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Conserved domains on  [gi|974005336|ref|NP_001305740|]
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SLIT and NTRK-like protein 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-211 3.95e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 3.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  93 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 172
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974005336 173 SKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR_8 pfam13855
Leucine rich repeat;
432-492 2.10e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 2.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005336  432 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
398-563 2.13e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 474
Cdd:COG4886  123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 475 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 553
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                        170
                 ....*....|
gi 974005336 554 ivQIDLNENP 563
Cdd:COG4886  276 --TLDLSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
562-597 4.12e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 4.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 974005336   562 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENL 597
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
LRRCT smart00082
Leucine rich repeat C-terminal domain;
232-270 3.54e-05

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 974005336   232 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-211 3.95e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 3.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  93 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 172
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974005336 173 SKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR_8 pfam13855
Leucine rich repeat;
105-161 2.29e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.29e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 974005336  105 SINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 161
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
432-492 2.10e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 2.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005336  432 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-563 2.13e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 474
Cdd:COG4886  123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 475 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 553
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                        170
                 ....*....|
gi 974005336 554 ivQIDLNENP 563
Cdd:COG4886  276 --TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-496 1.24e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISELlPRPL----NAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKSLFLNGNDIEKLTP 473
Cdd:COG4886  192 NQITDL-PEPLgnltNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                         90       100
                 ....*....|....*....|...
gi 974005336 474 GMfrGLQSLHYLYFEFNVIREIQ 496
Cdd:COG4886  268 LA--NLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 381-485 2.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 381 LHINDLGLTVnckergfnnIsELLPRPLNAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKS 460
Cdd:cd21340    7 LYLNDKNITK---------I-DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                         90       100
                 ....*....|....*....|....*
gi 974005336 461 LFLNGNDIEKLTpgmfrGLQSLHYL 485
Cdd:cd21340   73 LYLGGNRISVVE-----GLENLTNL 92
LRRCT smart00082
Leucine rich repeat C-terminal domain;
562-597 4.12e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 4.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 974005336   562 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENL 597
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
LRRCT smart00082
Leucine rich repeat C-terminal domain;
232-270 3.54e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 974005336   232 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-206 3.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  58 HIHCDSKgftNISQITEFwsRPFK----LYLQRN---SMRKLYTNSFL-HLNnavsinLGNNALQDIQTgaFNGLKILKR 129
Cdd:cd21340    6 HLYLNDK---NITKIDNL--SLCKnlkvLYLYDNkitKIENLEFLTNLtHLY------LQNNQIEKIEN--LENLVNLKK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 130 LYLHENKLDV---------------------------FRNDTFLGL-ESLEYLQADYNVIKRIESgaFRNLSKLRVLILN 181
Cdd:cd21340   73 LYLGGNRISVveglenltnleelhienqrlppgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                        170       180
                 ....*....|....*....|....*....
gi 974005336 182 DNLI----PMLPTnLFKAVSLTHLDLRGN 206
Cdd:cd21340  151 NNQIsdleELLDL-LSSWPSLRELDLTGN 178
LRR smart00370
Leucine-rich repeats, outliers;
455-478 8.91e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.91e-03
                           10        20
                   ....*....|....*....|....
gi 974005336   455 LPNLKSLFLNGNDIEKLTPGMFRG 478
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-211 3.95e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 3.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  93 YTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNVIKRIeSGAFRNL 172
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 974005336 173 SKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL 220
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-211 1.84e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 1.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  81 KLYLQRNSMRKLyTNSFLHLNNAVSINLGNNALQDIQTgAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNV 160
Cdd:COG4886  117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974005336 161 IKRIeSGAFRNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-233 4.23e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 4.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  81 KLYLQRNSMRKLyTNSFLHLNNAVSINLGNNALQDIqTGAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNV 160
Cdd:COG4886  140 ELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 974005336 161 IKRIeSGAFRNLSKLRVLILNDNLIPMLPtNLFKAVSLTHLDLRGNRLKVLFYRGMLDhigrSLMELQLEENP 233
Cdd:COG4886  217 LTDL-PEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLT----NLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-211 1.61e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 1.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  81 KLYLQRNSMRKLyTNSFLHLNNAVSINLGNNALQDIQTgAFNGLKILKRLYLHENKLDVFrNDTFLGLESLEYLQADYNV 160
Cdd:COG4886  163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974005336 161 IKRIESgaFRNLSKLRVLILNDNLIPMLPtNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  240 LTDLPE--LGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDL 287
LRR_8 pfam13855
Leucine rich repeat;
105-161 2.29e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 2.29e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 974005336  105 SINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVI 161
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
127-185 9.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 9.72e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 974005336  127 LKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLI 185
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
432-492 2.10e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 2.10e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974005336  432 SSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVI 492
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
409-468 1.37e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 1.37e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  409 NAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDI 468
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-563 2.13e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISEL---LPRPLNAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVqDGAFINLPNLKSLFLNGNDIEKLtPG 474
Cdd:COG4886  123 NQLTDLpeeLANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 475 MFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPtdAFAG-TSLARLNLRKNYFLYLPVAGVLEHLNa 553
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNlTNLEELDLSNNQLTDLPPLANLTNLK- 275

                        170
                 ....*....|
gi 974005336 554 ivQIDLNENP 563
Cdd:COG4886  276 --TLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-496 1.24e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISELlPRPL----NAKKLYLSSNLIQKIyRSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKSLFLNGNDIEKLTP 473
Cdd:COG4886  192 NQITDL-PEPLgnltNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                         90       100
                 ....*....|....*....|...
gi 974005336 474 GMfrGLQSLHYLYFEFNVIREIQ 496
Cdd:COG4886  268 LA--NLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-211 1.65e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  90 RKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYlhenKLDVFRNDTFLGLESLEYLQADYNVIKRIESgAF 169
Cdd:COG4886   58 RDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT----ELDLSGNEELSNLTNLESLDLSGNQLTDLPE-EL 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 974005336 170 RNLSKLRVLILNDNLIPMLPTNLFKAVSLTHLDLRGNRLKVL 211
Cdd:COG4886  133 ANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDL 174
LRR_8 pfam13855
Leucine rich repeat;
150-208 6.67e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 6.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  150 SLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKA-VSLTHLDLRGNRL 208
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
456-504 7.15e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 7.15e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 974005336  456 PNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMP 504
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLP 49
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
398-604 1.82e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 1.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 398 NNISELlPRPL----NAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDGAfiNLPNLKSLFLNGNDIEKLTp 473
Cdd:COG4886  215 NQLTDL-PEPLanltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLK- 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 474 gmfrgLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNA 553
Cdd:COG4886  289 -----LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 974005336 554 IVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENLTHRDVRT 604
Cdd:COG4886  364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 381-485 2.15e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 381 LHINDLGLTVnckergfnnIsELLPRPLNAKKLYLSSNLIQKIyrSDFWNFSSLDLLHLGNNRISYVQDgaFINLPNLKS 460
Cdd:cd21340    7 LYLNDKNITK---------I-DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                         90       100
                 ....*....|....*....|....*
gi 974005336 461 LFLNGNDIEKLTpgmfrGLQSLHYL 485
Cdd:cd21340   73 LYLGGNRISVVE-----GLENLTNL 92
LRRCT smart00082
Leucine rich repeat C-terminal domain;
562-597 4.12e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 4.12e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 974005336   562 NPWDCTCDLVPFKQWIETISSVSVVGDVLCRSPENL 597
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSL 36
LRR_8 pfam13855
Leucine rich repeat;
81-137 6.50e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 6.50e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 974005336   81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKL 137
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
232-270 3.54e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.03  E-value: 3.54e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 974005336   232 NPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGK 270
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 58-206 3.86e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  58 HIHCDSKgftNISQITEFwsRPFK----LYLQRN---SMRKLYTNSFL-HLNnavsinLGNNALQDIQTgaFNGLKILKR 129
Cdd:cd21340    6 HLYLNDK---NITKIDNL--SLCKnlkvLYLYDNkitKIENLEFLTNLtHLY------LQNNQIEKIEN--LENLVNLKK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 130 LYLHENKLDV---------------------------FRNDTFLGL-ESLEYLQADYNVIKRIESgaFRNLSKLRVLILN 181
Cdd:cd21340   73 LYLGGNRISVveglenltnleelhienqrlppgekltFDPRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDAS 150

                        170       180
                 ....*....|....*....|....*....
gi 974005336 182 DNLI----PMLPTnLFKAVSLTHLDLRGN 206
Cdd:cd21340  151 NNQIsdleELLDL-LSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-232 3.79e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336  98 LHLNNavsinlgnNALQDIqtGAFNGLKILKRLYLHENKLDVFRN-DTFLGLESLeYLQadYNVIKRIESgaFRNLSKLR 176
Cdd:cd21340    7 LYLND--------KNITKI--DNLSLCKNLKVLYLYDNKITKIENlEFLTNLTHL-YLQ--NNQIEKIEN--LENLVNLK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 177 VLILNDNLIPML-----PTNL-----------------FK-------AVSLTHLDLRGNRLKVLFYRGMLdhigRSLMEL 227
Cdd:cd21340   72 KLYLGGNRISVVeglenLTNLeelhienqrlppgekltFDprslaalSNSLRVLNISGNNIDSLEPLAPL----RNLEQL 147


                 ....*
gi 974005336 228 QLEEN 232
Cdd:cd21340  148 DASNN 152
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
379-562 1.18e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 1.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 379 CNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYRSDFWNFSSLDLLHLGNNRisyvqdgAFINLPNL 458
Cdd:COG4886   43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336 459 KSLFLNGNDIEKLtPGMFRGLQSLHYLYFEFNVIREIqPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTSLARLNLRKNY 538
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                        170       180
                 ....*....|....*....|....
gi 974005336 539 FLYLPVAgvLEHLNAIVQIDLNEN 562
Cdd:COG4886  194 ITDLPEP--LGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
173-233 3.37e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 974005336  173 SKLRVLILNDNLIPMLPTNLFKAVS-LTHLDLRGNRLKVLfYRGMLDHIgRSLMELQLEENP 233
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTL-SPGAFSGL-PSLRYLDLSGNR 60
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 87-206 4.63e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.29  E-value: 4.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974005336   87 NSMRKLYTNSFLHLNNAVSINLGNNaLQDIQTGAFNGLKiLKRLYLHENkldvfrndtflglesleylqadynvIKRIES 166
Cdd:pfam13306  20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-------------------------LTSIGE 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 974005336  167 GAFRNLSKLRVLILNDNLIpMLPTNLFKAVSLTHLDLRGN 206
Cdd:pfam13306  73 YAFSNCSNLKSITLPSNLT-SIGSYAFSNCSLKSITIPSS 111
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 433-473 6.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 6.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 974005336  433 SLDLLHLGNNRISYVQdgAFINLPNLKSLFLNGND-IEKLTP 473
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNkITDLSD 41
LRR smart00370
Leucine-rich repeats, outliers;
455-478 8.91e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.91e-03
                           10        20
                   ....*....|....*....|....
gi 974005336   455 LPNLKSLFLNGNDIEKLTPGMFRG 478
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
455-478 8.91e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 8.91e-03
                           10        20
                   ....*....|....*....|....
gi 974005336   455 LPNLKSLFLNGNDIEKLTPGMFRG 478
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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