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Conserved domains on  [gi|970414539|ref|NP_001305077|]
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rRNA N6-adenosine-methyltransferase ZCCHC4 isoform 2 [Homo sapiens]

Protein Classification

protein-lysine N-methyltransferase; DNA topoisomerase( domain architecture ID 12072592)

protein-lysine N-methyltransferase such as human EEF1A lysine methyltransferase 1 that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'| type I DNA topoisomerase releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
N6-adenineMlase pfam10237
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 169-297 8.23e-28

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


:

Pssm-ID: 463014  Cd Length: 118  Bit Score: 104.93  E-value: 8.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414539  169 TNAQYLFADRSCQFLVDLL--SALGFRRVLCVGTPRLHELIKLtasgDKKSNIKSLLLDIDFRYsQFYMEDsFCHYNMFN 246
Cdd:pfam10237   1 QLSQFWYSDETAETLAKELldGADKDTRIACLSAPSLYEALKK----LLPPRINSLLLEYDKRF-AVYGPD-FVFYDYNN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 970414539  247 HHFFDgktalevcrAFLqedKGEGIIMVTDPPFggLVEPLAITFKKLIAMW 297
Cdd:pfam10237  75 PLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 38-82 2.68e-11

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


:

Pssm-ID: 462017  Cd Length: 45  Bit Score: 57.80  E-value: 2.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 970414539   38 PLCPHGpTLLFVKV--TQGKEETRRFYACSACRDrKDCNFFQWEDEK 82
Cdd:pfam06839   1 PLCPCG-QRAVLLTvrKTGPNPGRQFYKCPVGRE-KQCGFFQWADEV 45
 
Name Accession Description Interval E-value
N6-adenineMlase pfam10237
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 169-297 8.23e-28

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


Pssm-ID: 463014  Cd Length: 118  Bit Score: 104.93  E-value: 8.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414539  169 TNAQYLFADRSCQFLVDLL--SALGFRRVLCVGTPRLHELIKLtasgDKKSNIKSLLLDIDFRYsQFYMEDsFCHYNMFN 246
Cdd:pfam10237   1 QLSQFWYSDETAETLAKELldGADKDTRIACLSAPSLYEALKK----LLPPRINSLLLEYDKRF-AVYGPD-FVFYDYNN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 970414539  247 HHFFDgktalevcrAFLqedKGEGIIMVTDPPFggLVEPLAITFKKLIAMW 297
Cdd:pfam10237  75 PLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 38-82 2.68e-11

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


Pssm-ID: 462017  Cd Length: 45  Bit Score: 57.80  E-value: 2.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 970414539   38 PLCPHGpTLLFVKV--TQGKEETRRFYACSACRDrKDCNFFQWEDEK 82
Cdd:pfam06839   1 PLCPCG-QRAVLLTvrKTGPNPGRQFYKCPVGRE-KQCGFFQWADEV 45
 
Name Accession Description Interval E-value
N6-adenineMlase pfam10237
Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which ...
 169-297 8.23e-28

Probable N6-adenine methyltransferase; This is a protein of approximately 200 residues which is conserved from plants to humans. It contains a highly conserved QFW motif close to the N-terminus and a DPPF motif in the centre. The DPPF motif is characteriztic of N-6 adenine-specific DNA methylases, and this family is found in eukaryotes.


Pssm-ID: 463014  Cd Length: 118  Bit Score: 104.93  E-value: 8.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 970414539  169 TNAQYLFADRSCQFLVDLL--SALGFRRVLCVGTPRLHELIKLtasgDKKSNIKSLLLDIDFRYsQFYMEDsFCHYNMFN 246
Cdd:pfam10237   1 QLSQFWYSDETAETLAKELldGADKDTRIACLSAPSLYEALKK----LLPPRINSLLLEYDKRF-AVYGPD-FVFYDYNN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 970414539  247 HHFFDgktalevcrAFLqedKGEGIIMVTDPPFggLVEPLAITFKKLIAMW 297
Cdd:pfam10237  75 PLDLP---------EFL---KGSFDRVVIDPPF--LSEECLTKLAKTAKLL 111
zf-GRF pfam06839
GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding ...
 38-82 2.68e-11

GRF zinc finger; This presumed zinc binding domain is found in a variety of DNA-binding proteins. It seems likely that this domain is involved in nucleic acid binding. It is named GRF after three conserved residues in the centre of the alignment of the domain. This zinc finger may be related to pfam01396.


Pssm-ID: 462017  Cd Length: 45  Bit Score: 57.80  E-value: 2.68e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 970414539   38 PLCPHGpTLLFVKV--TQGKEETRRFYACSACRDrKDCNFFQWEDEK 82
Cdd:pfam06839   1 PLCPCG-QRAVLLTvrKTGPNPGRQFYKCPVGRE-KQCGFFQWADEV 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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