLREED 286
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 40-276 2.44e-31

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 119.63  E-value: 2.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  40 AEFLATLIFVLLGVGSTIN---WGGSenplpVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIAKSV 116
Cdd:PLN00182  47 AEMIGTYFIIFSGCGVVVVnvlYGGT-----ITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQVP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 117 FYIIAQCLGAIIGAGILYL---VTPPSVVGglgvTTVHGnlTAGHGLLVELIITFQLVFTIFASCDSKRTdvTGSIA-LA 192
Cdd:PLN00182 122 LYIGAQLTGSLLASLTLRLmfnVTPEAFFG----TTPTD--SSGQALVAEIIISFLLMFVISGVATDSRA--VGELAgIA 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 193 IGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLKEA-FSKAAQ 271
Cdd:PLN00182 194 VGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIRFTDKPLRELTKSAsFLRSVS 273


                 ....*
gi 959994610 272 QTKGS 276
Cdd:PLN00182 274 QKHNA 278
PLN00184 PLN00184
aquaporin NIP1; Provisional
 34-263 5.67e-30

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 116.27  E-value: 5.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  34 FWKAVSAEFLATLIFVLLGVGSTINwgGSENPLPVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:PLN00184  53 FLQKLIAEVLGTYFLVFTGCASVVV--NMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 114 KSVFYIIAQCLGAIIGAGILYLV--TPPSVVGG-----LGVTTVHGNLTAghgLLVELIITFQLVFTIFASCDSKRTdvT 186
Cdd:PLN00184 131 QVPAYVISQVIGSTLAAATLRLLfgLDHDVCSGkhdvfIGSSPVGSDLQA---FVMEFIVTFYLMFIISGVATDNRA--I 205

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 959994610 187 GSIA-LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALYEYVFCPDVELKRRLK 263
Cdd:PLN00184 206 GELAgLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVRYTDKPLREITK 283
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 35-257 3.41e-23

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 97.50  E-value: 3.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  35 WKAVSAEFLATLIFVLLGVGSTINWggseNPLPVDMVLISLCFGLSIATMVQCF--GHISGGHINPAVTVAMVCTRKISI 112
Cdd:PTZ00016  50 VREYVAEFLGTFVLLFFGEGVVATT----HTVGNNGDYLAITIGWGLGVTFGLLvsAGISGGHLNPAVTLGNAVFGKFPW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 113 AKSVFYIIAQCLGAIIGAGILYLV----------------TPPSVVGGLGVTTVHGNLTagHGLLVELIITFQLVFTIFA 176
Cdd:PTZ00016 126 KKLPGYFVAQLLGAFVGAACVYGLyygffkdhgipelpweTMANGFAGVFATYPREGNF--YAIFSELILTAILLLVILA 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 177 SCDSKRTDVTGSIALAIGFSV-AIGHLFAINyTGASMNPARSFGP----AVIMGN----WANH--WIYWVGPIMGAVLAG 245
Cdd:PTZ00016 204 ITDPNNCPAFNYLPVAVGLLVfVIGISFGGN-TGYALNPARDLGPrlfsAILWGSevftKDNYyfWVPLVAPFVGAVLGM 282

                        250
                 ....*....|..
gi 959994610 246 ALYEYVFCPDVE 257
Cdd:PTZ00016 283 FLYDKFIPPLIE 294
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 36-248 3.87e-22

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 94.15  E-value: 3.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610  36 KAVSAEFLAT--LIFVLLGVGSTINWGGSEnplpVDMVLISLCFGLSIATMVQCFGHISGGHINPAVTVAMVCTRKISIA 113
Cdd:PLN00183  46 RMVLAEMVGTfiLMFCVCGIIASTQLSGGE----VGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959994610 114 KSVFYIIAQCLGAIIG---AGILYLVTPPsvvgglgVTTVHGNLTAGHGLLVELIITFQLVFtIFASCDSKRTDVTGSIA 190
Cdd:PLN00183 122 KVPLYITAQTVGSVLAtyvGVSVYGVKAD-------LMTTKPAQGCSSAFWVEFIATFIVMF-LAASLTSQPQSLGHLSG 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 959994610 191 LAIGFSVAIGHLFAINYTGASMNPARSFGPAVIMGNWANHWIYWVGPIMGAVLAGALY 248
Cdd:PLN00183 194 FVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMF 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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